A comprehensive review of AAV-mediated strategies targeting microglia for therapeutic intervention of neurodegenerative diseases
Open accessAbstract
Neurodegenerative diseases pose a significant health burden globally, with limited treatment options available. Among the various cell types involved in the pathogenesis of these disorders, microglia, the resident immune cells of the central nervous system, play a pivotal role. Dysregulated microglial activation contributes to neuroinflammation and neuronal damage, making them an attractive target for therapeutic intervention. Adeno-associated virus (AAV) vectors have emerged as powerful tools for delivering therapeutic genes to specific cell types in the central nervous system with remarkable precision and safety. In the current review, we discuss the strategies employed to achieve selective transduction of microglia, including the use of cell-specific promoters, engineered capsids, and microRNA (miRNA) strategies. Additionally, we address the challenges and future directions in the development of AAV-based therapies targeting microglia. Overall, AAV-mediated targeting of microglia holds promise as a novel therapeutic approach for neurodegenerative diseases, offering the potential to modify disease progression and improve patient outcomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Alterations in microglia can lead to alterations in behavior in mice.
“It is widely known that alterations in microglia can lead to alterations in behavior in mice5,13–15.”
From Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects in microglia (2026) · cites this paper as [14]
The Introduction links microglial dysfunction to neurodegenerative diseases and describes those diseases as causing cognitive decline and motor impairment. It does not report that altering microglia changes behavior in mice; searches for “behavior” and “behavioral” found no such passage. The general link is supported, but the mouse-specific claim is not. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179 · see citing works
Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968 · see citing works
Microglia in neurodegeneration
Hickman, S., Izzy, S., Sen, P., Morsett, L., & El Khoury, J. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0242-x · Cited by 1,710 · see citing works
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616 · see citing works
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000 · see citing works
Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future
Zhang, Y., Chen, H., Li, R., Sterling, K., & Song, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01484-7 · Cited by 988 · cited 1× · see citing works
“Recently, new treatments have emerged; for instance, Aβ antibody therapies for AD were approved by U.S. Food and Drug Administration (FDA) [10].”
BackgroundSelf-citationSmajić, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., et al. (2022) · Brain · doi:10.1093/brain/awab446 · Cited by 590 · see citing works
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
Kim, J., Krichevsky, A. M., Grad, Y. H., Hayes, G. D., Kosik, K. S., Church, G. M., & Ruvkun, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2333854100 · Cited by 570 · see citing works
Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
Efthymiou, A. G., & Goate, A. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0184-x · Cited by 562 · see citing works
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
Choi, I., Zhang, Y., Seegobin, S. P., Pruvost, M., Wang, Q., Purtell, K., Zhang, B., & Yue, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15119-w · Cited by 549 · cited 1× · see citing works
“This chronic inflammation further disrupts the regulatory mechanisms of microglial activity, impairing their ability to clear alpha-synuclein aggregates, a key pathological feature of PD [26, 27].”
BackgroundSelf-citationMicroglial subtypes: diversity within the microglial community
Stratoulias, V., Venero, J. L., Tremblay, M., & Joseph, B. (2019) · The EMBO Journal · doi:10.15252/embj.2019101997 · Cited by 536 · see citing works
Heckmann, B. L., Teubner, B. J. W., Tummers, B., Boada-Romero, E., Harris, L., Yang, M., Guy, C. S., Zakharenko, S. S., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.056 · Cited by 503 · see citing works
LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
Moehle, M. S., Webber, P. J., Tse, T., Sukar, N., Standaert, D. G., DeSilva, T. M., Cowell, R. M., & West, A. B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5601-11.2012 · Cited by 463 · see citing works
TREM2 in Neurodegenerative Diseases
Jay, T. R., von Saucken, V. E., & Landreth, G. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0197-5 · Cited by 427 · see citing works
Gray, S. J., Foti, S. B., Schwartz, J. W., Bachaboina, L., Taylor-Blake, B., Coleman, J., Ehlers, M. D., Zylka, M. J., McCown, T. J., & Samulski, R. J. (2011) · Human Gene Therapy · doi:10.1089/hum.2010.245 · Cited by 420 · see citing works
Grace, P. M., Strand, K. A., Galer, E. L., Urban, D. J., Wang, X., Baratta, M. V., Fabisiak, T., Anderson, N. D., Cheng, K., Greene, L. I., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602070113 · Cited by 363 · see citing works
Self-citationMutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
Crotti, A., Benner, C., Kerman, B. E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., Cattaneo, E., Gage, F. H., Cleveland, D. W., & Glass, C. K. (2014) · Nature Neuroscience · doi:10.1038/nn.3668 · Cited by 333 · see citing works
The Neuropathology of Huntington’s Disease
Waldvogel, H. J., Kim, E. H., Tippett, L. J., Vonsattel, J., & Faull, R. L. M. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_354 · Cited by 318 · see citing works
