Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study
Open accessAbstract
BACKGROUND: Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and its relationship with knee, hip, and lumbar spine OA by race (African American vs. Caucasian). METHODS: Data were from the Johnston County OA project, collected 2003-2010. GJH was defined as Beighton score ≥4. OA symptoms were defined as the presence of pain, aching, or stiffness on most days separately at the knee, hip, and lower back. Radiographic OA (rOA) of the knee or hip was defined as Kellgren-Lawrence grade 2-4. Lumbar spine rOA was disc space narrowing grade ≥1 and osteophyte grade ≥2 in ≥ 1 at the same lumbar level. Lumbar spine facet rOA was present in ≥ 1 lumbar levels. Separate logistic regression models stratified by race were used to examine the association between hypermobility and rOA or OA symptoms at each joint site, adjusting for age, sex, previous joint injury, and body mass index (BMI). RESULTS: ). Nearly 8% of Caucasians were hypermobile vs. 5% of African-Americans (p = 0.03). Hypermobility was associated with lower back symptoms in Caucasians (adjusted odds ratio (aOR) 1.54, 95% confidence interval (CI) 1.00, 2.39), but not in African-Americans (aOR 0.77, 95% CI 0.34, 1.72). Associations between hypermobility and other knee, hip, or lumbar spine/facet OA variables were not statistically significant. CONCLUSIONS: General joint hypermobility was more common in Caucasians than African-Americans. Although there were no associations between hypermobility and rOA, the association between hypermobility and lower back symptoms may differ by race.
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In a community-based study, 8% of Caucasians were hypermobile versus 5% of African Americans, a statistically significant difference.
“From this group, 8% of Caucasians were hypermobile vs. 5% of African Americans, a statistically significant difference.[22]”
From Hypermobility spectrum disorders: A review (2023) · cites this paper as [22]
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Cites
Articular mobility in an African population.
Beighton, P., Solomon, L., & Soskolne, C. L. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.5.413 · Cited by 1,727 · see citing works
A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
Srikanth, V. K., Fryer, J., Zhai, G., Winzenberg, T. M., Hosmer, D. W., & Jones, G. (2005) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.04.014 · Cited by 1,324 · see citing works
Oliveria, S. A., Felson, D. T., Reed, J. I., Cirillo, P. A., & Walker, A. M. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380817 · Cited by 902 · see citing works
Dillon, C. F., Rasch, E. K., Gu, Q., & Hirsch, R. (2006) · PubMed · Cited by 815 · see citing works
Jordan, J. M., Helmick, C. G., Renner, J. B., LUTA, G., DRAGOMIR, A. D., Woodard, J., FANG, F., Schwartz, T. A., Nelson, A. E., ABBATE, L. M., et al. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.080677 · Cited by 739 · see citing works
Self-citationJoint Injury in Young Adults and Risk for Subsequent Knee and Hip Osteoarthritis
Gelber, A. C., Hochberg, M. C., Mead, L. A., Wang, N., Wigley, F. M., & Klag, M. J. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-5-200009050-00007 · Cited by 676 · see citing works
(2007) · PubMed · Cited by 356 · see citing works
The impact of arthritis in rural populations
Jordan, J. M., Linder, G. F., Renner, J. B., et al. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1790080407 · Cited by 198 · see citing works
Self-citationImpact of Joint Laxity and Hypermobility on the Musculoskeletal System
Wolf, J. M., Cameron, K. L., & Owens, B. D. (2011) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-201108000-00002 · Cited by 176 · see citing works
Benefits and Disadvantages of Joint Hypermobility among Musicians
Larsson, L.-G., Baum, J., Mudholkar, G. S., & Kollia, G. D. (1993) · New England Journal of Medicine · doi:10.1056/nejm199310073291504 · Cited by 156 · see citing works
Sowers, M., Lachance, L., Hochberg, M. C., & Jamadar, D. A. (2000) · Osteoarthritis and Cartilage · doi:10.1053/joca.1999.0273 · Cited by 131 · see citing works
Dolan, A. L., Hart, D., Doyle, D., Grahame, R., & Spector, T. D. (2003) · PubMed · Cited by 91 · see citing works
Goode, A. P., Marshall, S. W., Renner, J. B., et al. (2012) · Arthritis Care & Research · doi:10.1002/acr.21720 · Cited by 80 · see citing works
Self-citationNelson, A. E., Braga, L., Renner, J. B., et al. (2010) · Arthritis Care & Research · doi:10.1002/acr.20067 · Cited by 79 · see citing works
Self-citationJOINT LAXITY LEADING TO OSTEOARTHROSIS
SCOTT, D., Bird, H. A., & Wright, V. A. (1979) · Lara D. Veeken · doi:10.1093/rheumatology/18.3.167 · Cited by 78 · see citing works
Generalized Joint Hypermobility and Its Relationship to Injury Patterns Among NCAA Lacrosse Players.
Decoster, L. C., Bernier, J. N., Lindsay, R. S., & Vailas, J. C. (1999) · Europe PMC (PubMed Central) · Cited by 77 · see citing works
Nelson, A. E., Renner, J. B., Schwartz, T. A., Kraus, V. B., Helmick, C. G., & Jordan, J. M. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30610 · Cited by 65 · see citing works
Self-citationJoint Stiffness: Effects of Exercise on Young and Old Men
Chapman, E. A., de Vries, H., & Swezey, R. R. (1972) · Journal of Gerontology · doi:10.1093/geronj/27.2.218 · Cited by 62 · see citing works
Quantitative study of stiffness in the knee joint.
