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Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex

Sethi, Prerna, Lukiw, Walter J.·2009·Neuroscience Letters
DOI 10.1016/j.neulet.2009.04.052
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Abstract

Micro-RNA (miRNA) mediated regulation of messenger RNA (mRNA) complexity in the central nervous system (CNS) is emerging as a critical factor in the control of CNS-specific gene expression during development, plasticity, aging and disease. In these studies, miRNA array and Northern blot based tracking of specific miRNA abundances and decay kinetics in human neural (HN) cells in primary culture and in short post-mortem interval (PMI, approximately 1h) human brain tissues showed a limited stability and relatively short half-life ( approximately 1-3.5h) for specific brain-enriched miRNAs. In short PMI Alzheimer's disease (AD)-affected temporal lobe neocortex, miRNA-9, miRNA-125b and miRNA-146a were found to be significantly up-regulated, an effect that was not seen in several related neurological disorders. The results suggest (a) that unless specifically stabilized, certain brain-enriched miRNAs represent a rapidly executed signaling system employing highly transient effectors of CNS gene expression, and (b) that in AD temporal lobe neocortex specific brain miRNAs are significantly up-regulated in abundance and strongly correlate with the presence of AD-type neuropatholgical change.

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Crossref · 10.1016/j.neulet.2009.04.052

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  • miRNAs play a critical role in post-transcriptional gene regulation in several biological processes of the central nervous system and in the pathogenesis of different disorders.

    “An increasing body of literature supports the critical role of miRNAs in post-transcriptional gene regulation in several biological processes of the central nervous system (CNS), as well as in the pathogenesis of different disorders (including developmental, neurodegenerative, vascular and neuroinflammatory disorders), and in oncogenesis [10]–[12].”

    From MicroRNA-146a: A Key Regulator of Astrocyte-Mediated Inflammatory Response (2012) · cites this paper as [10]

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Authors
Sethi, P., & Lukiw, W. J.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2009-08
Volume
459
Issue
2
Pages
100-104
ISSN
0304-3940
DOI
10.1016/j.neulet.2009.04.052
Cited by
339
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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