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Cited by 43T-cell and Retrovirus StudiesViral-associated cancers and disordersInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Human T-cell leukaemia virus type 1 associated pulmonary disease: clinical and pathological features of an under-recognised complication of HTLV-1 infection

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Einsiedel, Lloyd, Chiong, Fabian, Jersmann, Hubertus, Taylor, Graham P.·2021·Retrovirology
DOI 10.1186/s12977-020-00543-zPMC PMC7789585
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Abstract

The lung is one of several organs that can be affected by HTLV-1 mediated inflammation. Pulmonary inflammation associated with HTLV-1 infection involves the interstitium, airways and alveoli, resulting in several clinical entities including interstitial pneumonias, bronchiolitis and alveolitis, depending on which structures are most affected. Augmentation of the inflammatory effects of HTLV-1 infected lymphocytes by recruitment of other inflammatory cells in a positive feedback loop is likely to underlie the pathogenesis of HTLV-1 associated pulmonary disease, as has been proposed for HTLV-1 associated myelopathy. In contrast to the conclusions of early case series, HTLV-1 associated pulmonary disease can be associated with significant parenchymal damage, which may progress to bronchiectasis where this involves the airways. Based on our current understanding of HTLV-1 associated pulmonary disease, diagnostic criteria are proposed.

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  • HTLV-1 carries a broader burden of disease globally, being implicated in a range of immune-associated diseases and systemic inflammation.

    “Since its discovery, further characterisation has suggested that HTLV-1 carries a much broader burden of disease globally, being implicated in a range of immune-associated diseases and systemic inflammation, amongst other comorbidities [13,14,15,16,17].”

    From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [17]

  • HTLV-1 infection is associated with a range of other inflammatory diseases and infections.

    “HTLV-1 infection is also associated with a range of other inflammatory diseases and infections.”

    From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [17]

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Cited by

Sorted by citations

Authors
Einsiedel, L., Chiong, F., Jersmann, H., & Taylor, G. P.
Affiliations
  • Alice Springs Hospital (AU)
  • Royal Adelaide Hospital (AU)
  • Imperial College London (GB)
Corresponding author
Einsiedel, Lloyd
ORCID
Venue
Retrovirology
Publisher
Springer Science and Business Media LLC
Published
2021-01-06
Volume
18
Issue
1
Pages
1-1
ISSN
1742-4690 (ISSN-L)
DOI
10.1186/s12977-020-00543-z
PMC
PMC7789585
OpenAlex
W4205697305
Cited by
43
References
1
Citations by year
2026: 7 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 12 · 2021: 5
FWCI
0.79
Type
journal article
Language
en
Update notices
correction (2021-02-22)
Open access
Licence
Locations
  • Retrovirology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Spiral (Imperial College London) (submittedVersion, cc-by)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords
HTLV-1, lung disease, interstitial lung disease, bronchiolitis, alveolitis, bronchiectasis, lung pathology, inflammatory cell recruitment, positive feedback loop, diagnostic criteria
MeSH terms
Animals, Humans, Inflammation, Lung, Lung Diseases, Human T-lymphotropic virus 1, HTLV-I Infections, Paraparesis, Tropical Spastic, Mice

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