Aerobactin, but Not Yersiniabactin, Salmochelin, or Enterobactin, Enables the Growth/Survival of Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Ex Vivo and In Vivo

Russo, Thomas A.; Olson, Ruth; MacDonald, Ulrike; Beanan, Janet; Davidson, Bruce A.

doi:10.1128/iai.00430-15

Cited by 315Escherichia coli research studiesEnterobacteriaceae and Cronobacter ResearchAntibiotic Resistance in Bacteria

Aerobactin, but Not Yersiniabactin, Salmochelin, or Enterobactin, Enables the Growth/Survival of Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Ex Vivo and In Vivo

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Russo, Thomas A., Olson, Ruth, MacDonald, Ulrike, Beanan, Janet, Davidson, Bruce A.·2015·Infection and Immunity

DOI 10.1128/iai.00430-15PMC PMC4496593

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Abstract

The siderophore aerobactin is the dominant siderophore produced by hypervirulent Klebsiella pneumoniae (hvKP) and was previously shown to be a major virulence factor in systemic infection. However, strains of hvKP commonly produce the additional siderophores yersiniabactin, salmochelin, and enterobactin. The roles of these siderophores in hvKP infection have not been optimally defined. To that end, site-specific gene disruptions were created in hvKP1 (wild type), resulting in the generation of hvKP1Δ iucA (aerobactin deficient), hvKP1Δ iroB (salmochelin deficient), hvKP1Δ entB (enterobactin and salmochelin deficient), hvKP1Δ irp2 (yersiniabactin deficient), and hvKP1Δ entB Δ irp2 (enterobactin, salmochelin, and yersiniabactin deficient). The growth/survival of these constructs was compared to that of their wild-type parent hvKP1 ex vivo in human ascites fluid, human serum, and human urine and in vivo in mouse systemic infection and pulmonary challenge models. Interestingly, in contrast to aerobactin, the inability to produce enterobactin, salmochelin, or yersiniabactin individually or in combination did not decrease the ex vivo growth/survival in human ascites or serum or decrease virulence in the in vivo infection models. Surprisingly, none of the siderophores increased growth in human urine. In human ascites fluid supplemented with exogenous siderophores, siderophores increased the growth of hvKP1Δ iucA , with the relative activity being enterobactin > aerobactin > yersiniabactin > salmochelin, suggesting that the contribution of aerobactin to virulence is dependent on both innate biologic activity and quantity produced. Taken together, these data confirm and extend a role for aerobactin as a critical virulence factor for hvKP. Since it appears that aerobactin production is a defining trait of hvKP strains, this factor is a potential antivirulence target.

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The elaboration and acquisition of the latter three siderophores are associated with the pathogenesis and hypervirulence of K. pneumoniae.
“The elaboration and acquisition of the latter three siderophores are associated with the pathogenesis and hypervirulence of K. pneumoniae (1,44,53,54).”
From Siderophore-mediated iron acquisition by Klebsiella pneumoniae (2024) · cites this paper as [54]
The Abstract says hypervirulent K. pneumoniae commonly produces yersiniabactin, salmochelin, and enterobactin, but its experiments found that loss of these siderophores, individually or together, did not decrease virulence in the tested mouse infection models. It identifies aerobactin, rather than the other three, as a major virulence factor. No page number is available in our copy. (LLM, conf=0.88)
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Unlike FeEnt, FeAbn uptake was not inhibited by SCN, reinforcing its importance in the pathogenesis of hvKp1.
“However, unlike FeEnt, FeAbn uptake was not inhibited by SCN, reinforcing its importance in the pathogenesis of hvKp1 (54).”
From Siderophore-mediated iron acquisition by Klebsiella pneumoniae (2024) · cites this paper as [54]
The Results passage on growth in ascites fluid and serum, together with the Discussion, supports aerobactin’s importance to hvKP1 under the conditions tested. But our copy does not report that SCN inhibits FeEnt uptake while leaving FeAbn uptake unaffected; searches for SCN, siderocalin, and uptake did not establish that comparison. (LLM, conf=0.86)
Experimental — accuracy not yet measured
FeGEnt does not adsorb well to siderocalin, which promotes the pathogenesis of clinical isolates of E. coli, K. pneumoniae, and Salmonella typhimurium in human and animal hosts.
“The glucosylated ferric catecholate does not adsorb well to siderocalin ( Kumar et al., 2022 ), which promotes the pathogenesis of clinical isolates of E. coli, K. pneumoniae, and Salmonella typhimurium in human and animal hosts ( Russo et al., 2011 , 2015 ).”
From Specificity and mechanism of TonB-dependent ferric catecholate uptake by Fiu (2024) · cites this paper as Russo et al., 2015

