The DOI matches its Crossref record.
The miR-143/miR-145 cluster and the tumor microenvironment: unexpected roles
Open accessAbstract
miR-143 and miR-145 have been widely described as tumor suppressors. Recent findings suggest these microRNAs (miRNAs) have a critical role that affects the stroma rather than epithelial cells. Understanding the part played by the miR-143/miR-145 cluster in the tumor microenvironment is essential for the development of future miRNA-related therapies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dysfunction in one single miRNA can concomitantly impair several biological functions by acting on distinct mRNA targets.
“Remarkably, dysfunction in one single miRNA can concomitantly impair several biological functions by acting on distinct mRNA targets, as previously described by us16–20.”
From TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity (2020) · cites this paper as [19]
The Tumor suppression section says miRNAs regulate mRNA expression, and the Tumor promotion section describes effects on angiogenesis and intestinal regeneration. But those examples involve different members of the miR-143/miR-145 cluster and identify a different target for each; they do not establish that one single miRNA impairs several functions by acting on distinct mRNA targets. Our copy provides no page numbers for these sections. (LLM, conf=0.82)
Experimental — accuracy not yet measuredmiRNAs can be encapsulated into extracellular vesicles and mediate cell-to-cell communication.
“In addition, miRNAs can be encapsulated into extracellular vesicles, and mediate cell-to-cell communication19,21.”
From TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity (2020) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 10
- Berindan-Neagoe I, Calin GA. Molecular pathways: microRNAs, cancer cells, and microenvironment. Clin Cancer Res. 2014;20:6247–53. · DOI
- Almeida MI, Reis RM, Calin GA. MicroRNA history: discovery, recent applications, and next frontiers. Mutat Res. 2011;717:1–8. · DOI · Paper page
- Das AV, Pillai RM. Implications of miR cluster 143/145 as universal anti-oncomiRs and their dysregulation during tumorigenesis. Cancer Cell Int. 2015;15:92. · DOI
- Dimitrova N, Gocheva V, Bhutkar A, Resnick R, Jong RM, Miller KM, et al. Stromal expression of miR-143/145 promotes neoangiogenesis in lung cancer development. Cancer Discov. 2016;6:188–201. · DOI
- Chivukula RR, Shi G, Acharya A, Mills EW, Zeitels LR, Anandam JL, et al. An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration. Cell. 2014;157:1104–16. · DOI
- Kent OA, McCall MN, Cornish TC, Halushka MK. Lessons from miR-143/145: the importance of cell-type localization of miRNAs. Nucleic Acids Res. 2014;42:7528–38. · DOI · Paper page
- Lugli G, Kataria Y, Richards Z, Gann P, Zhou X, Nonn L. Laser-capture microdissection of human prostatic epithelium for RNA analysis. J Vis Exp. 2015;105:e53405.
- Sempere LF. Tissue slide-based microRNA characterization of tumors: how detailed could diagnosis become for cancer medicine? Expert Rev Mol Diagn. 2014;14:853–69. · DOI
- Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Non-viral vectors for gene-based therapy. Nat Rev Genet. 2014;15:541–55. · DOI · Paper page
- Challagundla KB, Wise PM, Neviani P, Chava H, Murtadha M, Xu T, et al. Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015;107:djv135. · DOI
Cited by
Sorted by citations
TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity
Brás, J. P., Bravo, J., Freitas, J., Barbosa, M. A., Santos, S. G., Summavielle, T., & Almeida, M. I. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2626-6 · Cited by 236
Self-citation
Metadata
- Authors
- Almeida, M. I., & Calin, G. A.
- Affiliations
- Universidade do Porto (PT)
- Corresponding author
- Almeida, Maria Inês
- ORCID
- Almeida, Maria Inês
- Venue
- Genome Medicine
- Published
- 2016-03-17
- Volume
- 8
- Issue
- 1
- Pages
- 29-29
- ISSN
- 1756-994X (ISSN-L)
- PMC
- PMC4797185
- OpenAlex
- W2298899095
- Cited by
- 38
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 2
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Genome Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- NIH/NCI (1UH2TR00943-01)
- National Institutes of Health (1 R01 CA1829-01)
- UT MD Anderson Cancer Center SPORE in Melanoma grant from NCI (P50 CA093459)
- Brain SPORE (2P50CA127001)
- FCT – Fundação para a Ciência e a Tecnologia (SFRH/BPD/91011/2012)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- miR-143, miR-145, miRNA clusters, tumor microenvironment, tumor stroma, tumor suppressor microRNA, miRNA-based therapy
- MeSH terms
- Multigene Family, Humans, Neoplasms, Gene Expression Regulation, Neoplastic, MicroRNAs, Tumor Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
