The global burden of sepsis: barriers and potential solutions
Rudd, Kristina E., Kissoon, Niranjan, Limmathurotsakul, Direk, Bory, Sotharith, Mutahunga, Birungi, Seymour, Christopher W., Angus, Derek C., West, T. Eoin·2018·Critical Care
Cited by (421)
Items 201–300 of 421
- Salvianolic acid A ameliorates sepsis through inhibiting inflammation via binding STING and modulating TBK1/IRF3 signaling pathwayXiangying Qin, Liyuan Zhang, Jiahui Tang, Fan Zhang, Ling Zhang, Yue Meng, Shihui Yu, Shuaishuai Gong, Fang Li, Boyang Yu et al. · 2025 · International Immunopharmacology
- Mettl1 mitigates sepsis-induced cardiomyopathy via inhibition of FDX1-dependent cuproptosisWei Siang, Wang Guoyun, Yan Feng, Lin Wenji · 2025 · Gene
- Decoding the HIF-1-driven metabolic-inflammatory-immune axis in sepsis-associated lung injury: a comprehensive overviewShuang Zhang, Buqu Hu, Yuang Fang, Mudi Liu, Qingmei Liu, Ye Chen, Jun Zhou · 2026 · Frontiers in Immunology
- Recovery from Sepsis: Management beyond Acute CareSarah K. Andersen, M. Herridge, Kirsten M. Fiest · 2024 · Seminars in Respiratory and Critical Care Medicine
- Improving ICU transitional care by combining quality management and nursing science – two scientific fields meet in a systematic literature reviewLilly‐Mari Sten, Pernilla Ingelsson, Ingela Bäckström, Marie Häggström · 2020 · International Journal of Quality and Service Sciences
- The diagnostic accuracy of an initial point-of-care lactate at the emergency department as a predictor of in-hospital mortality among adult patients with sepsis and septic shockB. Gicheru, Jasmit Shah, Benjamin W. Wachira, Geoffrey Omuse, Daniel Maina · 2023 · Frontiers in Medicine
- Effect of HMGB1 and HBD-3 Levels in the Diagnosis of Sepsis- A Comparative Descriptive StudyNourah Almansour, Ali Al Mahmeed, Khalid Mubarak Bindayna · 2022 · Biochemistry and Biophysics Reports
- THE RELATIONSHIP BETWEEN CIRCULATING IMMUNE CELL PHENOTYPES AND SEPSIS: A MENDELIAN RANDOMIZATION STUDYHongmei Liu, Liu Hai, Li Zhou, Shu Wen, T. T. Liu, Linqin Ju, Yiwen Liu · 2024 · Shock
- Mitochondrial abnormalities in septic cardiomyopathyFang Jin, Li-Jun LIU · 2024 · Minerva Anestesiologica
- The inability to walk unassisted at hospital admission as a valuable triage tool to predict hospital mortality in Rwandese patients with suspected infectionArthur Kwizera, Olivier Urayeneza, Pierre Mujyarugamba, Jens M. Meier, Andrew J. Patterson, Lori A. Harmon, Joseph Christopher Farmer, Martin W. Dünser, for the “Sepsis in Resource-Limited Nations” Task Force of the Surviving Sepsis Campaign · 2020 · PLoS ONE
- Hydrocortisone, ascorbic acid and thiamine for sepsis: Is the jury out?Paul Ellis Marik, Joseph Varón, Salim Surani · 2020 · World Journal of Diabetes
- The clinical significance of the SIRT2 expression level in the early stage of sepsis patientsHua Xu, Xin Yu, Bin Wang, Huihong Zhang, Jiafu Li, Hongmei Gao, Yongqiang Wang · 2020 · Annals of Palliative Medicine
- SysInflam HuDB, a Web Resource for Mining Human Blood Cells Transcriptomic Data Associated with Systemic Inflammatory Responses to SepsisMohammed Toufiq, Susie S.Y. Huang, Sabri Boughorbel, Mohamed Alfaki, Darawan Rinchai, Luís R. Saraiva, Damien Chaussabel, Mathieu Garand · 2021 · The Journal of Immunology