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Guide for the Care and Use of Laboratory Animals: Eighth Edition
(2011) · doi:10.17226/12910 · Cited by 16,199 · see citing works
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877 · see citing works
Siderophore-Based Iron Acquisition and Pathogen Control
Miethke, M., & Marahiel, M. A. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00012-07 · Cited by 1,774 · see citing works
Chemistry and biology of siderophores
Hider, R. C., & Kong, X. (2010) · Natural Product Reports · doi:10.1039/b906679a · Cited by 1,722 · see citing works
Guide for the Care and Use of Laboratory Animals (8th edn)
Albus, U. (2012) · Laboratory Animals · doi:10.1258/la.2012.150312 · Cited by 1,706 · see citing works
Iron and infection
Weinberg, E. D. (1978) · Microbiological Reviews · doi:10.1128/mmbr.42.1.45-66.1978 · Cited by 1,254 · see citing works
Microbial Iron Compounds
Neilands, J. B. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.003435 · Cited by 1,241 · see citing works
Hypervirulent (hypermucoviscous) Klebsiella pneumoniae
Shon, A. S. Y., Bajwa, R. P. S., & Russo, T. A. (2013) · Virulence · doi:10.4161/viru.22718 · Cited by 1,175 · see citing works
Self-citation
Untitled work
(2018) · doi:10.1001/jama · Cited by 932 · see citing works
Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing
Snitkin, E. S., Zelazny, A. M., Thomas, P. J., Stock, F., Program, N. C. S., Henderson, D. K., Palmore, T. N., & Segre, J. A. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004129 · Cited by 863 · see citing works
Primary Liver Abscess Due toKlebsiella pneumoniaein Taiwan
Wang, J., Liu, Y., Lee, S. S., Yen, M. Y., Yao‐Shen Chen, J. W., Wann, S., & Lin, H.-H. (1998) · Clinical Infectious Diseases · doi:10.1086/516369 · Cited by 602 · see citing works
Community-Acquired Klebsiella pneumoniae Bacteremia: Global Differences in Clinical Patterns
Ko, W., Paterson, D. L., Sagnimeni, A. J., Hansen, D. S., von Gottberg, A., Mohapatra, S., Casellas, J. M., Goossens, H., Mülazımoğlu, L., Trenholme, G. M., et al. (2002) · Emerging infectious diseases · doi:10.3201/eid0802.010025 · Cited by 566 · see citing works
Klebsiella pneumoniae Liver Abscess Associated With Septic Endophthalmitis
Liu, Y.-C. (1986) · Archives of Internal Medicine · doi:10.1001/archinte.1986.00360220057011 · Cited by 553 · see citing works
Vital signs: carbapenem-resistant Enterobacteriaceae.
(2013) · PubMed Central · Cited by 524 · see citing works
Virulent Clones of Klebsiella pneumoniae: Identification and Evolutionary Scenario Based on Genomic and Phenotypic Characterization
Brisse, S., Fèvre, C., Passet, V., Issenhuth-Jeanjean, S., Tournebize, R., Diancourt, L., & Grimont, P. A. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004982 · Cited by 493 · see citing works
Genome Sequencing and Comparative Analysis of Klebsiella pneumoniae NTUH-K2044, a Strain Causing Liver Abscess and Meningitis
Wu, K.-M., Li, L.-H., Yan, J.-J., Tsao, N., Liao, T.-L., Tsai, H.-C., Fung, C., Chen, H.-J., Liu, Y.-M., Wang, J.-T., et al. (2009) · Journal of Bacteriology · doi:10.1128/jb.00315-09 · Cited by 381 · see citing works
Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43
Chen, Y.-T., Chang, H.-Y., Lai, Y.-C., Pan, C.-C., Tsai, S.-F., & Peng, H.-L. (2004) · Gene · doi:10.1016/j.gene.2004.05.008 · Cited by 351 · see citing works
Septic metastatic lesions of pyogenic liver abscess. Their association with Klebsiella pneumoniae bacteremia in diabetic patients
Cheng, D. L. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.8.1557 · Cited by 344 · see citing works
Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes
Yu, W., Ko, W., Cheng, K.-C., Lee, C.-C., Lai, C.-C., & Chuang, Y.-C. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2008.04.007 · Cited by 324 · see citing works
NDM-1 — A Cause for Worldwide Concern
Moellering, R. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmp1011715 · Cited by 313 · see citing works
Klebsiella pneumoniae Yersiniabactin Promotes Respiratory Tract Infection through Evasion of Lipocalin 2
Bachman, M. A., Oyler, J. E., Burns, S. H., Caza, M., Lepine, F. L., Dozois, C. M., & Weiser, J. N. (2011) · Infection and Immunity · doi:10.1128/iai.05114-11 · Cited by 308 · see citing works
Aerobactin Mediates Virulence and Accounts for Increased Siderophore Production under Iron-Limiting Conditions by Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae
Russo, T. A., Olson, R., MacDonald, U., Metzger, D., Maltese, L. M., Drake, E. J., & Gulick, A. M. (2014) · Infection and Immunity · doi:10.1128/iai.01667-13 · Cited by 305 · see citing works
Self-citation
Increasing Occurrence of Antimicrobial-Resistant Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Isolates in China
Li, W., Sun, G., Yu, Y., Li, N., Chen, M., Jin, R., Jiao, Y., & Wu, H. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit675 · Cited by 304 · see citing works
Septic Metastatic Lesions of Pyogenic Liver Abscess
cheng, D.-L. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400080059010 · Cited by 294 · see citing works
Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor
Nassif, X., Fournier, J. M., Arondel, J., & Sansonetti, P. J. (1989) · Infection and Immunity · doi:10.1128/iai.57.2.546-552.1989 · Cited by 276 · see citing works
RmpA Regulation of Capsular Polysaccharide Biosynthesis in Klebsiella pneumoniae CG43
Cheng, H., Chen, Y., Wu, C.-C., Chang, H. Y., Lai, Y., & Peng, H. (2010) · Journal of Bacteriology · doi:10.1128/jb.00031-10 · Cited by 270 · see citing works
Clinical implications of hypermucoviscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community‐acquired bacteraemia
LEE, H. ‐., Chuang, Y., Yu, W., Lee, N. ‐., Chang, C., Ko, N., WANG, L. ‐., & Ko, W. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01641.x · Cited by 263 · see citing works
Redundancy and Specificity of Escherichia coli Iron Acquisition Systems during Urinary Tract Infection
Garcia, E. C., Brumbaugh, A. R., & Mobley, H. L. T. (2011) · Infection and Immunity · doi:10.1128/iai.01222-10 · Cited by 256 · see citing works
