Influence of Paleolithic diet on anthropometric markers in chronic diseases: systematic review and meta-analysis
Open accessAbstract
BACKGROUND: The Paleolithic diet has been studied in the scope of prevention and control of chronic noncommunicable diseases (CNCD). The objective of this study was to analyze the influence of the Paleolithic diet on the prevention and control of CNCD in humans, specifically on anthropometric markers, through a systematic review with meta-analysis. METHODS: What is the effect of the Paleolithic diet on anthropometric parameters (weight, body mass index and waist circumference) compared to other control diets based on recommendations in adults? We included only randomized studies with humans that used the Paleolithic Diet in the prevention and control of CNCD published in Portuguese, English or Spanish. The search period was until March 2019, in the LILACS, PubMed, Scielo, Science Direct, Medline, Web of Science and Scopus databases. The abstracts were evaluated by two researchers. We found 1224 articles, of which 24 were selected and 11 were included in the meta-analysis. The effect of dietary use on body weight, body mass index and waist circumference was evaluated. RESULTS: = 24%) of people who adopted the Paleolithic diet compared to diets based on recommendations. The analysis showed a positive association of adopting the Paleolithic diet in relation to weight loss. The effect was significant on weight, body mass index and waist circumference. CONCLUSION: The Paleolithic diet may assist in controlling weight and waist circumference and in the management of chronic diseases. However, more randomized clinical studies with larger populations and duration are necessary to prove health benefits. TRIAL REGISTRATION: CRD42015027849 .
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Studies of various lengths have shown improvements in weight and measures of glycemia with Paleo and VLCD/ketogenic patterns.
“Studies of various lengths have shown improvements in weight and measures of glycemia with these patterns.46,[84][85][86][87]”
From Popular dietary patterns: alignment with American Heart Association 2021 dietary guidance: a scientific statement from the American Heart Association. (2023) · cites this paper as [84]
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Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
Shamseer, L., Moher, D., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & the PRISMA-P Group (2015) · BMJ · doi:10.1136/bmj.g7647 · Cited by 13,120 · see citing works
GRADE guidelines: 3. Rating the quality of evidence
Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., & Norris, S. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.015 · Cited by 8,285 · see citing works
Diet, nutrition and the prevention of chronic diseases
Joint, W. (2002) · Medical Entomology and Zoology · Cited by 4,889 · see citing works
Origins and evolution of the Western diet: health implications for the 21st century1,2
Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., O’Keefe, J. H., & Brand-Miller, J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.341 · Cited by 2,397 · see citing works
Diet, Nutrition, and the Prevention of Chronic Diseases
Leong, A. (1992) · Pathology · doi:10.1016/s0031-3025(16)36541-2 · Cited by 1,633 · see citing works
Cordain, L., Miller, J. B., Eaton, S. B., Mann, N., Holt, S. H., & Speth, J. D. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.3.682 · Cited by 791 · see citing works
Assessment and management of nutrition in older people and its importance to health
Haboubi, N. (2010) · Clinical Interventions in Aging · doi:10.2147/cia.s9664 · Cited by 636 · see citing works
Salas-Salvadó, J., Fernández-Ballart, J., Ros, E., Martínez-González, M.-A., Fitó, M., Estruch, R., Corella, D., Fiol, M., Gómez-Gracia, E., Arós, F., et al. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.22.2449 · Cited by 463 · cited 2× · see citing works
“One of the most accepted diets for the treatment and prevention of CNCD is the Mediterranean diet, which is characterized by a high intake of cereals, vegetables, fruits and olive oil; a moderate intake of fish and alcohol, mainly wine; and low intake of dairy products, meat and sweets [7].”
BackgroundOral implant surfaces: Part 2--review focusing on clinical knowledge of different surfaces.
Albrektsson, T. O., & Wennerberg, A. (2005) · PubMed · Cited by 443 · see citing works
The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic
Cordain, L., Eaton, S., Brand-Miller, J. C., Mann, N. J., & Hill, K. R. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601353 · Cited by 418 · see citing works
Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet
Frassetto, L. A., Schloetter, M. C., Mietus-Synder, M., Morris, R. C., & Sébastian, A. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.4 · Cited by 282 · see citing works
Jönsson, T., Granfeldt, Y., Ahrén, B., Branell, U.-C., Pålsson, G., Hansson, A., Söderström, M., & Lindeberg, S. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-35 · Cited by 273 · see citing works
Lindeberg, S., Jönsson, T., Granfeldt, Y., Borgstrand, E., Soffman, J., Sjöström, K., & Ahrén, B. (2007) · Diabetologia · doi:10.1007/s00125-007-0716-y · Cited by 273 · see citing works
Mellberg, C., Sandberg, S., Ryberg, M., Eriksson, M., Brage, S., Larsson, C. L., Olsson, T., & Lindahl, B. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.290 · Cited by 187 · see citing works
Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis
Manheimer, E. W., van Zuuren, E. J., Fedorowicz, Z., & Pijl, H. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.113613 · Cited by 180 · see citing works
Effects of a short-term intervention with a paleolithic diet in healthy volunteers
Österdahl, M. F., Koctürk, T., Koochek, A., & Wändell, P. E. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602790 · Cited by 171 · see citing works
