Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets

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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

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Caspases in Cell Death, Inflammation, and Pyroptosis

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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

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Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against <i>Salmonella</i>

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The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

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T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 + T cells

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Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis

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DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

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The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

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Reassessing B cell contributions in multiple sclerosis

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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

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The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

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The NLRC 4 Inflammasome

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Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

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NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

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Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

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Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

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Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

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Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS

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Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

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More to Life than NF-κB in TNFR1 Signaling

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TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

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A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis)

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Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

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Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response

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Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome

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Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis

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Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity

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T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis

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How Inflammasomes Inform Adaptive Immunity

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NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients

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Radiation Exposure Induces Inflammasome Pathway Activation in Immune Cells

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Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis

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Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism

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Inflammasome Proteins As Biomarkers of Multiple Sclerosis

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Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

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Inflammasome proteins as biomarkers of traumatic brain injury

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NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis

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The NAIP/NLRC4 inflammasome in infection and pathology

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Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke

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Microglial Inflammasome Activation in Penetrating Ballistic-Like Brain Injury

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Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain

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Microglial NLRP3 inflammasome activation in multiple sclerosis

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NLRP3 and Potassium Efflux Drive Rapid IL-1β Release from Primary Human Monocytes during Toxoplasma gondii Infection

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Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis

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IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis

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Zuo, H., Peng, L. H., Li, W., Wang, Y., Du, X., Zou, X., Dong, Z., Li, Y., Yin, H., Quan, F., et al. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.105148 · Cited by 8 · see citing works

Identification of anti-inflammatory and anti-cancer compounds targeting the NF-κB-NLRP3 inflammasome pathway from a phytochemical library of the Sideritis genus

Yücer, R., Schröder, A., Topçu, G., & Efferth, T. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119074 · Cited by 8 · see citing works

Phyco-synthesized inorganic nanoparticles and their biomedical applications

Ramaraj, N., Thiripuranathar, G., Ekanayake, S., Attanayake, K., & Marapana, U. (2025) · RSC Sustainability · doi:10.1039/d5su00014a · Cited by 8 · see citing works

Histamine stimulates human microglia to alter cellular prion protein expression via the HRH2 histamine receptor

Pehar, M., Hewitt, M., Wagner, A., Sandhu, J. K., Khalili, A., Wang, X., Cho, J., Sim, V. L., & Kulka, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-75982-1 · Cited by 7 · see citing works

Tonabersat Significantly Reduces Disease Progression in an Experimental Mouse Model of Multiple Sclerosis

Kwakowsky, A., Chawdhary, B., de Souza, A., Meyer, E., Kaye, A. H., Green, C. R., Stylli, S. S., & Danesh-Meyer, H. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417454 · Cited by 7 · see citing works

Multiple sclerosis: the NLRP3 inflammasome, gasdermin D, and therapeutics

Brint, A. A., Greene, S., Fennig-Victor, A. R., & Wang, S. (2024) · Annals of Translational Medicine · doi:10.21037/atm-23-1960 · Cited by 7 · see citing works

Shared Molecular Signatures Across Zika Virus Infection and Multiple Sclerosis Highlight AP-1 Transcription Factor as a Potential Player in Post-ZIKV MS-Like Phenotypes

da Silva, E. V., Fontes-Dantas, F. L., Dantas, T. V., Dutra, A., Nascimento, O. J. M., & Alves‐Leon, S. V. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03305-y · Cited by 7 · see citing works

Exploring the mechanism of luteolin improving immune and inflammatory responses in systemic sclerosis based on systems biology and cell experiments

Ding, X., Liu, J., Chen, X., & Zhang, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112587 · Cited by 6 · see citing works

Innate and adaptive immune mechanisms regulating central nervous system remyelination

Creswell, R., & Dombrowski, Y. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2021.12.002 · Cited by 6 · see citing works

Genetic variations in the PSMA6 and PSMC6 proteasome genes are associated with multiple sclerosis and response to interferon‑β therapy in Latvians

Paramonova, N., Kalniņa, J., Dokane, K., Dišlere, K., Ilva, T., Sjakste, T., & Sjakste, N. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.9909 · Cited by 6 · see citing works

Mitochondrial dysfunction, iron accumulation, lipid peroxidation, and inflammasome activation in cellular models derived from patients with multiple sclerosis

García-Salas, R., Cilleros-Holgado, P., Spirito, A. D., Gómez-Fernández, D., Piñero-Pérez, R., Romero-Domínguez, J. M., Álvarez-Córdoba, M., Reche-López, D., Romero-González, A., López-Cabrera, A., et al. (2025) · Aging · doi:10.18632/aging.206198 · Cited by 5 · see citing works

A Preliminary Study on the Meaning of Inflammatory Indexes in MS: A Neda-Based Approach

Bünül, S. D., Alagöz, A. N., Çınar, B. P., Bunul, F., Erdogan, S., & Efendi, H. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13111537 · Cited by 5 · see citing works