Selective and Rapid Uptake of Adeno-Associated Virus Type 2 in Brain
Bartlett, J. S., Samulski, R. J., & McCown, T. J. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.8-1181 · Cited by 301 · see citing works
Neuroinflammation in frontotemporal dementia
Bright, F., Werry, E. L., Dobson-Stone, C., Piguet, O., Ittner, L. M., Halliday, G. M., Hodges, J. R., Kiernan, M. C., Loy, C. T., Kassiou, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0231-z · Cited by 280 · see citing works
Jovičić, A., Roshan, R., Moisoi, N., Pradervand, S., Moser, R., Pillai, B., & Luthi-Carter, R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0600-12.2013 · Cited by 251 · see citing works
The role of the LRRK2 gene in Parkinsonism
Li, J.-Q., Tan, L., & Yu, J.-T. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-47 · Cited by 249 · see citing works
Targeting the Microglial NLRP3 Inflammasome and Its Role in Parkinson's Disease
Haque, M. E., Akther, M., Jakaria, M., Kim, I., Azam, S., & Choi, D. (2019) · Movement Disorders · doi:10.1002/mds.27874 · Cited by 248 · see citing works
<i>CSF1R</i> -related leukoencephalopathy: A major player in primary microgliopathies
Konno, T., Kasanuki, K., Ikeuchi, T., Dickson, D. W., & Wszolek, Z. K. (2018) · Neurology · doi:10.1212/wnl.0000000000006642 · Cited by 208 · see citing works
Advancing cell therapy for neurodegenerative diseases
Temple, S. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.03.017 · Cited by 206 · see citing works
Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
Chakrabarty, P., Rosario, A. M., Cruz, P. E., Siemienski, Z. B., Ceballos‐Diaz, C., Crosby, K. W., Jansen, K. R., Borchelt, D., Kim, J., Jankowsky, J. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067680 · Cited by 201 · see citing works
Gene-based therapies for neurodegenerative diseases
Sun, J., & Roy, S. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00778-1 · Cited by 189 · see citing works
Directed evolution of adeno-associated virus for efficient gene delivery to microglia
Lin, R., Zhou, Y., Yan, T., Wang, R., Li, H., Wu, Z., Zhang, X., Zhou, X., Zhao, F., Zhang, L., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01547-7 · Cited by 171 · see citing works
TREM2 in CNS homeostasis and neurodegenerative disease
Painter, M. M., Atagi, Y., Liu, C.-C., Rademakers, R., Xu, H., Fryer, J. D., & Bu, G. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0040-9 · Cited by 169 · see citing works
Xie, M., Liu, Y. U., Zhao, S., Zhang, L., Bosco, D. B., Pang, Y.-P., Zhong, J., Sheth, U., Martens, Y. A., Zhao, N., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00975-6 · Cited by 157 · see citing works
Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids
Castle, M. J., Turunen, H. T., Vandenberghe, L. H., & Wolfe, J. H. (2016) · Methods in Molecular Biology · doi:10.1007/978-1-4939-3271-9_10 · Cited by 151 · cited 2× · see citing works
“…such as gene editing and gene delivery systems may offer novel approaches to correct aberrant microglial function and restore CNS homeostasis in various neurodegenerative disorders. the majority of current AAV serotypes or variants exhibit tropism primarily towards neurons or astrocytes [32].”
BackgroundTargeting microglia with lentivirus and AAV: Recent advances and remaining challenges
Maes, M. E., Colombo, G., Schulz, R., & Siegert, S. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134310 · Cited by 145 · see citing works
Microglia-specific targeting by novel capsid-modified AAV6 vectors
Rosario, A. M., Cruz, P. E., Ceballos‐Diaz, C., Strickland, M. R., Siemienski, Z. B., Pardo, M., Schob, K.-L., Li, A., Aslanidi, G., Srivastava, A., et al. (2016) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2016.26 · Cited by 119 · see citing works
Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer’s disease
Gabrielli, M., Prada, I., Joshi, P., Falcicchia, C., D’Arrigo, G., Rutigliano, G., Battocchio, E., Zenatelli, R., Tozzi, F., Radeghieri, A., et al. (2022) · Brain · doi:10.1093/brain/awac083 · Cited by 106 · see citing works
Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders
Hu, B., Duan, S., Wang, Z., Li, X., Zhou, Y., Zhang, X., Zhang, Y., Xu, H., & Zheng, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.789834 · Cited by 105 · see citing works
Self-citationNeuropathology of Huntington's Disease
Vonsattel, J. P., Keller, C. E., & Amaya, M. D. P. (2008) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)01256-0 · Cited by 101 · see citing works
Cucchiarini, M., Ren, X., Perides, G., & Terwilliger, E. F. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301925 · Cited by 100 · see citing works
Wu, Y., Shao, W., Todd, T. W., Tong, J., Yue, M., Koga, S., Castanedes-Casey, M., Librero, A. L., Lee, C. W., Mackenzie, I. R., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109581 · Cited by 91 · see citing works
Self-citationÅkerblom, M., Sachdeva, R., Quintino, L., Wettergren, E. E., Chapman, K. Z., Manfre, G., Lindvall, O., Lundberg, C., & Jakobsson, J. (2013) · Nature Communications · doi:10.1038/ncomms2801 · Cited by 86 · see citing works
Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy
Kempthorne, L., Yoon, H., Madore, C., Smith, S., Wszolek, Z. K., Rademakers, R., Kim, J., Butovsky, O., & Dickson, D. W. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00947-0 · Cited by 77 · cited 1× · see citing works
“In individuals with HDLS caused by CSF-1R mutations, the normal functioning of microglia is disrupted, resulting in chronic inflammation, impaired clearance of cellular debris, and damage to white matter in the brain [5, 9].”
