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Cited by 435

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome

Open access
Wang, Le, Cong, Hong-liang, Zhang, Jing-xia, Hu, Yue-cheng, Wei, Ao, Zhang, Ying-yi, Yang, Hua, Ren, Li-bin, Qi, Wei, Li, Wen-yu, Zhang, Rui, Xu, Jing-han·2020·Cardiovascular Diabetology
DOI 10.1186/s12933-020-01054-z
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Abstract

Background: The triglyceride-glucose index (TyG index) has been regarded as a reliable alternative marker of insulin resistance and an independent predictor of cardiovascular outcomes. Whether the TyG index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome (ACS) remains uncertain. The aim of this study was to investigate the prognostic value of the TyG index in patients with diabetes and ACS. Methods: A total of 2531 consecutive patients with diabetes who underwent coronary angiography for ACS were enrolled in this study. Patients were divided into tertiles according to their TyG index. The primary outcomes included the occurrence of major adverse cardiovascular events (MACEs), defined as all-cause death, non-fatal myocardial infarction and non-fatal stroke. The TyG index was calculated as the ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). Results: The incidence of MACE increased with TyG index tertiles at a 3-year follow-up. The Kaplan–Meier curves showed significant differences in event-free survival rates among TyG index tertiles (P = 0.005). Multivariate Cox hazards regression analysis revealed that the TyG index was an independent predictor of MACE (95% CI 1.201–1.746; P < 0.001). The optimal TyG index cut-off for predicting MACE was 9.323 (sensitivity 46.0%; specificity 63.6%; area under the curve 0.560; P = 0.001). Furthermore, adding the TyG index to the prognostic model for MACE improved the C-statistic value (P = 0.010), the integrated discrimination improvement value (P = 0.001) and the net reclassification improvement value (P = 0.019). Conclusions: The TyG index predicts future MACE in patients with diabetes and ACS independently of known cardiovascular risk factors, suggesting that the TyG index may be a useful marker for risk stratification and prognosis in patients with diabetes and ACS.

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Metadata

Authors
Wang, L., Cong, H.-L., Zhang, J.-X., Hu, Y.-C., Wei, A., Zhang, Y.-Y., Yang, H., Ren, L.-B., Qi, W., Li, W.-Y., Zhang, R., & Xu, J.-H.
Venue
Cardiovascular Diabetology
Publisher
Springer Science and Business Media LLC
Published
2020-06-13
Volume
19
Issue
1
Pages
80-80
ISSN
1475-2840 (ISSN-L)
DOI
10.1186/s12933-020-01054-z
OpenAlex
W3034654984
Cited by
435
References
42
FWCI
32.16
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome. https://app.cochat.ai/papers/10.1186/s12933-020-01054-z
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Wang, L., Cong, H.-L., Zhang, J.-X., Hu, Y.-C., Wei, A., Zhang, Y.-Y., Yang, H., Ren, L.-B., Qi, W., Li, W.-Y., Zhang, R., & Xu, J.-H. (2020). Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome. Cardiovascular Diabetology. https://doi.org/10.1186/s12933-020-01054-z

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