Facilitating the use of the target product profile in academic research: a systematic review
Open accessAbstract
BACKGROUND: The Target Product Profile (TPP) is a tool used in industry to guide development strategies by addressing user needs and fostering effective communication among stakeholders. However, they are not frequently used in academic research, where they may be equally useful. This systematic review aims to extract the features of accessible TPPs, to identify commonalities and facilitate their integration in academic research methodology. METHODS: We searched peer-reviewed papers published in English developing TPPs for different products and health conditions in four biomedical databases. Interrater agreement, computed on random abstract and paper sets (Cohen's Kappa; percentage agreement with zero tolerance) was > 0.91. We interviewed experts from industry contexts to gain insight on the process of TPP development, and extracted general and specific features on TPP use and structure. RESULTS: 138 papers were eligible for data extraction. Of them, 92% (n = 128) developed a new TPP, with 41.3% (n = 57) focusing on therapeutics. The addressed disease categories were diverse; the largest (47.1%, n = 65) was infectious diseases. Only one TPP was identified for several fields, including global priorities like dementia. Our analyses found that 56.5% of papers (n = 78) was authored by academics, and 57.8% of TPPs (n = 80) featured one threshold level of product performance. The number of TPP features varied widely across and within product types (n = 3-44). Common features included purpose/context of use, shelf life for drug stability and validation aspects. Most papers did not describe the methods used to develop the TPP. We identified aspects to be taken into account to build and report TPPs, as a starting point for more focused initiatives guiding use by academics. DISCUSSION: TPPs are used in academic research mostly for infectious diseases and have heterogeneous features. Our extraction of key features and common structures helps to understand the tool and widen its use in academia. This is of particular relevance for areas of notable unmet needs, like dementia. Collaboration between stakeholders is key for innovation. Tools to streamline communication such as TPPs would support the development of products and services in academia as well as industry.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Borrowing from industry, target product profiles may also guide AI-CAC development toward clinically useful, guideline-aligned and financially viable implementations.
“Borrowing from industry, target product profiles may also guide AI-CAC development toward clinically useful, guideline-aligned and financially viable implementations.67”
From Prognostication and clinical opportunities with AI for coronary artery calcium: a scoping review (2026) · cites this paper as [67]
The Introduction describes TPPs as an industry planning tool that guides product development, and the Discussion links them to clinical utility, regulatory considerations, marketability and reimbursement. The paper does not specifically address AI-CAC or alignment with clinical guidelines, so applying those points to AI-CAC is an extrapolation. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · BMJ · doi:10.1136/bmj.n71 · Cited by 108,283 · see citing works
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works
Phases of Biomarker Development for Early Detection of Cancer
Pepe, M. S., Etzioni, R., Feng, Z., Potter, J. D., Thompson, M. L., Thornquist, M., Winget, M., & Yasui, Y. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.14.1054 · Cited by 1,686 · see citing works
The Efficacy of Diagnostic Imaging
Fryback, D. G., & Thornbury, J. R. (1991) · Medical Decision Making · doi:10.1177/0272989x9101100203 · Cited by 1,294 · see citing works
New developments in anti-malarial target candidate and product profiles
Burrows, J. N., Duparc, S., Gutteridge, W. E., van Huijsduijnen, R. H., Kaszubska, W., Macintyre, F., Mazzuri, S., Möhrle, J. J., & Wells, T. N. C. (2017) · Malaria Journal · doi:10.1186/s12936-016-1675-x · Cited by 528 · see citing works
MRI and CSF biomarkers in normal, MCI, and AD subjects
Vemuri, P., Wiste, H. J., Weigand, S. D., Shaw, L. M. J., Trojanowski, J. Q., Weiner, M. W., Knopman, D. S., Petersen, R. C., & Jack, C. R. (2009) · Neurology · doi:10.1212/wnl.0b013e3181af79fb · Cited by 398 · see citing works
New diagnostic tools in schistosomiasis
Utzinger, J., Becker, S. L., van Lieshout, L., van Dam, G. J., & Knopp, S. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.03.014 · Cited by 282 · see citing works
A Research Agenda for Malaria Eradication: Vaccines
The malERA Consultative Group on Vaccines (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1000398 · Cited by 264 · see citing works
