The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.
Abstract
Extracts of Tripterygium wilfordii hook. f. (leigong teng, Thundergod vine) are effective in traditional Chinese medicine for treatment of immune inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus, nephritis and asthma. Characterisation of the terpenoids present in extracts of Tripterygium identified triptolide, a diterpenoid triepoxide, as responsible for most of the immunosuppressive, anti-inflammatory and antiproliferative effects observed in vitro. Triptolide inhibits lymphocyte activation and T-cell expression of interleukin-2 at the level of transcription. In all cell types examined, triptolide inhibits nuclear factor-kappaB transcriptional activation at a unique step in the nucleus after binding to DNA. Further characterisation of the molecular mechanisms of triptolide action will serve to elucidate pathways of immune system regulation.
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Metadata
- Authors
- Qiu, D., & Kao, P. N.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Kao, Peter N.
- ORCID
- Kao, Peter N.
- Venue
- Drugs in R & D
- Published
- 2003
- Volume
- 4
- Issue
- 1
- Pages
- 1-18
- ISSN
- 1174-5886 (ISSN-L)
- OpenAlex
- W1994342907
- Cited by
- 311
- References
- 103
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 10 · 2023: 9 · 2022: 19 · 2021: 9 · 2020: 13 · 2019: 12 · 2018: 10 · 2017: 23 · 2016: 8 · 2015: 15 · 2014: 20 · 2013: 24 · 2012: 14
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drugs in R&D (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-62588, R01HL062588)
- National Institute of Allergy and Infectious Diseases (R01AI039624, AI-39624)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Physical Sciences › Chemistry › Organic Chemistry › Bioactive Natural Diterpenoids Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- triptolide, Tripterygium wilfordii, diterpenoids, immunosuppression, anti-inflammatory mechanism, interleukin-2, T cell activation, lymphocyte activation, rheumatoid arthritis, systemic lupus erythematosus, nephritis, asthma, antiproliferative activity, traditional Chinese medicine
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Diterpenes, Drugs, Chinese Herbal, Epoxy Compounds, Humans, Immunosuppressive Agents, Phenanthrenes, Tripterygium
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