Cited by 44Malaria Research and ControlChild Nutrition and Water AccessBird parasitology and diseases

The RooPfs study to assess whether improved housing provides additional protection against clinical malaria over current best practice in The Gambia: study protocol for a randomized controlled study and ancillary studies

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Pinder, Margaret, Conteh, Lesong, Jeffries, David, Jones, Caroline, Knudsen, Jakob, Kandeh, Balla, Jawara, Musa, Sicuri, Elisa +2 more·2016·Trials

Abstract

BACKGROUND: In malaria-endemic areas, residents of modern houses have less malaria than those living in traditional houses. This study will determine if modern housing provides incremental protection against clinical malaria over the current best practice of long-lasting insecticidal nets (LLINs) and prompt treatment in The Gambia, determine the incremental cost-effectiveness of the interventions, and analyze the housing market in The Gambia. METHODS/DESIGN: A two-armed, household, cluster-randomized, controlled study will be conducted to assess whether improved housing and LLINs combine to provide better protection against clinical malaria in children than LLINs alone in The Gambia. The unit of randomization will be the household, defined as a house and its occupants. A total of 800 households will be enrolled and will receive LLINs, and 400 will receive improved housing before clinical follow-up. One child aged 6 months to 13 years will be enrolled from each household and followed for clinical malaria using active case detection to estimate malaria incidence for two malaria transmission seasons. Episodes of clinical malaria will be the primary endpoint. Study children will be surveyed at the end of each transmission season to estimate the prevalence of Plasmodium falciparum infection, parasite density, and the prevalence of anemia. Exposure to malaria parasites will be assessed using light traps, followed by detection of Anopheles gambiae species and sporozoite infection. Ancillary economic and social science studies will undertake a cost-effectiveness analysis and use qualitative and participatory methods to explore the acceptability of the housing modifications and to design strategies for scaling-up housing interventions. DISCUSSION: The study is the first of its kind to measure the efficacy of housing on reducing clinical malaria, assess the incremental cost-effectiveness of improved housing, and identify mechanisms for scaling up housing interventions. Trial findings will help inform policy makers on improved housing for malaria control in sub-Saharan Africa. TRIAL REGISTRATION: ISRCTN Registry, ISRCTN02622179 . Registered on 23 September 2014.

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  1. [31]Macdonald G The analysis of malaria parasite rates in infants Trop Dis Bull 1950 47 915 38 14798657

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Authors
Pinder, M., Conteh, L., Jeffries, D., Jones, C., Knudsen, J., Kandeh, B., Jawara, M., Sicuri, E., D’Alessandro, U., & Lindsay, S. W.
Affiliations
  • Durham University (GB)
  • Imperial College London (GB)
  • MRC Unit the Gambia (GM)
  • University of Oxford (GB)
  • Royal Danish Academy – Architecture, Design, Conservation (DK)
Corresponding author
Lindsay, Steve W.
Venue
Trials
Published
2016-06-03
Volume
17
Issue
1
Pages
275-275
ISSN
1745-6215 (ISSN-L)
OpenAlex
W2415720269
Cited by
44
References
31
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 2
FWCI
3.94
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Trials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Architecture, Design and Conservation (Aarhus School of Architecture, Design School Kolding, The Royal Danish Academy of Fine Arts, Schools of Architecture, Design and Conservation (KADK)) (publishedVersion, other-oa)
  • Durham Research Online (Durham University) (acceptedVersion, cc-by)
  • LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
  • Durham Research Online (Durham University) (submittedVersion, cc-by)
Funders
MRC-DfID-Wellcome Trust (MR/M007383/1)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Nursing › Nutrition and Dietetics › Child Nutrition and Water Access
  • Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
Keywords
improved housing, clinical malaria, Plasmodium falciparum, long-lasting insecticidal nets, malaria control, children, cost-effectiveness, housing market, Anopheles gambiae, sporozoite infection, parasite density, anemia, home modification, scaling up interventions, Gambia
MeSH terms
Adolescent, Age Factors, Anemia, Child, Child, Preschool, Cost-Benefit Analysis, Female, Gambia, Housing, Humans, Infant, Male, Mosquito Control, Research Design, Risk Factors, Seasons, Time Factors, Incidence, Prevalence, Malaria, Falciparum, Health Care Costs, Insecticide-Treated Bednets

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