Carballar‐Lejarazú, R., Ogaugwu, C., Tushar, T., Kelsey, A., Pham, T. B., Murphy, J., Schmidt, H., Lee, Y., Lanzaro, G. C., & James, A. A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010214117 · Cited by 226 · see citing works
A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic
Funk, C. D., Laferrière, C. A., & Ardakani, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00937 · Cited by 200 · see citing works
Defining the Needs for Next Generation Assays for Tuberculosis
Denkinger, C. M., Kik, S. V., Cirillo, D. M., Casenghi, M., Shinnick, T. M., Weyer, K., Gilpin, C., Boehme, C. C., Schito, M. L., Kimerling, M., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu821 · Cited by 167 · see citing works
Quality by design approach for formulation development: A case study of dispersible tablets
Charoo, N. A., Shamsher, A. A. A., Zidan, A. S., & Rahman, Z. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.12.024 · Cited by 159 · see citing works
Cunha, S., Costa, C. P., Loureiro, J. A., Alves, J., Peixoto, A. F. R. O., Forbes, B., Lobo, J. M. S., & Silva, A. C. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070599 · Cited by 156 · see citing works
Namjoshi, S., Dabbaghi, M., Roberts, M. S., Grice, J. E., & Mohammed, Y. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030287 · Cited by 153 · see citing works
Concise Review: Process Development Considerations for Cell Therapy
Campbell, A., Brieva, T. A., Raviv, L., Rowley, J. A., Niß, K., Brandwein, H. J., Oh, S., & Karnieli, O. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0294 · Cited by 150 · see citing works
Reinvigorating the public health response to dementia
Health, T. L. P. (2021) · The Lancet Public Health · doi:10.1016/s2468-2667(21)00215-2 · Cited by 145 · see citing works
Beg, S., Sandhu, P. S., Batra, R. S., Khurana, R. K., & Singh, B. (2014) · Drug Delivery · doi:10.3109/10717544.2014.900154 · Cited by 134 · see citing works
Point of care diagnostics for tuberculosis
García‐Basteiro, A. L., DiNardo, A. R., Saavedra, B., Silva, D. R., Palmero, D., Gegia, M., Migliori, G. B., Duarte, R., Mambuque, E., Centis, R., et al. (2018) · Pulmonology · doi:10.1016/j.rppnen.2017.12.002 · Cited by 132 · see citing works
Proposals for a Phased Evaluation of Medical Tests
Lijmer, J. G., Leeflang, M., & Bossuyt, P. M. (2009) · Medical Decision Making · doi:10.1177/0272989x09336144 · Cited by 118 · see citing works
Amasya, G., Badıllı, U., Aksu, B., & Tarımcı, N. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.01.003 · Cited by 111 · see citing works
Pallagi, E., Ambrus, R., Szabó‐Révész, P., & Csóka, I. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.06.018 · Cited by 111 · see citing works
Drugs for the Treatment of Zika Virus Infection
Bernatchez, J. A., Tran, L., Li, J., Luan, Y., Siqueira-Neto, J. L., & Li, R. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00775 · Cited by 109 · see citing works
Arora, D., & Nanda, S. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118448 · Cited by 104 · see citing works
Solomon, A. W., Engels, D., Bailey, R. L., Blake, I. M., BROOKER, S. J., Chen, J., Chen, J., Churcher, T. S., DRAKELEY, C. J., Edwards, T., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001746 · Cited by 102 · see citing works
Dittrich, S., Tadesse, B. T., Moussy, F. G., Chua, A., Zorzet, A., Tängdén, T., Dolinger, D. L., Page, A., Crump, J. A., D’Acremont, V., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161721 · Cited by 94 · see citing works
Awotwe‐Otoo, D., Agarabi, C. D., Wu, G. K., Casey, E., Read, E. K., Lute, S. C., Brorson, K., Khan, M. A., & Shah, R. B. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.08.033 · Cited by 91 · see citing works
Waghule, T., Dabholkar, N., Gorantla, S., Rapalli, V. K., Saha, R. N., & Singhvi, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111940 · Cited by 84 · see citing works
Porrás, A., Yadón, Z. E., Altcheh, J., Britto, C., Chaves, G. C., Flévaud, L., Martins‐Filho, O. A., Ribeiro, I., Schijman, A. G., Shikanai‐Yasuda, M. A., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003697 · Cited by 81 · see citing works
Multi-stakeholder consensus on a target product profile for an HIV cure
Lewin, S. R., Attoye, T., Bansbach, C., Doehle, B., Dubé, K., Dybul, M., SenGupta, D., Jiang, A., Johnston, R., Lamplough, R., et al. (2020) · The Lancet HIV · doi:10.1016/s2352-3018(20)30234-4 · Cited by 78 · see citing works
Chang, R.-K., Raw, A., Lionberger, R. A., & Yu, L. X. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9472-8 · Cited by 78 · see citing works
QbD based development of proliposome of lopinavir for improved oral bioavailability
Patel, G. M., Shelat, P., & Lalwani, A. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.08.057 · Cited by 76 · see citing works
Pharmaceutical Medicine and Translational Clinical Research
(2017) · Elsevier eBooks · doi:10.1016/c2014-0-01796-0 · Cited by 75 · see citing works
Garg, S., Tambwekar, K. R., Vermani, K., Kandarapu, R., Garg, A. B., Waller, D. P., & Zaneveld, L. J. D. (2003) · AIDS Patient Care and STDs · doi:10.1089/108729103322277402 · Cited by 73 · see citing works
