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Cited by 464MicroRNA in disease regulationPlant Molecular Biology ResearchCancer-related molecular mechanisms research

Regulatory mechanisms of microRNA expression

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Gulyaeva, Lyudmila F., Kushlinskiy, Nicolay E.·2016·Journal of Translational Medicine
DOI 10.1186/s12967-016-0893-xPMC PMC4873990
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Abstract

MicroRNAs (miRs, miRNAs) are small molecules of 18-22 nucleotides that serve as important regulators of gene expression at the post-transcriptional level. One of the mechanisms through which miRNAs regulate gene expression involves the interaction of their "seed" sequences primarily with 3'-end and more rarely with 5'-end, of mRNA transcribed from target genes. Numerous studies over the past decade have been devoted to quantitative and qualitative assessment of miRNAs expression and have shown remarkable changes in miRNA expression profiles in various diseases. Thus, profiling of miRNA expression can be an important tool for diagnostics and treatment of disease. However, less attention has been paid towards understanding the underlying reasons for changes in miRNA expression, especially in cancer cells. The purpose of this review is to analyze and systematize current data that explains reasons for changes in the expression of miRNAs. The review will cover both transcriptional (changes in gene expression and promoter hypermethylation) and post-transcriptional (changes in miRNA processing) mechanisms of regulation of miRNA expression, as well as effects of endogenous (hormones, cytokines) and exogenous (xenobiotics) compounds on the miRNA expression. The review will summarize the complex multilevel regulation of miRNA expression, in relation to cell type, physiological state of the body and various external factors.

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  • miRNAs are small (~22 nt) non-coding RNAs involved in diverse physiological and developmental processes, and their dysregulation leads to several diseases including cancer.

    “miRNAs are small (~22 nt) non-coding RNAs involved in diverse physiological and developmental processes, and their dysregulation lead to several diseases including cancer (14–16).”

    From Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma (2019) · cites this paper as [16]

    The Background describes miRNAs as 18–22-nucleotide regulators involved in many biological processes and reports altered expression in various diseases, especially cancer. The DNA methylation section says deregulated miRNA expression may contribute to cancer development, but the paper does not establish the broader causal claim that miRNA dysregulation leads to several diseases. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Gulyaeva, L. F., & Kushlinskiy, N. E.
Affiliations
  • Novosibirsk State University (RU)
  • Russian Cancer Research Center NN Blokhin (RU)
Corresponding author
Gulyaeva, Lyudmila F.
ORCID
Gulyaeva, Lyudmila F.
Venue
Journal of Translational Medicine
Publisher
Springer Science and Business Media LLC
Published
2016-05-20
Volume
14
Issue
1
Pages
143-143
ISSN
1479-5876 (ISSN-L)
DOI
10.1186/s12967-016-0893-x
PMC
PMC4873990
OpenAlex
W2406965650
Cited by
464
References
1
Citations by year
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FWCI
4.22
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Translational Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Russian Science Foundation (15-15-30012)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
miRNA expression regulation, post-transcriptional regulation, miRNA seed sequence, promoter hypermethylation, microRNA processing, miRNA expression profiling, cancer, hormones, cytokines, xenobiotics, disease biomarkers
MeSH terms
Animals, Gene Expression Regulation, Humans, RNA Processing, Post-Transcriptional, Xenobiotics, Cell Hypoxia, DNA Methylation, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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