Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics
Open accessAbstract
BACKGROUND: There is a lack of comprehensive patient-datasets regarding prevalence of severe hypertriglyceridemia (sHTG; triglycerides ≥10 mmol/L), frequency of co-morbidities, gene mutations, and gene characterization in sHTG. Using large surveys combined with detailed analysis of sub-cohorts of sHTG patients, we here sought to address these issues. METHODS: We used data from several large Norwegian surveys that included 681,990 subjects, to estimate the prevalence. Sixty-five sHTG patients were investigated to obtain clinical profiles and candidate disease genes. We obtained peripheral blood mononuclear cells (PBMC) from six male patients and nine healthy controls and examined expression of mRNAs involved in lipid metabolism. RESULTS: The prevalence of sHTG was 0.13 (95% CI 0.12-0.14)%, and highest in men aged 40-49 years and in women 60-69 years. Among the 65 sHTG patients, a possible genetic cause was found in four and 11 had experienced acute pancreatitis. The mRNA expression levels of carnitine palmitoyltransferase (CPT)-1A, CPT2, and hormone-sensitive lipase, were significantly higher in patients compared to controls, whereas those of ATP-binding cassette, sub-family G, member 1 were significantly lower. CONCLUSIONS: In Norway, sHTG is present in 0.1%, carries considerable co-morbidity and is associated with an imbalance of genes involved in lipid metabolism, all potentially contributing to increased cardiovascular morbidity in sHTG.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hypertriglyceridaemia prevalence is approximately 10% in the adult population, with considerable interregional variation.
“Its prevalence is ∼10% in the adult population with considerable interregional variation.1–5”
From Clinical review on triglycerides (2020) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Issues in Hypertriglyceridemic Pancreatitis
Scherer, J., Singh, V. P., Pitchumoni, C. S., & Yadav, D. K. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000436438.60145.5a · Cited by 482 · see citing works
Nonfasting mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis
Pedersen, S. B., Langsted, A., & Nordestgaard, B. G. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.6875 · Cited by 270 · see citing works
The cardiovascular disease study in Norwegian counties. Background and organization.
Bjartveit, K., Foss, O. P., Gjervig, T., & Lund‐Larsen, P. G. (1979) · PubMed · Cited by 227 · see citing works
Cohort Profile: Cohort of Norway (CONOR)
Næss, Ø., Søgaard, A. J., Arnesen, E., Beckstrøm, A. C., Bjertness, E., Engeland, A., Hjort, P. F., Holmen, J., Magnus, P. M., Njølstad, I., et al. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym217 · Cited by 206 · see citing works
Recent advances in pharmacotherapy for hypertriglyceridemia
Sahebkar, A., Chew, G. T., & Watts, G. F. (2014) · Progress in Lipid Research · doi:10.1016/j.plipres.2014.07.002 · Cited by 166 · see citing works
Prevalence of Severe (500 to 2,000 mg/dl) Hypertriglyceridemia in United States Adults
Christian, J. B., Bourgeois, N., Snipes, R., & Lowe, K. A. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.11.008 · Cited by 155 · see citing works
Severe Hypertriglyceridemia With Pancreatitis
Sacks, F. M., Stanesa, M., & Hegele, R. A. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.13309 · Cited by 119 · see citing works
Salmon, F., Grosios, K., & Petry, H. (2013) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2014.852065 · Cited by 93 · see citing works
Management of hypertriglyceridemia.
Oh, R., & Lanier, J. B. (2007) · PubMed · Cited by 77 · see citing works
Reproducibility and validity of a short food questionnaire for the assessment of dietary habits.
Svilaas, A., Strøm, E., Svilaas, T., et al. (2002) · PubMed · Cited by 62 · see citing works
Joshi, M., Eagan, J., Desai, N. K., et al. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2014.8 · Cited by 55 · see citing works
Tverdal, A., FOSS, O. P., Leren, P., Holme, I., Lund‐Larsen, P. G., & Bjartveit, K. (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115157 · Cited by 55 · see citing works
Jung, U. J., Seo, Y., Ryu, R., & Choi, M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002993 · Cited by 54 · see citing works
Hypertriglyceridemia: the importance of identifying patients at risk
Kushner, P. A., & Cobble, M. E. (2016) · Postgraduate Medicine · doi:10.1080/00325481.2016.1243005 · Cited by 47 · see citing works
A reversal of decreasing trends in population cholesterol levels in Västerbotten County, Sweden
Ng, N., Johnson, O., Lindahl, B., & Norberg, M. (2012) · Global Health Action · doi:10.3402/gha.v5i0.10367 · Cited by 37 · see citing works
Konieczna, J., Sánchez, J., van Schothorst, E. M., Torrens, J. M., Bunschoten, A., Palou, M., Picó, C., Keijer, J., & Palou, A. (2013) · Genes & Nutrition · doi:10.1007/s12263-013-0366-2 · Cited by 36 · see citing works
Coffee intake and oral–oesophageal cancer: follow-up of 389 624 Norwegian men and women 40–45 years
Tverdal, A., Hjellvik, V., & Selmer, R. M. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.192 · Cited by 30 · see citing works
Self-citationStefanutti, C., & Julius, U. (2015) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2015.02.017 · Cited by 23 · see citing works
Type 1 hyperlipoproteinemia due to a novel deletion of exons 3 and 4 in the GPIHBP1 gene
Berge, K. E., Retterstøl, K., Romeo, S., Pirazzi, C., & Leren, T. P. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.02.005 · Cited by 17 · see citing works
Self-citationEsteghamati, A., Hafezi‐Nejad, N., Sheikhbahaei, S., Heidari, B., Zandieh, A., Ebadi, M., & Nakhjavani, M. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.02.002 · Cited by 14 · see citing works
Ferreira, M. D. R., Camberos, M. D. C., Selenscig, D. A., Martucci, L., Chicco, A. G., Lombardo, Y. B., & Cresto, J. C. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12050 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clinical review on triglycerides
Laufs, U., Parhofer, K. G., Ginsberg, H. N., & Hegele, R. A. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz785 · Cited by 544 · see citing works
Hansen, S. E. J., Madsen, C. M., Varbo, A., & Nordestgaard, B. G. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.294926 · Cited by 121 · see citing works
The Diagnosis and Treatment of Hypertriglyceridemia
Parhofer, K. G., & Laufs, U. (2019) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2019.0825 · Cited by 110 · see citing works
- Authors
- Retterstøl, K., Narverud, I., Selmer, R., Berge, K. E., Osnes, I. V., Ulven, S. M., Halvorsen, B., Aukrust, P., Holven, K. B., & Iversen, P. O.
- Affiliations
- Oslo University Hospital (NO)
- Norwegian Institute of Public Health (NO)
- University of Oslo (NO)
- Corresponding author
- Iversen, Per O.
- ORCID
- Venue
- Lipids in Health and Disease
- Published
- 2017-06-12
- Volume
- 16
- Issue
- 1
- Pages
- 115-115
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC5469061
- OpenAlex
- W2627090023
- Cited by
- 36
- References
- 23
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- BIBSYS Brage (BIBSYS (Norway)) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Funders
- Throne Holst Foundation for Nutrition Research
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- severe hypertriglyceridemia, prevalence, acute pancreatitis, lipid metabolism, CPT1A, CPT2, hormone-sensitive lipase, ABCG1, mRNA expression, cardiovascular risk, Norway
- MeSH terms
- Adult, Aged, Sterol Esterase, Female, Humans, Leukocytes, Mononuclear, Male, Metabolic Diseases, Middle Aged, Mutation, Norway, Pancreatitis, Triglycerides, Hypertriglyceridemia, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