- In-vitro effectiveness of essential oils against isolated Klebsiella pneumoniae and Acinetobacter baumannii: A narrative reviewMohammed Anees T. M., Vijaya Kumar Deekshit, Veena Shetty · 2022 · Biomedicine
- Liang‐Ge Decoction Ameliorates Coagulation Dysfunction in Cecal Ligation and Puncture‐Induced Sepsis Model Rats through Inhibiting PAD4‐Dependent Neutrophil Extracellular Trap FormationWenju He, Qiang Xi, Huantian Cui, Pingping Zhang, Rui Huang, Taihuan Wang, Dongqiang Wang · 2023 · Evidence-based Complementary and Alternative Medicine
- Tackling sepsis-associated acute kidney injury using routinely collected dataRolando Claure‐Del Granado, Matthew Thomas James, Matthieu M. Legrand · 2023 · Intensive Care Medicine
- Pediatric Emergency Department Diagnostics: Global Challenges and InnovationsHamza A. Abdul‐Hafez, Mohammed Alsabri, Janna Ahmed Omran, Alaa Zayed, Hasiba Karimi, Vincent Tsoi, Cynthia Oghenekome Okaruefe, Lauren A. Carr · 2025 · Current Treatment Options in Pediatrics
- Research Progress on Virulence Factors ofVibrio alginolyticus: A Key Pathogenic Bacteria of SepsisHongyan Cai, Jiaying Yu, Qiu Li, Youyu Zhang, Lixing Huang · 2022 · IntechOpen eBooks
- Application of norepinephrine in the treatment of septic shock: a meta-analysisQiuyue Xu, Yan Jin, Li Fu, Ying Li · 2024 · Irish Journal of Medical Science (1971 -)
- Antecedente de trastorno mental en la UCI e interconsulta a psiquiatríaAlejandra Fernández Trujillo, Cristina Ortiz, Oriol Cuñat, B. del Hoyo Buxo, F.J. Parrilla, Antoni Serrano‐Blanco, Juan Zubiri · 2021 · Medicina Intensiva
- Correlation of Platelet-Lymphocyte Ratio (PLR) as 28-Days Sepsis Mortality Predictor in Intensive Care Unit of RSMH PalembangTiara Santi Rizal, Fredi Heru Irwanto, Rizal Zainal, Mgs. Irsan Saleh · 2021 · Journal of Anesthesiology and Clinical Research
- The Relationship Between Blood Culture, C-reactive Protein, and Neonatal Sepsis: A Cross-Sectional StudyAmjed A. Ali, Mustafa Mohammed Ahmed, Sufian K. Noor, Leena Mustafa, Waad Ibrahim, Mohamed Osman Elamin, Hatim Matooq Badri, Hatim A. Natto, Wahaj Anwar A. Khan, Ahmed A. Osman · 2024 · Cureus
- The concomitant use of ultra short beta-blockers with vasopressors and inotropes in critically ill patients with septic shock: A systematic review and meta-analysis of randomized controlled trialsKhalid A. Al Sulaiman, Hadeel Alkofide, Mashael AlFaifi, Sarah Sultan Aljohani, Abdullah F. Alharthi, Rahaf Ali Alqahtani, Alanood Alanazi, Lama H. Nazer, Abdulrahman I. Al Shaya, Ohoud A. Aljuhani · 2024 · Saudi Pharmaceutical Journal
- Citrulline and ADI-PEG20 reduce inflammation in a juvenile porcine model of acute endotoxemiaCaitlin E. Vonderohe, Barbara Stoll, Inka C. Didelija, Trung Cong Nguyen, Mahmoud Ali Mohammad, Yava Jones‐Hall, Miguel A. Cruz, Juan C. Marini, Douglas G. Burrin · 2024 · Frontiers in Immunology
- Barriers and facilitators when seeking healthcare for septic children in Ghana: a single-centre qualitative study of patient caregivers and emergency department cliniciansVanessa C. Denny, John Adabie Appiah, Vinay Nadkarni, Ebenezer Dassah, Ebenezer Mensah Gyimah, Timothy Kwabena Adjei, Justicia Amisah, Gustav Nettey, Larko Domeryo Owusu, Charlotte Z. Woods-Hill et al. · 2024 · BMJ Paediatrics Open
- Pathologic function and therapeutic potential of extracellular vesicle miRNA in sepsisRou Deng, Xiayu Cui, Runze Zhang, Changya Liu, Jielian Luo, Liang Liu, Wen Ji Zhang, Bangjiang Fang · 2024 · Frontiers in Pharmacology
