The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Macrophages as regulators of tumour immunity and immunotherapy
Open accessAbstract
Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest in targeting macrophages in cancer, and preclinical studies have demonstrated efficacy across therapeutic modalities and tumour types. Much of the observed efficacy can be traced to the suppressive capacity of macrophages, driven by microenvironmental cues such as hypoxia and fibrosis. As a result, tumour macrophages display an ability to suppress T cell recruitment and function as well as to regulate other aspects of tumour immunity. With the increasing impact of cancer immunotherapy, macrophage targeting is now being evaluated in this context. Here, we discuss the results of clinical trials and the future of combinatorial immunotherapy. In this Review, DeNardo and Ruffell describe how macrophages shape local immune responses in the tumour microenvironment to both suppress and promote immunity to tumours. The authors also discuss the potential of targeting tumour-associated macrophages to enhance antitumour immune responses.
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Cites
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Cited by
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059
Macrophages and metabolism in the tumor microenvironment
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Macrophages as tools and targets in cancer therapy
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The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
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A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
Cheng, S., Li, Z., Gao, R., Xing, B., Gao, Y., Yang, Y., Qin, S., Zhang, L., Ouyang, H., Du, P., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.010 · Cited by 1,601
Metadata
- Authors
- DeNardo, D. G., & Ruffell, B.
- Venue
- Nature Reviews Immunology
- Published
- 2019-02-04
- Volume
- 19
- Issue
- 6
- Pages
- 369-382
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2914311347
- Cited by
- 2,528
- References
- 46
- FWCI
- 18.30
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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