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Driessche, E. V., Nielsen, H. M., Franzyk, H., & Foged, C. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.07.014 · Cited by 71 · see citing works
Lim, M. D., Brooker, S. J., Belizario, V. Y., Gay‐Andrieu, F., Gilleard, J. S., Levecke, B., van Lieshout, L., Medley, G. F., Mekonnen, Z., Mirams, G., et al. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006213 · Cited by 69 · see citing works
Risk based approach for design and optimization of stomach specific delivery of rifampicin
Vora, C., Patadia, R., Mittal, K., & Mashru, R. C. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.07.043 · Cited by 67 · see citing works
Kuk, D.-H., Ha, E., Ha, D.-H., Sim, W., Lee, S.-K., Jeong, J.-S., Kim, J. S., Baek, I., Park, H., Choi, D. H., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11120688 · Cited by 65 · see citing works
A Tutorial for Developing a Topical Cream Formulation Based on the Quality by Design Approach
Simões, A., Veiga, F., Vitorino, C., & Figueiras, A. (2018) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2018.06.010 · Cited by 64 · see citing works
Target Product Profiles for medical tests: a systematic review of current methods
Cocco, P., Ayaz-Shah, A. A., Messenger, M. P., West, R. M., & Shinkins, B. (2020) · BMC Medicine · doi:10.1186/s12916-020-01582-1 · Cited by 63 · see citing works
Javed, M. N., Kohli, K., & Amin, S. (2018) · AAPS PharmSciTech · doi:10.1208/s12249-018-0951-1 · Cited by 62 · see citing works
Garg, B., Katare, O. P., Beg, S., Lohan, S., & Singh, B. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.02.012 · Cited by 61 · see citing works
Beg, S., Saini, S., Bandopadhyay, S., Katare, O. P., & Singh, B. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1395459 · Cited by 60 · see citing works
A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments
Huston, C. D., Spangenberg, T., Burrows, J. N., Willis, P. A., Wells, T. N. C., & A, W. C. V. V. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003987 · Cited by 59 · see citing works
Mishra, S. M., & Rohera, B. D. (2016) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2016.1199566 · Cited by 58 · see citing works
Hales, D., Vlase, L., Porav, A. S., Bodoki, A., Barbu–Tudoran, L., Achim, M., & Tomuță, I. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.01.006 · Cited by 56 · see citing works
Optimising diagnosis of viraemic hepatitis C infection: the development of a target product profile
Reipold, E. I., Easterbrook, P., Trianni, A., Panneer, N., Krakower, D., Ongarello, S., Roberts, T., Miller, V., & Denkinger, C. M. (2017) · BMC Infectious Diseases · doi:10.1186/s12879-017-2770-5 · Cited by 56 · see citing works
Target biomarker profile for the clinical management of paracetamol overdose
Vliegenthart, A. D. B., Antoine, D. J., & Dear, J. W. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12699 · Cited by 55 · see citing works
The biomarker-based diagnosis of Alzheimer's disease. 2—lessons from oncology
Boccardi, M., Gallo, V., Yasui, Y., Vineis, P., Padovani, A., Mosimann, U. P., Giannakopoulos, P., Gold, G., Dubois, B., Jack, C. R., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.021 · Cited by 55 · see citing works
Self-citationCosta, C. P., Cunha, S., Moreira, J. N., Silva, R., Gil-Martins, E., Silva, V., Azevedo, L. F., Peixoto, A. F. R. O., Lobo, J. M. S., & Silva, A. C. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120933 · Cited by 54 · see citing works
Considerations in Developing a Target Product Profile for Parenteral Pharmaceutical Products
Lambert, W. J. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9521-x · Cited by 54 · see citing works
Donadeu, M., Fahrion, A. S., Olliaro, P., & Abela-Ridder, B. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005875 · Cited by 54 · see citing works
Cryptosporidiosis Drug Discovery: Opportunities and Challenges
Manjunatha, U. H., Chao, A. T., Leong, F. J., & Diagana, T. T. (2016) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.6b00094 · Cited by 52 · see citing works
Leng, D., Thanki, K., Fattal, E., Foged, C., & Yang, M. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.08.094 · Cited by 52 · see citing works
Current and future priorities for the development of optimal HIV drugs
Vitória, M., Rangaraj, A., Ford, N. P., & Doherty, M. C. (2018) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000527 · Cited by 51 · see citing works
Dormenval, C., Lokras, A. G., Cano-Garcia, G., Wadhwa, A., Thanki, K., Rose, F., Thakur, A., Franzyk, H., & Foged, C. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2663-y · Cited by 51 · see citing works
Pellé, K. G., Rambaud-Althaus, C., D'Acremont, V., Moran, G., Sampath, R., Katz, Z., Moussy, F. G., Mehl, G. L., & Dittrich, S. (2020) · BMJ Global Health · doi:10.1136/bmjgh-2019-002067 · Cited by 51 · see citing works