- Association Between Low Serum Vitamin D Levels and Sepsis: A Single-Center Study in Tehran, IranMasume Bayat, Latif Gachkar, Mahya Zahirnia, Fahimeh Hadavand · 2021 · Archives of Clinical Infectious Diseases
- Scope and mortality of adult medical ICU patients in an Eastern Cape tertiary hospitalRobert Freercks, Nkululo Gigi, Ryan E. Aylward, J Enser, Elizabeth van der Merwe · 2022 · Southern African Journal of Critical Care
- Assessment of Opioid-Induced Immunomodulation in Experimental and Clinical SepsisBrittany D. Bissell, Jamie Sturgill, Maria E. C. Bruno, Erick D. Lewis, Marlene E. Starr · 2023 · Critical Care Explorations
- Point-of-Care Procalcitonin to Guide the Discontinuation of Antibiotic Treatment in the Intensive Care Unit: A Malaysian Randomised Controlled TrialWan Fadzlina Wan Muhd Shukeri, Mohd Basri Mat Nor, Azrina Mohd Ralib, Mohd Zulfakar Mazlan, Mohd Hasyizan Hassan · 2022 · Malaysian Journal of Medicine and Health Sciences
- Evaluation of computer‐based training and high‐fidelity simulation to improve early recognition of sepsis on the adult general wardWilliam Marsack, Jennie Chang De Gagne, Joseph Reid, Katherine Pakieser-Reed, Mary Ann Francisco, Hee Sun Kang · 2023 · Nursing Open
- The molecular landscape of sepsis severity in infants: enhanced coagulation, innate immunity, and T cell repressionSusie Shih Yin Huang, Mohammed Toufiq, Pirooz Eghtesady, Nicholas van Panhuys, Mathieu Garand · 2024 · Frontiers in Immunology
- Compliance With the Surviving Sepsis Campaign Bundle: A Multicenter Study From Turkeyİlhan Bahar, Hafize Öksüz, Nimet Şenoğlu, Hilmi Demirkıran, Mustafa Said Aydoğan, Yakup Tomak, Mehmet Selim Çömez, Sinem Yalçın Bayrakçı, Edip Gönüllü, Mustafa Berktaş · 2021 · Cureus
- The Quick Sepsis-related Organ Failure Assessment Score in Brazil: Insights for Future Use in Diverse SettingsKimberley M. DeMerle, Kristina E. Rudd · 2020 · American Journal of Respiratory and Critical Care Medicine
- Understanding Heterogeneity in Acute Care Trials: Resource Availability Impacts OutcomesChristopher J. Yarnell, Hiroki Saito, John C. Marshall · 2024 · American Journal of Respiratory and Critical Care Medicine
- Sepsis in obstetric care for the emergency clinician: A reviewAnna Stacy, Puloma Bishnu, Rachel E. Solnick · 2024 · Seminars in Perinatology
- Rapid and accurate sepsis diagnostics via a novel probe-based multiplex real-time PCR systemMarco Favaro, Christian Fini, Maurizio Capannari, Ivano Petriccione, Claudia Rotondo, Assunta Navarra, Chiara Stellitano, Chiara De Giuli, Antonella Vulcano, Carla Fontana · 2025 · Microbiology Spectrum
- Global Sepsis EpidemiologyCarolyne Njoki, Sahil Angelo, Miriam Wambui, Elisabeth D. Riviello · 2025 · Clinics in Chest Medicine
- Molecular analysis of immune cell subsets and cytokine profiles in septic Vietnamese patientsChien Dinh Huynh, Phuong Minh Nguyen, Trung Dinh Ngo, Xuan‐Hung Nguyen, Tu Dac Nguyen, Hien Thi, Huyen Thi Le, Duy Mai Hoang, Linh Khac Le, Quan Khoi Nguyen et al. · 2025 · Clinical and Experimental Medicine
- The Frame of Survival for Sepsis: A Practical Systems Framework for Time-Sensitive Critical Illness in Low-Resource SettingsJorge L. Hidalgo, Samuel Akech, Subhash P. Acharya, Craig M. Coopersmith, Shevin T. Jacob, Cíntia Johnston, Niranjan “Tex” Kissoon, Flavia R. Machado, Ryan C. Maves, Elizabeth Molyneux et al. · 2026 · Critical Care Medicine
