MicroRNA history: Discovery, recent applications, and next frontiers
Abstract
Since 1993, when the first small non-coding RNA was identified, our knowledge about microRNAs has grown exponentially. In this review, we focus on the main progress in this field and discuss the most important findings under a historical perspective. In addition, we examine microRNAs as markers of disease diagnosis and prognosis, and as new therapeutic targets.
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miRNAs regulate gene expression at the post-transcriptional level by inducing mRNA translation inhibition or degradation.
“miRNAs are short, single-stranded, non-protein coding RNAs, which regulate gene expression at the post-transcriptional level by inducing mRNA translation inhibition or degradation16.”
From TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity (2020) · cites this paper as [16]
Dysfunction in one single miRNA can concomitantly impair several biological functions by acting on distinct mRNA targets.
“Remarkably, dysfunction in one single miRNA can concomitantly impair several biological functions by acting on distinct mRNA targets, as previously described by us16–20.”
From TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity (2020) · cites this paper as [16]
miRNAs act by degradation or translation inhibition of their target mRNAs.
“miRNAs act by degradation or translation inhibition of their target mRNAs16.”
From TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity (2020) · cites this paper as [16]
Cites
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605 · see citing works
MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation
Sonkoly, E., Ståhle, M., & Pivarcsi, A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.01.005 · Cited by 523 · cited 2× · see citing works
“Treatments using anti-TNF agents, such as infliximab, etanercept or adalimumab are effective for psoriasis [69,70].”
Alterations of the microRNA network cause neurodegenerative disease
Hébert, S. S., & De Strooper, B. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.003 · Cited by 452 · see citing works
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Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works
Large-scale investigation of the reasons why potentially important genes are ignored
Stoeger, T., Gerlach, M., Morimoto, R. I., & Nunes Amaral, L. A. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2006643 · Cited by 261 · see citing works
TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity
Brás, J. P., Bravo, J., Freitas, J., Barbosa, M. A., Santos, S. G., Summavielle, T., & Almeida, M. I. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2626-6 · Cited by 236 · see citing works
Self-citationA mouse tissue atlas of small noncoding RNA
Isakova, A., Fehlmann, T., Keller, A., & Quake, S. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002277117 · Cited by 119 · see citing works
Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works
Self-citationEpigenetic Alteration in Colorectal Cancer: Potential Diagnostic and Prognostic Implications
Cao, Q., Tian, Y., Deng, Z., Yang, F., & Chen, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063358 · Cited by 60 · see citing works
Johnston, D. G. W., Kearney, J., Zasłona, Z., Williams, M. A., O'Neill, L. A. J., & Corr, S. C. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00201 · Cited by 44 · see citing works
“MiRNA are short, non-coding RNAs that have been shown to affect numerous cellular processes in a posttranscriptional manner (Bartel, 2004; He and Hannon, 2004; Almeida et al., 2011).”
BackgroundHe, C., Aziguli, A., Zhen, J., Jiao, A., Liao, H., Du, C., Liu, W., Aihemaitijiang, K., & Xu, A. (2022) · Translational Cancer Research · doi:10.21037/tcr-22-1732 · Cited by 7 · see citing works
- Authors
- Almeida, M. I., Reis, R. M., & Calin, G. A.
- Venue
- Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 717
- Issue
- 1-2
- Pages
- 1-8
- ISSN
- 1386-1964
- Cited by
- 349
- References
- 7
- Language
- en
- Licence
- Funders
- CLL Global Research Foundation
- National Institutes of Health
- U.S. Department of Defense
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