Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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Identification of stem cells in small intestine and colon by marker gene Lgr5

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Wnt/β-catenin signaling and disease

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Lessons from hereditary colorectal cancer

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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The ground state of embryonic stem cell self-renewal

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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

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Functional interaction of β-catenin with the transcription factor LEF-1

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The Genomic Landscapes of Human Breast and Colorectal Cancers

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β‐catenin is a target for the ubiquitin–proteasome pathway

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510 · see citing works

Wnt proteins are lipid-modified and can act as stem cell growth factors

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LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

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Organoid models of human and mouse ductal pancreatic cancer

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

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WNT signaling in bone homeostasis and disease: From human mutations to treatments

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

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Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

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Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

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Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

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Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

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XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

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Romosozumab Treatment in Postmenopausal Women with Osteoporosis

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

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High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

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Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es, J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.11.013 · Cited by 1,547 · see citing works

A new member of the frizzled family from Drosophila functions as a Wingless receptor

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The complex world of WNT receptor signalling

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Designer matrices for intestinal stem cell and organoid culture

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Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

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Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF.

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A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

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Single-cell messenger RNA sequencing reveals rare intestinal cell types

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Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

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Towards an integrated view of Wnt signaling in development

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

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YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

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WNT Signals Are Required for the Initiation of Hair Follicle Development

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Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

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Can we safely target the WNT pathway?

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Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

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Active Wnt proteins are secreted on exosomes

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Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

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Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

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Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

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Lgr5 marks cycling, yet long-lived, hair follicle stem cells

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Recurrent R-spondin fusions in colon cancer

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

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Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

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Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

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Structural basis of Wnt recognition by Frizzled

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A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription

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Vascular Development in the Retina and Inner Ear

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling

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In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

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Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

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Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion.

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Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

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Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

Malladi, S., Macalinao, D. G., Jin, X., He, L., Basnet, H., Zou, Y., de Stanchina, E., & Massagué, J. (2016) · Cell · doi:10.1016/j.cell.2016.02.025 · Cited by 791 · see citing works

Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells

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REST and stress resistance in ageing and Alzheimer’s disease

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Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers

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<i>Lgr6</i> Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

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Integrated genomic characterization of adrenocortical carcinoma

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Drosophila Tcf and Groucho interact to repress Wingless signalling activity

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Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

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Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

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Isolation and in vitro expansion of human colonic stem cells

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Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer

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Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation

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Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila

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Purification and Ex Vivo Expansion of Fully Functional Salivary Gland Stem Cells

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Wnt Signals Can Function as Positional Cues in Establishing Cell Polarity

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Lgr5-EGFP Marks Taste Bud Stem/Progenitor Cells in Posterior Tongue

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GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

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Stearoyl CoA Desaturase Is Required to Produce Active, Lipid-Modified Wnt Proteins

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A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities

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DVL1 Frameshift Mutations Clustering in the Penultimate Exon Cause Autosomal-Dominant Robinow Syndrome

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WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion

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Kinetic Responses of β-Catenin Specify the Sites of Wnt Control

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Derivation of a robust mouse mammary organoid system for studying tissue dynamics

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Ueber die secernirenden Zellen des Dünndarm-Epithels

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Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia

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Axin2 marks quiescent hair follicle bulge stem cells that are maintained by autocrine Wnt/β-catenin signaling

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A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction

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Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling

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Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3

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Dynamics of Lgr6 + Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis

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Mutations in WNT10B Are Identified in Individuals with Oligodontia

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Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation

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Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

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Structural Studies of Wnts and Identification of an LRP6 Binding Site

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A unique type of GSK-3 inhibitor brings new opportunities to the clinic

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Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells

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Control of Cell Polarity and Asymmetric Division in C. elegans

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Wnt proteins synergize to activate β-catenin signaling

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Polarized Wnt Signaling Regulates Ectodermal Cell Fate in Xenopus

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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

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Targeting the Wnt/β-catenin signaling pathway in cancer

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Wnt signaling in colorectal cancer: Pathogenic role and therapeutic target

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Wnt/β-catenin signaling in cancers and targeted therapies

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Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

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Mutations and mechanisms of WNT pathway tumour suppressors in cancer

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Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer

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Cell-cell communication: New insights and clinical implications

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The Immunomodulatory Functions of Butyrate

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The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic

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Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy

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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease

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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

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Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

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Wnt signaling deregulation in the aging and Alzheimer’s brain

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Intrinsically disordered proteins play diverse roles in cell signaling

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Single cell transcriptomics of human epidermis identifies basal stem cell transition states

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Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

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Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

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Spatial sorting enables comprehensive characterization of liver zonation

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Spatial sorting enables comprehensive characterization of liver zonation

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Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options

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Cutaneous barrier dysfunction in allergic diseases

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Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders

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Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

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A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer

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Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation

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Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide

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Casein kinase 1α: biological mechanisms and theranostic potential

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Lung cancer stem cell markers as therapeutic targets: An update on signaling pathways and therapies

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Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure–function continuum with intrinsic disorder-based proteoforms

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WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

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The role of PI3K signaling pathway in Alzheimer’s disease

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Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway

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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

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Dysregulated Wnt Signalling in the Alzheimer’s Brain

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EGFR is required for Wnt9a/Fzd9b signalling specificity in haematopoietic stem cells

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One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids

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SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells

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A New Wave of Targeting ‘Undruggable’ Wnt Signaling for Cancer Therapy: Challenges and Opportunities

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TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis

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Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis

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Mouse liver assembloids model periportal architecture and biliary fibrosis

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Representing dynamic biological networks with multi-scale probabilistic models

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Activation of Wnt/β‐catenin signaling restores insulin sensitivity in insulin resistant neurons through transcriptional regulation of IRS‐1

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Two Wnt genes regulate the expression levels of antimicrobial peptides during Vibrio infection in Macrobrachium nipponense

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CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease

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Hepatocyte Cell Cycle Progression Depends on a Transcriptional Repressor Cascade Downstream of Wnt Signaling

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Primary cell cultures versus immortalized cell lines: critical comparative insights into biological fidelity and translational applications

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High-throughput Analysis of WNT Signaling Pathway in Osteoblasts

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