Exploring the role of inflammatory cytokines in multiple sclerosis: A comparative perspective

Al-ofi, E. A., Agab, M., Alotaibi, A. A., Karami, M. M., Agab, A. A., Albarqi, S., & Alrafiah, A. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106611 · Cited by 4 · see citing works

β-hydroxybutyrate attenuates demyelination, modulates microglial phenotype and supports blood-brain barrier integrity in a cuprizone-induced mouse model of demyelination

Zhang, N., Li, L., Li, S., Khan, M. A., Tahir, A. H., Rahim, M. F., Wang, T., Zhao, J.-Y., & Zhang, R.-Y. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105580 · Cited by 4 · see citing works

Bioactive Phytochemicals in Experimental Models of Multiple Sclerosis: Mechanisms, Efficacy, and Translational Potential

Guo, W.-M., Meydani, S., & Wu, D.-Y. (2026) · Nutrients · doi:10.3390/nu18020278 · Cited by 4 · see citing works

Exploring wave dynamics and disease progression in a fractional-order β-derivative multiple sclerosis model

Islam, B., Ali, M., Yeasmin, S., Rony, M. A. A., & Kumar, D. (2025) · AIP Advances · doi:10.1063/5.0296885 · Cited by 3 · see citing works

Prospects of treatment of progressive forms of multiple sclerosis by transplantation of stem cells (review)

Sorokovikova, T. V., Morozov, A. M., Kryukova, A. N., Naumova, S. A., & Belyak, M. A. (2023) · Bulletin of the Medical Institute REAVIZ (REHABILITATION DOCTOR AND HEALTH) · doi:10.20340/vmi-rvz.2023.4.tx.3 · Cited by 3 · see citing works

Exploring Inflammasome Complex as a Therapeutic Approach in Inflammatory Diseases

Sultana, S., Viet, T. D., Oishy, T. A., Kazi, E., Micolucci, L., Mollah, A. K. M. M., Akhtar, M. M., & Islam, M. S. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040048 · Cited by 3 · see citing works

Drug Repurposing and Screening for Multiple Sclerosis Targeting Microglia and Macrophages

Bao, N., Liu, J., Wang, H., Xing, L., Xie, Z., Liu, C., Jin, S., Jia, J., Zhang, M., & Fan, J. J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04602-w · Cited by 3 · see citing works

Urokinase, CX3CL1, CCL2, TRAIL and IL‐18 induced by interferon‐β treatment

Zhukovsky, C., Herman, S., Wiberg, A., Cunningham, J. L., Kultima, K., & Burman, J. (2021) · Acta Neurologica Scandinavica · doi:10.1111/ane.13400 · Cited by 3 · see citing works

Pathogenesis of Multiple Sclerosis with Special Consideration of Iron Metabolism, Ferroptosis and Other Forms of Programmed Cell Death

Nafe, R., & Hattingen, E. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl45799 · Cited by 2 · see citing works

The Roles of Interleukin-18 in Inflammation and Autoimmune Disease

Zhao, Y., Tang, Y. Y., Zhu, X., Hou, Y., Li, H., Ciccia, F., Zou, H., & Lu, L. (2026) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-026-09139-5 · Cited by 2 · see citing works

Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review

Monsour, M., Gordon, J., Lockard, G., & Borlongan, C. V. (2023) · Cell Transplantation · doi:10.1177/09636897231184596 · Cited by 2 · see citing works

Effects of Acute Probenecid Administration on Histopathological and Functional Outcomes after Spinal Cord Injury in Rats

Asari, T., Tanaka, S., Pearse, D. D., Vaccari, J. P. D. R., Sawada, T., Ishibashi, Y., Keane, R. W., & Dietrich, W. D. (2025) · Neurotrauma Reports · doi:10.1089/neur.2025.0044 · Cited by 2 · see citing works

Impact of genetic polymorphisms in the interleukin-18 and interleukin-21 genes on the risk and clinical outcomes of multiple sclerosis

Bakr, N. M., Hashim, N. A., El‐Eshmawy, M. A., & El-Baz, H. A. (2026) · BMC Neurology · doi:10.1186/s12883-026-04869-7 · Cited by 1 · see citing works

The role of NLRP3 inflammasome in necrotizing enterocolitis

Chen, X., Long, R., Xu, F., Ye, W., & Li, N. (2025) · Pediatric Research · doi:10.1038/s41390-025-04081-2 · Cited by 1 · see citing works

Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter and immune cells in multiple sclerosis

Otálora-Alcaraz, A., Sun, M. C., Hofman, N., Costelloe, L., KEARNEY, H. F., Prenderville, J. A., & Downer, E. J. (2026) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2026.107040 · Cited by 1 · see citing works

Modulation of the immunological and neuroinflammatory microenvironment in older people with multiple sclerosis

