The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Regulation of the master regulator FOXM1 in cancer
Open accessAbstract
FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis. In most human cancers, FOXM1 is overexpressed, and this indicates a poor prognosis for cancer patients. FOXM1 maintains cancer hallmarks by regulating the expression of target genes at the transcriptional level. Due to its potential role as molecular target in cancer therapy, FOXM1 was named the Molecule of the Year in 2010. However, the mechanism of FOXM1 dysregulation remains indistinct. A comprehensive understanding of FOXM1 regulation will provide novel insight for cancer and other diseases in which FOXM1 plays a major role. Here, we summarize the transcriptional regulation, post-transcriptional regulation and post-translational modifications of FOXM1, which will provide extremely important implications for novel strategies targeting FOXM1.
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Cited by
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Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity
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Retracted
Metadata
- Authors
- Liao, G.-B., Li, X.-Z., Zeng, S., Liu, C., Yang, S.-M., Yang, L., Hu, C.-J., & Bai, J.-Y.
- Venue
- Cell Communication and Signaling
- Published
- 2018-09-12
- Volume
- 16
- Issue
- 1
- Pages
- 57-57
- ISSN
- 1478-811X (ISSN-L)
- OpenAlex
- W2890410994
- Cited by
- 417
- References
- 110
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liao, G.-B., Li, X.-Z., Zeng, S., Liu, C., Yang, S.-M., Yang, L., Hu, C.-J., & Bai, J.-Y. (2018). Regulation of the master regulator FOXM1 in cancer. Cell Communication and Signaling. https://doi.org/10.1186/s12964-018-0266-6
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