C-reactive Protein
Open accessAbstract
C-reactive protein (CRP) is a phylogenetically highly conserved plasma protein, with homologs in vertebrates and many invertebrates, that participates in the systemic response to inflammation. Its plasma concentration increases during inflammatory states, a characteristic that has long been employed for clinical purposes. CRP is a pattern recognition molecule, binding to specific molecular configurations that are typically exposed during cell death or found on the surfaces of pathogens. Its rapid increase in synthesis within hours after tissue injury or infection suggests that it contributes to host defense and that it is part of the innate immune response. Recently, an association between minor CRP elevation and future major cardiovascular events has been recognized, leading to the recommendation by the Centers for Disease Control and the American Heart Association that patients at intermediate risk of coronary heart disease might benefit from measurement of CRP. This review will largely focus on our current understanding of the structure of CRP, its ligands, the effector molecules with which it interacts, and its apparent functions.
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“Nevertheless, these findings are interesting given that IL-6 is thought to trigger CRP expression (Black et al., 2004), yet CRP was higher in the AthletesOC group though this group displayed a trend for lower IL-6 concentrations, and there was no difference in CRP between AthletesNC in the follicular and luteal phases…”
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Inflammation Through a Psychoneuroimmunological Lens
Bennett, J. M., Gillie, B. L., Lindgren, M. E., Fagundes, C. P., & Kiecolt-Glaser, J. K. (2013) · Handbook of Systems and Complexity in Health · doi:10.1007/978-1-4614-4998-0_19 · Cited by 15 · see citing works
- Authors
- Black, S., Kushner, I., & Samols, D.
- Affiliations
- Case Western Reserve University (US)
- MetroHealth (US)
- Corresponding author
- Samols, David
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-11
- Volume
- 279
- Issue
- 47
- Pages
- 48487-48490
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2048521619
- Cited by
- 1,844
- References
- 50
- Citations by year
- 2026: 48 · 2025: 97 · 2024: 82 · 2023: 89 · 2022: 87 · 2021: 105 · 2020: 96 · 2019: 68 · 2018: 65 · 2017: 72 · 2016: 99 · 2015: 105 · 2014: 118 · 2013: 90 · 2012: 85
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- C-reactive protein, inflammation, innate immunity, pattern recognition, host defense, cardiovascular risk, coronary artery disease, ligand binding, plasma proteins
- MeSH terms
- Animals, Arteriosclerosis, C-Reactive Protein, Gene Expression Regulation, Humans, Inflammation, Models, Molecular, Phosphorylcholine, Phylogeny, Protein Binding, Protein Conformation, Complement C1q, Protein Structure, Secondary, Protein Structure, Tertiary
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