Simões, A., Veiga, F., Figueiras, A., & Vitorino, C. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.052 · Cited by 49 · see citing works
Gurumukhi, V. C., & Bari, S. B. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01014-4 · Cited by 49 · see citing works
Ingvarsson, P. T., Yang, M., Mulvad, H., Nielsen, H. M., Rantanen, J., & Foged, C. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1096-2 · Cited by 49 · see citing works
Toskin, I., Murtagh, M. M., Peeling, R. W. W., Blondeel, K., Cordero, J. P., & Kiarie, J. N. (2017) · Sexually Transmitted Infections · doi:10.1136/sextrans-2016-053071 · Cited by 48 · see citing works
Swindells, S., Siccardi, M., Barrett, S. E., Olsen, D. B., Grobler, J. A., Podany, A. T., Nuermberger, E. L., Kim, P., Barry, C. E., Owen, A., et al. (2018) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.17.0486 · Cited by 48 · see citing works
Alonso-Padilla, J., Abril, M. C., de Noya, B. A., de Almeida, I. C., Angheben, A., Jorge, T. A., Chatelain, E., Esteva, M. I., Gascón, J., Grijalva, M. J., et al. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008035 · Cited by 47 · see citing works
Patel, H., Chaudhari, P. S., Gandhi, P. A., Desai, B. V., Desai, D. T., Dedhiya, P. P., Vyas, B., & Maulvi, F. A. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120474 · Cited by 45 · see citing works
Diagnostic Approaches For COVID-19: Lessons Learned and the Path Forward
Alafeef, M., & Pan, D. (2022) · ACS Nano · doi:10.1021/acsnano.2c01697 · Cited by 45 · see citing works
Peraman, R., Bhadraya, K., reddy, Y., reddy, C., & Lokesh, T. R. (2015) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.174971 · Cited by 45 · see citing works
Reinhard-Rupp, J., & Klohe, K. (2017) · Infectious Diseases of Poverty · doi:10.1186/s40249-017-0336-9 · Cited by 45 · see citing works
Dailey, P. J., Osborn, J., Ashley, E. A., Baron, E. J., Dance, D. A. B., Fusco, D., Fanello, C. A., Manabe, Y. C., Mokomane, M., Newton, P. N., et al. (2019) · Diagnostics · doi:10.3390/diagnostics9010010 · Cited by 45 · see citing works
Application of the QbD-based approach in the early development of liposomes for nasal administration
Pallagi, E., Jójárt‐Laczkovich, O., Németh, Z., Szabó‐Révész, P., & Csóka, I. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.03.021 · Cited by 45 · see citing works
Human leishmaniasis vaccines: Use cases, target population and potential global demand
Malvolti, S., Malhame, M., Mantel, C. F., Rutte, E. A. L., & Kaye, P. M. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009742 · Cited by 44 · see citing works
Sylvester, B., Tefas, L. R., Vlase, L., Tomuță, I., & Porfire, A. S. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.06.018 · Cited by 44 · see citing works
Molecular assays for antimalarial drug resistance surveillance: A target product profile
Nsanzabana, C., Ariey, F., Beck, H., Ding, X. C., Kamau, E. T., Krishna, S., Legrand, E., Lucchi, N. W., Miotto, O., Nag, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204347 · Cited by 44 · see citing works
Macintyre, F., Ramachandruni, H., Burrows, J. N., Holm, R., Thomas, A., Möhrle, J. J., Duparc, S., van Huijsduijnen, R. H., Greenwood, B. M., Gutteridge, W. E., et al. (2018) · Malaria Journal · doi:10.1186/s12936-018-2549-1 · Cited by 42 · see citing works
Target Product Profile of a Molecular Drug-Susceptibility Test for Use in Microscopy Centers
Denkinger, C. M., Dolinger, D. L., Schito, M. L., Wells, W. A., Cobelens, F. G. J., Pai, M., Matteo Zignol, E., Cirillo, D. M., Alland, D., Casenghi, M., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu682 · Cited by 41 · see citing works
Target Product Profile for a point-of-care diagnostic test for dermal leishmaniases
Cruz, I., Albertini, A., Barbeitas, M. M., Arana, B. A., Picado, A., Ruiz-Postigo, J. A., & Ndung’u, J. M. (2019) · Parasite Epidemiology and Control · doi:10.1016/j.parepi.2019.e00103 · Cited by 41 · see citing works
Timpe, C., Stegemann, S., Barrett, A., & Mujumdar, S. K. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14388 · Cited by 40 · see citing works
Gurumukhi, V. C., & Bari, S. B. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01083-5 · Cited by 40 · see citing works
Workshop report: Schistosomiasis vaccine clinical development and product characteristics
Mo, A. X. Y., & Colley, D. G. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.12.032 · Cited by 38 · see citing works
Chagas Disease: Current View of an Ancient and Global Chemotherapy Challenge
Martín‐Escolano, J., Medina‐Carmona, E., & Martín‐Escolano, R. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00353 · Cited by 38 · see citing works
Ding, X. C., Ade, M. P., Baird, J. K., Cheng, Q., Cunningham, J. A., Dhorda, M., DRAKELEY, C. J., Felger, I., Gamboa, D., Harbers, M., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005516 · Cited by 36 · see citing works
Redefining typhoid diagnosis: what would an improved test need to look like?
