The smell of lung disease: a review of the current status of electronic nose technology
Open accessAbstract
There is a need for timely, accurate diagnosis, and personalised management in lung diseases. Exhaled breath reflects inflammatory and metabolic processes in the human body, especially in the lungs. The analysis of exhaled breath using electronic nose (eNose) technology has gained increasing attention in the past years. This technique has great potential to be used in clinical practice as a real-time non-invasive diagnostic tool, and for monitoring disease course and therapeutic effects. To date, multiple eNoses have been developed and evaluated in clinical studies across a wide spectrum of lung diseases, mainly for diagnostic purposes. Heterogeneity in study design, analysis techniques, and differences between eNose devices currently hamper generalization and comparison of study results. Moreover, many pilot studies have been performed, while validation and implementation studies are scarce. These studies are needed before implementation in clinical practice can be realised. This review summarises the technical aspects of available eNose devices and the available evidence for clinical application of eNose technology in different lung diseases. Furthermore, recommendations for future research to pave the way for clinical implementation of eNose technology are provided.
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Several cohort studies using different eNose devices have shown that breathprints differed significantly between patients with ILD and healthy controls (100% accuracy), IPF and healthy controls (98.5% accuracy) and IPF and non-IPF ILD (91% accuracy).
“Several cohort studies using different eNose devices have shown that breathprints differed significantly between patients with ILD and healthy controls (100% accuracy), IPF and healthy controls (98.5% accuracy) and IPF and non-IPF ILD (91% accuracy) (Ibrahim et al., 2021; van der Sar et al., 2021).”
From Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies (2023) · cites this paper as van der Sar et al., 2021
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- Authors
- van der Sar, I. G., Wijbenga, N., Nakshbandi, G., Aerts, J. G. J. V., Manintveld, O. C., Wijsenbeek, M. S., Hellemons, M. E., & Moor, C. C.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Moor, C. C.
- Venue
- Respiratory Research
- Published
- 2021-09-17
- Volume
- 22
- Issue
- 1
- Pages
- 246-246
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- PMC
- PMC8448171
- OpenAlex
- W3201380385
- Cited by
- 87
- References
- 116
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 25 · 2023: 26 · 2022: 7 · 2021: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Respiratory Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Odor and Emission Control Technologies
- Physical Sciences › Chemistry › Spectroscopy › Spectroscopy and Laser Applications
- Keywords
- electronic nose, breath analysis, lung disease, non-invasive diagnosis, breath biomarkers, clinical validation, disease surveillance, clinical implementation
- MeSH terms
- Machine Learning, Humans, Lung Diseases, Smell, Exhalation, Precision Medicine, Electronic Nose
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