Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways
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BACKGROUND: As a new anti-diabetic medicine, Liraglutide (LIRA), one of GLP-1 analogues, has been found to have an anti-atherosclerotic effect. Since vascular smooth muscle cells (VSMCs) play pivotal roles in the occurrence of diabetic atherosclerosis, it is important to investigate the role of LIRA in reducing the harmful effects of high-glucose (HG) treatment in cultured VSMCs, and identifying associated molecular mechanisms. METHODS: Primary rat VSMCs were exposed to low or high glucose-containing medium with or without LIRA. They were challenged with HG in the presence of phosphatidylinositol 3-kinase (PI3K), extracellular signal-regulated kinase (ERK)1/2, or glucagon-like peptide receptor (GLP-1R) inhibitors. Cell proliferation and viability was evaluated using a Cell Counting Kit-8. Cell migration was determined by Transwell migration and scratch wound assays. Flow cytometry and Western blotting were used to determine apoptosis and protein expression, respectively. RESULTS: Under the HG treatment, VSMCs exhibited increased migration, proliferation, and phosphorylation of protein kinase B (Akt) and ERK1/2, along with reduced apoptosis (all p < 0.01 vs. control). These effects were significantly attenuated with LIRA co-treatment (all p < 0.05 vs. HG alone). Inhibition of PI3K kinase and ERK1/2 similarly attenuated the HG-induced effects (all p < 0.01 vs. HG alone). GLP-1R inhibitors effectively reversed the beneficial effects of LIRA on HG treatment (all p < 0.05). CONCLUSIONS: HG treatment may induce abnormal phenotypes in VSMCs via PI3K and ERK1/2 signaling pathways activated by GLP-1R, and LIRA may protect cells from HG damage by acting on these same pathways.
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GLP-1 receptor agonists improve microvascular function, myocardial structure, insulin sensitivity, and vascular protection; and reduce inflammation, oxidative stress, and neurohormonal activation.
“GLP-1 receptor agonists improve microvascular function, 37 myocardial structure, 38 insulin sensitivity, 39 and vascular protection; 40,41 and reduce inflammation, 39,42 oxidative stress, 43 and neurohormonal activation 44”
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- Authors
- Shi, L., Ji, Y., Jiang, X., Zhou, L., Xu, Y., Li, Y., Jiang, W., Meng, P., & Liu, X.
- Affiliations
- Harbin Medical University (CN)
- Venue
- Cardiovascular Diabetology
- Published
- 2015-02-07
- Volume
- 14
- Issue
- 1
- Pages
- 18-18
- ISSN
- 1475-2840 (ISSN-L)
- PMC
- PMC4327797
- OpenAlex
- W2140943644
- Cited by
- 91
- References
- 76
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 6 · 2022: 14 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 4
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cardiovascular Diabetology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81201437)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- liraglutide, GLP-1 receptor, vascular smooth muscle cells, high glucose, diabetic atherosclerosis, cell migration, cell proliferation, apoptosis, PI3K/Akt signaling, ERK signaling, GLP-1 receptor antagonists, atherosclerosis treatment
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Liraglutide, Phosphoinositide-3 Kinase Inhibitors, Glucagon-Like Peptide-1 Receptor Agonists, Animals, Cell Movement, Cells, Cultured, Glucose, Hypoglycemic Agents, Male, Muscle, Smooth, Vascular, Rats, Sprague-Dawley, Apoptosis, Phosphatidylinositol 3-Kinases, MAP Kinase Signaling System, Myocytes, Smooth Muscle, Cell Proliferation, Proto-Oncogene Proteins c-akt, Rats
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