Mather, R. G., Hopkins, H., Parry, C. M., & Dittrich, S. (2019) · BMJ Global Health · doi:10.1136/bmjgh-2019-001831 · Cited by 36 · see citing works
Accelerated drug discovery by rapid candidate drug identification
Bergström, F., & Lindmark, B. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.03.026 · Cited by 35 · see citing works
Wyber, R., Boyd, B. J., Colquhoun, S., Currie, B. J., Engel, M. E., Kado, J. H., Karthikeyan, G., Sullivan, M. T., Saxena, A., Sheel, M., et al. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0313-z · Cited by 35 · see citing works
Update on Zika Diagnostic Tests and WHO’s Related Activities
Chua, A., Prat, I., Nübling, C. M., Wood, D., & Moussy, F. G. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005269 · Cited by 35 · see citing works
Hastings, I. M., & Hodel, E. M. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-62 · Cited by 34 · see citing works
Beg, S., Katare, O. P., & Singh, B. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.08.050 · Cited by 34 · see citing works
Crcarevska, M. S., Dimitrovska, A., Sibinovska, N., Mladenovska, K., Raichki, R. S., & Dodov, M. G. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.04.038 · Cited by 32 · see citing works
A Proposed Methodology for a Risk Assessment-Based Liposome Development Process
Németh, Z., Pallagi, E., Dobó, D. G., & Csóka, I. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121164 · Cited by 32 · see citing works
Improved Morphine-Loaded Hydrogels for Wound-Related Pain Relief
Mateus, D. C., Marto, J. M., Trindade, P., Gonçalves, H., Salgado, A., Machado, P., Gouveia, A. M., Ribeiro, H. M., & Almeida, A. J. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020076 · Cited by 31 · see citing works
Zhang, E., Xie, L., Qin, P., Lu, L., Xu, Y., Gao, W., Wang, L., Xie, M. H., Jiang, W., & Liu, S. (2020) · The AAPS Journal · doi:10.1208/s12248-020-00454-z · Cited by 31 · see citing works
Heal, D. J., & Smith, S. L. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211032475 · Cited by 31 · see citing works
Diagnosing Tuberculosis: What Do New Technologies Allow Us to (Not) Do?
Abdulgader, S. M., Okunola, A. O., Ndlangalavu, G., Reeve, B. W. P., Allwood, B., Koegelenberg, C. F. N., Warren, R. M., & Theron, G. (2022) · Respiration · doi:10.1159/000525142 · Cited by 30 · see citing works
Romano, J., Manning, J., Hemmerling, A., McGrory, E., & Holt, B. Y. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.09.016 · Cited by 29 · see citing works
Kadam, R., White, W., Banks, N., Katz, Z., Dittrich, S., & Cirino, C. K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228311 · Cited by 29 · see citing works
COVID-19 Point-of-Care Diagnostics That Satisfy Global Target Product Profiles
Ghaffari, A., Meurant, R., & Ardakani, A. (2021) · Diagnostics · doi:10.3390/diagnostics11010115 · Cited by 29 · see citing works
Walsh, J., Schaufelberger, D. E., Iurian, S., Klein, S., Batchelor, H. K., Turner, R., Gizurarson, S. S., Boltri, L., Alessandrini, E., & Tuleu, C. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14989 · Cited by 28 · see citing works
Arranja, A., Gouveia, L. F., Gener, P., Rafael, D. F. D. S., Pereira, C. A., Schwartz, S., & Videira, M. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.01.075 · Cited by 27 · see citing works
A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria
Burrows, J. N., Slater, H., Macintyre, F., Rees, S., Thomas, A., Okumu, F. O., van Huijsduijnen, R. H., Duparc, S., & Wells, T. N. C. (2018) · Malaria Journal · doi:10.1186/s12936-018-2598-5 · Cited by 27 · see citing works
Tanaka, T., Hanaoka, H., & Sakurai, S. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.08.002 · Cited by 27 · see citing works
Structured approach for designing drug-loaded solid products by binder jetting 3D printing
Wang, Y., Müllertz, A., & Rantanen, J. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106280 · Cited by 27 · see citing works
Development of an emulgel for the treatment of rosacea using quality by design approach
Torregrosa, A., Ochoa-Andrade, A. T., PARENTE, M. E., Vidarte, A., Guarinoni, G., & Savio, E. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2020.1717515 · Cited by 26 · see citing works
Walsh, J., Masini, T., Huttner, B. D., Moja, L., Penazzato, M., & Cappello, B. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030473 · Cited by 26 · see citing works
Lokras, A. G., Thakur, A., Wadhwa, A., Thanki, K., Franzyk, H., & Foged, C. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.601155 · Cited by 24 · see citing works
Chudiwal, V. S., Shahi, S., & Chudiwal, S. S. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1413111 · Cited by 22 · see citing works
Apolinário, A. C., Ferraro, R. B., de Oliveira, C. A., Pessoa, A., & Rangel‐Yagui, C. D. O. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1465-1 · Cited by 22 · see citing works
Ignjatović, J., Djuriš, J., Cvijić, S., Dobričić, V., Montepietra, A., Lombardi, C., Ibric, S. R., & Rossi, A. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105588 · Cited by 22 · see citing works