Yersiniabactin Is a Virulence Factor for Klebsiella pneumoniae during Pulmonary Infection
Lawlor, M. S., O'Connor, C., & Miller, V. L. (2007) · Infection and Immunity · doi:10.1128/iai.00372-06 · Cited by 255 · see citing works
The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
Bearden, S. W., & Perry, R. D. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01360.x · Cited by 254 · see citing works
Clinical and phenotypic differences between classic and hypervirulent Klebsiella pneumonia: an emerging and under-recognized pathogenic variant
Pomakova, D. K., Hsiao, C.-B., Beanan, J. M., Olson, R., MacDonald, U., Keynan, Y., & Russo, T. A. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1396-6 · Cited by 244 · see citing works
Self-citation
Serum‐Induced Iron‐Acquisition Systems and TonB Contribute to Virulence inKlebsiella pneumoniaeCausing Primary Pyogenic Liver Abscess
Hsieh, P., Lin, T., Lee, C., Tsai, S., & Wang, J.-T. (2008) · The Journal of Infectious Diseases · doi:10.1086/588383 · Cited by 240 · see citing works
The role of Klebsiella pneumoniae rmpA in capsular polysaccharide synthesis and virulence revisited
Hsu, C., Lin, T., Chen, Y.-C., Chou, H.-C., & Wang, J. (2011) · Microbiology · doi:10.1099/mic.0.050336-0 · Cited by 233 · see citing works
Lipocalin 2 Is Required for Pulmonary Host Defense against Klebsiella Infection
Chan, Y. R., Liu, J. S., Pociask, D. A., Zheng, M., Mietzner, T. A., Berger, T., Mak, T. W., Clifton, M. C., Strong, R. K., Ray, P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803282 · Cited by 220 · see citing works
Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation
Perry, R. D., Balbo, P., Jones, H. A., Fetherston, J. D., & DeMoll, E. (1999) · Microbiology · doi:10.1099/13500872-145-5-1181 · Cited by 178 · see citing works
Interaction of lipocalin 2, transferrin, and siderophores determines the replicative niche of Klebsiella pneumoniae during pneumonia
Bachman, M. A., Lenio, S., Schmidt, L., Oyler, J. E., & Weiser, J. N. (2012) · mBio · doi:10.1128/mbio.00224-11 · Cited by 168 · see citing works
Hypervirulent K. Pneumoniae Secretes More and More Active Iron-Acquisition Molecules than “Classical” K. Pneumoniae Thereby Enhancing its Virulence
Russo, T. A., Shon, A. S., Beanan, J. M., Olson, R., MacDonald, U., Pomakov, A. O., & Visitacion, M. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026734 · Cited by 153 · see citing works
Self-citation
Aerobactin-mediated utilization of transferrin iron
Konopka, K., Bindereif, A., & Neilands, J. B. (1982) · Biochemistry · doi:10.1021/bi00268a028 · Cited by 116 · see citing works
Effect of serum albumin on siderophore-mediated utilization of transferrin iron
Konopka, K., & Neilands, J. B. (1984) · Biochemistry · doi:10.1021/bi00305a003 · Cited by 108 · see citing works
Penicillin‐Binding Protein 7/8 Contributes to the Survival ofAcinetobacter baumanniiIn Vitro and In Vivo
Russo, T. A., MacDonald, U., Beanan, J. M., Olson, R., MacDonald, I. J., Sauberan, S. L., Luke, N. R., Schultz, L. W., & Umland, T. C. (2009) · The Journal of Infectious Diseases · doi:10.1086/596317 · Cited by 100 · see citing works
Self-citation
Enhancement of extracapsular polysaccharide synthesis in Klebsiella pneumoniae by RmpA2, which shows homology to NtrC and FixJ
Wacharotayankun, R., Arakawa, Y., Ohta, M., Tanaka, K., Akashi, T., Mori, M., & Kato, N. (1993) · Infection and Immunity · doi:10.1128/iai.61.8.3164-3174.1993 · Cited by 97 · see citing works
Doxorubicin-conjugated quantum dots to target alveolar macrophages and inflammation
Chakravarthy, K. V., Davidson, B. A., Helinski, J. D., Ding, H. Y., Law, W., Yong, K., Prasad, P. N., & Knight, P. R. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.09.001 · Cited by 95 · see citing works
Self-citation
Genetic Requirements for Klebsiella pneumoniae -Induced Liver Abscess in an Oral Infection Model
Tu, Y.-C., Lu, M., Chiang, M., Huang, S.-P., Peng, H., Chang, H., Jan, M., & Lai, Y. (2009) · Infection and Immunity · doi:10.1128/iai.01523-08 · Cited by 95 · see citing works
Expression of Type IV Pili by Moraxella catarrhalis Is Essential for Natural Competence and Is Affected by Iron Limitation
Luke, N. R., Howlett, A. J., Shao, J., & Campagnari, A. A. (2004) · Infection and Immunity · doi:10.1128/iai.72.11.6262-6270.2004 · Cited by 78 · see citing works
“Nightmare” Bacteria on the Rise in US Hospitals, Long-term Care Facilities
Kuehn, B. M. (2013) · JAMA · doi:10.1001/jama.2013.2922 · Cited by 53 · see citing works
Plasmid transferability of KPC into a virulent K2 serotype Klebsiella pneumoniae
Siu, L.-K. K., Huang, D. B., & Chiang, T. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-176 · Cited by 51 · see citing works
Metabolomic Analysis of Siderophore Cheater Mutants Reveals Metabolic Costs of Expression in Uropathogenic Escherichia coli
Lv, H., Hung, C., & Henderson, J. P. (2014) · Journal of Proteome Research · doi:10.1021/pr4009749 · Cited by 51 · see citing works
Growth stimulation ofEscherichia coliin serum by iron(III) aerobactin. Recycling of aerobactin
Braun, V., Brazel-Faisst, C., & Schneider, R. (1984) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1984.tb00193.x · Cited by 35 · see citing works
Virulence and Transferability of Resistance Determinants in a Novel Klebsiella pneumoniae Sequence Type 1137 in China
Liu, Y., Li, X., Wan, L., Jiang, W.-Y., Yang, J.-H., & Li, F.-Q. (2013) · Microbial Drug Resistance · doi:10.1089/mdr.2013.0107 · Cited by 26 · see citing works
Draft Genome Sequence of the Hypervirulent Klebsiella pneumoniae Strain hvKP1, Isolated in Buffalo, New York
Russo, T. A., & Gill, S. R. (2013) · Genome Announcements · doi:10.1128/genomea.00065-13 · Cited by 24 · see citing works
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[18]18. M enterobactin, with the addition of 1.28 M yersiniabactin, and with 640 nM and 1.28 M aerobactin compared to growth in the absence of exogenous siderophore (*, P Ͻ 0.05/6, two-tailed unpaired t test). ulence revisited. Microbiology 157:3446 -3457. http://dx.doi.org/10.1099 /mic.0.050336-0.

