Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies

Inflammation as a risk factor for atrial fibrillation

Aviles, R. J., Martin, D. O., Apperson-Hansen, C., Houghtaling, P. L., Rautaharju, P., Kronmal, R. A., Tracy, R. P., Van Wagoner, D. R., Psaty, B. M., Lauer, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103131.70301.4f · Cited by 1,425 · see citing works

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

Schotten, U., Verheule, S., Kirchhof, P., & Goette, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2009 · Cited by 1,273 · see citing works

Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation

Nattel, S., Maguy, A., Bouter, S. L., & Yeh, Y. (2007) · Physiological Reviews · doi:10.1152/physrev.00014.2006 · Cited by 857 · see citing works

Recent advances in the molecular pathophysiology of atrial fibrillation

Wakili, R., Voigt, N., Kääb, S., Dobrev, D., & Nattel, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46315 · Cited by 543 · see citing works

Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells

Isoda, K., Young, J. L., Zirlik, A., MacFarlane, L. A., Tsuboi, N., Gerdes, N., Schönbeck, U., & Libby, P. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000201938.78044.75 · Cited by 499 · see citing works

Metabolic Syndrome and Risk of Development of Atrial Fibrillation: The Niigata Preventive Medicine Study

Watanabe, H., Tanabe, N., Watanabe, T., Darbar, D., Roden, D. M., Sasaki, S., & Aizawa, Y. (2008) · Circulation · doi:10.1161/circulationaha.107.744466 · Cited by 427 · see citing works

Relationship between C-reactive protein concentrations during glucocorticoid therapy and recurrent atrial fibrillation

Dernellis, J. M. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.04.025 · Cited by 290 · see citing works

Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase

Park, C. S., Bang, B., Kwon, H., Moon, K., Kim, T., Lee, K., Moon, H., & Cho, Y. S. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.09.025 · Cited by 208 · see citing works

Metabolic syndrome and incidence of atrial fibrillation among blacks and whites in the Atherosclerosis Risk in Communities (ARIC) Study

Chamberlain, A. M., Agarwal, S. K., Ambrose, M., Folsom, A. R., Soliman, E. Z., & Alonso, Á. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.02.005 · Cited by 190 · see citing works

Atrial cardiomyocyte tachycardia alters cardiac fibroblast function: A novel consideration in atrial remodeling☆

Burstein, B., Qi, X., Yeh, Y., Calderone, A., & Nattel, S. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.07.013 · Cited by 152 · see citing works

Metformin Attenuates the Exacerbation of the Allergic Eosinophilic Inflammation in High Fat-Diet-Induced Obesity in Mice

Calixto, M. C., Lintomen, L., André, D. M., Leiria, L. O., Ferreira, D. D. S., Lellis‐Santos, C., Anhê, G. F., Bordin, S. A., Landgraf, R. G., & Antunes, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076786 · Cited by 150 · see citing works

Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7‐year follow‐up study

Lin, C.-H., & Sheu, W. H. (2012) · Journal of Internal Medicine · doi:10.1111/joim.12000 · Cited by 149 · see citing works

Effect of C-reactive protein reduction on paroxysmal atrial fibrillation

Dernellis, J. M., & Panaretou, M. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.06.032 · Cited by 119 · see citing works

Thiazolidinediones as anti‐inflammatory and anti‐atherogenic agents

Ceriello, A. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.790 · Cited by 109 · see citing works

Metformin, an Antidiabetic Agent, Suppresses the Production of Tumor Necrosis Factor and Tissue Factor by Inhibiting Early Growth Response Factor-1 Expression in Human Monocytes in Vitro

Arai, M., Uchiba, M., Komura, H., Mizuochi, Y., Harada, N., & Okajima, K. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.164970 · Cited by 107 · see citing works

Thiazolidinediones can prevent new onset atrial fibrillation in patients with non-insulin dependent diabetes

Chao, T., Leu, H., Huang, C., Chen, J., Chan, W., Lin, S., & Chen, S.-A. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.08.081 · Cited by 102 · see citing works

The effects of rosiglitazone and metformin on inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus

Fidan, E., Ersöz, H. Ö., Yılmaz, M., Yilmaz, H., Koçak, M., Karahan, C., & Erem, C. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0276-y · Cited by 102 · see citing works

Time trend analysis of the prevalence and incidence of diagnosed type 2 diabetes among adults in Taiwan from 2000 to 2007: a population-based study

Lin, C., Li, C.-I., Hsiao, C.-Y., Liu, C. S., Yang, S.-Y., Lee, C. C., & Li, T.-C. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-318 · Cited by 101 · see citing works

Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation

Yeh, Y., Kuo, C.-T., Lee, Y.-S., Lin, Y., Nattel, S., Tsai, F., & Chen, W.-J. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.11.013 · Cited by 83 · see citing works

The combined effect of metformin and l-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats

