Determinants and impact of suboptimal asthma control in Europe: the international cross-sectional and longitudinal assessment on asthma control (LIAISON) study
Open accessAbstract
BACKGROUND: According to the Global Initiative of Asthma, the aim of asthma treatment is to gain and maintain control. In the INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study, we evaluated the level of asthma control and quality of life (QoL), as well as their determinants and impact in a population consulting specialist settings. METHODS: LIAISON is a prospective, multicentre, observational study with a cross-sectional and a 12-month longitudinal phase. Adults with an asthma diagnosis since at least 6 months, receiving the same asthma treatment in the 4 weeks before enrolment were included. Asthma control was assessed with the 6-item Asthma Control Questionnaire (ACQ) and QoL with the MiniAsthma Quality of Life Questionnaire (MiniAQLQ). RESULTS: Overall, 8111 asthmatic patients were enrolled in 12 European countries. Asthma control was suboptimal in 56.5 % of patients and it was associated with poorer asthma-related QoL, higher risk of exacerbations and greater consumption of healthcare resources. Variables associated with suboptimal control were age, gender, obesity, smoking and comorbidities. Major determinants of poor asthma control were seasonal worsening and persisting exposure to allergens/irritants/triggers, followed by treatment-related issues. CONCLUSIONS: The cross-sectional phase results confirm that suboptimal control is frequent and has a high individual and economic impact. TRIAL REGISTRATION: The clinicaltrials.gov identifier is NCT01567280 .
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A diagnosis of asthma and a comorbid anxiety disorder increase the risk for poor asthma control, impaired quality of life, and increased health care utilization.
“A diagnosis of asthma and a comorbid anxiety disorder increase the risk for poor asthma control, impaired quality of life as well as increased health care utilization (Braido et al., 2016; Strine et al., 2008).”
From Targeting excessive avoidance behavior to reduce anxiety related to asthma: A feasibility study of an exposure-based treatment delivered online (2021) · cites this paper as Braido et al., 2016
The Results (‘Asthma control and quality of life,’ Tables 2–3; page unavailable) associate psychological disturbances with poorer asthma control and quality of life. The Discussion (‘Impact of poor asthma control’; page unavailable) links poor control with greater healthcare resource use. The paper does not establish these outcomes specifically for a comorbid anxiety disorder, or show that anxiety causes increased healthcare use. (LLM, conf=0.86)
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Nonallergic Triggers and Comorbidities in Asthma Exacerbations and Disease Severity
Ioachimescu, O. C., & Desai, N. S. (2018) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2018.10.005 · Cited by 11 · see citing works
Main Contributory Factors on Asthma Control and Health-Related Quality of Life in Elderly Asthmatics
Enriquez, A. S. R., Fernández-Rodríguez, C., Andres, E. M., & Fernández-Crespo, J. (2019) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0430 · Cited by 11 · see citing works
Healthy diet associated with better asthma outcomes in elderly women of the French Asthma-E3N study
Ait‐hadad, W., Bédard, A., Chanoine, S., Dumas, O., Laouali, N., Moual, N. L., Leynaert, B., MacDonald, C. J., Siroux, V., Boutron‐Ruault, M., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02815-0 · Cited by 11 · see citing works
Dias, A., Santos, I. C. L., Delphim, L., Fernandes, G., Endlich, L. R., Cafasso, M. O. S. D., Maranhão, A. L., da Silva, S. R., de Andrade, R. M., Agrawal, A., et al. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.06.001 · Cited by 11 · see citing works
