Cited by 146Diabetes Treatment and ManagementCardiovascular Function and Risk FactorsCardiovascular Health and Disease Prevention

Effects of 6-month treatment with the glucagon like peptide-1 analogue liraglutide on arterial stiffness, left ventricular myocardial deformation and oxidative stress in subjects with newly diagnosed type 2 diabetes

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Lambadiari, Vaia, Pavlidis, George, Kousathana, Foteini, Varoudi, Maria, Vlastos, Dimitrios, Maratou, Eirini, Georgiou, Dimitrios, Andreadou, Ioanna +6 more·2018·Cardiovascular Diabetology

Abstract

Abstract Background Incretin-based therapies are used in the treatment of type 2 diabetes mellitus (T2DM) and obesity. We investigated the changes in arterial stiffness and left ventricular (LV) myocardial deformation after 6-month treatment with the GLP-1 analogue liraglutide in subjects with newly diagnosed T2DM. Methods We randomized 60 patients with newly diagnosed and treatment-naive T2DM to receive either liraglutide (n = 30) or metformin (n = 30) for 6 months. We measured at baseline and after 6-month treatment: (a) carotid-femoral pulse wave velocity (PWV) (b) LV longitudinal strain (GLS), and strain rate (GLSR), peak twisting (pTw), peak twisting velocity (pTwVel) and peak untwisting velocity (pUtwVel) using speckle tracking echocardiography. LV untwisting was calculated as the percentage difference between peak twisting and untwisting at MVO (%dpTw–UtwMVO), at peak (%dpTw–UtwPEF) and end of early LV diastolic filling (%dpTw–UtwEDF) (c) Flow mediated dilatation (FMD) of the brachial artery and percentage difference of FMD (FMD%) (d) malondialdehyde (MDA), protein carbonyls (PCs) and NT-proBNP. Results After 6-months treatment, subjects that received liraglutide presented with a reduced PWV (11.8 ± 2.5 vs. 10.3 ± 3.3 m/s), MDA (0.92 [0.45–2.45] vs. 0.68 [0.43–2.08] nM/L) and NT-proBNP (p < 0.05) in parallel with an increase in GLS (− 15.4 ± 3 vs. − 16.6 ± 2.7), GLSR (0.77 ± 0.2 vs. 0.89 ± 0.2), pUtwVel (− 97 ± 49 vs. − 112 ± 52°, p < 0.05), %dpTw–UtwMVO (31 ± 10 vs. 40 ± 14), %dpTw–UtwPEF (43 ± 19 vs. 53 ± 22) and FMD% (8.9 ± 3 vs. 13.2 ± 6, p < 0.01). There were no statistically significant differences of the measured markers in subjects that received metformin except for an improvement in FMD. In all subjects, PCs levels at baseline were negatively related to the difference of GLS (r = − 0.53) post-treatment and the difference of MDA was associated with the difference of PWV (r = 0.52) (p < 0.05 for all associations) after 6-month treatment. Conclusions Six-month treatment with liraglutide improves arterial stiffness, LV myocardial strain, LV twisting and untwisting and NT-proBNP by reducing oxidative stress in subjects with newly diagnosed T2DM. ClinicalTrials.gov Identifier NCT03010683

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Authors
Lambadiari, V., Pavlidis, G., Kousathana, F., Varoudi, M., Vlastos, D., Maratou, E., Georgiou, D., Andreadou, I., Parissis, J., Triantafyllidi, H., Lekakis, J., Iliodromitis, E., Dimitriadis, G., & Ikonomidis, I.
Affiliations
National and Kapodistrian University of Athens (GR)
Corresponding author
Lambadiari, Vaia
Venue
Cardiovascular Diabetology
Published
2018-01-08
Volume
17
Issue
1
Pages
8-8
ISSN
1475-2840 (ISSN-L)
OpenAlex
W2782989965
Cited by
146
References
52
Citations by year
2026: 10 · 2025: 13 · 2024: 18 · 2023: 16 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 22 · 2018: 7
FWCI
14.31
Type
journal article
Language
en
Open access
Locations
  • Cardiovascular Diabetology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
liraglutide, GLP-1 receptor agonists, type 2 diabetes, newly diagnosed diabetes, arterial stiffness, left ventricular myocardial deformation, oxidative stress, metformin, pulse wave velocity, flow-mediated dilation, malondialdehyde, protein carbonyls, NT-proBNP, speckle tracking echocardiography
MeSH terms
Glucagon-Like Peptide-1 Receptor, Liraglutide, Glucagon-Like Peptide-1 Receptor Agonists, Adult, Biomechanical Phenomena, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Greece, Humans, Hypoglycemic Agents, Male, Middle Aged, Myocardial Contraction, Peptide Fragments, Time Factors, Biomarkers, Ventricular Function, Left, Treatment Outcome, Oxidative Stress, Natriuretic Peptide, Brain, Incretins, Diabetic Cardiomyopathies, Vascular Stiffness

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