Cited by 2,425MicroRNA in disease regulationRNA Interference and Gene DeliveryPlant Molecular Biology Research

MicroRNA

Open access
Lu, Thomas X., Rothenberg, Marc E.·2018·Journal of Allergy and Clinical Immunology

Abstract

MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development. MiRNA mimics and miRNA inhibitors currently in preclinical development have shown promise as novel therapeutic agents. Multiple technological platforms have been developed for miRNA isolation, miRNA quantitation, miRNA profiling, miRNA target detection, and modulating miRNA levels in vitro and in vivo. Here we will review the major technological platforms with consideration given for the advantages and disadvantages of each platform.

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Crossref · 10.1016/j.jaci.2017.08.034

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  1. [1]Rebane A microRNA: Medical Evidence From Molecular Biology to Clinical Practice Foreword, Chapter 17: microRNA and Allergy Microrna: Medical Evidence: From Molecular Biology to Clinical Practice 2015 888 331 52

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Authors
Lu, T. X., & Rothenberg, M. E.
Affiliations
  • University of Chicago (US)
  • Cincinnati Children's Hospital Medical Center (US)
Corresponding author
Rothenberg, Marc E.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2018-04
Volume
141
Issue
4
Pages
1202-1207
ISSN
0091-6749 (ISSN-L)
OpenAlex
W4247544731
Cited by
2,425
References
43
Citations by year
2026: 168 · 2025: 300 · 2024: 397 · 2023: 455 · 2022: 478 · 2021: 431 · 2020: 184 · 2019: 11 · 2018: 1
FWCI
5.46
Type
journal article
Language
en
Open access
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R37AI045898, R01AI124355)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
microRNA, allergy, post-transcriptional regulation, biomarkers, miRNA mimics, miRNA inhibitors, miRNA expression profiling
MeSH terms
Gene Expression Regulation, Genetic Markers, Humans, Hypersensitivity, MicroRNAs, In Vitro Techniques

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