The impact of the stone age diet on gingival conditions in the absence of oral hygiene
Baumgartner, S., Imfeld, T., Schicht, O., Rath, C., Persson, R. E., & Persson, G. R. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080376 · Cited by 167 · see citing works
Jönsson, T., Granfeldt, Y. E., Lindeberg, S., & Hallberg, A. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-105 · Cited by 106 · see citing works
Genoni, A., Lyons‐Wall, P., Lo, J., & Devine, A. (2016) · Nutrients · doi:10.3390/nu8050314 · Cited by 104 · see citing works
Boers, I., Muskiet, F. A. J., Berkelaar, E., Schut, E., Penders, R., Hoenderdos, K., Wichers, H. J., & Jong, M. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-160 · Cited by 100 · see citing works
Bligh, H. F. J., Godsland, I. F., Frost, G. S., Hunter, K., Murray, P., MacAulay, K., Hyliands, D., Talbot, D. C. S., Casey, J., MULDER, T. P. J., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004012 · Cited by 91 · see citing works
Masharani, U., Sherchan, P., Schloetter, M., Stratford, S., Xiao, A., Sebastian, A., Nolte Kennedy, M., & Frassetto, L. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2015.39 · Cited by 88 · see citing works
Bisht, B., Darling, W. G., Grossmann, R. E., et al. (2014) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2013.0188 · Cited by 86 · see citing works
Fontes‐Villalba, M., Lindeberg, S., Granfeldt, Y. E., Knop, F. K., Memon, A. A., Carrera‐Bastos, P., Picazo, Ó., Chanrai, M., Sunquist, J., Sundquist, K., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0398-1 · Cited by 85 · see citing works
Jönsson, T., Granfeldt, Y. E., Erlanson‐Albertsson, C., Åhrén, B., & Lindeberg, S. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-85 · Cited by 84 · see citing works
Hammarström, A., Wiklund, A. F., Lindahl, B., Larsson, C., & Ahlgren, C. (2014) · BMC Women's Health · doi:10.1186/1472-6874-14-59 · Cited by 78 · see citing works
Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention
Otten, J., Mellberg, C., Ryberg, M., Sandberg, S., Kullberg, J., Lindahl, B., Larsson, C. L., Hauksson, J. B., & Olsson, T. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.4 · Cited by 59 · see citing works
Diet-Induced Weight Loss Alters Functional Brain Responses during an Episodic Memory Task
Boraxbekk, C., Stomby, A., Ryberg, M., Lindahl, B., Larsson, C. L., Nyberg, L. H., & Olsson, T. (2015) · Obesity Facts · doi:10.1159/000437157 · Cited by 54 · see citing works
Ryberg, M., Sandberg, S., Mellberg, C., Stegle, O., Lindahl, B., Larsson, C. L., Hauksson, J. B., & Olsson, T. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12048 · Cited by 49 · see citing works
Myhill, S., Booth, N. E., & McLaren-Howard, J. (2013) · Europe PMC (PubMed Central) · Cited by 45 · see citing works
Pastore, R. L., Brooks, J., & Carbone, J. W. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.05.002 · Cited by 41 · see citing works
Stomby, A., Šimonytė, K., Mellberg, C., Ryberg, M., Stimson, R. H., Larsson, C. L., Lindahl, B., Andrew, R., Walker, B. R., & Olsson, T. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.188 · Cited by 38 · see citing works
Blomquist, C., Chorell, E., Ryberg, M., Mellberg, C., Vorrsjö, E., Makoveichuk, E., Larsson, C. L., Lindahl, B., Olivecrona, G., & Olsson, T. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1558-0 · Cited by 31 · see citing works
Frassetto, L. A., Shi, L., Schloetter, M., et al. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.124 · Cited by 20 · see citing works
Blomquist, C., Alvehus, M., Burén, J., Ryberg, M., Larsson, C. L., Lindahl, B., Mellberg, C., Söderström, I., Chorell, E., & Olsson, T. (2017) · Obesity · doi:10.1002/oby.21815 · Cited by 19 · see citing works
Ahlgren, C., Hammarström, A., Sandberg, S., Lindahl, B., Olsson, T., Larsson, C. L., & Fjellman‐Wiklund, A. (2015) · International Journal of Behavioral Medicine · doi:10.1007/s12529-015-9495-x · Cited by 16 · see citing works
Smith, M., Trexler, E. T., Sommer, A. J., STARKOFFǂ, E., & Devor, S. T. (2014) · Cited by 15 · see citing works
Revisão Sistemática de Estudos Observacionais com Metanálise
Fuchs, S. C. P. C., & Paim, B. S. (2010) · Americanae (AECID Library) · Cited by 14 · see citing works
[Evaluation of biological and clinical potential of paleolithic diet].
Kowalski, L. M., & Bujko, J. (2012) · PubMed · Cited by 13 · see citing works
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- [3]Institute of Medicine. Living well with chronic disease: a call for public health action. Washington, D.C.: The National Academic Press; 2012.
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Gardner, C. D., Vadiveloo, M. K., Petersen, K. S., Anderson, C. A. M., Springfield, S., Van Horn, L., Khera, A., Lamendola, C., Mayo, S. M., Joseph, J. J., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001146 · Cited by 172 · see citing works
- Authors
- de Menezes, E. V. A., Sampaio, H. A. D. C., Carioca, A. A. F., Parente, N. A., Brito, F. O., Moreira, T. M. M., de Souza, A. C. C., & Arruda, S. P. M.
- Affiliations
- Universidade Estadual do Ceará (BR)
- Universidade de São Paulo (BR)
- ORCID
- Venue
- Nutrition Journal
- Published
- 2019-07-23
- Volume
- 18
- Issue
- 1
- Pages
- 41-41
- ISSN
- 1475-2891 (ISSN-L)
- PMC
- PMC6647066
- OpenAlex
- W2963672951
- Cited by
- 50
- References
- 41
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 8
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nutrition Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- Paleolithic diet, anthropometric markers, body mass index, waist circumference, body weight, weight loss, non-communicable diseases, diet and disease prevention
- MeSH terms
- Anthropometry, Body Weight, Chronic Disease, Humans, Biomarkers, Body Mass Index, Waist Circumference, Diet, Paleolithic
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