Cited by 274Sperm and Testicular FunctionAntioxidant Activity and Oxidative StressReproductive Biology and Fertility

Role of antioxidants in the treatment of male infertility

Open access
Kefer, John C, Agarwal, Ashok, Sabanegh, Edmund·2009·International Journal of Urology

Abstract

Male infertility continues to be a clinical challenge of increasing significance. While male factors such as decreased semen quality are responsible for 25% of all infertility issues, the etiology of suboptimal semen quality is poorly understood. Many physiological, environmental, and genetic factors have been implicated, including oxidative stress. Oxidative stress is induced by reactive oxygen species (ROS), or free radicals, and although ROS are required for critical aspects of sperm function, excessive levels of ROS can negatively impact sperm quality. The origin of ROS generation, and the etiologies of increased ROS in men with suboptimal sperm quality have only recently been elucidated, offering multiple targets for potential therapy. Here, we present a critical review of the literature describing the role of oxidative stress on decreased sperm function, as well as the role of antioxidants in the treatment of male factor infertility.

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Crossref · 10.1111/j.1442-2042.2009.02280.x

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98 of 98 references verified0 citation errors · 0 not checkable

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  • Oxidative stress can be reduced by the antioxidant properties of fruits and vegetables, since these antioxidants act as scavengers and reduce reactive oxygen species.

    “According to Salas-Huetos et al., oxidative stress can be reduced by the antioxidant properties of fruits and vegetables, since these antioxidants act as scavengers and reduce reactive oxygen species [89,90].”

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Authors
Kefer, J. C., Agarwal, A., & Sabanegh, E.
Affiliations
Cleveland Clinic (US)
Corresponding author
Agarwal, Ashok
Venue
International Journal of Urology
Publisher
Wiley
Published
2009-04-28
Volume
16
Issue
5
Pages
449-457
ISSN
  • 0919-8172 (ISSN-L)
  • 1442-2042
OpenAlex
W2166623820
Cited by
273
References
97
Citations by year
2026: 4 · 2025: 10 · 2024: 10 · 2023: 20 · 2022: 16 · 2021: 14 · 2020: 21 · 2019: 17 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 16 · 2014: 23 · 2013: 19 · 2012: 19
FWCI
2.54
Type
journal article
Language
en
Open access
Locations
  • International Journal of Urology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
male infertility, antioxidants, oxidative stress, reactive oxygen species, semen quality, male factor infertility, antioxidant therapy, sperm function
MeSH terms
Antioxidants, Humans, Infertility, Male, Male, Spermatozoa, Oxidants, Oxidative Stress

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