Salman, Z. K., Refaat, R., Selima, E., Sarha, A. E., & Ismail, M. A. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.07.002 · Cited by 77 · see citing works

Association of the Metabolic Syndrome With Atrial Fibrillation Among United States Adults (from the REasons for Geographic and Racial Differences in Stroke [REGARDS] Study)

Tanner, R. M., Baber, U., Carson, A. P., Voeks, J. H., Brown, T. M., Soliman, E. Z., Howard, V. J., & Muntner, P. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.03.026 · Cited by 76 · see citing works

Transforming growth factor-β and oxidative stress mediate tachycardia-induced cellular remodelling in cultured atrial-derived myocytes

Yeh, Y., Kuo, C.-T., Chan, T.-H., Chang, G., Qi, X., Tsai, F., Nattel, S., & Chen, W.-J. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr041 · Cited by 70 · see citing works

Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis

Koufany, M., Moulin, D., Bianchi, A., Muresan, M., Sébillaud, S., Netter, P., Weryha, G., & Jouzeau, J. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2354 · Cited by 67 · see citing works

Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection

Buckingham, R. E. (2005) · Hepatology Research · doi:10.1016/j.hepres.2005.09.027 · Cited by 62 · see citing works

Mechanism of the Anti-Inflammatory Effect of Thiazolidinediones: Relationship with the Glucocorticoid Pathway

Ialenti, A., Grassia, G., Meglio, P. D., Maffia, P., Rosa, M. D., & Ianaro, A. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.004895 · Cited by 61 · see citing works

Impact of the Metabolic Syndrome on Atrial Size in Patients With New-Onset Atrial Fibrillation

Nicolaou, V. N., Papadakis, J. E., Karatzis, E. N., Dermitzaki, S. I., Tsakiris, A. K., & Skoufas, P. D. (2007) · Angiology · doi:10.1177/0003319706297913 · Cited by 50 · see citing works

Use of Thiazolidinediones and the Risk of Colorectal Cancer in Patients With Diabetes

Chen, S.-W., Tsan, Y.-T., Chen, J.-D., Hsieh, H.-I., Lee, C.-H., Lin, H.-H., Wang, J.-D., Chen, P.-C., & Health Data Analysis in Taiwan Research Group (2013) · Diabetes Care · doi:10.2337/dc11-2197 · Cited by 37 · see citing works

Comparative Effects of Glibenclamide and Metformin on C-Reactive Protein and Oxidant - Antioxidant Status in Patients with Type II Diabetes Mellitus

Abdulkadir, A. A. A., & Thanoon, I. A. J. (2012) · Sultan Qaboos University medical journal · doi:10.12816/0003088 · Cited by 29 · see citing works

Effects of a vildagliptin/metformin combination on markers of atherosclerosis, thrombosis, and inflammation in diabetic patients with coronary artery disease

Klempfner, R., Leor, J., Tenenbaum, A., Fisman, E. Z., & Goldenberg, I. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-60 · Cited by 28 · see citing works

Risk for atrial fibrillation in patients with hypertrophic cardiomyopathy: Association with insulin resistance

Shigematsu, Y., Hamada, M., Nagai, T., Nishimura, K., Inoue, K., Suzuki, J., Ogimoto, A., & Higaki, J. (2011) · Journal of Cardiology · doi:10.1016/j.jjcc.2011.03.001 · Cited by 28 · see citing works

Blockade of reactive oxygen species and Akt activation is critical for anti-inflammation and growth inhibition of metformin in phosphatase and tensin homolog-deficient RAW264.7 cells

Lin, C., Young, K.-C., Bai, C., Yu, B., Ma, C.-T., Chien, Y.-C., Su, H., Wang, H., Liao, C., Lai, H.-W., et al. (2013) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2013.837059 · Cited by 19 · see citing works

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS).

Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J., Blomström-Lundqvist, C., Boriani, G., Castellá, M., Dan, G., Dilaveris, P. E., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 2,605 · see citing works

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works

2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Gelder, I. C. V., Rienstra, M., Bunting, K. V., Casado-Arroyo, R., Caso, V., Crijns, H. J. G. M., Potter, T. J. R. D., Dwight, J., Guasti, L., Hanke, T., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae176 · Cited by 3,338 · see citing works

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works

The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society Comprehensive Guidelines for the Management of Atrial Fibrillation

Andrade, J. G., Aguilar, M., Atzema, C. L., Bell, A., Cairns, J. A., Cheung, C. C., Cox, J. L., Dorian, P., Gladstone, D. J., Healey, J. S., et al. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.09.001 · Cited by 568 · see citing works

Lifestyle and Risk Factor Modification for Reduction of Atrial Fibrillation: A Scientific Statement From the American Heart Association

