MicroRNA
Open accessAbstract
MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development. MiRNA mimics and miRNA inhibitors currently in preclinical development have shown promise as novel therapeutic agents. Multiple technological platforms have been developed for miRNA isolation, miRNA quantitation, miRNA profiling, miRNA target detection, and modulating miRNA levels in vitro and in vivo. Here we will review the major technological platforms with consideration given for the advantages and disadvantages of each platform.
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Non-coding microRNAs post-transcriptionally regulate mRNA expression by targeting the 3ʹ-UTR region and play a significant role in cellular functions such as differentiation, proliferation and apoptosis.
“Non-coding microRNAs (miRNAs) can post-transcriptionally regulate the mRNA expression by targeting the 3ʹ-UTR region, and thus play a significant role in various cellular functions such as differentiation, proliferation and apoptosis.15,16”
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Cites
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462 · see citing works
Predicting effective microRNA target sites in mammalian mRNAs
Agarwal, V., Bell, G. W., Nam, J.-W., & Bartel, D. P. (2015) · eLife · doi:10.7554/elife.05005 · Cited by 7,318 · see citing works
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462 · see citing works
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,931 · see citing works
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741 · see citing works
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796 · see citing works
MicroRNA targets in Drosophila
Enright, A. J., John, B., Gaul, U., Tuschl, T., Sander, C., & Marks, D. S. (2003) · Genome Biology · doi:10.1186/gb-2003-5-1-r1 · Cited by 3,597 · see citing works
The MicroRNA Spectrum in 12 Body Fluids
Weber, J. A., Baxter, D. H., Zhang, S., Huang, D. Y. C., Huang, K., Lee, M., Galas, D. J., & Wang, K. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.147405 · Cited by 2,754 · see citing works
The microRNA.org resource: targets and expression
Betel, D., Wilson, M. T., Gabow, A. P., Marks, D. S., & Sander, C. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm995 · Cited by 2,490 · see citing works
Towards a molecular understanding of microRNA-mediated gene silencing
Jonas, S., & Izaurralde, E. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3965 · Cited by 1,872 · see citing works
MicroRNA profiling: approaches and considerations
Pritchard, C. C., Cheng, H. H., & Tewari, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3198 · Cited by 1,765 · see citing works
Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
Betel, D., Koppal, A., Agius, P., Sander, C., & Leslie, C. (2010) · Genome Biology · doi:10.1186/gb-2010-11-8-r90 · Cited by 1,592 · see citing works
Facile Means for Quantifying Microrna Expression by Real-Time PCR
Shi, R., & Chiang, V. L. (2005) · BioTechniques · doi:10.2144/000112010 · Cited by 707 · see citing works
MiRNA Biogenesis and Regulation of Diseases: An Overview
Vishnoi, A., & Rani, S. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6524-3_1 · Cited by 694 · see citing works
Identification and consequences of miRNA–target interactions — beyond repression of gene expression
Hausser, J., & Zavolan, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3765 · Cited by 620 · see citing works
Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing
Shin, C., Nam, J.-W., Farh, K. K.-H., Chiang, H. R., Shkumatava, A., & Bartel, D. P. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.005 · Cited by 611 · see citing works
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
Kloosterman, W. P., Wienholds, E., de Bruijn, E., Kauppinen, S., & Plasterk, R. H. A. (2006) · Nature Methods · doi:10.1038/nmeth843 · Cited by 540 · see citing works
Regulatory mechanisms of microRNA expression
Gulyaeva, L. F., & Kushlinskiy, N. E. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0893-x · Cited by 464 · see citing works
