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Lipid nanoparticles loading triptolide for transdermal delivery: mechanisms of penetration enhancement and transport properties

Gu, Yongwei, Yang, Meng, Tang, Xiaomeng, Wang, Ting, Yang, Dishun, Zhai, Guangxi, Liu, Jiyong·2018·Journal of Nanobiotechnology
DOI 10.1186/s12951-018-0389-3PMC PMC6138933
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Fig. 1 TEM micrographs of TPL-NLC (a, ×20,000), DLS analysis of TPL-NLC (b, ×50,000), TEM micrographs of TPL-SLN (c), DLS analysis of TPL-SLN (d). In vitro permeation profiles of TPL-NLC and TPL-SLN (e). Each value is represented as the mean ± SD (n = 5)
Fig. 1 TEM micrographs of TPL-NLC (a, ×20,000), DLS analysis of TPL-NLC (b, ×50,000), TEM micrographs of TPL-SLN (c), DLS analysis of TPL-SLN (d). In vitro permeation profiles of TPL-NLC and TPL-SLN (e). Each value is represented as the mean ± SD (n = 5)CC BY · PubMed Central
Fig. 2 SEM photomicrographs (×500) of skin treated with normal saline (a), Blank-NLC (b), Blank-SLN (c), TPL-NLC (d) and TPL-SLN (e)
Fig. 2 SEM photomicrographs (×500) of skin treated with normal saline (a), Blank-NLC (b), Blank-SLN (c), TPL-NLC (d) and TPL-SLN (e)CC BY · PubMed Central
Fig. 3 Histopathological photomicrographs (×200) of skin treated with normal saline (a), Blank-NLC (b), Blank-SLN (c), TPL-NLC (d), TPL-SLN (e)
Fig. 3 Histopathological photomicrographs (×200) of skin treated with normal saline (a), Blank-NLC (b), Blank-SLN (c), TPL-NLC (d), TPL-SLN (e)CC BY · PubMed Central
Fig. 4 The DSC thermograms of skin tissue treated with normal saline, Blank-NLC, Blank-SLN, TPL-NLC, and TPL-SLN
Fig. 4 The DSC thermograms of skin tissue treated with normal saline, Blank-NLC, Blank-SLN, TPL-NLC, and TPL-SLNCC BY · PubMed Central
Fig. 5 Infrared spectra of skin samples treated with normal saline, Blank-SLN, Blank-NLC, TPL-SLN, and TPL-NLC
Fig. 5 Infrared spectra of skin samples treated with normal saline, Blank-SLN, Blank-NLC, TPL-SLN, and TPL-NLCCC BY · PubMed Central
Fig. 6 CLSM images (×100) of skin samples treated with free C-6, C-6/NLC and C-6/SLN (a), enlarged CLSM Figure (×200) (b), fluorescence intensity in receptor fluid at various times (c)
Fig. 6 CLSM images (×100) of skin samples treated with free C-6, C-6/NLC and C-6/SLN (a), enlarged CLSM Figure (×200) (b), fluorescence intensity in receptor fluid at various times (c)CC BY · PubMed Central
Fig. 7 Cellular uptake of C-6 solution, C-6/SLN, C-6/NLC. a Intracellular distribution of the formulations in HaCaT cells. b, c: fluorescence intensity profiles of HaCaT cell treated with C-6 solution, C-6/NLC and C-6/SLN. Each value is represented as the mean ± SD (n = 3)
Fig. 7 Cellular uptake of C-6 solution, C-6/SLN, C-6/NLC. a Intracellular distribution of the formulations in HaCaT cells. b, c: fluorescence intensity profiles of HaCaT cell treated with C-6 solution, C-6/NLC and C-6/SLN. Each value is represented as the mean ± SD (n = 3)CC BY · PubMed Central
Fig. 8 Cell viability affected by Blank-NLC, Blank-SLN (a) and TPL solution, TPL-NLC, TPL-SLN (b, n = 3). Effect of TPL solution and TPL-NPs on the expression of skin inflammatory factors (c, n = 3). Each value is represented as the mean ± SD, * means P < 0.05, ** means P < 0.01
Fig. 8 Cell viability affected by Blank-NLC, Blank-SLN (a) and TPL solution, TPL-NLC, TPL-SLN (b, n = 3). Effect of TPL solution and TPL-NPs on the expression of skin inflammatory factors (c, n = 3). Each value is represented as the mean ± SD, * means P < 0.05, ** means P < 0.01CC BY · PubMed Central
Fig. 9 Photograph of the abdomen of Wistar rat exposed to the various formulations: normal saline (a), xylene (b), TPL-NLC (c), TPL-SLN (d)
Fig. 9 Photograph of the abdomen of Wistar rat exposed to the various formulations: normal saline (a), xylene (b), TPL-NLC (c), TPL-SLN (d)CC BY · PubMed Central

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Metadata

Authors
Gu, Y., Yang, M., Tang, X., Wang, T., Yang, D., Zhai, G., & Liu, J.
Venue
Journal of Nanobiotechnology
Publisher
Springer Science and Business Media LLC
Published
2018-09-15
Volume
16
Issue
1
ISSN
1477-3155
DOI
10.1186/s12951-018-0389-3
PMC
PMC6138933
Cited by
72
References
1
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (tdm)
Funders
  • National Natural Science Foundation of China (81573613)
  • Science and Technology Commission of Shanghai Municipality (15401900600, 18401931500, 16401901900)
  • Development Fund for Shanghai Talents (201658)
  • Open Project Program of State Key Laboratory of Natural Medicines (SKLNMKF201809)

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