Chung, M. K., Eckhardt, L. L., Chen, L. Y., Ahmed, H. M., Gopinathannair, R., Joglar, J. A., Noseworthy, P. A., Pack, Q. R., Sanders, P., & Trulock, K. M. (2020) · Circulation · doi:10.1161/cir.0000000000000748 · Cited by 549 · see citing works

Atrial Fibrillation and Diabetes Mellitus

Wang, A., Green, J. B., Halperin, J. L., & Piccini, J. P. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.07.020 · Cited by 403 · see citing works

Epidemiology and modifiable risk factors for atrial fibrillation

Elliott, A. D., Middeldorp, M. E., Gelder, I. C. V., Albert, C. M., & Sanders, P. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00820-8 · Cited by 380 · see citing works

2020 Clinical guidelines for Atrial fibrillation and atrial flutter

Arakelyan, M. S., Bockeria, L. A., Vasilieva, E., Sp, G., Golukhova, E. Z., Gorev, M. V., Davtyan, K. V., Drapkina, O. M., Станиславовна, К. Е., Kuchinskaya, Е. А., et al. (2021) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2021-4594 · Cited by 255 · see citing works

The Increasing Role of Rhythm Control in Patients With Atrial Fibrillation

Camm, A. J., Naccarelli, G. V., Mittal, S., Crijns, H. J. G. M., Hohnloser, S. H., Ma, C., Natale, A., Turakhia, M. P., & Kirchhof, P. F. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.03.337 · Cited by 210 · see citing works

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

Heijman, J., Algalarrondo, V., Voigt, N., Melka, J., Wehrens, X. H. T., Dobrev, D., & Nattel, S. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv275 · Cited by 198 · see citing works

Atrial fibrillation and its arrhythmogenesis associated with insulin resistance

Chan, Y., Chang, G., Lai, Y., Chen, W.-J., Chang, S., Hung, L., Kuo, C.-T., & Yeh, Y. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0928-8 · Cited by 175 · see citing works

Atrial fibrillation and stroke prevention: 25 years of research at EP Europace journal

Lip, G. Y. H., Proietti, M., Potpara, T., MANSOUR, M. C., Savelieva, I., Tse, H., Goette, A., Camm, A. J., Blomström‐Lundqvist, C., Gupta, D., et al. (2023) · EP Europace · doi:10.1093/europace/euad226 · Cited by 171 · see citing works

Risk Factor Management in Atrial Fibrillation

Brandes, A., Smit, M. D., Nguyen, B. O., Rienstra, M., & Gelder, I. C. V. (2018) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2018.18.2 · Cited by 155 · see citing works

Diabetes and Arrhythmias: Pathophysiology, Mechanisms and Therapeutic Outcomes

Grisanti, L. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01669 · Cited by 157 · see citing works

Atrial fibrillation and type 2 diabetes: Prevalence, etiology, pathophysiology and effect of anti‐diabetic therapies

Bell, D. S. H., & Gonçalves, E. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13512 · Cited by 139 · see citing works

Cardiac Arrhythmias in Autoimmune Diseases

Gawalko, M. M., Balsam, P., Lodziński, P., Grabowski, M., Krzowski, B., Opolski, G., & Kosiuk, J. (2020) · Circulation Journal · doi:10.1253/circj.cj-19-0705 · Cited by 134 · see citing works

Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies

Goudis, C. A., Korantzopoulos, P. G., Ntalas, I. V., Kallergis, E. M., Liu, T., & Ketikoglou, D. G. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.052 · Cited by 132 · see citing works

European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS)

Görenek, B., Pelliccia, A., Benjamin, E. J., Boriani, G., Crijns, H. J. G. M., Fogel, R. I., Gelder, I. C. V., Halle, M., Kudaiberdieva, G., Lane, D. A., et al. (2016) · EP Europace · doi:10.1093/europace/euw242 · Cited by 128 · see citing works

Management of Atrial Fibrillation in Patients 75 Years and Older

Volgman, A. S., Nair, G. G., Lyubarova, R., Merchant, F. M., Mason, P. K., Curtis, A. B., WENGER, N. K., Aggarwal, N. T., Kirkpatrick, J. N., & Benjamin, E. J. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.10.037 · Cited by 124 · see citing works

Atrial fibrillation and coronary artery disease: An integrative review focusing on therapeutic implications of this relationship

Batta, A., Hatwal, J., Batta, A., Verma, S., & Sharma, Y. P. (2023) · World Journal of Cardiology · doi:10.4330/wjc.v15.i5.229 · Cited by 116 · see citing works

Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK ‐dependent mechanisms

Bu, Y., Peng, M., Tang, X., Xu, X., Wu, Y., Chen, A. F., & Yang, X. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17519 · Cited by 109 · see citing works

European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS)

Görenek, B., Pelliccia, A., Benjamin, E. J., Boriani, G., Crijns, H. J. G. M., Fogel, R. I., Gelder, I. C. V., Halle, M., Kudaiberdieva, G., Lane, D. A., et al. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316676037 · Cited by 103 · see citing works