Fujiki, R., Kawayama, T., Furukawa, K., Kinoshita, T., Matsunaga, K., & Hoshino, T. (2023) · Journal of Asthma and Allergy · doi:10.2147/jaa.s401505 · Cited by 10 · see citing works
Prevalence and burden of asthma in five European countries: a retrospective cross-sectional study
Khan, A. H., Gouia, I., Jacob-Nara, J. A., Kamat, S., Jaffe, D. H., Mackie, D. S., Balkaran, B. L., & Wisnivesky, J. P. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-085175 · Cited by 11 · see citing works
Small airway disease and asthma control
Sağmen, S. B., Eraslan, B. Z., Demirer, E., Kıral, N., & Cömert, S. Ş. (2023) · Journal of Asthma · doi:10.1080/02770903.2023.2185894 · Cited by 10 · see citing works
The influence of self-assessment of asthma control on the Asthma Control Test outcome
Przybyszowski, M., Stachura, T., Szafraniec, K., Sładek, K., & Bochenek, G. (2019) · Journal of Asthma · doi:10.1080/02770903.2019.1708098 · Cited by 10 · see citing works
Almonacid, C., Moreno, C. M., Gancedo, S. Q., Sánchez-Herrero, M. G., Gutiérrez, F. J. Á., Conejero, D. B., Cardona, V., & Soriano, J. B. (2020) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0483 · Cited by 10 · see citing works
Kiljander, T. O., Poussa, T. A., Helin, T., Jaakkola, A., Venho, K., & Lehtimäki, L. A. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-1127-9 · Cited by 10 · see citing works
Tsegaye, T., Gebretekle, G. B., Ahmed, M. H., Bayisa, T., & Habte, B. M. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s373479 · Cited by 9 · see citing works
Fatal Anaphylactic Shock Induced by Intravenous Gelatin Colloid: A Postmortem Allergological Work-up
Molina-Molina, G.-J., Carrasco-González, M., Viñas-Giménez, L., Sanz-Martínez, M. T., Galvan‐Blasco, P., Luengo, O., Guilarte, M., Sala-Cunill, A., Cardona, V., & Labrador‐Horrillo, M. (2019) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0459 · Cited by 8 · see citing works
Toh, M. R., Ng, G. X. Z., Goel, I., Lam, S. W., Wu, J. T., Lee, C. F., Ong, M. E. H., Matchar, D. B., Tan, N. C., Loo, C. M., et al. (2024) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-024-00391-w · Cited by 8 · see citing works
Relationship of Nutritional Status and Spirometric Parameters in Children with Bronchial Asthma
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Belachew, E. A., Tadess, S., Alemayehu, M., & Ayele, E. M. (2022) · Asthma Research and Practice · doi:10.1186/s40733-022-00087-3 · Cited by 8 · see citing works
Nationwide pulmonary function test rates in South Korean asthma patients
Choi, J. Y., Yoon, H. K., Lee, J. H., Yoo, K. H., Kim, B., Bae, H. W., Kim, Y. K., & Rhee, C. K. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.06.109 · Cited by 8 · see citing works
Multi-Factor Analysis of Single-Center Asthma Control in Xiamen, China
Zhu, Y., Zhong, T., Ge, D., Li, Q., & Wu, J. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00498 · Cited by 8 · see citing works
Latorre, M., Rizzi, A., Paggiaro, P., Baiardini, I., Bagnasco, D., Giacco, S. D., Lombardi, C., Patella, V., Nucera, E., Parente, R., et al. (2024) · Journal of Asthma · doi:10.1080/02770903.2024.2338863 · Cited by 7 · see citing works
Eliseeva, T. I., Geppe, N. A., Ignatov, S. K., Келдибековна, С. С., Tush, Е. V., Khaletskaya, О. V., Потемина, Т. Е., Malakhov, A. B., Kubysheva, N. I., & Solovyov, V. A. (2017) · Современные технологии в медицине · doi:10.17691/stm2017.9.1.18 · Cited by 7 · see citing works
Loerbroks, A., Bosch, J. A., Sheikh, A., Yamamoto, S. S., & Herr, R. M. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.12.008 · Cited by 8 · see citing works
Prostaglandin D 2 receptor antagonism: a novel therapeutic option for eosinophilic asthma?
