Combining malaria vaccination with chemoprevention: a promising new approach to malaria control.
Open accessAbstract
malaria vaccine and seasonal malaria chemoprevention led to a substantial reduction in clinical cases of malaria, severe malaria, and malaria deaths compared with the administration of either intervention given alone suggests that there may be other epidemiological/clinical situations in which a combination of malaria vaccination and chemoprevention could be beneficial. Some of these potential opportunities are considered in this paper. These include combining vaccination with intermittent preventive treatment of malaria in infants, with intermittent preventive treatment of malaria in pregnancy (through vaccination of women of child-bearing age before or during pregnancy), or with post-discharge malaria chemoprevention in the management of children recently admitted to hospital with severe anaemia. Other potential uses of the combination are prevention of malaria in children at particular risk from the adverse effects of clinical malaria, such as those with sickle cell disease, and during the final stages of a malaria elimination programme when vaccination could be combined with repeated rounds of mass drug administration. The combination of a pre-erythrocytic stage malaria vaccine with an effective chemopreventive regimen could make a valuable contribution to malaria control and elimination in a variety of clinical or epidemiological situations, and the potential of this approach to malaria control needs to be explored.
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New tools are increasingly available for use in malaria control and elimination, specifically malaria vaccines could increasingly feature in reducing the burden of malaria in pregnancy, potentially in combination with malaria chemoprevention.
“New tools are increasingly available for use in malaria control and elimination, specifically malaria vaccines could increasingly feature in reducing the burden of malaria in pregnancy, potentially in combination with malaria chemoprevention [43].”
From Global estimates of pregnancies at risk of Plasmodium falciparum and Plasmodium vivax infection in 2020 and changes in risk patterns since 2000 (2022) · cites this paper as [43]
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- [8]Chandramohan D Zongo I Sagara I Cairns M Yerbanga RS Diarra M Seasonal vaccination with the RTS,S/AS01E malaria vaccine with or without seasonal malaria chemoprevention N Engl J Med 2020 10.1136/bmjopen-2019-035433 · DOI
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- Authors
- Greenwood, B., Cairns, M., Chaponda, M., Chico, R. M., Dicko, A., Ouedraogo, J.-B., Phiri, K. S., ter Kuile, F. O., & Chandramohan, D.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- Tropical Diseases Research Centre (ZM)
- Université des Sciences, des Techniques et des Technologies de Bamako (ML)
- Kamuzu University of Health Sciences (MW)
- Corresponding author
- Greenwood, Brian
- ORCID
- Venue
- Malaria Journal
- Published
- 2021-09-06
- Volume
- 20
- Issue
- 1
- Pages
- 361-361
- ISSN
- 1475-2875 (ISSN-L)
- PMC
- PMC8419817
- OpenAlex
- W3197587914
- Cited by
- 32
- References
- 30
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 3 · 2023: 10 · 2022: 6
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Malaria Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LSTM Online Archive (Liverpool School of Tropical Medicine) (acceptedVersion, other-oa)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Funders
- wellcome trust (220658/Z/20/Z)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- malaria vaccination, seasonal malaria chemoprevention, intermittent preventive treatment, intermittent preventive treatment in pregnancy, severe anemia, sickle cell disease, mass drug administration, malaria elimination, malaria control
- MeSH terms
- Communicable Disease Control, Humans, Malaria, Vaccination, Malaria Vaccines, Chemoprevention
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