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Kochan, T. J., Nozick, S., Valdes, A., Mitra, S. D., Cheung, B. H., Lebrun-Corbin, M., Medernach, R. L., Vessely, M., Mills, J. O., Axline, C. M. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43802-1 · Cited by 136 · see citing works
Clinical Implications of Genomic Adaptation and Evolution of Carbapenem-Resistant Klebsiella pneumoniae
Gomez‐Simmonds, A., & Uhlemann, A. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw378 · Cited by 130 · see citing works
Selection and validation of reference genes for gene expression studies in Klebsiella pneumoniae using Reverse Transcription Quantitative real-time PCR
Gomes, A. É. I., Stuchi, L. P., Siqueira, N. M. G., Henrique, J. B., Vicentini, R., Ribeiro, M. L., Darrieux, M., & Ferraz, L. F. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-27420-2 · Cited by 127 · see citing works
Metabolite Transporter PEG344 Is Required for Full Virulence of Hypervirulent Klebsiella pneumoniae Strain hvKP1 after Pulmonary but Not Subcutaneous Challenge
Bulger, J. L., MacDonald, U., Olson, R., Beanan, J. M., & Russo, T. A. (2017) · Infection and Immunity · doi:10.1128/iai.00093-17 · Cited by 125 · see citing works
Self-citation
Clinical, microbiological, and molecular epidemiological characteristics of Klebsiella pneumoniae-induced pyogenic liver abscess in southeastern China
Zhang, S., Zhang, X., Wu, Q. F., Zheng, X., Dong, G., Fang, R., Zhang, Y., Cao, J., & Zhou, T. (2019) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-019-0615-2 · Cited by 122 · see citing works
Klebsiella pneumoniae : Prevalence, Reservoirs, Antimicrobial Resistance, Pathogenicity, and Infection: A Hitherto Unrecognized Zoonotic Bacterium
Hu, Y., Anes, J., Devineau, S., & Fanning, S. (2020) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2020.2847 · Cited by 113 · see citing works
Whole genome analysis of hypervirulent Klebsiella pneumoniae isolates from community and hospital acquired bloodstream infection
Shankar, C., Veeraraghavan, B., Nabarro, L., Ravi, R., Ragupathi, N. K. D., & Rupali, P. (2018) · BMC Microbiology · doi:10.1186/s12866-017-1148-6 · Cited by 111 · see citing works
Epidemiological characteristics and molecular evolution mechanisms of carbapenem-resistant hypervirulent Klebsiella pneumoniae
Han, Y., Wen, X., Zhao, W., Cao, X., Wen, J.-X., Wang, J., Hu, Z.-D., & Zheng, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1003783 · Cited by 111 · see citing works
Hypervirulent Klebsiella pneumoniae induced ventilator-associated pneumonia in mechanically ventilated patients in China
Yan, Q., Zhou, M., Zou, M., & Liu, W.-E. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-015-2551-2 · Cited by 107 · see citing works
The making of hypervirulent Klebsiella pneumoniae
Dai, P., & Hu, D. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24743 · Cited by 102 · see citing works
Hypervirulent Klebsiella pneumoniae: a Call for Consensus Definition and International Collaboration
Harada, S., & Doi, Y. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.00959-18 · Cited by 100 · see citing works
The Basics of Bacteriuria: Strategies of Microbes for Persistence in Urine
Ipe, D. S., Horton, E. M., & Ulett, G. C. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00014 · Cited by 98 · see citing works
Colibactin Contributes to the Hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in Mouse Meningitis Infections
Lu, M., Chen, Y.-T., Chiang, M., Wang, Y., Hsiao, P.-Y., Huang, Y.-J., Lin, C.-T., Cheng, C., Liang, C.-L., & Lai, Y. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00103 · Cited by 95 · see citing works
Genomic surveillance for multidrug-resistant or hypervirulent Klebsiella pneumoniae among United States bloodstream isolates
Kochan, T. J., Nozick, S., Medernach, R. L., Cheung, B. H., Gatesy, S. W. M., Lebrun-Corbin, M., Mitra, S. D., Khalatyan, N., Krapp, F., Qi, C., et al. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07558-1 · Cited by 91 · see citing works
Towards new antibiotics classes targeting bacterial metallophores
Ezzeddine, Z., & Ghssein, G. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106221 · Cited by 92 · see citing works
Characteristics of Hypervirulent Klebsiella pneumoniae: Does Low Expression of rmpA Contribute to the Absence of Hypervirulence?
Lin, Z., Zheng, J., Bai, B., Xu, G., Lin, F.-J., Chen, Z., Sun, X., Qu, D., Yu, Z., & Deng, Q.-W. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00436 · Cited by 84 · see citing works
Identification and Characterization of NDM-1-producing Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae in China
Liu, Z., Gu, Y., Li, X., Liu, Y., Ye, Y., Guan, S., & Li, J. (2018) · Annals of Laboratory Medicine · doi:10.3343/alm.2019.39.2.167 · Cited by 83 · see citing works
Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
Mendes, G., Santos, M. L., Ramalho, J. F., Duarte, A., & Caneiras, C. S. G. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1325077 · Cited by 83 · see citing works
High prevalence of hypervirulent Klebsiella pneumoniae infection in the genetic background of elderly patients in two teaching hospitals in China
Liu, C., Shi, J., & Guo, J. X. (2018) · Infection and Drug Resistance · doi:10.2147/idr.s161075 · Cited by 84 · see citing works
Anatomy of an extensively drug-resistant Klebsiella pneumoniae outbreak in Tuscany, Italy
Martin, M. J., Corey, B. W., Sannio, F., Hall, L. R., MacDonald, U., Jones, B. T., Mills, E. G., Harless, C., Stam, J. A., Maybank, R. A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110227118 · Cited by 75 · see citing works
Self-citation
An Assessment of Siderophore Production, Mucoviscosity, and Mouse Infection Models for Defining the Virulence Spectrum of Hypervirulent Klebsiella pneumoniae
Russo, T. A., MacDonald, U., Hassan, S., Camanzo, E., Lebreton, F., Corey, B. W., & McGann, P. (2021) · mSphere · doi:10.1128/msphere.00045-21 · Cited by 76 · see citing works
Self-citation
Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens
Gulick, A. M. (2017) · Natural Product Reports · doi:10.1039/c7np00029d · Cited by 73 · see citing works
Klebsiella pneumoniae producing bacterial toxin colibactin as a risk of colorectal cancer development - A systematic review
Straková, N., Kořená, K., & Karpíšková, R. (2021) · Toxicon · doi:10.1016/j.toxicon.2021.04.007 · Cited by 75 · see citing works
Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence
Shankar, C., Basu, S., Lal, B., Shanmugam, S., Vasudevan, K., Mathur, P., Ramaiah, S., Anbarasu, A., & Veeraraghavan, B. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.709681 · Cited by 73 · see citing works
High Serum Iron level is Associated with Increased Mortality in Patients with Sepsis
Lan, P., Pan, K.-H., Wang, S., Shi, Q., Yu, Y., Fu, Y., Chen, Y., Jiang, Y., Hua, X., Zhou, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29353-2 · Cited by 75 · see citing works
From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models
Joseph, L., Merciecca, T., Forestier, C., Balestrino, D., & Miquel, S. (2021) · Microorganisms · doi:10.3390/microorganisms9061282 · Cited by 72 · see citing works
Mobilizable plasmids drive the spread of antimicrobial resistance genes and virulence genes in Klebsiella pneumoniae