Practical Aspects of microRNA Target Prediction
Witkos, T. M., Kościańska, E., & Krzyżosiak, W. J. (2011) · Current Molecular Medicine · doi:10.2174/156652411794859250 · Cited by 463 · see citing works
Methodological challenges in utilizing mi<scp>RNA</scp>s as circulating biomarkers
Moldovan, L., Batte, K. E., Trgovcich, J., Wisler, J., Marsh, C. B., & Piper, M. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12236 · Cited by 436 · see citing works
Chemical modification and design of anti-miRNA oligonucleotides
Lennox, K. A., & Behlke, M. A. (2011) · Gene Therapy · doi:10.1038/gt.2011.100 · Cited by 432 · see citing works
Specific and sensitive quantitative RT-PCR of miRNAs with DNA primers
Balcells, I., Cirera, S., & Busk, P. K. (2011) · BMC Biotechnology · doi:10.1186/1472-6750-11-70 · Cited by 310 · see citing works
Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines
Ho, T.-T., Zhou, N., Huang, J., Koirala, P., Xu, M., Fung, R., Wu, F., & Mo, Y. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1198 · Cited by 244 · see citing works
Importance of RNA isolation methods for analysis of exosomal RNA: Evaluation of different methods
Eldh, M., Lötvall, J. O., Malmhäll, C., & Ekström, K. M. (2012) · Molecular Immunology · doi:10.1016/j.molimm.2012.02.001 · Cited by 227 · see citing works
Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases
Lu, T. X., & Rothenberg, M. E. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.039 · Cited by 221 · see citing works
Self-citationKim, Y. K., Yeo, J., Kim, B., Ha, M., & Kim, V. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.036 · Cited by 221 · see citing works
Transfection of microRNA Mimics Should Be Used with Caution
Jin, H. Y., González-Martín, A., Miletic, A. V., Lai, M., Knight, S., Sabouri-Ghomi, M., Head, S. R., Macauley, M. S., Rickert, R. C., & Xiao, C. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00340 · Cited by 194 · see citing works
Lentivirus-mediated antagomir expression for specific inhibition of miRNA function
Scherr, M., Venturini, L., Battmer, K., Schaller-Schoenitz, M., Schaefer, D., Dallmann, I., Ganser, A., & Eder, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm971 · Cited by 190 · see citing works
A Resource for the Conditional Ablation of microRNAs in the Mouse
Park, C. Y., Jeker, L. T., Carver-Moore, K., Oh, A., Liu, H. J., Cameron, R., Richards, H. W., Li, Z., Adler, D., Yoshinaga, Y., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.008 · Cited by 174 · see citing works
On Measuring miRNAs after Transient Transfection of Mimics or Antisense Inhibitors
Thomson, D. W., Bracken, C. P., Szubert, J. M., & Goodall, G. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055214 · Cited by 118 · see citing works
Specificity and functionality of microRNA inhibitors
Robertson, B., Dalby, A. B., Karpilow, J. M., Khvorova, A., Leake, D., & Vermeulen, A. (2010) · Silence · doi:10.1186/1758-907x-1-10 · Cited by 79 · see citing works
Takyar, S. S., Vasavada, H. H., Zhang, J., Ahangari, F., Niu, N., Liu, Q., Lee, C. G., Cohn, L. E., & Elias, J. A. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121200 · Cited by 67 · see citing works
Dissanayake, E., & Inoue, Y. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0648-z · Cited by 64 · see citing works
MicroRNA In Situ Hybridization
Nielsen, B. S. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-427-8_5 · Cited by 63 · see citing works
MicroRNA in Chronic Rhinosinusitis and Allergic Rhinitis
Zhang, X., Zhang, Y., & Liu, Z. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-013-0415-3 · Cited by 53 · see citing works
Passenger strand loading in overexpression experiments using microRNA mimics
Søkilde, R., Newie, I., Persson, H., Borg, Å., & Rovira, C. (2015) · RNA Biology · doi:10.1080/15476286.2015.1020270 · Cited by 50 · see citing works
Carré, J. L., Lamon, S., & Léger, B. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00413 · Cited by 34 · see citing works
MicroRNA in United Airway Diseases