The association between SGLT2 inhibitors and new-onset arrhythmias: a nationwide population-based longitudinal cohort study

Chen, H.-Y., Huang, J., Siao, W.-Z., & Jong, G. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01048-x · Cited by 102 · see citing works

Atrial fibrillation: comorbidities, lifestyle, and patient factors

Shantsila, E., Choi, E., Lane, D. A., Joung, B., & Lip, G. Y. H. (2024) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2023.100784 · Cited by 104 · see citing works

Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications

Bode, D., Pronto, J. R. D., Schiattarella, G. G., & Voigt, N. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01038-6 · Cited by 95 · see citing works

Metabolic Considerations in Atrial Fibrillation ― Mechanistic Insights and Therapeutic Opportunities ―

Harada, M., Melka, J., Sobue, Y., & Nattel, S. (2017) · Circulation Journal · doi:10.1253/circj.cj-17-1058 · Cited by 85 · see citing works

Antihyperglycemic drugs use and new-onset atrial fibrillation: a population-based nested case control study

Liou, Y.-S., Yang, F.-Y., Chen, H.-Y., & Jong, G.-P. (2018) · PLOS ONE · doi:10.1371/journal.pone.0197245 · Cited by 75 · see citing works

Heart failure with preserved ejection fraction based on aging and comorbidities

Lin, Y. H., Fu, S., Yao, Y., Li, Y., Zhao, Y., & Luo, L. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02935-x · Cited by 78 · see citing works

2021 ISHNE/HRS/EHRA/APHRS Expert Collaborative Statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals: From the International Society for Holter and Noninvasive Electrocardiology/Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society

Varma, N., Cygankiewicz, I., Turakhia, M. P., Heidbuchel, H., Hu, Y.-F., Chen, L. Y., Couderc, J.-P., Cronin, E. M., Estep, J. D., Grieten, L., et al. (2021) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.120.009204 · Cited by 74 · see citing works

Risks of cardiovascular diseases associated with dipeptidyl peptidase-4 inhibitors and other antidiabetic drugs in patients with type 2 diabetes: a nation-wide longitudinal study

Ou, H., Chang, K., Li, C., & Wu, J. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0350-4 · Cited by 71 · see citing works

Dipeptidyl peptidase-4 inhibitor decreases the risk of atrial fibrillation in patients with type 2 diabetes: a nationwide cohort study in Taiwan

Chang, C., Yeh, Y., Chan, Y., Liu, J., Chang, S., Lee, H., Wu, L., Yen, K., Kuo, C.-T., & See, L. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0640-5 · Cited by 71 · see citing works

Atrial Fibrillation, Type 2 Diabetes, and Non–Vitamin K Antagonist Oral Anticoagulants

Plitt, A., McGuire, D. K., & Giugliano, R. P. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2016.5224 · Cited by 69 · see citing works

The risk of new-onset atrial fibrillation in patients with type 2 diabetes mellitus treated with sodium glucose cotransporter 2 inhibitors versus dipeptidyl peptidase-4 inhibitors

Ling, A. W.-C., Chan, C.-C., Chen, S., Kao, Y., Huang, C.-Y., Chan, Y., & Chu, P. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01162-w · Cited by 69 · see citing works

Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway

Bai, F., Liu, Y., Tu, T., Li, B., Xiao, Y., Ma, Y., Qin, F., Xie, J., Zhou, S., & Liu, Q. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1059-7 · Cited by 66 · see citing works

Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction in Patients With Nonalcoholic Fatty Liver Disease

Packer, M. (2019) · The American Journal of Medicine · doi:10.1016/j.amjmed.2019.09.002 · Cited by 65 · see citing works

Digital Health in Older Adults for the Prevention and Management of Cardiovascular Diseases and Frailty. A Clinical Consensus Statement from the ESC Council for Cardiology Practice/Taskforce on Geriatric Cardiology, the ESC Digital Health Committee and the ESC Working Group on e-Cardiology

Guasti, L., Dilaveris, P., Mamas, M. A., Richter, D. J., Christodorescu, R., Lumens, J., Schuuring, M. J., Carugo, S., Afilalo, J., Ferrini, M., et al. (2022) · ESC Heart Failure · doi:10.1002/ehf2.14022 · Cited by 66 · see citing works

Drugs That Ameliorate Epicardial Adipose Tissue Inflammation May Have Discordant Effects in Heart Failure With a Preserved Ejection Fraction as Compared With a Reduced Ejection Fraction

Packer, M. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.09.002 · Cited by 65 · see citing works

Metformin regulates adiponectin signalling in epicardial adipose tissue and reduces atrial fibrillation vulnerability

Li, B., Po, S. S., Zhang, B., Bai, F., Li, J., Qin, F., Liu, N., Sun, C., Xiao, Y., Tu, T., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15407 · Cited by 63 · see citing works

Effect of metformin monotherapy on cardiovascular diseases and mortality: a retrospective cohort study on Chinese type 2 diabetes mellitus patients

Fung, C. S. C., Wan, E. Y. F., Wong, C. K. H., Jiao, F., & Chan, A. K. C. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0304-2 · Cited by 62 · see citing works

Do Most Patients with Obesity or Type 2 Diabetes, and Atrial Fibrillation, Also have Undiagnosed Heart Failure? A Critical Conceptual Framework for Understanding Mechanisms and Improving Diagnosis and Treatment

Packer, M. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1646 · Cited by 63 · see citing works

Antithrombotic therapy in diabetes: which, when, and for how long?

