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Cited by 48Sperm and Testicular FunctionVitamin D Research StudiesMale Reproductive Health Studies

The effects of Vitamin D3 supplementation on Spermatogram and endocrine factors in asthenozoospermia infertile men: A randomized, triple blind, placebo-controlled clinical trial

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Maghsoumi-Norouzabad, Leila, Zare Javid, Ahmad, Mansoori, Anahita, Dadfar, Mohammadreza, Serajian, Amirarsalan·2021·Reproductive Biology and Endocrinology
DOI 10.1186/s12958-021-00789-yPMC PMC8256550
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Abstract

Objective: Evaluate the effects of vitamin D3 (VD3) on sperm parameters and endocrine markers in infertile men with asthenozoospermia. Materials and methods: This randomized, triple-masking, placebo-controlled clinical trial conducted on 86 asthenozoospermia infertile men with serum 25 hydroxy vitamin D3 (25(OH)VD3)< 30 ng/ml in the infertility clinic of Ahvaz Jahad daneshgahi, Iran.Patients were randomly allocated to groups A and B, who received daily 4000 IU VD3 and matching placebo respectively for 3 months. Demographic data, dietary intake, physical activity, sun exposure, anthropometric indices, serum 25(OH)VD3, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), estradiol (E2),, sex hormone-binding globulin (SHBG), free androgen index (FAI = T/SHBG. 100), T/LH and T/E2 ratios, prolactin (PRO), parathyroid hormone (PTH), osteocalcin (OCN), phosphorus and sperm parameters were assessed. Results: Three months VD3 supplementation with 4000 IU/day had no significant effects body weight, body mass index (BMI), waist circumference (WC), body fat (BF), serum, OCN, LH, FSH, T, E2, SHBG, PRO, T/E2 ratio, FAI, semen volume, sperm count and normal sperm morphology.It increases serum 25(OH)VD3, PTH and phosphorus and seminal and serum calcium, T/LH ratio and total and progressive sperm motility and decreased significantly compared to the baseline and placebo group. Conclusion: VD3 supplementation may affect sperm motility in men with asthenozoospermia and serum 25(OH)VD3 < 30 ng/ml. Trial registration: Iran Clinical Trials Registry, ID: IRCT20151128025274N4, registered on 28 March 2018, URL of trial registry record:https://www.irct.ir/trial/29983

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Authors
Maghsoumi-Norouzabad, L., Zare Javid, A., Mansoori, A., Dadfar, M., & Serajian, A.
Affiliations
Ahvaz Jundishapur University of Medical Sciences (IR)
ORCID
Venue
Reproductive Biology and Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2021-07-05
Volume
19
Issue
1
Pages
102-102
ISSN
1477-7827 (ISSN-L)
DOI
10.1186/s12958-021-00789-y
PMC
PMC8256550
OpenAlex
W3179395765
Cited by
48
References
8
Citations by year
2026: 8 · 2025: 7 · 2024: 10 · 2023: 16 · 2022: 7
FWCI
6.92
Type
journal article
Language
en
Open access
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  • Reproductive Biology and Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ahvaz Jundishapur University of Medical Sciences
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
Keywords
vitamin D3 supplementation, asthenozoospermia, male infertility, sperm motility, 25-hydroxyvitamin D3, luteinizing hormone, follicle-stimulating hormone, testosterone, sex hormone-binding globulin, free androgen index, parathyroid hormone, osteocalcin, phosphorus, seminal parameters
MeSH terms
Adult, Cholecalciferol, Double-Blind Method, Follow-Up Studies, Humans, Infertility, Male, Luteinizing Hormone, Male, Parathyroid Hormone, Semen, Sperm Motility, Testosterone, Treatment Outcome, Dietary Supplements, Asthenozoospermia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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