CoChat
Sign Up
Cited by 127Curcumin's Biomedical ApplicationsNatural Antidiabetic Agents StudiesFatty Acid Research and Health

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial

Open access
Thota, Rohith N., Acharya, Shamasunder H., Garg, Manohar L.·2019·Lipids in Health and Disease
DOI 10.1186/s12944-019-0967-xPMC PMC6347796
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Lowering insulin resistance and dyslipidaemia may not only enhance glycaemic control but also preserve the β-cell function, reducing the overall risk of developing type 2 diabetes (T2D). The current study was aimed to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) supplementation on glycaemic control and blood lipid levels in individuals at high risk of developing T2D. METHODS: This was a 2 × 2 factorial, randomised, double-blinded, placebo-controlled study. Participants were allocated to either double placebo (PL) or curcumin plus placebo matching for LCn-3PUFA (CC), or LCn-3PUFA plus placebo matching for curcumin (FO), or curcumin plus LCn-3PUFA (CC-FO) for twelve weeks. Primary outcome of the trial was glycaemic indices (HbA1C, fasting glucose and insulin). Insulin resistance and sensitivity is measured using homeostatic model assessment model. RESULTS: A total of sixty-four participants (PL, n = 16; CC, n = 15; FO, n = 17, CC-FO, n = 16) were included in the final analysis. Post-intervention, HbA1c and fasting glucose remained unchanged across all the groups. Insulin sensitivity was significantly improved in the CC supplemented group (32.7 ± 10.3%) compared to PL (P = 0.009). FO and CC-FO tended to improve insulin sensitivity by 14.6 ± 8.5% and 8.8 ± 7.7% respectively, but the difference did not reach significance. Triglyceride levels were further increased in the PL (26.9 ± 7.4%), however, CC and CC-FO supplementation reduced the triglycerides, FO resulted in the greatest reduction in triglycerides (- 16.4 ± 4.5%, P < 0.001). CONCLUSION: Reduction in insulin resistance and triglycerides by curcumin and LCn-3PUFA appears to be attractive strategies for lowering the risk of developing T2D. However, this study failed to demonstrate complimentary benefits of curcumin and LCn-3PUFA on glycaemic control. TRAIL REGISTRATION: ACTRN12615000559516 .

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s12944-019-0967-x

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Figures

Fig. 1 Consolidated Standards of Reporting Trials (CONSORT) flow chart– trial protocol
Fig. 1 Consolidated Standards of Reporting Trials (CONSORT) flow chart– trial protocolCC BY · PubMed Central
Fig. 2 Changes in the outcome measures from baseline to post intervention with-in and between double placebo (PL), curcumin (CC), fish oil (FO) and curcumin + fish oil (CC-FO); a Change in the serum glucose (%); b Change in the serum insulin (%). c Change in homeostatic model assessment for insulin resistance (log transformed) (HOMA2 IR); d Change in insulin sensitivity. Data presented as mean ± SEM or median (IQR) as appropriate. Significant changes from baseline indicated by * p < 0.05, ** p < 0.01. Means with same lower letter indicate significant differences between the groups
Fig. 2 Changes in the outcome measures from baseline to post intervention with-in and between double placebo (PL), curcumin (CC), fish oil (FO) and curcumin + fish oil (CC-FO); a Change in the serum glucose (%); b Change in the serum insulin (%). c Change in homeostatic model assessment for insulin resistance (log transformed) (HOMA2 IR); d Change in insulin sensitivity. Data presented as mean ± SEM or median (IQR) as appropriate. Significant changes from baseline indicated by * p < 0.05, ** p < 0.01. Means with same lower letter indicate significant differences between the groupsCC BY · PubMed Central
Fig. 3 Changes in the outcome measures from baseline to post intervention and between double placebo (PL), curcumin (CC), fish oil (FO) and curcumin + fish oil (CC-FO); a Change in the serum triglyceride (%). b Change in the serum HDL-Cholesterol (%); c Change in atherogenic index of plasma (AIP) d. Change in InsuTAG (log transformed). Data presented as mean ± SEM or median (IQR) as appropriate. Significant changes from baseline indicated by * p < 0.05, ** p < 0.01. Means with same lower letter indicate significant differences between the groups
Fig. 3 Changes in the outcome measures from baseline to post intervention and between double placebo (PL), curcumin (CC), fish oil (FO) and curcumin + fish oil (CC-FO); a Change in the serum triglyceride (%). b Change in the serum HDL-Cholesterol (%); c Change in atherogenic index of plasma (AIP) d. Change in InsuTAG (log transformed). Data presented as mean ± SEM or median (IQR) as appropriate. Significant changes from baseline indicated by * p < 0.05, ** p < 0.01. Means with same lower letter indicate significant differences between the groupsCC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

Sorted by citations

See all 127

Related

See all

Metadata

Authors
Thota, R. N., Acharya, S. H., & Garg, M. L.
Affiliations
  • Riddet Institute (NZ)
  • John Hunter Hospital (AU)
Corresponding author
Garg, Manohar L.
ORCID
Venue
Lipids in Health and Disease
Publisher
Springer Science and Business Media LLC
Published
2019-01-26
Volume
18
Issue
1
Pages
31-31
ISSN
1476-511X (ISSN-L)
DOI
10.1186/s12944-019-0967-x
PMC
PMC6347796
OpenAlex
W2913281433
Cited by
127
References
40
Citations by year
2026: 9 · 2025: 17 · 2024: 25 · 2023: 18 · 2022: 22 · 2021: 17 · 2020: 14 · 2019: 5
FWCI
5.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Lipids in Health and Disease (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • NOVA (University of Newcastle Australia) (submittedVersion, other-oa)
  • NOVA (University of Newcastle Australia) (submittedVersion, cc-by)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
curcumin, omega-3 polyunsaturated fatty acids, insulin resistance, insulin sensitivity, type 2 diabetes prevention, dyslipidemia, triglycerides, serum lipids, glycemic control, HbA1c, fasting blood glucose, HOMA-IR, dietary supplementation, beta-cell function, high-risk individuals
MeSH terms
Adult, Aged, Blood Glucose, Curcumin, Diabetes Mellitus, Type 2, Fasting, Female, Humans, Insulin, Insulin Resistance, Lipids, Male, Middle Aged, Risk Factors, Triglycerides, Fatty Acids, Omega-3, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review