Cited by 1,844Biomarkers in Disease MechanismsImmune Response and InflammationAdipokines, Inflammation, and Metabolic Diseases

C-reactive Protein

Open access
Black, Steven, Kushner, Irving, Samols, David·2004·Journal of Biological Chemistry

Abstract

C-reactive protein (CRP) is a phylogenetically highly conserved plasma protein, with homologs in vertebrates and many invertebrates, that participates in the systemic response to inflammation. Its plasma concentration increases during inflammatory states, a characteristic that has long been employed for clinical purposes. CRP is a pattern recognition molecule, binding to specific molecular configurations that are typically exposed during cell death or found on the surfaces of pathogens. Its rapid increase in synthesis within hours after tissue injury or infection suggests that it contributes to host defense and that it is part of the innate immune response. Recently, an association between minor CRP elevation and future major cardiovascular events has been recognized, leading to the recommendation by the Centers for Disease Control and the American Heart Association that patients at intermediate risk of coronary heart disease might benefit from measurement of CRP. This review will largely focus on our current understanding of the structure of CRP, its ligands, the effector molecules with which it interacts, and its apparent functions.

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Research works printed but not linked: 4

  1. Volanakis, J. E., and Kaplan, M. H. (1971) Proc. Soc. Exp. Biol. Med. 136, 612-614
  2. Samols, D., Agrawal, A., and Kushner, I. (2002) in Cytokine Reference On-Line (Feldman, M., and Oppenheim, J. J., eds) Academic Press, London 4. Kushner, I., Jiang, S. L., Zhang, D., Lozanski, G., and Samols, D. (1995) Ann. N. Y. Acad. Sci. 762, 102-107
  3. Chang, M. K., Binder, C. J., Torzewski, M., and Witztum, J. L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 13043-13048
  4. Xia, D., and Samols, D. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2575-2580

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Authors
Black, S., Kushner, I., & Samols, D.
Affiliations
  • Case Western Reserve University (US)
  • MetroHealth (US)
Corresponding author
Samols, David
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2004-11
Volume
279
Issue
47
Pages
48487-48490
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2048521619
Cited by
1,844
References
50
Citations by year
2026: 48 · 2025: 97 · 2024: 82 · 2023: 89 · 2022: 87 · 2021: 105 · 2020: 96 · 2019: 68 · 2018: 65 · 2017: 72 · 2016: 99 · 2015: 105 · 2014: 118 · 2013: 90 · 2012: 85
FWCI
5.40
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
C-reactive protein, inflammation, innate immunity, pattern recognition, host defense, cardiovascular risk, coronary artery disease, ligand binding, plasma proteins
MeSH terms
Animals, Arteriosclerosis, C-Reactive Protein, Gene Expression Regulation, Humans, Inflammation, Models, Molecular, Phosphorylcholine, Phylogeny, Protein Binding, Protein Conformation, Complement C1q, Protein Structure, Secondary, Protein Structure, Tertiary

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