The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Role of exosomal proteins in cancer diagnosis
Open accessAbstract
Exosomes are emerging as a new type of cancer biomarkers. Exosome is a bilayered nano-sized vesicle secreted by various living cells in all body fluids. Based on the expanding albeit incomplete knowledge of their biogenesis, secretion by cells and cancer cell-specific molecular and genetic contents, exosomes are viewed as promising, clinically-relevant surrogates of cancer progression and response to therapy. Preliminary proteomic, genetic and functional profiling of cancer cell-derived or cancer plasma-derived exosomes confirms their unique characteristics. Alterations in protein or nucleic acid profiles of exosomes in plasma correlate with pathological processes of many diseases including cancer. However, previous studies on exosome application in cancer diagnosis and treatment mainly focussed on miRNAs. With the development of rapid large-scale production, purification, extraction and screening of exosomal contents, exosomal protein application can be explored for early stage cancer diagnosis, monitoring and prognosis evaluation. Here, we summarized the recent developments in application of exosomal proteins for cancer diagnosis.
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1 retracted
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Cited by
Exosomes as a new frontier of cancer liquid biopsy
Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 855
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Cancer associated-fibroblast-derived exosomes in cancer progression
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Exosome-like Nanoparticles: A New Type of Nanocarrier
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Metadata
- Authors
- Li, W., Li, C., Zhou, T., Liu, X., Liu, X., Li, X., & Chen, D.
- Venue
- Molecular Cancer
- Published
- 2017-08-29
- Volume
- 16
- Issue
- 1
- Pages
- 145-145
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2750813302
- Cited by
- 447
- References
- 140
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- gold
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