Ajjan, R., Kietsiriroje, N., Badimón, L., Vilahur, G., Gorog, D. A., Angiolillo, D. J., Russell, D., Rocca, B., & Storey, R. F. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab128 · Cited by 62 · see citing works

Body weight and risk of atrial fibrillation in 7,169 patients with newly diagnosed type 2 diabetes; an observational study

Grundvold, I., Bodegård, J., Nilsson, P. M., Svennblad, B., Johansson, G., Östgren, C. J., & Sundström, J. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0170-3 · Cited by 61 · see citing works

Clinical Overview of Obesity and Diabetes Mellitus as Risk Factors for Atrial Fibrillation and Sudden Cardiac Death

Homan, E. A., Reyes, M. V., Hickey, K. T., & Morrow, J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01847 · Cited by 61 · see citing works

The National Consensus statement on the management of adult patients with non-alcoholic fatty liver disease and main comorbidities

Maevskaya, M. V., Kotovskaya, Y. V., Ivashkin, V. T., Ткачева, О. Н., Troshina, E. A., Shestakova, M. V., Breder, V. V., Geyvandova, N. I., Doshchitsin, V. L., Dudinskaya, Е. N., et al. (2022) · Terapevticheskii arkhiv · doi:10.26442/00403660.2022.02.201363 · Cited by 65 · see citing works

METFORMIN: NONGLYCEMIC EFFECTS AND POTENTIAL NOVEL INDICATIONS.

Anabtawi, A., & Miles, J. (2016) · Endocrine Practice · doi:10.4158/ep151145.ra · Cited by 51 · see citing works

Is diabetes a hypercoagulable state? A critical appraisal

Pomero, F., Minno, M. N. D. D., Fenoglio, L. M., Gianni, M., Ageno, W., & Dentali, F. (2015) · Acta Diabetologica · doi:10.1007/s00592-015-0746-8 · Cited by 57 · see citing works

Metformin Is Associated With a Lower Risk of Atrial Fibrillation and Ventricular Arrhythmias Compared With Sulfonylureas

Ostropolets, A., Elias, P. A., Reyes, M. V., Wan, E. Y., Pajvani, U. B., Hripcsak, G. M., & Morrow, J. (2021) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.120.009115 · Cited by 57 · see citing works

Autophagy was involved in the protective effect of metformin on hyperglycemia-induced cardiomyocyte apoptosis and connexin43 downregulation in H9c2 cells

Wang, G.-Y., Bi, Y.-G., Liu, X.-D., Zhao, Y., Han, J.-F., Wei, M., & Zhang, Q.-Y. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.19800 · Cited by 53 · see citing works

Disease–treatment interactions in the management of patients with obesity and diabetes who have atrial fibrillation: the potential mediating influence of epicardial adipose tissue

Packer, M. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0927-9 · Cited by 52 · see citing works

Transcriptomics-Based Network Medicine Discovery and Population-Based Validation Identifies Metformin as a Candidate Drug for Atrial Fibrillation

Lal, J. C., Mao, C., Zhou, Y., Gore-Panter, S. R., Rennison, J. H., Lovano, B. S., Castel, L., Shin, J., Gillinov, A. M., Smith, J. D., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100749 · Cited by 47 · see citing works

2021 ISHNE/ HRS/ EHRA/ APHRS collaborative statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals

Varma, N., Cygankiewicz, I., Turakhia, M. P., Heidbüchel, H., Hu, Y., Chen, L. Y., Couderc, J., Cronin, E. M., Estep, J. D., Grieten, L., et al. (2021) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12795 · Cited by 50 · see citing works

Treatment of type 2 diabetes patients with heart conditions

Aktaş, G., Tel, B. M. A., Tel, M. R., & Balci, B. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2204941 · Cited by 48 · see citing works

Management of atrial fibrillation: two decades of progress — a scientific statement from the European Cardiac Arrhythmia Society

Lévy, S., Steinbeck, G., Santini, L., Näbauer, M., Penela, D., Kantharia, B. K., Saksena, S. V., & Cappato, R. (2022) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-022-01195-z · Cited by 50 · see citing works

The risk of incident atrial fibrillation in patients with type 2 diabetes treated with sodium glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase-4 inhibitors: a nationwide cohort study

