The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Sepsis-associated hyperlactatemia
Open accessAbstract
There is overwhelming evidence that sepsis and septic shock are associated with hyperlactatemia (sepsis-associated hyperlactatemia (SAHL)). SAHL is a strong independent predictor of mortality and its presence and progression are widely appreciated by clinicians to define a very high-risk population. Until recently, the dominant paradigm has been that SAHL is a marker of tissue hypoxia. Accordingly, SAHL has been interpreted to indicate the presence of an `oxygen debt’ or `hypoperfusion’, which leads to increased lactate generation via anaerobic glycolysis. In light of such interpretation of the meaning of SAHL, maneuvers to increase oxygen delivery have been proposed as its treatment. Moreover, lactate levels have been proposed as a method to evaluate the adequacy of resuscitation and the nature of the response to the initial treatment for sepsis. However, a large body of evidence has accumulated that strongly challenges such notions. Much evidence now supports the view that SAHL is not due only to tissue hypoxia or anaerobic glycolysis. Experimental and human studies all consistently support the view that SAHL is more logically explained by increased aerobic glycolysis secondary to activation of the stress response (adrenergic stimulation). More importantly, new evidence suggests that SAHL may actually serve to facilitate bioenergetic efficiency through an increase in lactate oxidation. In this sense, the characteristics of lactate production best fit the notion of an adaptive survival response that grows in intensity as disease severity increases. Clinicians need to be aware of these developments in our understanding of SAHL in order to approach patient management according to biological principles and to interpret lactate concentrations during sepsis resuscitation according to current best knowledge.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694
The Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup*, Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-012-2769-8 · Cited by 7,290
Intravenous Fluids and Acute Kidney Injury
Ding, X., Cheng, Z., & Qian, Q. (2017) · Blood Purification · doi:10.1159/000452702 · Cited by 6,827
Elevation of Systemic Oxygen Delivery in the Treatment of Critically Ill Patients
Hayes, M. A., Timmins, A. C., Yau, E., Palazzo, M., Hinds, C. J., & Watson, D. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406163302404 · Cited by 1,538
Association between mitochondrial dysfunction and severity and outcome of septic shock
Brealey, D., Brand, M., Hargreaves, I., Heales, S., Land, J., Smolenski, R., Davies, N. A., Cooper, C. E., & Singer, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09459-x · Cited by 1,503
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock*
Nguyen, H. B., Rivers, E. P., Knoblich, B. P., Jacobsen, G., Muzzin, A., Ressler, J. A., & Tomlanovich, M. C. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000132904.35713.a7 · Cited by 1,228
Jones, A. E. (2010) · JAMA · doi:10.1001/jama.2010.158 · Cited by 1,077
Jansen, T. C., van Bommel, J., Schoonderbeek, F. J., Sleeswijk Visser, S. J., van der Klooster, J. M., Lima, A. P., Willemsen, S. P., & Bakker, J. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1918oc · Cited by 894
Effect of Stored-Blood Transfusion on Oxygen Delivery in Patients With Sepsis
Marik, P. E. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03500230106037 · Cited by 812
Self-citationThe microcirculation is the motor of sepsis.
İnce, C. (2005) · Critical Care · doi:10.1186/cc3753 · Cited by 804
Cited by
Sepsis: pathophysiology and clinical management
Gotts, J. E., & Matthay, M. A. (2016) · BMJ · doi:10.1136/bmj.i1585 · Cited by 1,243
Hernández, G., Ospina-Tascón, G. A., Damiani, L. P., Estenssoro, E., Dubin, A., Hurtado, J., Friedman, G., Castro, R., Alegría, L., Teboul, J.-L., et al. (2019) · JAMA · doi:10.1001/jama.2019.0071 · Cited by 946
Lactate as a fulcrum of metabolism
Brooks, G. A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101454 · Cited by 724
The anaerobic threshold: 50+ years of controversy
Poole, D. C., Rossiter, H. B., Brooks, G. A., & Gladden, L. B. (2021) · The Journal of Physiology · doi:10.1113/jp279963 · Cited by 312
Lactate in contemporary biology: a phoenix risen
Brooks, G. A., Arevalo, J. A., Osmond, A. D., Leija, R. G., Curl, C. C., & Tovar, A. P. (2022) · The Journal of Physiology · doi:10.1113/jp280955 · Cited by 269
Metadata
- Authors
- Garcia-Alvarez, M., Marik, P., & Bellomo, R.
- Venue
- Critical Care
- Published
- 2014-09-09
- Volume
- 18
- Issue
- 5
- Pages
- 503-503
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2152154097
- Cited by
- 506
- References
- 81
- FWCI
- 18.20
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sepsis-associated hyperlactatemia. https://app.cochat.ai/papers/10.1186/s13054-014-0503-3
- The paper
- Garcia-Alvarez, M., Marik, P., & Bellomo, R. (2014). Sepsis-associated hyperlactatemia. Critical Care. https://doi.org/10.1186/s13054-014-0503-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