Salami, K., Gsell, P., Olayinka, A., Maïga, D., Formenty, P., Smith, P. G., & Moorthy, V. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.01.017 · Cited by 21 · see citing works
Gavan, A. D., Porfire, A. S., Marina, C. D. L. C., & Tomuță, I. (2017) · Acta Pharmaceutica · doi:10.1515/acph-2017-0009 · Cited by 20 · see citing works
Quality-by-design approach for the development of telmisartan potassium tablets
Oh, G.-H., Park, J., Shin, H., Kim, J.-E., & Park, Y.-J. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1414233 · Cited by 20 · see citing works
Reddy, C., Bhargav, E., Marikunte, V. V., Chinthaginjala, H., Jyothi, M. V., Pisay, M., Jutur, M., Mahammad, M. S., Poura, M., Yadav, S., et al. (2019) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2019.032 · Cited by 20 · see citing works
Zidan, A. S., Ahmed, O. A. A., & Aljaeid, B. M. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s102945 · Cited by 19 · see citing works
Taipale-Kovalainen, K., Karttunen, A.-P., Ketolainen, J., & Korhonen, O. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.12.021 · Cited by 19 · see citing works
Gal, M., Francis, N. A., Hood, K., Villacian, J. S., Goossens, H., Watkins, A. K., & Butler, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200531 · Cited by 19 · see citing works
The Need for Antiviral Drugs for Pandemic Coronaviruses From a Global Health Perspective
Villamagna, A. H., Gore, S. J., Lewis, J. S., & Doggett, J. S. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.596587 · Cited by 19 · see citing works
Jaffaraghaei, M., Khanipour, F., Maghsoudi, A., Sarvestani, R., Mohammadian, M., Maleki, M., Havasi, F., Rahmani, H., Karagah, A.-H., & Kazemali, M. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106171 · Cited by 19 · see citing works
Thanki, K., Papai, S., Lokras, A. G., Rose, F., Falkenberg, E., Franzyk, H., & Foged, C. (2019) · Pharmaceutical Research · doi:10.1007/s11095-018-2566-3 · Cited by 18 · see citing works
Quality by Design Micro-Engineering Optimisation of NSAID-Loaded Electrospun Fibrous Patches
Nazari, K., Mehta, P., Arshad, M. S., Ahmed, S., Andriotis, E. G., Singh, N., Qutachi, O., Chang, M., Fatouros, D. G., & Ahmad, Z. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics12010002 · Cited by 18 · see citing works
A Comparison Between Lab-Scale and Hot-Melt-Extruder-Based Anti-inflammatory Ointment Manufacturing
Thakkar, R., Ashour, E. A., Shukla, A., Wang, R., Chambliss, W. G., Bandari, S., Murthy, N., & Repka, M. A. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01738-5 · Cited by 18 · see citing works
WHO target product profiles to shape global research and development
Charnaud, S. C., Moorthy, V., Reeder, J. C., & Ross, A. L. (2023) · Bulletin of the World Health Organization · doi:10.2471/blt.22.289521 · Cited by 18 · see citing works
Singh, B., Kaur, A., Dhiman, S., Garg, B., Khurana, R. K., & Beg, S. (2015) · AAPS PharmSciTech · doi:10.1208/s12249-015-0367-0 · Cited by 17 · see citing works
Target product profile for a dengue pre-vaccination screening test
Fongwen, N. T., Wilder‐Smith, A., Gubler, D. J., Ooi, E. E., Salvaña, E. M. T., de Lamballerie, X. N., Olliaro, P., & Peeling, R. W. W. (2021) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0009557 · Cited by 17 · see citing works
Quality by design approach for the preparation of fat-soluble vitamins lipid injectable emulsion
Deng, Y., Zhong, G., Wang, Y., Wang, N., Yu, Q., & Yu, X. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118717 · Cited by 17 · see citing works
Patadia, R., Vora, C., Mittal, K., & Mashru, R. C. (2016) · AAPS PharmSciTech · doi:10.1208/s12249-016-0590-3 · Cited by 15 · see citing works
Chudiwal, S. S., & Dehghan, M. H. (2016) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2016.1160108 · Cited by 15 · see citing works
Monath, T. P. C., Kortekaas, J., Watts, D. M., Christofferson, R. C., LaBeaud, A. D., Gowen, B. B., Peters, C. J., Smith, D. R., Swanepoel, R., Morrill, J. C., et al. (2020) · Vaccine X · doi:10.1016/j.jvacx.2020.100060 · Cited by 15 · see citing works
Development of a target product profile for a point-of-care cardiometabolic device
Vetter, B., Beran, D., Boulle, P., Chua, A., de la Tour, R., Hattingh, L., Perel, P., Roglić, G., Sampath, R., Woodman, M., et al. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02298-7 · Cited by 15 · see citing works
Risk-based approach for systematic development of gastroretentive drug delivery system
Mirani, A. G., Patankar, S., & Kadam, V. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0315-x · Cited by 13 · see citing works
Alternative administration routes and delivery technologies for polio vaccines
Kraan, H., van der Stel, W., Kersten, G. F. A., & Amorij, J. (2016) · Expert Review of Vaccines · doi:10.1586/14760584.2016.1158650 · Cited by 12 · see citing works
Target Product Profile and Development Path for Shigellosis Treatment with Antibacterials
Arnold, S. L. M. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00889 · Cited by 12 · see citing works
Implementation of Quality by Design for Formulation of Rebamipide Gastro-retentive Tablet