Chan, Y., Chao, T., Chen, S., Lee, H., Li, P., Chen, W.-M., Yeh, Y., Kuo, C.-T., See, L., & Lip, G. Y. H. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01549-x · Cited by 46 · see citing works

Left Atrial Myopathy in Atrial Fibrillation and Heart Failure: Clinical Implications, Mechanisms, and Therapeutic Targets

Peigh, G., Shah, S. J., & Patel, R. B. (2021) · Current Heart Failure Reports · doi:10.1007/s11897-021-00510-5 · Cited by 44 · see citing works

Diabetes mellitus and atrial fibrillation-from pathophysiology to treatment

Leopoulou, M., Theofilis, P., Kordalis, A., Παπαγεωργίου, Ν., Sagris, Μ., Oikonomou, E. K., & Tousoulis, D. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i5.512 · Cited by 43 · see citing works

Mitochondrial Dysfunction in Atrial Fibrillation—Mechanisms and Pharmacological Interventions

Muszyński, P., & Bonda, T. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112385 · Cited by 43 · see citing works

Effects of metformin on atrial and ventricular arrhythmias: evidence from cell to patient

Nantsupawat, T., Wongcharoen, W., Chattipakorn, S. C., & Chattipakorn, N. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01176-4 · Cited by 41 · see citing works

Effect of metformin on outcomes of catheter ablation for atrial fibrillation

Deshmukh, A., Ghannam, M., Liang, J. J., Saeed, M., Cunnane, R. T., Ghanbari, H., Latchamsetty, R., Crawford, T. C., Batul, S. A., Chung, E. H., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14954 · Cited by 42 · see citing works

Epicardial fat and atrial fibrillation: the perils of atrial failure

Poggi, A. L., Gaborit, B., Schindler, T. H., Liberale, L., Montecucco, F., & Carbone, F. (2022) · EP Europace · doi:10.1093/europace/euac015 · Cited by 40 · see citing works

Antihyperglycemic drugs use and new‐onset atrial fibrillation in elderly patients

Chen, H., Yang, F., Jong, G., & Liou, Y. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12754 · Cited by 40 · see citing works

Obesity as a risk factor for cardiac arrhythmias

Patel, K. H. K., Reddy, R. K., Sau, A., Sivanandarajah, P., Ardissino, M., & Ng, F. S. (2022) · BMJ Medicine · doi:10.1136/bmjmed-2022-000308 · Cited by 42 · see citing works

Research Priorities in the Secondary Prevention of Atrial Fibrillation: A National Heart, Lung, and Blood Institute Virtual Workshop Report

Benjamin, E. J., Al‐Khatib, S. M., Desvigne-Nickens, P. M., Alonso, Á., Djoussé, L., Forman, D. E., Gillis, A. M., Hendriks, J., Hills, M. T., Kirchhof, P. F., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021566 · Cited by 38 · see citing works

HFpEF Is the Substrate for Stroke in Obesity and Diabetes Independent of Atrial Fibrillation

Packer, M. (2019) · JACC Heart Failure · doi:10.1016/j.jchf.2019.09.002 · Cited by 38 · see citing works

2021 ISHNE/HRS/EHRA/APHRS collaborative statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals

Varma, N., Cygankiewicz, I., Turakhia, M. P., Heidbüchel, H., Hu, Y., Chen, L. Y., Couderc, J., Cronin, E. M., Estep, J. D., Grieten, L., et al. (2021) · Journal of Arrhythmia · doi:10.1002/joa3.12461 · Cited by 37 · see citing works

2025 Clinical practice guidelines for Atrial fibrillation and flutter

Golukhova, E. Z., Sp, G., Михайлов, Е. Н., Revishvili, A. S. H., Arakelyan, M. G., Vasilyeva, E. Y., Davtyan, K. V., Drapkina, O. M., Drozdova, L. Y., Станиславовна, К. Е., et al. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6668 · Cited by 44 · see citing works

Data Linking Diabetes Mellitus and Atrial Fibrillation—How Strong Is the Evidence? From Epidemiology and Pathophysiology to Therapeutic Implications

Şerban, R. C., & Scridon, A. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2018.08.018 · Cited by 37 · see citing works

Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway

Xue, X., Ling, X., Wang, X., Wang, P., Sun, J., Yang, Q., & Xiao, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11291 · Cited by 36 · see citing works

Association of a Family History of Atrial Fibrillation With Incidence and Outcomes of Atrial Fibrillation

Chang, S., Kuo, C., Chou, I., See, L., Yu, K., Luo, S., Huang, L.-H., Zhang, W., Doherty, M., Wen, M., et al. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.1855 · Cited by 35 · see citing works

The Warburg effect: A new insight into atrial fibrillation

Liu, Y., Bai, F., Liu, N., Ouyang, F. O., & Liu, Q. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.08.029 · Cited by 35 · see citing works