Zhang, J., Xu, Y., Wang, M., Li, X., Liu, Z., Kuang, D., Deng, Z., Ou, H., & Qu, J. (2023) · Genome Medicine · doi:10.1186/s13073-023-01260-w · Cited by 69 · see citing works
Characteristics of ventilator-associated pneumonia due to hypervirulent Klebsiella pneumoniae genotype in genetic background for the elderly in two tertiary hospitals in China
Liu, C., & Guo, J. X. (2018) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-018-0371-8 · Cited by 70 · see citing works
Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae
Bailey, D. C., Alexander, E. M., Rice, M. R., Drake, E. J., Mydy, L. S., Aldrich, C. C., & Gulick, A. M. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002798 · Cited by 67 · see citing works
Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395
Shaidullina, E., Schwabe, M., Rohde, T. D., Shapovalova, V. V., Dyachkova, M. S., Дмитриевна, М. А., Savochkina, Y. A., Shelenkov, A. A., Mikhaylova, Y., Sydow, K., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01159-6 · Cited by 65 · see citing works
An overview of recent progress in siderophore-antibiotic conjugates
Kong, H., Cheng, W., Han, W., Yuan, Y., Yang, Z., & Zhang, X. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111615 · Cited by 62 · see citing works
Potential therapeutic targets of Klebsiella pneumoniae: a multi-omics review perspective
Ali, S., Alam, M., Hasan, G. M., & Hassan, M. I. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab038 · Cited by 62 · see citing works
Whole‐genome analysis of Klebsiella pneumoniae from bovine mastitis milk in the U.S.
Zheng, Z., Gorden, P. J., Xia, X.-Q., Zheng, Y., & Li, G. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15721 · Cited by 59 · see citing works
Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents
Füzi, M., Rodríguez‐Baño, J., & Tóth, Á. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00271 · Cited by 57 · see citing works
Frequency of virulence factors in high biofilm formation bla producing Klebsiella pneumoniae strains from hospitals
Fu, L., Huang, M., Zhang, X., Yang, X., Liu, Y., Zhang, L., Zhang, Z., Wang, G., & Zhou, Y. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.01.030 · Cited by 56 · see citing works
Capsular polysaccharide enables Klebsiella pneumoniae to evade phagocytosis by blocking host-bacteria interactions
Liu, X., Xu, Q., Yang, X., Heng, H., Yang, C., Yang, G., Peng, M., Chan, E. W., & Chen, S. (2025) · mBio · doi:10.1128/mbio.03838-24 · Cited by 52 · see citing works
Hypervirulent Klebsiella pneumoniae: Insights into Virulence, Antibiotic Resistance, and Fight Strategies Against a Superbug
Hetta, ‏. F., Alanazi, F. E., Ali, M. A. S., Alatawi, A. D., Aljohani, H. M., Ahmed, R., Alansari, N. A., Alkhathami, F., Albogmi, A. A., Alharbi, B. M., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18050724 · Cited by 52 · see citing works
Klebsiella pneumoniae Asparagine tDNAs Are Integration Hotspots for Different Genomic Islands Encoding Microcin E492 Production Determinants and Other Putative Virulence Factors Present in Hypervirulent Strains
Marcoleta, A. E., Berríos-Pastén, C., Núñez, G., Monasterio, O., & Lagos, R. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00849 · Cited by 50 · see citing works
New putative vaccine candidates against Acinetobacter baumannii using the reverse vaccinology method
Fereshteh, S., Abdoli, S., Shahcheraghi, F., Ajdary, S., Nazari, M., & Badmasti, F. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104114 · Cited by 51 · see citing works
Whole-Genome-Sequencing characterization of bloodstream infection-causing hypervirulent Klebsiella pneumoniae of capsular serotype K2 and ST374
Wang, X., Xie, Y., Li, G., Liu, J., Li, X., Tian, L., Sun, J., Ou, H., & Qu, H. (2018) · Virulence · doi:10.1080/21505594.2017.1421894 · Cited by 50 · see citing works
Targeting human pathogenic bacteria by siderophores: A proteomics review
Ferreira, D., Seca, A. M. L., Diana, C. G. A., & Silva, A. M. S. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.04.006 · Cited by 49 · see citing works
Understanding carbapenem-resistant hypervirulent Klebsiella pneumoniae: Key virulence factors and evolutionary convergence
Chen, T., Ying, L., Xiong, L., Wang, X., Lu, P., Wang, Y., Shen, P., & Xiao, Y. (2024) · hLife · doi:10.1016/j.hlife.2024.06.005 · Cited by 47 · see citing works
A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae fepB Mutant
Palacios, M., Broberg, C. A., Walker, K. A., & Miller, V. L. (2017) · mSphere · doi:10.1128/msphere.00341-17 · Cited by 50 · see citing works
Bactericidal, anti-biofilm, and anti-virulence activity of vitamin C against carbapenem-resistant hypervirulent Klebsiella pneumoniae
Xu, C., Dong, N., Chen, K., Yang, X., Zeng, P., Hou, C., Chan, E. W., Yao, X., & Chen, S. (2022) · iScience · doi:10.1016/j.isci.2022.103894 · Cited by 47 · see citing works
Deciphering the relative importance of genetic elements in hypervirulent Klebsiella pneumoniae to guide countermeasure development
Russo, T. A., MacDonald, U., Drayer, Z. J., Davies, C. J., Alvarado, C. L., Hutson, A. D., Luo, T. L., Martin, M. J., McGann, P., & Lebreton, F. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105302 · Cited by 46 · see citing works
Self-citation
Photodynamic treatment for multidrug-resistant Gram-negative bacteria: Perspectives for the treatment of Klebsiella pneumoniae infections
Valenzuela, M., González, I., & Palavecino, C. E. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.08.012 · Cited by 45 · see citing works
Virulence Factors in Klebsiella pneumoniae: A Literature Review
Monteiro, A. D. S. S., Cordeiro, S. M., & Pedreira, J. N. R. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01247-0 · Cited by 49 · see citing works
Evaluating Different Virulence Traits of Klebsiella pneumoniae Using Dictyostelium discoideum and Zebrafish Larvae as Host Models
Marcoleta, A. E., Varas, M. A., Ortíz-Severín, J., Vásquez, L., Berríos-Pastén, C., Sabag, A., Chávez, F. P., Allende, M. L., Santiviago, C. A., Monasterio, O., et al. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00030 · Cited by 44 · see citing works
Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds Against Klebsiella pneumoniae
Weber, B. S., Jong, A. M. D., Guo, A. B. Y., Dharavath, S., French, S., Fiebig‐Comyn, A., Coombes, B. K., Magolan, J., & Brown, E. D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107927 · Cited by 43 · see citing works
Innate Host Defense against Klebsiella pneumoniae and the Outlook for Development of Immunotherapies
Opoku‐Temeng, C., Małachowa, N., Kobayashi, S. D., & DeLeo, F. R. (2021) · Journal of Innate Immunity · doi:10.1159/000518679 · Cited by 45 · see citing works
Siderophore-mediated iron acquisition by Klebsiella pneumoniae
Kumar, A., Chakravorty, S., Yang, T., Russo, T. A., Newton, S. M., & Klebba, P. E. (2024) · Journal of Bacteriology · doi:10.1128/jb.00024-24 · Cited by 42 · see citing works
Self-citation
Acquisition of the Conjugative Virulence Plasmid From a CG23 Hypervirulent Klebsiella pneumoniae Strain Enhances Bacterial Virulence
Tian, D., Wang, W., Li, M., Chen, W., Zhou, Y., Huang, Y., Sheng, Z.-K., & Jiang, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.752011 · Cited by 42 · see citing works