Oreja‐Guevara, C., Meuth, S. G., Grigoriadis, N., Vermersch, P., Hartung, H. P., Sørensen, P. S., Leocani, L., Schmierer, K., Gold, R., & Fernandez, O. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1832582 · Cited by 1 · see citing works

The Microglial NLRP3 Inflammasome in Multiple Sclerosis: Bridging Innate Immunity, Chronic Inflammation, and IFN-β Response

Koyya, P., Alavilli, H., Pandrangi, S. L., & Manthari, R. K. (2026) · Immunological Investigations · doi:10.1080/08820139.2026.2702083 · Cited by 1 · see citing works

Heritability Estimation of Multiple Sclerosis Related Plasma Protein Levels in Sardinian Families with Immunochip Genotyping Data

Nova, A., Baldrighi, G. N., Fazia, T., Graziano, F., Saddi, V., Piras, M., Beecham, A. H., McCauley, J. L., & Bernardinelli, L. (2022) · Life · doi:10.3390/life12071101 · Cited by 1 · see citing works

DAMPs in Organ-Specific Autoimmune Diseases

Land, W. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-21776-0_8 · Cited by 1 · see citing works

PARP-1 gene promoter region may be associated with progression in multiple sclerosis

Yılmaz, B., Genç, G. Ç., Çelik, S., Çınar, B. P., Açıkgöz, M., & Dursun, A. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120275 · Cited by 1 · see citing works

Exploring the mediating role of cerebrospinal fluid metabolites in the pathway from circulating inflammatory proteins to multiple sclerosis: A Mendelian randomization study

Mao, X., Lu, X., Liu, Y., Wu, H., Li, B., & Bi, X. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106440 · Cited by 1 · see citing works

Meeting abstracts from the 2021 UCD School of Medicine Summer Student Research Awards (SSRA 2021)

(2022) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-022-02939-6

EVALUATION OF APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN (ASC) AND B-CELL LYMPHOMA PROTEIN (BCL-6) IN RELATION TO PERIPHERAL BLOOD BIOMARKERS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS

Youssry, S., Kotkata, K., Abdelhamid, A., & Hussein, A. (2022) · Journal of the Medical Research Institute /Journal of Medical Research Institute · doi:10.21608/jmalexu.2022.295162

Inflammasomes as a Prognostic Marker and Possible Therapeutic Target in Multiple Sclerosis: A Rapid Review of the Literature

de la Salud, F. U. D. C., Cuenca, N. T. R., Lamas, D. P., Scientific, P. P. O. T., Hawa, R. F., Clínica Unión Médica del Norte, P. U. C. M. Y. M., Quezada, K., Health, T. O. I., García, L., Marroquín, U. F., et al. (2023) · Principles and Practice of Clinical Research Journal · doi:10.21801/ppcrj.2023.92.7

Multiple Sclerosis: New Insights into Molecular Pathogenesis and Novel Platforms for Disease Treatment

Dejbakht, M., Akhzari, M., Jalili, S., Faraji, F., & Barazesh, M. (2023) · Current Drug Research Reviews · doi:10.2174/2589977516666230915103730

Etifoxine inhibits NLRP3 inflammasome activity in human and murine myeloid cellsPreprint

Osmond, J. M., Williams, J. B., Matthews, P. M., Owen, D. R., & Moore, C. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.19.558428

Fibrinogen signalling in human iPSC-derived microgliaPreprint

Cosker, K., Boorman, E., Vasilopoulou, F., Mallach, A., Piers, T. M., & Pocock, J. M. (2024) · Research Square · doi:10.21203/rs.3.rs-4324378/v1

The role of inflammasomes in multiple sclerosis

Yavarpour‐Bali, H., & Ghasemi‐Kasman, M. (2020) · Multiple Sclerosis Journal · doi:10.1177/1352458520932776 · Cited by 4 · see citing works

Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics

Cui, Y., Yu, H., Bu, Z., Wen, L., Yan, L.-L., & Feng, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.894298 · Cited by 79 · see citing works

CNS Inflammasome Activation and Modulation in Multiple Sclerosis (P5.333)

McKenzie, B., Mamik, M. K., Lu, J., Branton, W. G., & Power, C. (2016) · Neurology · doi:10.1212/wnl.86.16_supplement.p5.333

Beyond the innate immune system: rethinking inflammasomes in multiple sclerosis

Duran, G., Verreycken, J., Dombrowski, Y., Lamkanfi, M., Baeten, P., & Broux, B. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.10.014 · Cited by 2 · see citing works

The NLRP3 inflammasome: A central player in multiple sclerosis

Otálora-Alcaraz, A., Reilly, T. P., Oró-Nolla, M., Sun, M. C., Costelloe, L., KEARNEY, H. F., Patra, P. H., & Downer, E. J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116667 · Cited by 9 · see citing works