Ha, J.-M., Seo, J.-W., Kim, S.-H., Kim, J.-Y., Park, C., Rhee, Y.-S., & Park, E. (2017) · AAPS PharmSciTech · doi:10.1208/s12249-017-0797-y · Cited by 11 · see citing works
Adepoyibi, T., Lilis, L., Greb, H., & Boyle, D. (2018) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.17.0312 · Cited by 11 · see citing works
SAYDAM, M., & Takka, S. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2018.1496450 · Cited by 11 · see citing works
Bengtson, M., Bharadwaj, M., ten Bosch, A., Nyakundi, H., Matoke-Muhia, D., Dekker, C., & Diehl, J. C. (2020) · Global Health Science and Practice · doi:10.9745/ghsp-d-20-00028 · Cited by 11 · see citing works
A blueprint for the worldwide research response to dementia
Cataldi, R., Chowdhary, N., Seeher, K. M., Moorthy, V., & Dua, T. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00269-1 · Cited by 11 · see citing works
Chudiwal, S. S., & Dehghan, M. H. (2016) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2016.1236130 · Cited by 10 · see citing works
Mercuri, A. (2016) · Current Drug Delivery · doi:10.2174/1567201813666160325131831 · Cited by 10 · see citing works
An Industry Perspective on Dengue Drug Discovery and Development
Hernández‐Morales, I., & Loock, M. V. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-8727-1_23 · Cited by 10 · see citing works
Human leishmaniasis vaccines: use cases, target population and potential global demandPreprint
Malvolti, S., Malhame, M., Mantel, C. F., Rutte, E. A. L., & Kaye, P. M. (2021) · medRxiv · doi:10.1101/2021.07.09.21260268 · Cited by 10 · see citing works
Patel, H., Patel, K., Tiwari, S., Pandey, S. S., Shah, S. A., & Gohel, M. C. (2016) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/1872211310666160709193540 · Cited by 9 · see citing works
Nakas, A., Dalatsi, A. M., Kapourani, A., Kontogiannopoulos, K. N., Assimopoulou, A. N., & Barmpalexis, P. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01678-0 · Cited by 9 · see citing works
Development and Optimization of Asenapine Sublingual Film Using QbD Approach
Dalal, R., Shah, J., Gorain, B., Choudhury, H., Jacob, S., Mehta, T. A., Shah, H., & Nair, A. B. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-02132-5 · Cited by 8 · see citing works
Target Product Profile and Clinical Development Plan
Singh, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802103-3.00005-5 · Cited by 8 · see citing works
Development of Atovaquone Nanosuspension: Quality by Design Approach
Kakade, P., Gite, S., & Patravale, V. B. (2019) · Current Drug Delivery · doi:10.2174/1567201817666191227095019 · Cited by 8 · see citing works
Ebels, K., Clerk, C., Crudder, C., McGray, S., Magnuson, K., Tietje, K. M., & LaBarre, P. (2014) · IEEE Global Humanitarian Technology Conference (GHTC) · doi:10.1109/ghtc.2014.6970338 · Cited by 7 · see citing works
Joshi, M., Yadav, K. S., & Prabhakar, B. R. (2021) · Current Drug Delivery · doi:10.2174/1567201818666210212090451 · Cited by 7 · see citing works
Staunton, K. M., Liu, J., Townsend, M., Desnoyer, M., Howell, P. I., Crawford, J. E., Xiang, W., Snoad, N., Burkot, T. R., & Ritchie, S. A. (2021) · Insects · doi:10.3390/insects12050388 · Cited by 7 · see citing works
Perrier, Q., Piquemal, M., Leenhardt, J., Choisnard, L., Mazet, R., Desruet, M.-D., Durand, M., & Bedouch, P. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106275 · Cited by 7 · see citing works
Assessing the Dengue Diagnosis Capability Gap in the Military Health System
Pal, S., Jasper, L. E., Lawrence, K. L., Walter, M., Gilliland, T. H., Dauner, A. L., Palys, T. J., & Wu, S.-J. L. (2016) · Military Medicine · doi:10.7205/milmed-d-15-00231 · Cited by 6 · see citing works
Research Techniques Made Simple: An Introduction to Drug Discovery for Dermatology
Bell, M. E., Webster, L., & Woodland, A. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.07.699 · Cited by 5 · see citing works
Neale, G., Gaihre, S., O’Gorman, P., Price, R. K., Balzategi, A. G., Barrientos, C. H., Rawal, S., Morgan, M., & McNulty, H. (2021) · Journal of Medical Engineering & Technology · doi:10.1080/03091902.2021.1946181 · Cited by 4 · see citing works
Translational medicines “Ecosystem”
Mahant, V. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02325-9 · Cited by 4 · see citing works
Russell, C. A., Hussain, M., Huen, D. S., Rahman, A., & Mohammed, A. R. (2020) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2020.1839496 · Cited by 2 · see citing works
The R&D Marketing Interface in Biopharma and MedTech
Jambulingam, T. (2019) · Journal of Commercial Biotechnology · doi:10.5912/jcb924 · Cited by 2 · see citing works
Boccardi, M. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04507-7 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [1]FDA. Guidance for Industry and Review Staff Target Product Profile — A Strategic Development Process Tool. 2007.
- [154]guideline IQRPd-S. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. PMC1364893 8054244
Cited by
Sorted by citations
Why should academia care about the Target Product Profile?