Identification of hypervirulent Klebsiella pneumoniae based on biomarkers and Galleria mellonella infection model
Mai, D., Wu, A., Li, R., Cai, D., Tong, H., Wang, N., & Tan, J. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03124-0 · Cited by 41 · see citing works
Clinical and laboratory insights into the threat of hypervirulent Klebsiella pneumoniae
Han, X., Yao, J., He, J., Liu, H., Jiang, Y., Zhao, D., Shi, Q., Zhou, J., Hu, H., Lan, P., et al. (2024) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2024.107275 · Cited by 43 · see citing works
Getting hypervirulent Klebsiella pneumoniae on the radar screen
Sellick, J. A., & Russo, T. A. (2018) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000464 · Cited by 40 · see citing works
Self-citation
Molecular validation of clinical Pantoea isolates identified by MALDI-TOF
Soutar, C. D., & Stavrinides, J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224731 · Cited by 40 · see citing works
Molecular Typing of Klebsiella pneumoniae Clinical Isolates by Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction
Sedighi, P., Zarei, O., Karimi, K., Taheri‬, M., Karami, P., & Shokoohizadeh, L. (2020) · International Journal of Microbiology · doi:10.1155/2020/8894727 · Cited by 40 · see citing works
Limited Transmission of Klebsiella pneumoniae among Humans, Animals, and the Environment in a Caribbean Island, Guadeloupe (French West Indies)
Dereeper, A., Gruel, G., Pot, M., Couvin, D., Barbier, E., Bastian, S., Bambou, J., Gelu‐Siméon, M., Ferdinand, S., Guyomard-Rabenirina, S., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01242-22 · Cited by 38 · see citing works
Antimicrobial Resistance Pattern, Pathogenicity and Molecular Properties of Hypervirulent Klebsiella pneumonia (hvKp) among Hospital-Acquired Infections in the Intensive Care Unit (ICU)
Alharbi, M. T., Almuhayawi, M. S., Nagshabandi, M. K., Tarabulsi, M. K., Alruhaili, M. H., Gattan, H. S., Jaouni, S. K. A., Selim, S., Alanazi, A., Alruwaili, Y. S., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11030661 · Cited by 38 · see citing works
The pathogenicity of rmpA or aerobactin-positive Klebsiella pneumoniae in infected mice
Li, G., Sun, S., Zhao, Z. Y., & Sun, Y. (2019) · Journal of International Medical Research · doi:10.1177/0300060519863544 · Cited by 38 · see citing works
Detection of carbapenem-resistant hypervirulent Klebsiella pneumoniae ST11-K64 co-producing NDM-1 and KPC-2 in a tertiary hospital in Wuhan
Huang, Y., Li, J., Wang, Q., Tang, K., Cai, X., & Li, C. (2022) · Journal of Hospital Infection · doi:10.1016/j.jhin.2022.09.014 · Cited by 37 · see citing works
Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence
Royer, G., Clermont, O., Marin, J., Condamine, B., Dion, S., Blanquart, F., Galardini, M., & Denamur, É. (2023) · Nature Communications · doi:10.1038/s41467-023-39428-y · Cited by 37 · see citing works
Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae
Bailey, D. C., Drake, E. J., Grant, T. D., & Gulick, A. M. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00409 · Cited by 39 · see citing works
Aerobactin Synthesis Proteins as Antivirulence Targets in Hypervirulent Klebsiella pneumoniae
Russo, T. A., & Gulick, A. M. (2019) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.9b00117 · Cited by 37 · see citing works
Self-citation
Interplay between siderophores and colibactin genotoxin in Escherichia coli
Martín, P., Tronnet, S., Garcie, C., & Oswald, É. (2017) · IUBMB Life · doi:10.1002/iub.1612 · Cited by 35 · see citing works
Sewage-based surveillance shows presence of Klebsiella pneumoniae resistant against last resort antibiotics in the population in Bergen, Norway
Radisic, V., Grevskott, D. H., Lunestad, B. T., Øvreås, L., & Marathe, N. P. (2022) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2022.114075 · Cited by 33 · see citing works
Whole-genome sequencing of Egyptian multidrug-resistant Klebsiella pneumoniae isolates: a multi-center pilot study
Sherif, M. M., Palmieri, M., Mirande, C., El‐Mahallawy, H. A., Rashed, H. G., Reheem, F. A. E., Elmanakhly, A. R., Rabea, R. A., Aboulela, A., Saeed, L. Y., et al. (2021) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-021-04177-7 · Cited by 36 · see citing works
Global surveillance of antimicrobial resistance and hypervirulence in Klebsiella pneumoniae from LMICs: An in-silico approach
Silvester, R., Madhavan, A., Kokkat, A., Parolla, A., Adarsh, B. M., Harikrishnan, M., & Abdulla, M. H. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.149859 · Cited by 35 · see citing works
Clinical and Bacterial Characteristics of Klebsiella pneumoniae Affecting 30-Day Mortality in Patients With Bloodstream Infection
Wu, X., Shi, Q., Shen, S., Huang, C., & Wu, H. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.688989 · Cited by 35 · see citing works
Virulence Factors and Carbapenem-Resistance Mechanisms in Hypervirulent Klebsiella Pneumoniae
Liao, Y., Gong, J., Yuan, X., Wang, X., Huang, Y., & Chen, X. (2024) · Infection and Drug Resistance · doi:10.2147/idr.s461903 · Cited by 34 · see citing works
Virulence among different types of hypervirulent Klebsiella pneumoniae with multi-locus sequence type (MLST)-11, Serotype K1 or K2 strains
Wang, T.-C., Lin, J., Chang, J.-C., Hiaso, Y.-W., Wang, C.-H., Chiu, S., Fung, C., Chang, F., & Siu, L.-K. K. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00439-z · Cited by 34 · see citing works
The Role of Plasmid and Resistance Gene Acquisition in the Emergence of ST23 Multi-Drug Resistant, Hypervirulent Klebsiella pneumoniae
Du, P., Liu, C., Fan, S., Baker, S. G., & Guo, J. X. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01929-21 · Cited by 34 · see citing works
Hypervirulent carbapenem-resistant Klebsiella pneumoniae causing highly fatal meningitis in southeastern China
Huang, N., Jia, H., Zhou, B., Zhou, C., Cao, J., Liao, W., Liu, S., Wang, L., Chen, L., Chen, L., et al. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.991306 · Cited by 34 · see citing works
Genomic Epidemiology of Carbapenem-Resistant Klebsiella in Qatar: Emergence and Dissemination of Hypervirulent Klebsiella pneumoniae Sequence Type 383 Strains
Tsui, C. K. M., Abid, F. B., Ismail, K. A., McElheny, C. L., Maslamani, M. A. R. S. A., Omrani, A. S., & Doi, Y. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00030-23 · Cited by 34 · see citing works
In Vitro Activity of Ceftazidime-Avibactam against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates
Yu, F., Lv, J., Niu, S., Du, H., Tang, Y., Bonomo, R. A., Kreiswirth, B. N., & Chen, L. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01031-18 · Cited by 32 · see citing works
Fluorescent sensors of siderophores produced by bacterial pathogens
Kumar, A., Yang, T., Chakravorty, S., Majumdar, A., Nairn, B. L., Six, D. A., Marcondes dos Santos, N., Price, S. L., Lawrenz, M. B., Actis, L. A., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101651 · Cited by 28 · see citing works
Self-citation
Detection of carbapenemase-producing, hypervirulent Klebsiella spp. in wastewater and their potential transmission to river water and WWTP employees
Rolbiecki, D., Harnisz, M., Korzeniewska, E., Buta, M., Hubeny, J., & Zieliński, W. (2021) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2021.113831 · Cited by 33 · see citing works