Epicardial Adipose Tissue Inflammation Can Cause the Distinctive Pattern of Cardiovascular Disorders Seen in Psoriasis

Packer, M. (2019) · The American Journal of Medicine · doi:10.1016/j.amjmed.2019.08.027 · Cited by 33 · see citing works

Antidiabetic agents and risk of atrial fibrillation/flutter: A comparative critical analysis with a focus on differences between SGLT2 inhibitors and GLP-1 receptor agonists

Scheen, A. J. (2022) · Diabetes & Metabolism · doi:10.1016/j.diabet.2022.101390 · Cited by 34 · see citing works

Estándares SEA 2022 para el control global del riesgo cardiovascular

Mostaza, J. M., Pintó, X., Armario, P., Masana, L., Real, J. T., Valdivielso, P., Arrobas-Velilla, T., Baeza‐Trinidad, R., Calmarza, P., Cebollada, J., et al. (2022) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2021.11.003 · Cited by 35 · see citing works

Risk stratification of cardiac arrhythmias and sudden cardiac death in type 2 diabetes mellitus patients receiving insulin therapy: A population‐based cohort study

Lee, S., Jeevaratnam, K., Liu, T., Chang, D., Chang, C., Wong, W. T., Wong, I. C. K., Lip, G. Y. H., & Tse, G. (2021) · Clinical Cardiology · doi:10.1002/clc.23728 · Cited by 30 · see citing works

Autonomic Nervous System and Cardiac Metabolism

Chakraborty, P., Farhat, K., Po, S. S., Armoundas, A. A., & Stavrakis, S. (2023) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2023.02.019 · Cited by 29 · see citing works

New-Onset Atrial Fibrillation in Patients With Type 2 Diabetes Treated With Novel Glucose-Lowering Therapies

Hsiao, F., Yen, K., Chao, T., Chen, S., Chan, Y., & Chu, P. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac402 · Cited by 29 · see citing works

Metformin restores electrophysiology of small conductance calcium-activated potassium channels in the atrium of GK diabetic rats

Fu, X., Pan, Y., Cao, Q., Li, B., Wang, S., Du, H., Duan, N., & Li, X. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-018-0805-5 · Cited by 28 · see citing works

Effect of antidiabetic drugs on the risk of atrial fibrillation: mechanistic insights from clinical evidence and translational studies

Lee, T.-W., Lee, T.-I., Lin, Y.-K., Chen, Y.-C., Kao, Y.-H., & Chen, Y.-J. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03648-y · Cited by 27 · see citing works

Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats

Liu, C.-H., Hua, N., Fu, X., Pan, Y., Li, B., & Li, X. (2018) · BMC Cardiovascular Disorders · doi:10.1186/s12872-018-0950-x · Cited by 27 · see citing works

Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation

Özcan, C., Dixit, G., & Li, Z. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-10069-6 · Cited by 28 · see citing works

Guía ESC 2020 sobre el diagnóstico y tratamiento de la fibrilación auricular, desarrollada en colaboración de la European Association of Cardio-Thoracic Surgery (EACTS)

Hindricks, G., Potpara, T. S., Dagres, N., Arbelo, E., Bax, J. J., Blomström-Lundqvist, C., Boriani, G., Castellá, M., Dan, G., Dilaveris, P. E., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.10.022 · Cited by 24 · see citing works

Nonalcoholic fatty liver disease and atrial fibrillation: possible pathophysiological links and therapeutic interventions

Haghbin, H. (2020) · Annals of Gastroenterology · doi:10.20524/aog.2020.0550 · Cited by 27 · see citing works

Linking cellular energy state to atrial fibrillation pathogenesis: Potential role of adenosine monophosphate–activated protein kinase

Chakraborty, P., Nattel, S., & Nanthakumar, K. (2020) · Heart Rhythm · doi:10.1016/j.hrthm.2020.03.025 · Cited by 26 · see citing works

Metformin Use Is Associated With a Lower Incidence of Hospitalization for Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus

Tseng, C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.592901 · Cited by 26 · see citing works

Mitochondrial Dysfunction in Atrial Fibrillation: The Need for a Strong Pharmacological Approach

Mauriello, A., Correra, A., Molinari, R., Vecchio, G. E. D., Tessitore, V., D’Andrea, A., & Russo, V. (2024) · Biomedicines · doi:10.3390/biomedicines12122720 · Cited by 25 · see citing works

Metformin: evidence from preclinical and clinical studies for potential novel applications in cardiovascular disease

Dihoum, A., Rena, G., Pearson, E. R., Lang, C. C., & Mordi, I. R. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2196010 · Cited by 25 · see citing works

Atrial Fibrillation and Diabetes Mellitus: Dangerous Liaisons or Innocent Bystanders?