Boccardi, M., Gold, M., Mahant, V., Marincola, F. M., & Gunn, A. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05520-0 · Cited by 8 · see citing works
Self-citationDesigning Clinically Useful AI: A Blueprint for Impact
Parsa, S., Keyes, T., Dash, D., Char, D. S., Mello, M. M., Callahan, A., Smith, M. A., Lee, S., Wang, T., Salisbury, H., et al. (2026) · NEJM AI · doi:10.1056/aip2500808 · Cited by 7 · see citing works
Macdonald, T., Hogg, H. D. J., Dinnes, J., Verrinder, L., Maniatopoulos, G., Taylor‐Phillips, S., Shinkins, B., Dunbar, J. K., Solebo, A. L., Sutton, H., et al. (2025) · Frontiers in Health Services · doi:10.3389/frhs.2025.1537016 · Cited by 5 · see citing works
Kaló, Z., Imre, A., Tatár, M., & Nagy, B. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116634 · Cited by 4 · see citing works
A scoping review of modelling in target product profile development for medical innovation
Chong, Y. J., Phasitthanaphak, N., Wiwatpanit, T., Teerawattananon, Y., & Wang, Y. (2025) · Health Policy and Technology · doi:10.1016/j.hlpt.2025.101070 · Cited by 3 · see citing works
How fast can you invent a medicine?
Ashkar, S. R., & Cernak, T. (2025) · Medicinal Chemistry Research · doi:10.1007/s00044-025-03501-6 · Cited by 2 · see citing works
Addressing challenges along the ‘access cascade’ for new TB regimens
Servello, J., de Colombani, P., Dall’Olio, L., Gargioni, G., & Raviglione, M. C. (2026) · IJTLD OPEN · doi:10.5588/ijtldopen.25.0610 · Cited by 4 · see citing works
Kaló, Z., Imre, A., Varga, G., Kovács, S., Timár, G., & Nagy, B. (2025) · British Journal of Clinical Pharmacology · doi:10.1002/bcp.70192 · Cited by 1 · see citing works
Nguyen, T., & Koustova, E. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104573 · Cited by 1 · see citing works
Wang, Y., Phasitthanaphak, N., Wiwatpanit, T., Fernández-Barceló, C., Liu, S., Chuanchaiyakul, T., Athibodee, T., & Teerawattananon, Y. (2026) · Health Policy and Technology · doi:10.1016/j.hlpt.2026.101245 · Cited by 1 · see citing works
Kierkegaard, P., Su, B., Moghul, M. R., Cahill, D., & James, N. D. (2026) · Implementation Science Communications · doi:10.1186/s43058-026-01041-7 · Cited by 1 · see citing works
Prognostication and clinical opportunities with AI for coronary artery calcium: a scoping review
McDonald, V. J. F., Parsa, S., Mastrodicasa, D., Rodriguez, F., Langlotz, C., Maron, D. J., Sandhu, A. T., Dudum, R., & Jain, S. S. (2026) · BMJ Digital Health & AI · doi:10.1136/bmjdh-2026-000053
Chen, T., Chen, M., Song, R., Chen, J., Wang, Y., & Yu, X. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126525
Darawsheh, H. M., Shumkova, M. M., Buraya, L. M., Pomytkina, M. V., Pouya, G., Bakieva, F., Grin, M. A., Бахрушина, Е. О., Kireeva, N. V., Dydykin, S. S., et al. (2026) · Journal of Functional Biomaterials · doi:10.3390/jfb17020092
Bührman, E. A. M., Cornel, M. C., Oliveira‐Martins, S., de Kort, M., Boon, W., & Rigter, T. (2026) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-026-04551-8
Shen, T.-Y., Chen, C., Lin, K.-R., & Pan, Y.-C. (2026) · Lecture notes in computer science · doi:10.1007/978-3-032-30089-8_27
Multi-objective optimization in the context of generative chemistry
Torren-Peraire, P., Schneider, N., Rodríguez-Pérez, R., Fairhurst, R. A., & Lanini, J. (2026) · Nature Communications · doi:10.1038/s41467-026-77324-3
Harguindeguy, M., Hawe, A., & Menzen, T. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5416-3_36
Smith, A. F., Cocco, P., Green, K., Ponzo, A., Davies, K., Bell, K., Shinkins, B., Leeflang, M., Hayward, G., & Messenger, M. (2026) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2026-0956
Angelone, L. M., Nguyen, T., & Koustova, E. (2026) · Substance Use & Misuse · doi:10.1080/10826084.2026.2748450
- Authors
- Ibnidris, A., Liaskos, N., Eldem, E., Gunn, A., Streffer, J., Gold, M., Rea, M., Teipel, S., Gardiol, A., & Boccardi, M.
- Affiliations
- University of Cape Town (ZA)
- German Center for Neurodegenerative Diseases (DE)
- University of Antwerp (BE)
- Queen Mary University of London (GB)
- Corresponding author
- Boccardi, Marina
- Venue
- Journal of Translational Medicine
- Published
- 2024-07-29
- Volume
- 22
- Issue
- 1
- Pages
- 693-693
- ISSN
- 1479-5876 (ISSN-L)
- PMC
- PMC11288132
- OpenAlex
- W4401158091
- Cited by
- 20
- References
- 153
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 1
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Translational Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (acceptedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Funders
- Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) in der Helmholtz-Gemeinschaft
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- target product profile, academic research, infectious diseases, therapeutics, dementia, unmet medical needs, stakeholder collaboration, drug development, drug stability
- MeSH terms
- Academia, Humans, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
