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Preventive and therapeutic effects of Trichinella spiralis adult extracts on allergic inflammation in an experimental asthma mouse model

Sun, Siying, Li, Huihui, Yuan, Yuan, Wang, Liyuan, He, Wenxin, Xie, Hong, Gao, Shifang, Cheng, Ruoxue, Qian, Haichun, Jiang, Hui, Wang, Xiaoli, Zhan, Bin, Fang, Qiang, Yang, Xiaodi·2019·Parasites & Vectors
DOI 10.1186/s13071-019-3561-1PMC PMC6599242
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Fig. 1 Regimen for mouse OVA sensitization and treatment
Fig. 1 Regimen for mouse OVA sensitization and treatmentCC BY · PubMed Central
Fig. 2 Histopathological changes of pulmonary tissues of OVA-sensitized/challenged mice with treatment of Ts-AE or Ts-MLE in preventive or therapeutic regimens (×200) (a), and the improved inflammatory score of lung tissues with treatment of Ts-AE or Ts-MLE in preventive or therapeutic regimens (b) (n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001
Fig. 2 Histopathological changes of pulmonary tissues of OVA-sensitized/challenged mice with treatment of Ts-AE or Ts-MLE in preventive or therapeutic regimens (×200) (a), and the improved inflammatory score of lung tissues with treatment of Ts-AE or Ts-MLE in preventive or therapeutic regimens (b) (n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001CC BY · PubMed Central
Fig. 3 Reduced eosinophil cell count in BALF from mice treated with Ts-AE or Ts-MLE. Data are expressed as mean ± SEM from two independent experiments (n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001
Fig. 3 Reduced eosinophil cell count in BALF from mice treated with Ts-AE or Ts-MLE. Data are expressed as mean ± SEM from two independent experiments (n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001CC BY · PubMed Central
Fig. 4 Treatment with Ts-AE and Ts-MLE reduced the OVA-specific IgE level in sera of mice upon OVA sensitization/challenge. The levels of OVA-specific IgE and total IgE were measured by ELISA in sera of OVA-sensitized mice treated with Ts-AE or Ts-MLE in preventive and therapeutic models. Data are expressed as mean ± SEM from two independent experiments (n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001
Fig. 4 Treatment with Ts-AE and Ts-MLE reduced the OVA-specific IgE level in sera of mice upon OVA sensitization/challenge. The levels of OVA-specific IgE and total IgE were measured by ELISA in sera of OVA-sensitized mice treated with Ts-AE or Ts-MLE in preventive and therapeutic models. Data are expressed as mean ± SEM from two independent experiments (n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001CC BY · PubMed Central
Fig. 5 The cytokine levels of IL-4 (a), IFN-γ (b), IL-10 (c) and TGF-β (d) were measured in BALF of OVA-sensitized mice upon the treatment of Ts-AE and Ts-MLE in preventive and therapeutic models. Data are expressed as mean ± SEM from two independent experiments (n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001
Fig. 5 The cytokine levels of IL-4 (a), IFN-γ (b), IL-10 (c) and TGF-β (d) were measured in BALF of OVA-sensitized mice upon the treatment of Ts-AE and Ts-MLE in preventive and therapeutic models. Data are expressed as mean ± SEM from two independent experiments (n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001CC BY · PubMed Central

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Citations

Cites

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Metadata

Authors
Sun, S., Li, H., Yuan, Y., Wang, L., He, W., Xie, H., Gao, S., Cheng, R., Qian, H., Jiang, H., Wang, X., Zhan, B., Fang, Q., & Yang, X.
Venue
Parasites & Vectors
Publisher
Springer Science and Business Media LLC
Published
2019-06-28
Volume
12
Issue
1
ISSN
1756-3305
DOI
10.1186/s13071-019-3561-1
PMC
PMC6599242
Cited by
40
References
1
Language
en
Licence
Funders
  • Scientific Research Innovation Platform Team of University (2016-40)
  • Natural Science Foundation of Anhui Province (1508085QH158)
  • Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province (gxyqZD2016159, 2018H174)
  • University Natural Science Research Project of Anhui Province (KJ2017A235)
  • Science Foundation of Bengbu Medical College (BYKY1624ZD, BYKY1757)
  • National University Students’ Innovation and Entrepreneurship Training Program (201810367012)

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