Liu, Z., Zhang, X.-H., Callejas, F. D. B., & Mullol, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050716 · Cited by 33 · see citing works
Hodzic, J., Sie, D., Vermeulen, A., & van Beusechem, V. W. (2017) · Human Gene Therapy · doi:10.1089/hum.2016.143 · Cited by 28 · see citing works
Functional Analysis of microRNA in Multiple Myeloma
Martino, M. T. D., Amodio, N., Tassone, P., & Tagliaferri, P. (2015) · Methods in molecular biology · doi:10.1007/7651_2015_250 · Cited by 18 · see citing works
Lentiviral Overexpression of miRNAs
Zöllner, H., Hahn, S. A., & Maghnouj, A. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-703-7_15 · Cited by 14 · see citing works
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- [1]Rebane A microRNA: Medical Evidence From Molecular Biology to Clinical Practice Foreword, Chapter 17: microRNA and Allergy Microrna: Medical Evidence: From Molecular Biology to Clinical Practice 2015 888 331 52
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GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Liu, Y., Wan, Y., Jiang, Y., Zhang, L., & Cheng, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188890 · Cited by 536 · see citing works
GPX4, ferroptosis, and diseases
Zhang, W., Liu, Y., Yan, L., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 447 · see citing works
Iantomasi, T., Romagnoli, C., Palmini, G., Donati, S., Falsetti, I., Miglietta, F., Aurilia, C., Marini, F., Giusti, F., & Brandi, M. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043772 · Cited by 395 · see citing works
Huang, G., Liang, M., Liu, H., Huang, J., Li, P., Wang, C., Zhang, Y., Lin, Y., & Jiang, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03276-1 · Cited by 325 · see citing works
Recent advances in exosome-mediated nucleic acid delivery for cancer therapy
Zhang, Y., Liu, Q., Zhang, X., Huang, H., Tang, S., Chai, Y., Xu, Z., Li, M., Chen, X., Liu, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01472-z · Cited by 306 · see citing works
The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease
Zheng, D., Huo, M., Li, B., Wang, W., Piao, H., Wang, Y., Zhu, Z., Li, D., Wang, T., & Liu, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.616161 · Cited by 251 · see citing works
Wang, J., Deng, B., Liu, Q., Huang, Y., Chen, W., Li, J., Zhou, Z., Zhang, L., Liang, B., He, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02777-3 · Cited by 223 · see citing works
miR-182-5p and miR-378a-3p regulate ferroptosis in I/R-induced renal injury
Ding, C., Ding, X., Zheng, J., Wang, B., Yang, L., Xiang, H., Dou, M., Qiao, Y., Tian, P., & Xue, W. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03135-z · Cited by 213 · see citing works
Noncoding RNAs regulate alternative splicing in Cancer
Liu, Y., Liu, X., Lin, C., Jia, X., Zhu, H., Song, J. H., & Zhang, Y. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01798-2 · Cited by 183 · see citing works
Ding, J., Zhang, Y., Cai, X., Zhang, Y., Yan, S., Wang, J., Zhang, S., Yin, T., Yang, C., & Yang, J. (2021) · Theranostics · doi:10.7150/thno.58731 · Cited by 170 · see citing works
Wei, Z., Chen, Z., Zhao, Y., Fan, F., Xiong, W., Song, S., Yin, Y., Hu, J., Yang, K., Yang, L., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121000 · Cited by 163 · see citing works
Liu, M., Wang, Y., Zhang, Y.-B., Hu, D., Tang, L., Zhou, B., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02112-8 · Cited by 174 · see citing works
Gao, L., Qiu, F., Cao, H., Li, H., Dai, G., Ma, T., Gong, Y., Luo, W., Zhu, D., Qiu, Z., et al. (2023) · Theranostics · doi:10.7150/thno.73568 · Cited by 145 · see citing works
The role of miRNAs in colorectal cancer progression and chemoradiotherapy
Zhang, N., Hu, X., Du, Y., & Du, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111099 · Cited by 145 · see citing works
Extracellular vesicles: Emerging tools as therapeutic agent carriers
Liu, S., Wu, X., Chandra, S., Lyon, C. J., Ning, B., Jiang, L., Fan, J., & Hu, Y. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.05.002 · Cited by 146 · see citing works
Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance
Song, J., Yang, P. X., Chen, C., Ding, W., Tillement, O., Bai, H., & Zhang, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02266-z · Cited by 145 · see citing works
Tong, P., Zhu, L. Z., Zang, Y., Li, J. X., He, X., & James, T. D. (2021) · Chemical Communications · doi:10.1039/d1cc05157a · Cited by 126 · see citing works
Wei, Z., Hang, S., Ocansey, D. K. W., Zhang, Z., Wang, B., Zhang, X., & Mao, F. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01951-x · Cited by 119 · see citing works
Target c-Myc to treat pancreatic cancer
Ala, M. (2022) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.2017223 · Cited by 119 · see citing works
Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer
Hou, Y.-F., Cai, S., Yu, S., & Lin, H. (2021) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa180 · Cited by 116 · see citing works
Wu, H., Ma, H., Wang, L., Zhang, H., Lu, L., Xiao, T., Cheng, C., Wang, P., Yang, Y., Wu, M., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.65861 · Cited by 116 · see citing works
MiRNAs and Cancer: Key Link in Diagnosis and Therapy
Shi, Y., Liu, Z., Lin, Q., Luo, Q., Cen, Y., Li, J., Fang, X., & Gong, C. (2021) · Genes · doi:10.3390/genes12081289 · Cited by 115 · see citing works
Liu, Q., Tang, J., Chen, S., Hu, S., Shen, C., Xiang, J., Chen, N., Wang, J., Ma, X., Zhang, Y., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106440 · Cited by 111 · see citing works
CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis
Zheng, F., & Xu, R. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109828 · Cited by 110 · see citing works
Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy
Zhao, R., Fu, J., Zhu, L., Chen, Y., & Liu, B. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01230-6 · Cited by 109 · see citing works
The Progress and Promise of RNA Medicine─An Arsenal of Targeted Treatments
Sasso, J. M., Ambrose, B. J. B., Tenchov, R., Datta, R. S., Basel, M. T., DeLong, R. K., & Zhou, Q. A. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00024 · Cited by 104 · see citing works
Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes
Gąsecka, A., Siwik, D., Gajewska, M., Jaguszewski, M. J., Mazurek, T., Filipiak, K. J., Postula, M. A., & Eyileten, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092807 · Cited by 103 · see citing works
MiR-27a-3p Promotes Non-Small Cell Lung Cancer Through SLC7A11-Mediated-Ferroptosis
Lu, X., Kang, N., Ling, X.-X., Pan, M., Du, W., & Gao, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.759346 · Cited by 103 · see citing works
Li, H., Zhang, L., & Chen, X. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac397 · Cited by 101 · see citing works
Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B/BMP2/BMF axis
Zhang, Y., Liu, J., Su, M., Wang, X., & Xie, C. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02091-x · Cited by 100 · see citing works
Hui, X., Yang, C., Li, D., He, X., Huang, H., Zhou, H., Chen, M., Lee, C., & Mu, X. (2021) · Advanced Science · doi:10.1002/advs.202100583 · Cited by 99 · see citing works
Chen, S., Liu, X., & Peng, Y. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14079 · Cited by 97 · see citing works
Liu, J., He, J., Ge, L., Xiao, H., Huang, Y., Zeng, L., Jiang, Z., Lü, M., & Hu, Z. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02480-w · Cited by 97 · see citing works
Recent Advances and Challenges in Gene Delivery Mediated by Polyester-Based Nanoparticles
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Xu, R., Pan, J., Zhou, W., Ji, G., & Dang, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113331 · Cited by 97 · see citing works
Blood biomarkers for assessment of mitochondrial dysfunction: An expert review
Hubens, W. H. G., Vallbona-Garcia, A., de Coo, I. F. M., van Tienen, F. H. J., Webers, C. A. B., Smeets, H. J. M., & Gorgels, T. G. M. F. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.10.008 · Cited by 94 · see citing works
