Microglial NLRP3 inflammasome activation in multiple sclerosis

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Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

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Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

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PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

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Microglia innately develop within cerebral organoids

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Hsp90 inhibition attenuates the 1, 2-Dichloroethane-induced cognitive impairment by blocking NLRP3 inflammasome activation in mice

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ASC- and caspase-1-deficient C57BL/6 mice do not develop demyelinating disease after infection with Theiler’s murine encephalomyelitis virus

Li, D., Bühler, M., Runft, S., Gerold, G., Marek, K., Baumgärtner, W., Strowig, T., & Gerhauser, I. (2023) · Scientific Reports · doi:10.1038/s41598-023-38152-3 · Cited by 3 · see citing works

Edaravone protects against cuprizone-induced demyelination in rats by modulating TNF-α/NF-ĸB/NLRP3 signaling and the kynurenine pathway

Mahmoud, A. M. A., Helal, M. G., El‐Sherbiny, M., Said, E., Nader, M. A., & Shehatou, G. S. G. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177686 · Cited by 3 · see citing works

Assessing the inflammation in pediatric MOGAD: Significance of CSF HMGB1 and related biomarkers

Wang, X., Zhao, R., Fan, J., Liu, C., Li, Z., Yang, H., & Wang, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1534172 · Cited by 1 · see citing works

2-Hydroxy-4-n-octyloxybenzophenone induces developmental neurotoxicity and multiple sclerosis-like symptoms through cacna1a regulated Ca2 + inward flow and microglial activation

Li, X., Gao, X., Liu, S., Liu, S., Liu, Y., Li, G., Xia, L., Liu, K., & Jin, M. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118154 · Cited by 1 · see citing works

GPR40 Attenuates Age-Related Macular Degeneration by Suppressing Retinal Microglial NLRP3 Inflammasome Activation Via ERK Signaling

Tan, X., Kang, J., Zhao, H., Fang, F., Xia, Y., Luo, C., Zou, Y., & Li, Y. (2026) · Inflammation · doi:10.1007/s10753-025-02380-8 · Cited by 1 · see citing works

The Role of NLRP3 Inflammasomes in Neurological Disorders: Mechanistic Understanding and Phytochemical‐Based Therapeutics

Rahi, S., Sharma, A., & Sah, S. P. (2026) · Phytotherapy Research · doi:10.1002/ptr.70215 · Cited by 1 · see citing works

Mechanistic insights from experimental autoimmune encephalomyelitis into immune regulation, autophagy, gut microbiota, blood-brain barrier integrity, and NLRP3 inflammasome-mediated pyroptosis in multiple sclerosis: potential clinical implications

Zhang, S.-M., Tang, W.-C., Liu, F.-F., Bai, Q.-Q., Guo, Y., Bai, X.-Z., Wang, Y. J., Xw, M., Pan, S.-J., Yang, Y.-H., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1803309 · Cited by 1 · see citing works

Deconstructing the Master Switch: Advances in Direct NLRP3 Inhibition

Xu, Y., & Murphy, S. (2026) · Pharmaceuticals · doi:10.3390/ph19071104 · Cited by 1 · see citing works

DAMPs in Organ-Specific Autoimmune Diseases

Land, W. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-21776-0_8 · Cited by 1 · see citing works

Proteomics and phosphoproteomics profiling in glutamatergic neurons and microglia in an iPSC model of Jansen de Vries SyndromePreprint

Aguilan, J. T., Pedrosa, E., Dolstra, H., Baykara, R. N., Barnes, J., Zhang, J., Sidoli, S., & Lachman, H. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.08.548192

Glial Cells, Cytokines, and Inflammasomes in Neurodegeneration

Patil, V. S., Desai, A., & Meena, H. (2025) · Springer eBooks · doi:10.1007/978-981-95-3945-1_3

A novel multiplexed biomarker panel reveals key molecular pathways in progressive multiple sclerosis

Heiss, C. N., Novakova, L., Axelsson, M., Tan, K., Pola, I., Traichel, W., Pesämaa, I., Johnsson, M., Sandgren, S., Malmeström, C., et al. (2026) · Brain Communications · doi:10.1093/braincomms/fcag142

Associations Between Neuromuscular Fatigue, Anxiety, and Peripheral Biomarkers of Neuronal Injury, Inflammation, and Mitochondrial Dysfunction in Treatment‐Naïve Relapsing‐Remitting Multiple Sclerosis

Steckert, A. V., Feltrin, K. D., Rodrigues, L. F. S., de Liz, F. M., Muller, M. M. F., Bortoluzzi, D. P., Mayer, A. B., Ceretta, L. B., Barichello, T., Dal‐Pizzol, F., et al. (2026) · Brain and Behavior · doi:10.1002/brb3.71707

Discovery of a brain penetrant NLRP3 inflammasome inhibitor that reduces neuropathic pain in mice

Xu, Y., Namme, J. N., Yang, L., Xu, Y., Biby, S., Lü, Q., Tuck, T., Gomm, A., Sarkar, N., Liu, Z., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119319

Naringenin confers neuroprotection in a cuprizone-induced mouse model of multiple sclerosis with upregulation of PPAR-γ expression

Behairy, S., Fahmy, M. I., Sayed, R. H., & El-Yamany, M. F. (2026) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgag113

Disability and Depressiveness are Related to IL-18 Serum Levels in the Remission of Multiple Sclerosis

Vesić, K., Arsenijević, A., Milovanović, J., Mijailović, N. R., & Gavrilović, A. (2026) · EABR. Experimental and Applied Biomedical Research · doi:10.2478/eabr-2024-0002

BindingDB Entry 50021524: Design and Discovery of Novel NLRP3 Inhibitors and PET Imaging Radiotracers Based on a 1,2,3-Triazole-Bearing Scaffold.

BindingDB (2025) · UC San Diego · doi:10.7270/q2mw2nrn

Microglial Mayhem NLRP3 Inflammasome's Role in Multiple Sclerosis Pathology

Fan, H., Fu, Q., Du, G., Ling, Q., Shi, X., Wang, D., & Yang, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70135 · Cited by 13 · see citing works

The Microglial NLRP3 Inflammasome in Multiple Sclerosis: Bridging Innate Immunity, Chronic Inflammation, and IFN-β Response

Koyya, P., Alavilli, H., Pandrangi, S. L., & Manthari, R. K. (2026) · Immunological Investigations · doi:10.1080/08820139.2026.2702083 · Cited by 1 · see citing works

Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics

Cui, Y., Yu, H., Bu, Z., Wen, L., Yan, L.-L., & Feng, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.894298 · Cited by 79 · see citing works

The role of NLRP3 inflammasome in multiple sclerosis: pathogenesis and pharmacological application

Zhang, W., Zheng, X.-R., Yao, Y., Sun, W., & Shao, B. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1572140 · Cited by 5 · see citing works

CNS Inflammasome Activation and Modulation in Multiple Sclerosis (P5.333)

McKenzie, B., Mamik, M. K., Lu, J., Branton, W. G., & Power, C. (2016) · Neurology · doi:10.1212/wnl.86.16_supplement.p5.333