Such, C. H., Unsworth, A., Wright, V. A., et al. (1975) · Annals of the Rheumatic Diseases · doi:10.1136/ard.34.4.286 · Cited by 60 · see citing works
Artlett, C. M., Cox, L. A., & Jiménez, S. A. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200005)43:5 · Cited by 56 · see citing works
Incidence of Joint Hypermobility Syndrome in a Military Population: Impact of Gender and Race
Scher, D. L., Owens, B. D., Sturdivant, R. X., & Wolf, J. M. (2009) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-009-1182-2 · Cited by 47 · see citing works
Wood, P. H. N. (1971) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591577106400650 · Cited by 39 · see citing works
Chen, H., Shah, S. H., Li, Y., Stäbler, T., Jordan, J. M., & Kraus, V. B. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24319 · Cited by 39 · see citing works
Self-citationMoss, A., Murphy, L. B., Helmick, C. G., et al. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.04.012 · Cited by 39 · see citing works
Kopec, J. A., Sayre, E. C., Schwartz, T. A., et al. (2012) · Arthritis Care & Research · doi:10.1002/acr.21924 · Cited by 35 · see citing works
Self-citationGrahame, R. (1989) · Lara D. Veeken · doi:10.1093/rheumatology/28.4.320 · Cited by 29 · see citing works
Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis
Goode, A. P., Cleveland, R. J., Schwartz, T. A., Nelson, A. E., Kraus, V. B., Hillstrom, H. J., Hannan, M. T., Flowers, P., Renner, J. B., Jordan, J. M., et al. (2019) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-019-2523-2 · Cited by 29 · see citing works
Self-citationGoode, A. P., Nelson, A. E., Kraus, V. B., Renner, J. B., & Jordan, J. M. (2017) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2017.07.007 · Cited by 26 · see citing works
Self-citationNelson, A. E., Renner, J. B., Shi, X., et al. (2010) · Arthritis Care & Research · doi:10.1002/acr.20210 · Cited by 15 · see citing works
Self-citationGeneral joint hypermobility and hip osteoarthritis: the Johnston County osteoarthritis project
Golightly, Y. M., Nelson, A. E., Kraus, V. B., et al. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.02.280 · Cited by 10 · see citing works
Self-citationBihlet, A. R., Karsdal, M. A., Byrjalsen, I., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-eular.5877 · Cited by 4 · see citing works
Golightly, Y. M., Goode, A. P., Cleveland, R. J., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-eular.4361 · Cited by 3 · see citing works
Self-citationSAT0614 Joint Hypermobility and Ankle Osteoarthritis in A Community-Based Cohort
Golightly, Y. M., Nelson, A. E., Hannan, M. T., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-eular.5041 · Cited by 1 · see citing works
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Hypermobility spectrum disorders: A review
Carroll, M. B. (2023) · Rheumatology and Immunology Research · doi:10.2478/rir-2023-0010 · Cited by 45 · see citing works
Prevalence and dynamic characteristics of generalized joint hypermobility in college students
Zhong, G., Zeng, X., Xie, Y., Lai, J., Wu, J., Xu, H., Lin, C., Li, H., Cui, C., Ma, L., et al. (2021) · Gait & Posture · doi:10.1016/j.gaitpost.2020.12.002 · Cited by 33 · see citing works
- Authors
- Flowers, P. P. E., Cleveland, R. J., Schwartz, T. A., Nelson, A. E., Kraus, V. B., Hillstrom, H. J., Goode, A. P., Hannan, M. T., Renner, J. B., Jordan, J. M., & Golightly, Y. M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Duke University (US)
- Hospital for Special Surgery (US)
- Hebrew SeniorLife (US)
- Corresponding author
- Golightly, Yvonne M.
- ORCID
- Venue
- Arthritis Research & Therapy
- Published
- 2018-04-18
- Volume
- 20
- Issue
- 1
- Pages
- 76-76
- ISSN
- 1478-6354 (ISSN-L)
- 1478-6362
- PMC
- PMC5907300
- OpenAlex
- W2804369361
- Cited by
- 28
- References
- 33
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 2
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Arthritis Research & Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR071440-01A1, R01AR067743, R01AR067743-02S1)
- NIH/NIAMS Multipurpose Arthritis and Musculoskeletal Diseases Center (P60AR30701)
- NIH/NIAMS Multidisciplinary Clinical Research Center (P60AR064166)
- Centers for Disease and Prevention Control / Association of Schools of Public Health (S043, S3486)
- Centers for Disease Control and Prevention (U01DP006266)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Keywords
- osteoarthritis, racial differences, African Americans, Caucasians, knee osteoarthritis, hip osteoarthritis, lumbar spine osteoarthritis, Beighton score, low back pain, radiographic osteoarthritis, Johnston County Osteoarthritis Project
- MeSH terms
- Aged, Black or African American, Cross-Sectional Studies, Female, Humans, Joint Instability, Lumbosacral Region, Male, Middle Aged, Osteoarthritis, Osteoarthritis, Hip, Prevalence, Odds Ratio, Osteoarthritis, Knee, White People, Osteoarthritis, Spine
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