Dose–response relationship between device-measured physical activity and incident type 2 diabetes: findings from the UK Biobank prospective cohort study
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Background: Most studies investigating the association between physical activity (PA) and the risk of type 2 diabetes are derived from self-reported questionnaires, with limited evidence using device-based measurements. Therefore, this study aimed to investigate the dose–response relationship between device-measured PA and incident type 2 diabetes. Methods: This prospective cohort study included 40,431 participants of the UK Biobank. Wrist-worn accelerometers were used to estimate total, light, moderate, vigorous and moderate-to-vigorous PA. The associations between PA and incident type 2 diabetes were analysed using Cox-proportional hazard models. The mediating role of body mass index (BMI) was tested under a causal counterfactual framework. Results: The median follow-up period was 6.3 years (IQR: 5.7–6.8), with 591 participants developing type 2 diabetes. Compared to those achieving < 150 min/week of moderate PA, people achieving 150–300, 300–600 and > 600 min/week were at 49% (95% CI 62–32%), 62% (95% CI 71–50%) and 71% (95% CI 80–59%) lower risk of type 2 diabetes, respectively. For vigorous PA, compared to those achieving < 25 min/week, individuals achieving 25–50, 50–75 and > 75 min/week were at 38% (95% CI 48–33%), 48% (95% CI 64–23%) and 64% (95% CI 78–42%) lower type 2 diabetes risk, respectively. Twelve per cent and 20% of the associations between vigorous and moderate PA and type 2 diabetes were mediated by lower BMI, respectively. Conclusions: PA has clear dose-response relationship with a lower risk of type 2 diabetes. Our findings support the current aerobic PA recommendations but suggest that additional PA beyond the recommendations is associated with even greater risk reduction. Trial registration: The UK Biobank study was approved by the North West Multi-Centre Research Ethics Committee (Ref 11/NW/0382 on June 17, 2011).
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The composite outcome, as defined by CDC 2021 standards, comprises elements each associated with reduced risk of progression to diabetes.
“The composite outcome, as defined by the CDC in its 2021 standards,29 comprises elements that have each been associated with reduced risk of progression to diabetes.30-34”
From An AI-Powered Lifestyle Intervention vs Human Coaching in the Diabetes Prevention Program: A Randomized Clinical Trial (2025) · cites this paper as [33]
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Research works printed but not linked: 1
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- Authors
- Boonpor, J., Parra-Soto, S., Petermann-Rocha, F., Lynskey, N., Cabanas-Sánchez, V., Sattar, N., Gill, J. M. R., Welsh, P., Pell, J. P., Gray, S. R., Ho, F. K., & Celis-Morales, C.
- Affiliations
- Kasetsart University (TH)
- University of Bío-Bío (CL)
- University of Glasgow (GB)
- Catholic University of the Maule (CL)
- Corresponding author
- Celis-Morales, Carlos
- ORCID
- Venue
- BMC Medicine
- Published
- 2023-05-24
- Volume
- 21
- Issue
- 1
- Pages
- 191-191
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC10210409
- OpenAlex
- W4378172650
- Cited by
- 31
- References
- 36
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 5
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- British Heart Foundation
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- physical activity, type 2 diabetes, dose-response relationship, accelerometry, wrist-worn accelerometers, high-intensity exercise, moderate physical activity, body mass index, mediation analysis, physical activity guidelines, UK Biobank
- MeSH terms
- Diabetes Mellitus, Type 2, United Kingdom, Humans, Prospective Studies, Exercise, Biological Specimen Banks
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