The DOI matches its Crossref record; 466 of the 466 references it cites were found in a registry or an index.
Challenges and new technologies in adoptive cell therapy
Open accessAbstract
Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and chimeric antigen receptor (CAR)-T cell therapies, many novel strategies for cancer treatment have been developed. Owing to its promising outcomes, CAR-T cell therapy has revolutionized the field of ACTs, particularly for hematologic malignancies. Despite these advances, CAR-T cell therapy still has limitations in both autologous and allogeneic settings, including practicality and toxicity issues. To overcome these challenges, researchers have focused on the application of CAR engineering technology to other types of immune cell engineering. Consequently, several new cell therapies based on CAR technology have been developed, including CAR-NK, CAR-macrophage, CAR-γδT, and CAR-NKT. In this review, we describe the development, advantages, and possible challenges of the aforementioned ACTs and discuss current strategies aimed at maximizing the therapeutic potential of ACTs. We also provide an overview of the various gene transduction strategies employed in immunotherapy given their importance in immune cell engineering. Furthermore, we discuss the possibility that strategies capable of creating a positive feedback immune circuit, as healthy immune systems do, could address the flaw of a single type of ACT, and thus serve as key players in future cancer immunotherapy.
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Cites
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Cited by
Zhang, M., Liu, C., Tu, J., Tang, M., Ashrafizadeh, M., Nabavi, N., Sethi, G., Zhao, P., & Liu, S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02305-x · Cited by 259
TNC‑targeted CAR‑macrophage therapy alleviates liver fibrosis in mice
Chen, K., Lin, Z., Chen, L., Zhou, Y., Zhang, W., Wan, H., Huo, Y., Fu, Q., Gao, Z., Cheng, H., et al. (2025) · Military Medical Research · doi:10.1186/s40779-025-00667-3 · Cited by 11
Metadata
- Authors
- Zhang, P., Zhang, G., & Wan, X.
- Venue
- Journal of Hematology & Oncology
- Published
- 2023-08-18
- Volume
- 16
- Issue
- 1
- Pages
- 97-97
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W4385996357
- Cited by
- 259
- References
- 466
- FWCI
- 26.81
- Type
- journal article
- Language
- en
- Open access
- gold
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