Klebsiella pneumoniae: an increasing threat to public health
Open accessAbstract
Objectives: This review fills the paucity of information on K. pneumoniae as a nosocomial pathogen by providing pooled data on epidemiological risk factors, resistant trends and profiles and resistant and virulent genes of this organism in Asia. Methods: Exhaustive search was conducted using PubMed, Web of Science, and Google scholar for most studies addressing the prevalence, risk factors, drug resistant-mediated genes and/or virulent factors of K. pneumoniae in Asia. Data extracted for meta-analysis were analyzed using comprehensive meta-analysis version 3. Trends data for the isolation rate and resistance rates were entered into Excel spread sheet and the results were presented in graphs. Results: The prevalence rate of drug resistance in K. pneumoniae were; amikacin (40.8%) [95% CI 31.9–50.4], aztreonam (73.3%) [95% CI 59.9–83.4], ceftazidime (75.7%) [95% CI 65.4–83.6], ciprofloxacin (59.8%) [95% CI 48.6–70.1], colistin (2.9%) [95% CI 1.8–4.4], cefotaxime (79.2%) [95% CI 68.0–87.2], cefepime (72.6) [95% CI 57.7–83.8] and imipenem (65.6%) [95% CI 30.8–89.0]. TEM (39.5%) [95% CI 15.4–70.1], SHV-11 (41.8%) [95% CI 16.2–72.6] and KPC-2 (14.6%) [95% CI 6.0–31.4] were some of the resistance mediated genes observed in this study. The most virulent factors utilized by K. pneumoniae are; hypermucoviscous phenotype and mucoviscosity-related genes, genes for biosynthesis of lipopolysaccharide, iron uptake and transport genes and finally, adhesive genes. Conclusion: It can be concluded that, antimicrobial resistant in K. pneumoniae is a clear and present danger in Asia which needs strong surveillance to curb this menace. It is very important for public healthcare departments to monitor and report changes in antimicrobial-resistant isolates.
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The global rise in antimicrobial resistance (AMR), including the emergence of MDR isolates, is of growing concern.
“The global rise in antimicrobial resistance (AMR), including the emergence of MDR isolates, is of growing concern [38].”
From Microbiological Quality of Coconut Water Sold in the Grande Vitória Region, Brazil, and Phenogenotypic Antimicrobial Resistance of Associated Enterobacteria (2024) · cites this paper as [38]
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Peterle, V. M., Cardoso, J. A. B., Ferraz, C. M., Sousa, D. F. D., Pereira, N., Nassar, A. F. D. C., Castro, V., Mathias, L. A., Cardozo, M. V., & Rossi, G. A. M. (2024) · Microorganisms · doi:10.3390/microorganisms12091883
“The global rise in antimicrobial resistance (AMR), including the emergence of MDR isolates, is of growing concern [38].”
Background
- Authors
- Effah, C. Y., Sun, T., Liu, S., & Wu, Y.
- Affiliations
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Corresponding author
- Wu, Yongjun
- Venue
- Annals of Clinical Microbiology and Antimicrobials
- Published
- 2020-01-09
- Volume
- 19
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1476-0711 (ISSN-L)
- PMC
- PMC7050612
- OpenAlex
- W2999214061
- Cited by
- 558
- References
- 60
- Citations by year
- 2026: 71 · 2025: 101 · 2024: 135 · 2023: 76 · 2022: 89 · 2021: 58 · 2020: 27 · 2019: 1
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Annals of Clinical Microbiology and Antimicrobials (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Enterobacteriaceae and Cronobacter Research
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- Klebsiella pneumoniae, antimicrobial resistance, nosocomial infections, risk factors, virulence factors, TEM beta-lactamase, KPC-2, hypermucoviscosity, lipopolysaccharide biosynthesis, iron uptake genes, Asia, resistance monitoring, carbapenem resistance, cephalosporin resistance
- MeSH terms
- Anti-Bacterial Agents, Asia, Bacterial Proteins, Cross Infection, Genes, Bacterial, Humans, Klebsiella Infections, Klebsiella pneumoniae, Microbial Sensitivity Tests, Public Health, Risk Factors, Drug Resistance, Multiple, Bacterial, Virulence Factors
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