Aerobactin Mediates Virulence and Accounts for Increased Siderophore Production under Iron-Limiting Conditions by Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae
Russo, T. A., Olson, R., MacDonald, U., Metzger, D., Maltese, L. M., Drake, E. J., & Gulick, A. M. (2014) · Infection and Immunity · doi:10.1128/iai.01667-13 · Cited by 305 · see citing works
Self-citation
Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae
Bailey, D. C., Alexander, E. M., Rice, M. R., Drake, E. J., Mydy, L. S., Aldrich, C. C., & Gulick, A. M. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002798 · Cited by 67 · see citing works
Essentiality of the virulence plasmid-encoded factors in disease pathogenesis of the major lineage of hypervirulent Klebsiella pneumoniae varies in different infection niches
Lim, C., Zhang, C.-Y., Cheam, G., Chu, W. H. W., Chen, Y., Yong, M., Lim, K. Y. E., Lam, M. M. C., Teo, T., & Gan, Y. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105683 · Cited by 29 · see citing works
MP064 A novel fibrinogen binding protein from Streptococcus agalactiae is required for the bacterial invasion of human epithelial cells
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Yersiniabactin Is a Virulence Factor for Klebsiella pneumoniae during Pulmonary Infection
Lawlor, M. S., O'Connor, C., & Miller, V. L. (2007) · Infection and Immunity · doi:10.1128/iai.00372-06 · Cited by 255 · see citing works