Brusselle, G., Provoost, S., & Maes, T. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)30201-6 · Cited by 7 · see citing works
Verhamme, K. M. C., Lucet, C., MEERHAEGHE, A. V., Brusselle, G., & Lambert, M. (2019) · ERJ Open Research · doi:10.1183/23120541.00253-2018 · Cited by 7 · see citing works
Determinants associated with uncontrolled asthma in Portugal: A national population-based study
Camarinha, C., Fernandes, M., Alarcão, V., Franco, J., Manaças, M. E., Bárbara, C., & Nicola, P. (2020) · Pulmonology · doi:10.1016/j.pulmoe.2020.02.014 · Cited by 6 · see citing works
Kellerer, C., Schultz, K., Linde, K., Köhler, B., Hapfelmeier, A., & Schneider, A. (2022) · Journal of Asthma · doi:10.1080/02770903.2022.2040027 · Cited by 6 · see citing works
Lartey, S. T., Lung, T. W.-C., Serhal, S., Bereznicki, L., Bereznicki, B. J., Emmerton, L., Bosnic-Anticevich, S. Z., Saini, B., Billot, L., Krass, I., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0279748 · Cited by 7 · see citing works
da Rocha, C. B., Nascimento, A. P. C., da Silva, A. M. C., & Botelho, C. F. (2021) · Cadernos de Saúde Pública · doi:10.1590/0102-311x00072220 · Cited by 6 · see citing works
Rhinitis and Asthma Patient Perspective (RAPP): Clinical Utility and Predictive Value
Baiardini, I., Fasola, S., Grutta, S. L., Trucco, E., Canonica, G. W., & Braido, F. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.10.025 · Cited by 6 · see citing works
Treatable Traits in Pregnant Women with Asthma
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Przybyszowski, M., Piliński, R., Śliwka, A., Polczyk, R., Nowobilski, R., Sładek, K., & Bochenek, G. (2020) · Journal of Asthma · doi:10.1080/02770903.2020.1841791 · Cited by 5 · see citing works
Beerthuizen, T., Rikkers-Mutsaerts, E. R. V. M., Snoeck-Stroband, J. B., & Sont, J. K. (2021) · JMIR Pediatrics and Parenting · doi:10.2196/17959 · Cited by 5 · see citing works
Variables associated with asthma control among adult patients
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Effect of educational intervention on quality of life of asthma patients: A systematic review
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Lual, K. P., & Yizengaw, M. A. (2021) · The Open Respiratory Medicine Journal · doi:10.2174/1874306402115010035 · Cited by 5 · see citing works
Type 2 Inflammation and the Evolving Profile of Uncontrolled Persistent Asthma
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Particularité des patients asthmatiques au Sahara : exemple de la région de Guelmim Oued Noun, Maroc
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The Role of Spirometry and MMEF in Pediatric Asthma Monitoring and Prediction of Exacerbations
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Association between asthma control and healthcare costs: Results from a German linked data study
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Impact of asthma control on quality of life in an outpatient setting in Brazil
Lourenco, C. B., Martins, F. C., Fiss, E., & Grumach, A. S. (2022) · Journal of Asthma · doi:10.1080/02770903.2022.2097092 · Cited by 4 · see citing works
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Validity and Reliability of the Assessment Tool for Asthma (ATA) Questionnaire: the ATA Study
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The evidence on tiotropium bromide in asthma: from the rationale to the bedside
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- Authors
- on behalf of the LIAISON Study Group, Braido, F., Brusselle, G., Guastalla, D., Ingrassia, E., Nicolini, G., Price, D., Roche, N., Soriano, J. B., & Worth, H.
- Affiliations
- Ospedale Policlinico San Martino (IT)
- Ghent University Hospital (BE)
- Chiesi (Italy) (IT)
- University of Aberdeen (GB)
- Hospital Universitario de La Princesa (ES)
- Corresponding author
- Ingrassia, Eleonora
- Venue
- Respiratory Research
- Published
- 2016-05-14
- Volume
- 17
- Issue
- 1
- Pages
- 51-51
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- PMC
- PMC4894377
- OpenAlex
- W2360510406
- Cited by
- 152
- References
- 22
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 11 · 2023: 13 · 2022: 19 · 2021: 21 · 2020: 19 · 2019: 21 · 2018: 14 · 2017: 9 · 2016: 2
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Respiratory Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion)
- Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (acceptedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- Biblos-e Archivo (Universidad Autónoma de Madrid) (submittedVersion, public-domain)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Hispana (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Chiesi Farmaceutici
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- asthma control, asthma quality of life, asthma exacerbations, healthcare resource utilization, Asthma Control Questionnaire, smoking, obesity, comorbidities
- MeSH terms
- Adult, Age Factors, Aged, Asthma, Cross-Sectional Studies, Europe, Female, Health Resources, Humans, Longitudinal Studies, Lung, Male, Middle Aged, Obesity, Prospective Studies, Quality of Life, Surveys and Questionnaires, Risk Factors, Seasons, Sex Factors, Smoking, Time Factors, Comorbidity, Drug Costs, Treatment Outcome, Disease Progression, Anti-Asthmatic Agents, Medication Adherence
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