Lorenzo-Almorós, A., Casado, J., Walther, L. A. Á.-S., Méndez‐Bailón, M., & Lorenzo, Ó. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082868 · Cited by 25 · see citing works

Atrial fibrillation: primary prevention, secondary prevention, and prevention of thromboembolic complications: part 1

Trohman, R. G., Huang, H. D., & Sharma, P. S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1060030 · Cited by 28 · see citing works

Estándares SEA 2019 para el control global del riesgo cardiovascular

Mostaza, J. M., Pintó, X., Armario, P., Masana, L., Ascaso, J. F., Valdivielso, P., Velilla, T. A., Brea, Á., Calmarza, P., Cebollada, J., et al. (2019) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2019.03.004 · Cited by 24 · see citing works

Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific

Tan, E. S. J., Tay, W. T., Teng, T. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., Ong, H. Y., Jaufeerally, F. R., Ng, T. P., Poppe, K., et al. (2019) · Heart · doi:10.1136/heartjnl-2018-314077 · Cited by 24 · see citing works

Association of Atrial Fibrillation with Diabetes Mellitus, High Risk Comorbidities

Gherasim, L. (2022) · MAEDICA – a Journal of Clinical Medicine · doi:10.26574/maedica.2022.17.1.143 · Cited by 24 · see citing works

Concomitant diabetes with atrial fibrillation and anticoagulation management considerations

Kreutz, R. H., Camm, A. J., & Rossing, P. R. (2020) · European Heart Journal Supplements · doi:10.1093/eurheartj/suaa182 · Cited by 22 · see citing works

Lifestyle changes in atrial fibrillation management and intervention

Yang, L., & Chung, M. K. (2023) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15803 · Cited by 22 · see citing works

Managing thrombotic risk in patients with diabetes

Camm, A. J., Sabbour, H. M., Schnell, O., Summaria, F., & Verma, A. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01581-x · Cited by 23 · see citing works

Physical Activity Changes and the Risk of Incident Atrial Fibrillation in Patients With Type 2 Diabetes Mellitus: A Nationwide Longitudinal Follow-up Cohort Study of 1.8 Million Subjects

Park, C. S., Choi, E., Kyung-DoHan, Yoo, J., Ahn, H., Kwon, S., Lee, S., Oh, S., & Lip, G. Y. H. (2022) · Diabetes Care · doi:10.2337/dc22-1655 · Cited by 21 · see citing works

Risk Factor Management and Atrial Fibrillation Clinics: Saving the Best for Last?

Mahajan, R., Pathak, R. K., Thiyagarajah, A., Lau, D. H., Marchlinski, F. E., Dixit, S., Day, J. D., Hendriks, J., Carrington, M. J., Kalman, J. M., et al. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.05.123 · Cited by 21 · see citing works

Association of Antihyperglycemic Therapy with Risk of Atrial Fibrillation and Stroke in Diabetic Patients

Lăcătușu, C.-M., Grigorescu, E.-D., Stătescu, C., Sascău, R. A., Onofriescu, A., & Mihai, B. M. (2019) · Medicina · doi:10.3390/medicina55090592 · Cited by 21 · see citing works

Dipeptidyl Peptidase-4 Inhibitors and the Risk of Acute Pancreatitis in Patients With Type 2 Diabetes in Taiwan

Lai, Y., Hu, H., Chen, H., & Chou, P. (2015) · Medicine · doi:10.1097/md.0000000000001906 · Cited by 20 · see citing works

Metformin reduces new-onset atrial fibrillation risk rather than atrial fibrillation burden in type 2 diabetes patients: A case-control study

Zhong, C., Bai, J., Qu, X., Liu, Y., Zhu, L., Hao, H., Qiao, S., Zhang, Z., Xu, X., Si, J., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30992 · Cited by 5 · see citing works

1093-P: Association between First-Line Monotherapy with Metformin and the Risk of Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus

Tekin, Z., Milinovich, A., Ji, X., Bauman, J. M., Kattan, M. W., Pantalone, K. M., Zimmerman, R. S., Chung, M. K., & Kashyap, S. (2020) · Diabetes · doi:10.2337/db20-1093-p

VASCULAR

(2015)

Metformin and Risk of New-Onset Atrial Fibrillation in Type 2 Diabetes: A Systematic Review and Meta-Analysis

Vempati, R., Damarlapally, N., Roy, P., Mylavarapu, M., Vasudevan, S. S., Reguram, R., Vora, T., Jain, H., Ahmed, R., & Krishnamoorthy, G. (2025) · Diagnostics · doi:10.3390/diagnostics15182288 · Cited by 2 · see citing works

The effect of metformin use on the risk of atrial fibrillation in patients with type 2 diabetes: data from the UK biobank

Guo, T., Zhao, C., Chen, T., Tang, M., Ning, Y., Wang, D. L., Yuan, Z., & Li, G. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae666.3307 · Cited by 1 · see citing works