Authors: Russo, T. A., Olson, R., MacDonald, U., Beanan, J., & Davidson, B. A.
Affiliations: VA Western New York Healthcare System (US)
ORCID: Russo, Thomas A.
MacDonald, Ulrike
Davidson, Bruce A.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2015-08
Volume: 83
Issue: 8
Pages: 3325-3333
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.00430-15
PMC: PMC4496593
OpenAlex: W2283434174
Semantic Scholar: e716de1372bc2153e94e76130028b8b30a86c6b0
Cited by: 305
References: 49
Citations by year: 2026: 32 · 2025: 32 · 2024: 34 · 2023: 33 · 2022: 56 · 2021: 28 · 2020: 25 · 2019: 16 · 2018: 24 · 2017: 11 · 2016: 13 · 2015: 1
FWCI: 12.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health (W81XWH)
National Institute of Allergy and Infectious Diseases (R21AI088318)
Telemedicine and Advanced Technology Research Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Enterobacteriaceae and Cronobacter Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Keywords: aerobactin, yersiniabactin, salmochelin, enterobactin, siderophores, hypervirulent Klebsiella pneumoniae, hypermucoviscous Klebsiella pneumoniae, virulence factors, iron acquisition, iucA, IRP2, entB, iroB, systemic infection, pulmonary infection, ascitic fluid, human serum, human urine
MeSH terms: Animals, Enterobactin, Glucosides, Humans, Hydroxamic Acids, Klebsiella Infections, Klebsiella pneumoniae, Male, Phenols, Thiazoles, Virulence, Siderophores, Microbial Viability, Mice, Young Adult

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Aerobactin, but Not Yersiniabactin, Salmochelin, or Enterobactin, Enables the Growth/Survival of Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Ex Vivo and In Vivo

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