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THE IMPORTANCE OF MOSQUITO BEHAVIOURAL ADAPTATIONS TO MALARIA CONTROL IN AFRICA

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Gatton, Michelle L., Chitnis, Nakul, Churcher, Thomas, Donnelly, Martin J., Ghani, Azra C., Godfray, H. Charles J., Gould, Fred, Hastings, Ian +5 more·2013·Evolution
DOI 10.1111/evo.12063PMC PMC3655544
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Abstract

Over the past decade the use of long-lasting insecticidal nets (LLINs), in combination with improved drug therapies, indoor residual spraying (IRS), and better health infrastructure, has helped reduce malaria in many African countries for the first time in a generation. However, insecticide resistance in the vector is an evolving threat to these gains. We review emerging and historical data on behavioral resistance in response to LLINs and IRS. Overall the current literature suggests behavioral and species changes may be emerging, but the data are sparse and, at times unconvincing. However, preliminary modeling has demonstrated that behavioral resistance could have significant impacts on the effectiveness of malaria control. We propose seven recommendations to improve understanding of resistance in malaria vectors. Determining the public health impact of physiological and behavioral insecticide resistance is an urgent priority if we are to maintain the significant gains made in reducing malaria morbidity and mortality.

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  • Physiological resistance mechanisms are closely interacting with behavioural adaptations in malaria vectors.

    “Finally, physiological resistance mechanisms are closely interacting with behavioural adaptations in malaria vectors.”

    From Mapping insecticide resistance in Anopheles gambiae (s.l.) from Côte d'Ivoire (2018) · cites this paper as [52]

    In “Is It All Bad News?” (page unavailable), the paper reports that physiological resistance can reduce mosquitoes’ behavioral responsiveness to insecticides. But it says the effect is usually unquantified and depends on the resistance mechanism; “The Way Forward” calls for better understanding of it. The unqualified claim of close interaction is stronger than the evidence presented. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • There is increasing evidence that malaria vector populations behave differently after wide insecticide pressure, due to large LLINs distribution.

    “There is an increasing number of evidence that malaria vector populations behave differently after wide insecticide pressure, due to a large LLINs distribution.”

    From Mapping insecticide resistance in Anopheles gambiae (s.l.) from Côte d'Ivoire (2018) · cites this paper as [52]

    The 'Mosquito Behavior' section reports changes in feeding behavior following LLIN introduction, and 'Changes in Vector Dominance' describes apparent shifts where LLIN deployment increased. But the paper calls behavioral findings mixed and says evidence that LLINs cause behavioral or species changes is sparse and sometimes unconvincing; the claim presents that causal link more firmly than the source does. Page numbers are unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • These behavioural changes may affect the effectiveness of LLINs or IRS by reducing the possibility for a mosquito to contact insecticides.

    “These behavioural changes may affect the effectiveness of LLINs or IRS by reducing the possibility for a mosquito to contact insecticides in multiple ways as reviewed in Gatton et al. [52].”

    From Mapping insecticide resistance in Anopheles gambiae (s.l.) from Côte d'Ivoire (2018) · cites this paper as [52]

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Authors
Gatton, M. L., Chitnis, N., Churcher, T., Donnelly, M. J., Ghani, A. C., Godfray, H. C. J., Gould, F., Hastings, I., Marshall, J., Ranson, H., Rowland, M., Shaman, J., & Lindsay, S. W.
Affiliations
  • National Institutes of Health (US)
  • Swiss Tropical and Public Health Institute (CH)
  • Imperial College London (GB)
  • Liverpool School of Tropical Medicine (GB)
  • University of Liverpool (GB)
  • London School of Hygiene & Tropical Medicine (GB)
Corresponding author
Gatton, Michelle L.
ORCID
Venue
Evolution
Publisher
Oxford University Press (OUP)
Published
2013-02-15
Volume
67
Issue
4
Pages
1218-1230
ISSN
  • 0014-3820 (ISSN-L)
  • 1558-5646
DOI
10.1111/evo.12063
PMC
PMC3655544
OpenAlex
W2126256240
Cited by
336
References
9
Citations by year
2026: 16 · 2025: 17 · 2024: 29 · 2023: 29 · 2022: 30 · 2021: 20 · 2020: 29 · 2019: 27 · 2018: 30 · 2017: 28 · 2016: 29 · 2015: 24 · 2014: 20 · 2013: 8
FWCI
3.86
Type
journal article
Language
en
Open access
Licence
Locations
  • Evolution (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Durham Research Online (Durham University) (acceptedVersion)
  • LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
  • QUT ePrints (Queensland University of Technology) (submittedVersion)
  • Durham Research Online (Durham University) (submittedVersion, cc-by)
  • LSTM Online Archive (Liverpool School of Tropical Medicine) (submittedVersion)
  • Spiral (Imperial College London) (submittedVersion, other-oa)
Funders
  • U.S. Department of Homeland Security
  • Bill and Melinda Gates Foundation
  • National Institutes of Health
  • Medical Research Council (MR/K010174/1, MR/J012254/1)
  • National Health and Medical Research Council
  • National Institute of Allergy and Infectious Diseases (R01AI091980)
  • Fogarty International Center
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
  • Social Sciences › Sociology and Political Science › Dengue and Mosquito Control Research
Keywords
insecticide resistance, malaria vectors, long-lasting insecticidal nets, indoor residual spraying, malaria control, Anopheles, vector behavior
MeSH terms
Adaptation, Biological, Africa, Animals, Anopheles, Behavior, Animal, Humans, Insecticide Resistance, Insecticides, Malaria, Evolution, Molecular, Mosquito Nets

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