BackgroundAdenoassociated virus serotype 9-mediated gene therapy for x-linked adrenoleukodystrophy
Gong, Y., Mu, D., Prabhakar, S., Moser, A., Musolino, P., Ren, J., Breakefield, X. O., Maguire, C. A., & Eichler, F. S. (2015) · Molecular Therapy · doi:10.1038/mt.2015.6 · Cited by 74 · see citing works
Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening
Börner, K., Kienle, E., Huang, L., Weinmann, J., Sacher, A., Bayer, P., Stüllein, C., Fakhiri, J., Zimmermann, L., Westhaus, A., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.02.009 · Cited by 72 · see citing works
Translational Neurodegeneration in the era of fast growing international brain research
Zheng, J., & Chen, S. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-021-00276-9 · Cited by 59 · see citing works
Okada, Y., Hosoi, N., Matsuzaki, Y., Fukai, Y., Hiraga, A., Nakai, J., Nitta, K., Shinohara, Y., Konno, A., & Hirai, H. (2022) · Communications Biology · doi:10.1038/s42003-022-04200-3 · Cited by 58 · see citing works
Gene Therapy for Huntington’s Disease: The Final Strategy for a Cure?
Byun, S., Lee, M., & Kim, M. (2021) · Journal of Movement Disorders · doi:10.14802/jmd.21006 · Cited by 40 · see citing works
Park, T.-Y., Jeon, J., Cha, Y., & Kim, K. (2024) · Cell Research · doi:10.1038/s41422-024-00971-y · Cited by 34 · see citing works
Su, W., Kang, J., Sopher, B. L., Gillespie, J., Aloi, M. S., Odom, G. L., Hopkins, S., Case, A., Wang, D. B., Chamberlain, J. S., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13081 · Cited by 32 · see citing works
Young, A. M. H., Neumann, B., Segel, M., Chen, C. Z.-Y., Tourlomousis, P., & Franklin, R. J. M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302997120 · Cited by 29 · see citing works
Strong ubiquitous micro-promoters for recombinant adeno-associated viral vectors
Chai, S., Wakefield, L., Norgard, M. A., Li, B., Enicks, D., Marks, D. L., & Grompe, M. (2023) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2023.05.013 · Cited by 29 · see citing works
Maes, M. E., Wögenstein, G. M., Colombo, G., Casado-Polanco, R., & Siegert, S. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.09.006 · Cited by 12 · see citing works
Opening the door to gene therapy for ALS
Stower, H. (2020) · Nature Medicine · doi:10.1038/s41591-020-1029-7 · Cited by 2 · see citing works
Tamaoka, A. (2017) · PubMed · doi:10.11477/mf.1416200629 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Wood H. α-Synuclein-activated microglia are implicated in PD pathogenesis. Nat Reviews Neurol. 2022;18(4):188–188.