Sun, W., Li, Y., Ma, D., Liu, Y., Xu, Q., Cheng, D., Li, G., & Ni, C. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00329-5 · Cited by 93 · see citing works
MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets
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Lipid Lowering Therapy: An Era Beyond Statins
Abdul‐Rahman, T., Bukhari, S. M. A., Cantu‐Herrera, E., Awuah, W. A., Lawrence, J. A., de Andrade, H., Patel, N., Shah, R. M., Shaikh, R., Capriles, C. A. A., et al. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101342 · Cited by 91 · see citing works
Biomarkers in Breast Cancer: An Old Story with a New End
Alves, L. N. R., Meira, D. D., Merigueti, L. P., Casotti, M. C., Ventorim, D. P., Almeida, J. F. F., de Sousa, V. P., Sant’Ana, M. C., da Cruz, R. G. C., Louro, L. S., et al. (2023) · Genes · doi:10.3390/genes14071364 · Cited by 90 · see citing works
Müller Glia-Mediated Retinal Regeneration
Gao, H., Luodan, A., Huang, X., Chen, X., & Xu, H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02274-w · Cited by 83 · see citing works
Yuan, F., Peng, W., Yang, Y., Xu, J., Liu, Y., Xie, Y., Huang, T., Shi, C., Ding, Y., Li, C., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02833-7 · Cited by 86 · see citing works
MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia
Li, Y., Tan, J., Miao, Y., & Zhang, Q. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00670-2 · Cited by 82 · see citing works
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The Role of miRNA in Ovarian Cancer: an Overview
Zhao, L., Liang, X., Wang, L., & Zhang, X. (2022) · Reproductive Sciences · doi:10.1007/s43032-021-00717-w · Cited by 76 · see citing works
Pekarek, L., Torres‐Carranza, D., Fraile‐Μartinez, O., Montero, C. G., Pekarek, T., Sáez, M. A., Rueda-Correa, F., Pimentel-Martinez, C., Guijarro, L. G., Dı́az, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087268 · Cited by 76 · see citing works
Liu, W., Long, Q., Zhang, W., Zeng, D., Hu, B., Liu, S., & Chen, L. (2021) · Aging · doi:10.18632/aging.203388 · Cited by 74 · see citing works
Osteoprotective Roles of Green Tea Catechins
Huang, H., Cheng, T., Lin, S., Ho, C.-J., Chyu, J., Yang, R., Chen, C., & Shen, C. (2020) · Antioxidants · doi:10.3390/antiox9111136 · Cited by 70 · see citing works
Hu, S., Xu, Y., Teng, X., Fan, R., Jiang, T., Cao, M., Shi, L., & Song, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109941 · Cited by 72 · see citing works
RetractedQi, Z., Liu, R., Ju, H.-N., Huang, M., Li, Z., Li, W., & Wang, Y. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82287 · Cited by 73 · see citing works
Kong, G., Liu, J., Wang, J., Yu, X., Li, C., Deng, M., Liu, M., Wang, S., Tang, C., Xiong, W., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c14675 · Cited by 72 · see citing works
Developing hydrogels for gene therapy and tissue engineering
Su, C., Lin, D., Huang, X., Feng, J., Jin, A., Wang, F., Lv, Q., Lei, L., & Pan, W. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02462-z · Cited by 72 · see citing works
Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction
Quaglia, M., Merlotti, G., Guglielmetti, G., Castellano, G., & Cantaluppi, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155404 · Cited by 69 · see citing works
MicroRNAs as important players in regulating cancer through PTEN/PI3K/AKT signalling pathways
Selvakumar, S. C., Preethi, K. A., & Sekar, D. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188904 · Cited by 68 · see citing works
Hong, L. Z., Zhou, L., Zou, R., Khoo, C. M., Chew, A. L. S., Chin, C., & Shih, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-83365-z · Cited by 69 · see citing works
MicroRNA in multiple sclerosis
Gao, Y., Han, D. K., & Feng, J. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.01.020 · Cited by 67 · see citing works
Matrix stiffness regulates macrophage polarization in atherosclerosis
Wang, Y., Shi, R., Zhai, R., Yang, S., Peng, T., Zheng, F., Shen, Y., Li, M., & Li, L. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106236 · Cited by 66 · see citing works
The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy
Wang, H., Zhou, X., Li, C., Yan, S., Feng, C., He, J., Li, Z., & Tu, C. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01365-6 · Cited by 67 · see citing works
TOP2A promotes proliferation and metastasis of hepatocellular carcinoma regulated by miR-144-3p
Wang, T., Lu, J., Wang, R., Cao, W., & Xu, J. (2022) · Journal of Cancer · doi:10.7150/jca.64017 · Cited by 66 · see citing works
Shi, W., Wartmann, T., Accuffi, S., Al-Madhi, S., Perrakis, A., Kahlert, C., Link, A., Venerito, M., Keitel, V., Bruns, C. J., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02488-4 · Cited by 65 · see citing works
Non-Coding RNAs in Human Cancer and Other Diseases: Overview of the Diagnostic Potential
Beňačka, R., Szabóová, D., Guľašová, Z., Hertelyová, Z., & Radoňak, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216213 · Cited by 65 · see citing works
Liu, D., Liu, F., Li, Z., Pan, S., Xie, J., Zhao, Z., Liu, Z., Zhang, J., & Liu, Z. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03460-x · Cited by 63 · see citing works
Polo-Like Kinase 4’s Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy
Zhang, X., Wei, C., Liang, H., & Han, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.587554 · Cited by 61 · see citing works
Gu, P., Sun, M., Li, L., Yang, Y., Jiang, Z., Ge, Y., Wang, W., Mu, W., & Wang, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.657158 · Cited by 63 · see citing works
The role of apoptosis in the pathogenesis of osteoarthritis
Xiao, S., Cheng, M., Wang, L., Cao, J., Fang, L., Zhou, X.-P., He, X.-J., & Hu, Y.-F. (2023) · International Orthopaedics · doi:10.1007/s00264-023-05847-1 · Cited by 63 · see citing works
Ma, C., Wang, C., Zhang, Y., Li, Y., Fu, K., Gong, L., Zhou, H., & Li, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114264 · Cited by 61 · see citing works
Xu, D., Zhang, X., Chen, X., Yang, S., & Chen, H. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117980 · Cited by 61 · see citing works
Exosomal miR-21-5p contributes to ovarian cancer progression by regulating CDK6
Cao, J., Zhang, Y., Mu, J., Yang, D., Gu, X., & Zhang, J. (2021) · Human Cell · doi:10.1007/s13577-021-00522-2 · Cited by 61 · see citing works
Qin, S., Mao, Y., Xue, C., Xiao, J., Qin, Y., & Zhao, L. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62767 · Cited by 61 · see citing works
Liao, J., Li, Q., Hu, Z., Yu, W., Zhang, K., Ma, F., Han, Q., Zhang, H., Guo, J., Hu, L., et al. (2021) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126899 · Cited by 61 · see citing works
Wang, X., Simayi, A., Fu, J., Zhao, X., & Xu, G. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00227.2021 · Cited by 61 · see citing works
Recent Advance of Liposome Nanoparticles for Nucleic Acid Therapy
Gao, Y., Liu, X., Chen, N., Yang, X., & Tang, F. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010178 · Cited by 62 · see citing works
Molecular pathways of liver regeneration: A comprehensive review
Kiseleva, Y. V., Antonyan, S. Z., Zharikova, T. S., Tupikin, K. A., Kalinin, D. V., & Zharikov, Y. O. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i3.270 · Cited by 62 · see citing works
Li, D., Zhang, J., Yang, J., Wang, J., Zhang, R., Li, J., & Zhang, R. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04464-3 · Cited by 60 · see citing works
Wang, Z.-Y., Wen, Z.-J., Xu, H.-M., Zhang, Y., & Zhang, Y.-F. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1004221 · Cited by 58 · see citing works
Zhang, X., Li, L., Tan, H., Xue, H., Yuan, Q., Hou, F. F., Zhou, L., & Liu, Y. (2023) · Theranostics · doi:10.7150/thno.89105 · Cited by 60 · see citing works
JAK/STAT3 signaling in cardiac fibrosis: a promising therapeutic target
Jiang, H., Yang, J., Li, T., Wang, X., Fan, Z., Ye, Q., & Du, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1336102 · Cited by 61 · see citing works
Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions
Zhao, Y., Zeng, Y., Zeng, D., Wang, H., Zhou, M., Sun, N., Xin, J., Khalique, A., Rajput, D. S., Pan, K., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.604462 · Cited by 63 · see citing works
