The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
A novel and compact review on the role of oxidative stress in female reproduction
Open accessAbstract
In recent years, the study of oxidative stress (OS) has become increasingly popular. In particular, the role of OS on female fertility is very important and has been focused on closely. The occurrence of OS is due to the excessive production of reactive oxygen species (ROS). ROS are a double-edged sword; they not only play an important role as secondary messengers in many intracellular signaling cascades, but they also exert indispensable effects on pathological processes involving the female genital tract. ROS and antioxidants join in the regulation of reproductive processes in both animals and humans. Imbalances between pro-oxidants and antioxidants could lead to a number of female reproductive diseases. This review focuses on the mechanism of OS and a series of female reproductive processes, explaining the role of OS in female reproduction and female reproductive diseases caused by OS, including polycystic ovary syndrome (PCOS), endometriosis, preeclampsia and so on. Many signaling pathways involved in female reproduction, including the Keap1-Nrf2, NF-κB, FOXO and MAPK pathways, which are affected by OS, are described, providing new ideas for the mechanism of reproductive diseases.
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Cites
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Cited by
Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing
Sadeghi, H. M., Adeli, I., Calina, D., Docea, A. O., Mousavi, T., Daniali, M., Nikfar, S., Tsatsakis, A., & Abdollahi, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020583 · Cited by 445
Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 359
The Role of Oxidative Stress and Antioxidant Balance in Pregnancy
Hussain, T., Murtaza, G., Metwally, E., Kalhoro, D. H., Kalhoro, M. S., Rahu, B. A., Sahito, R. G. A., Yin, Y., Yang, H., Chughtai, M. I., et al. (2021) · Mediators of Inflammation · doi:10.1155/2021/9962860 · Cited by 265
Targeting Oxidative Stress Involved in Endometriosis and Its Pain
Clower, L., Fleshman, T., Geldenhuys, W. J., & Santanam, N. (2022) · Biomolecules · doi:10.3390/biom12081055 · Cited by 145
“This relationship is particularly important as oxidative stress has been implicated in various disease processes and may be responsible for local tissue destruction in endometriosis [52].”
BackgroundDou, P., Zhang, T.-T., Xu, Y., Xue, Q., Zhang, Y., Shang, J., & Yang, X.-L. (2024) · Endocrine, Metabolic & Immune Disorders - Drug Targets · doi:10.2174/0118715303286777240223074922 · Cited by 15
Metadata
- Authors
- Lu, J., Wang, Z., Cao, J., Chen, Y., & Dong, Y.
- Venue
- Reproductive Biology and Endocrinology
- Published
- 2018-08-20
- Volume
- 16
- Issue
- 1
- Pages
- 80-80
- ISSN
- 1477-7827 (ISSN-L)
- OpenAlex
- W2888676896
- Cited by
- 481
- References
- 130
- FWCI
- 31.05
- Type
- journal article
- Language
- en
- Open access
- gold
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