Cited by
Sorted by citations
He, C., Chen, B., Yang, H., & Zhou, X. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1554398 · Cited by 37 · see citing works
Jobling, A. I., Greferath, U., Dixon, M., Quiriconi, P., Eyar, B., van Koeverden, A. K., Mills, S. A., Vessey, K. A., Bui, B. V., & Fletcher, E. L. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101349 · Cited by 31 · see citing works
Glial Cell Dynamics in Neuroinflammation: Mechanisms, Interactions, and Therapeutic Implications
García‐Domínguez, M. (2026) · Biomedicines · doi:10.3390/biomedicines14010115 · Cited by 29 · see citing works
Niche-specific therapeutic targeting of myeloid cells in the central nervous system
Frosch, M., & Prinz, M. (2025) · Immunity · doi:10.1016/j.immuni.2025.03.016 · Cited by 17 · see citing works
Wu, D., Wei, Y., Hou, L.-X., Du, Y., Yan, Q., Liu, L., Zhao, Y., Yan, R., Yu, C., Zhong, Z.-G., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01698-7 · Cited by 17 · see citing works
Swarts, E. A., & Brennan, F. H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1621789 · Cited by 12 · see citing works
Shifting Microglial Phenotypes: Targeting Disease-Associated Microglia in Neurodegeneration
Sasidharan, A., Somayaji, Y., & Fernandes, R. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00159 · Cited by 10 · see citing works
Expression of anti-amyloid CARs in microglia promotes efficient and selective phagocytosis of Aβ1‒42
Heiss, C. N., Riise, R. E., Hanse, E., Fruhwürth, S., Zetterberg, H., & Björefeldt, A. (2025) · Gene Therapy · doi:10.1038/s41434-025-00534-9 · Cited by 9 · see citing works
Sharma, S., Joshi, V., & Kumar, V. (2025) · Clinical and Translational Neuroscience · doi:10.3390/ctn9030032 · Cited by 7 · see citing works
Axonopathy: mechanisms and potential therapeutic targets for neurodegenerative diseases
Shen, R., Sung, K., Ding, J., & Wu, C. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00543-7 · Cited by 6 · see citing works
Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects in microglia
Mroue-Ruiz, F. H., Desai, B., Garvin, M. M., Shehu, J. H., Kamau, F., Kar, U., & Bolton, J. L. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153657 · Cited by 3 · see citing works
From Salt to Gut: The Health Benefits of Halophiles in Fermented Foods and Gut Microbiota
Nwankwo, C. E. I., Mao, Y., Hou, J., & Cui, H. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2503476 · Cited by 3 · see citing works
Wang, Y., & Ohshima, T. (2024) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08814-0 · Cited by 3 · see citing works
Self-citationOligodendrocytes, the Forgotten Target of Gene Therapy
Ozgür-Gunes, Y., Stunff, C. L., & Bougneres, P. F. (2024) · Cells · doi:10.3390/cells13231973 · Cited by 4 · see citing works
Wu, Z., Lv, F., Shao, S., Chen, Y., Weng, N., & Xia, Y. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121355 · Cited by 2 · see citing works
Revisiting TREM2: from multi-omics signaling networks to clinical translation
Yang, J., Wan, D., Ren, L., Lv, Y., & Zhao, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1782384 · Cited by 2 · see citing works
Pottorf, T. S., Lane, E. L., & Álvarez, F. J. (2025) · Cells · doi:10.3390/cells14191520 · Cited by 1 · see citing works
Gomes, C. M., Silva, G. P. D. L., Aleixo, M. M., Simão, D. F., Holtkamp, S., Lobo, D. D., Harish, P., Jenkins, R., Dahal, L. N., Nobre, R. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.07.662807
Revolutionizing Gene Therapy: An Explicative Review on Engineering Adeno-associated Virus Vectors
Nandi, S., Chandra, S., Biswas, K., Mazumder, K., Mukherjee, S., Karati, D., Bandyopadhyay, S. N., & Toro, P. D. (2026) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-026-00561-x
Liu, F., Xue, X., Li, H., He, Z., Wang, R., Guo, Y., & Wang, Y. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106768
Self-citationYang, Y., Lin, W.-J., Zhuo, Y.-F., Yang, J.-L., Wei, Y., Pan, W.-D., Liao, Y.-L., & Yao, Y.-S. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158338
Han, W., & Zi-Long, Q. I. U. (2026) · Shengming kexue · doi:10.3724/cbls.2026070
Saadatpour, F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40467-2.00008-7
Roy, B. S., & Rajagopal, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33887-8.00014-3
Ramani, M., Nguyen, N., Solis, J., Tenen, D. G., & Trinh, B. Q. (2026) · Biology · doi:10.3390/biology15181657
Wang, R., Yang, Q., Cao, Z., Zhou, J., Tian, B., Wang, X., Zhang, X., Xiang, Q., & Chen, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1859981
- Authors
- Zhou, L., Wang, Y., Xu, Y., Zhang, Y., & Zhu, C.
- Affiliations
- Zhengzhou University (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Corresponding author
- Zhou, Livia
- Zhu, Changlian
- Venue
- Journal of Neuroinflammation
- Published
- 2024-09-19
- Volume
- 21
- Issue
- 1
- Pages
- 232-232
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC11414267
- OpenAlex
- W4402622588
- Semantic Scholar
- 75bd877fec223b930ce9e90c348fa7f6bdb18ba4
- Cited by
- 26
- References
- 52
- Citations by year
- 2026: 13 · 2025: 11 · 2024: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Gothenburg
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- adeno-associated virus vectors, neurodegenerative diseases, microglial activation, neuroinflammation, cell-specific promoters, microRNA targeting, gene therapy
- MeSH terms
- Dependovirus, Animals, Genetic Vectors, Humans, Genetic Therapy, Microglia, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