miR-30c-5p Alleviated Pyroptosis During Sepsis-Induced Acute Kidney Injury via Targeting TXNIP
Li, X., Yao, L., Zeng, X.-M., Hu, B., Zhang, X., Wang, J., Zhu, R., & Yu, Q. (2020) · Inflammation · doi:10.1007/s10753-020-01323-9 · Cited by 59 · see citing works
Gessner, I., Fries, J. W. U., Brune, V., & Mathur, S. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb02165b · Cited by 59 · see citing works
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Han, M., Sun, H., Zhou, Q., Liu, J., Hu, J., Yuan, W., & Sun, Z. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01879-8 · Cited by 59 · see citing works
Therapeutic RNA Strategies for Chronic Obstructive Pulmonary Disease
Mei, D. F., Tan, W. S. D., Tay, Y., Mukhopadhyay, A., & Wong, W. S. F. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.04.007 · Cited by 59 · see citing works
Non-coding RNAs in gastric cancer
Xie, S., Chang, Y., Jin, H., Yang, F., Xu, Y., Yan, X., Lin, A., Shu, Q., & Zhou, T. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.06.022 · Cited by 58 · see citing works
Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging
Wang, H., Yuan, T., Wang, Y., Liu, C., Li, D., Li, Z., & Sun, S. (2024) · Aging Cell · doi:10.1111/acel.14092 · Cited by 60 · see citing works
MicroRNAs as critical biomarkers of major depressive disorder: a comprehensive perspective
Ortega, M. A., Alvarez-Mon, M. A., García-Montero, C., Fraile-Martinez, O., Lahera, G., Monserrat, J., Muñoz-Merida, L., Mora, F., Rodríguez-Jiménez, R., Fernandez-Rojo, S., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9111659 · Cited by 57 · see citing works
Epigenetic regulation of gene expression in response to environmental exposures: From bench to model
Li, D., Yang, Y. X., Li, Y., Zhu, X., & Li, Z. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145998 · Cited by 56 · see citing works
Interaction of ncRNA and Epigenetic Modifications in Gastric Cancer: Focus on Histone Modification
Yang, Q., Chen, Y., Guo, R., Dai, Y., Tang, L., Zhao, Y., Wu, X., Li, M., Du, F., Shen, J., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.822745 · Cited by 56 · see citing works
Epigenetic modification regulates tumor progression and metastasis through EMT (Review)
Tan, T., Shi, P., Abbas, M. N., Wang, Y., Xu, J., Chen, Y., & Cui, H. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5360 · Cited by 56 · see citing works
Rahimian, N., Nahand, J. S., Hamblin, M. R., & Mirzaei, H. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2823-2_2 · Cited by 56 · see citing works
The role of microRNAs in depression
Ding, R., Su, D., Zhao, Q., Wang, Y., Wang, J., Lv, S., & Ji, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1129186 · Cited by 57 · see citing works
Zhou, S., Abdihamid, O., Tan, F., Zhou, H., Liu, H., Li, Z., Xiao, S., & Li, B. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01411-x · Cited by 62 · see citing works
Xun, J., Li, C., Liu, M., Mei, Y., Zhou, Q., Wu, B., Xie, F., Liu, Y., & Dai, R.-C. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02449-9 · Cited by 55 · see citing works
- Authors
- Lu, T. X., & Rothenberg, M. E.
- Affiliations
- University of Chicago (US)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Rothenberg, Marc E.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 141
- Issue
- 4
- Pages
- 1202-1207
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC5889965
- OpenAlex
- W4247544731
- Cited by
- 2,425
- References
- 43
- Citations by year
- 2026: 168 · 2025: 300 · 2024: 397 · 2023: 455 · 2022: 478 · 2021: 431 · 2020: 184 · 2019: 11 · 2018: 1
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R37AI045898, R01AI124355)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, allergy, post-transcriptional regulation, biomarkers, miRNA mimics, miRNA inhibitors, miRNA expression profiling
- MeSH terms
- Gene Expression Regulation, Genetic Markers, Humans, Hypersensitivity, MicroRNAs, In Vitro Techniques
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