- Recent advances in the biosensing platforms for sepsis diagnosisVishwesh Dutt Mishra, Mohit Pandey, Hemant Kumar, Pradipta Kumar Panigrahi, Shantanu Bhattacharya · 2026 · RSC Advances
- Rapid diagnosis of sepsis and bloodstream infectionsMatthew Wester, J-S Lim, Mohammadreza Ghaderinia, Katherine Koprowski, An Bao Van, John Heredia, Karen White, James S Kumar, Enrique Valera, Rashid Bashir · 2026 · Nature Reviews Bioengineering
- Prediction of short-term mortality in elderly patients with sepsis using immunoglobulin G2: An observational studyFang Zhang, Tiantian Wan, Xin Liu, Shubin Guo · 2022 · Heliyon
- Consenso Latinoamericano de manejo de Sepsis en niños: Task Force de la Sociedad Latinoamericana de Cuidados Intensivos Pediátricos (SLACIP)Jaime Fernández Sarmiento · 2022 · Acta Pediátrica de México
- Prognostic Accuracy of Screening Tools for Clinical Deterioration in Adults With Suspected Sepsis in Northeastern Thailand: A Cohort Validation StudyJenna Wixon-Genack, Shelton W. Wright, Natalie L Cobb Ortega, Viriya Hantrakun, Kristina E. Rudd, Prapit Teparrukkul, Direk Limmathurotsakul, Timothy Eoin West · 2024 · Open Forum Infectious Diseases
- Pericytes mediate neuroinflammation via Fli-1 in endotoxemia and sepsis in micePengfei Li, Liu Liu, Perry V. Halushka, Maria E. Trojanowska, Guirong Wang, Adviye Ergul, Hongkuan Fan · 2025 · Inflammation Research
- Number of ICD-10 diagnosis fields required to capture sepsis in administrative data and truncation bias: A nationwide prospective registry studyNina Vibeche Skei, Jan Kristian Damås, Lise Tuset Gustad · 2025 · PLoS ONE
- Biomarkers as Beacons: Illuminating Sepsis-Associated Hepato-Renal InjuryMaria Antoanela Pasare, Cristian Sorin Prepeliuc, Maria Gabriela Grigoriu, Ionela-Larisa Miftode, Egidia Gabriela Miftode · 2025 · International Journal of Molecular Sciences
- Comparison of Ventilator-Free Days at 14 and 28 days as a Clinical Trial Outcome in Low- and Middle-Income CountriesArun Kumar Baranwal, Praveen M Kumar, Pramod Gupta · 2020 · Indian Journal of Critical Care Medicine
- Mortality in mechanically ventilated patients in middle-income countries: a call for actionPericles A D Duarte, Álvaro Réa-Neto · 2021 · The Lancet Global Health
- Outcomes of evidence-based modified sepsis protocol in an emergency department in TanzaniaMehrunnissa Taj, Sherin Kassamali, Bilquis Khan Jiwani, Zeenat Sulaiman, Vinciya Pandian · 2022 · International Emergency Nursing
- Utility and Impact of Early Diagnostic Assessment of Sepsis on Mortality in an Emergency Department of a Tertiary Hospital in Lagos, NigeriaIorhen E. Akase, Henry Akujobi, Oziegbe Oghide, Akinsanya Daniel Olusegun-Joseph, Chukwuemeka Abraham Agbarakwe, Adefolarin Opawoye · 2023 · Nigerian Postgraduate Medical Journal
- Terminology and ontology development for semantic annotation: A use case on sepsis and adverse eventsMelissa Y. Yan, Lise Tuset Gustad, Lise Husby Høvik, Øystein Nytrø A · 2023 · Semantic Web
- Recognizing Sepsis in Children in Low-Resourced Settings: Guidelines for Frontline CliniciansSagar Tungal, Nitin Dhochak, Rakesh Lodha · 2023 · Current Pediatrics Reports
- CHANGES OF HISTIDINE-RICH GLYCOPROTEIN LEVELS IN CRITICALLY ILL SEPTIC PATIENTSAyu Nabila Kusuma Pradana, Tomohiko Akahoshi, Jie Guo, Yukie Mizuta, Shuntaro Matsunaga, Sayoko Narahara, Masaharu Murata, Ken Yamaura · 2024 · Shock
- Modelling climate impacts on paediatric sepsis incidence and severity in BangladeshGazi Md. Salahuddin Mamun, Katelyn Moretti, Farzana Afroze, Ben J. Brintz, A Rahman, Monique Gainey, Monira Sarmin, Shamsun Nahar Shaima, Mohammod Jobayer Chisti, Adam C. Levine et al. · 2024 · Journal of Global Health
- CARD8 polymorphisms among bacterial meningitis patients in North-West EthiopiaMeseret Belayneh, Mesfin Mengesha, Berhane Asfaw Idosa, Surafel Fentaw, Biniyam Moges, Zelalem Tazu Bonger, Meseret Assefa, Örjan Garpenholt, Alexander Persson, Eva Särndahl et al. · 2024 · BMC Infectious Diseases
- Critical Care in Resource-Limited Settings: Shedding Light and Providing Light…and Hope*Mervyn Mer · 2024 · Critical Care Medicine
- Is Presepsin a Reliable Marker of Sepsis Diagnosis in Pediatric Intensive Care Unit?HebatAllah Fadel Algebaly, Hala M. Fouad, Maha M. Elkholy, Sally kamal Ibrahim, Nermine Magdi Riad · 2020 · Open Access Macedonian Journal of Medical Sciences
- Evaluation Value and Clinical Significance of Cardiac Troponin Level and Pediatric Sequential Organ Failure Score in the Definition of Sepsis 3.0 in Critically Ill ChildrenYunDuo Wu, Wenli Shen, Qizheng Wang, Changqiang Cui, Li Zha, Yan Jiao Lu, Rui Liu, Xiaofei Lin, Hongli Zhu · 2022 · Computational and Mathematical Methods in Medicine · Retracted
- Probiotics for the Management of Sepsis: Advances in Animal Models and Intensive Care Unit EnvironmentsVinicios R. dos Santos, Gabriela Oliveira de Carvalho, José Bruno Nunes Ferreira Silva · 2021 · Microbiology Research
- Dahuang Fuzi decoction reduces inflammation levels and alleviates intestinal mucosal barrier damage in septic ratsFusheng Liu, Chun-Yue Yu, Jin Liu, Nadia L. Johnson, Yin Zhang, Zeqi Su, Chen‐Chen Sun, Xia Ding · 2020 · Journal of Traditional Chinese Medical Sciences
- Burden and bacteriological profile of sepsis among adult medical emergencies presenting to a national referral hospital in Kampala, UgandaSharon Nyesiga, Jane Nakibuuka, Henry Kajumbula, Ronald Ssenyonga, Pauline Byakika‐Kibwika · 2022 · medRxiv
- Single-cell transcriptomics identifies different immune signatures between macrophage activation-like syndrome and immune paralysis in sepsisInge Grondman, Valerie A. C. M. Koeken, Athanasios Karageorgos, Wenchao Li, Nikolaos Antonakos, Bowen Zhang, Georgia Damoraki, Cheng‐Jian Xu, Evangelos J. Giamarellos‐Bourboulis, Yang Li et al. · 2023 · medRxiv
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- Systematic review and meta-analysis of plant-derived antimicrobials in WHO priority pathogensCarina Harkin · 2022 · International Journal of Complementary & Alternative Medicine
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- Mendelian randomization analysis identifies causal associations between serum lipidomic profile, amino acid biomarkers and sepsisZigang Zhu, Jiawei Ma, Dandan Ji, Qianqian Li, Xinyu Diao, Jie Bao · 2024 · Heliyon
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- What would Vilfredo Pareto do if he was an intensivist treating sepsis in a sparsely-resourced setting? … Seeking solid sustainable solutions for sepsis care in LMICsMervyn Mer, Marcus Josephus Schultz, Martin W. Dünser · 2025 · Intensive and Critical Care Nursing
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