Adult-onset Still’s disease biological treatment strategy may depend on the phenotypic dichotomy
Open accessAbstract
OBJECTIVES: Adult-onset Still's disease (AOSD) phenotype appears to be dichotomized in systemic or chronic articular forms. As biologicals and particularly interleukin (IL)-1 and IL-6 blockers play a more and more prominent role in the treatment, their place requires clarification. This study aimed to identify factors predictive of treatment response to anakinra or tocilizumab and investigate whether the choice of biotherapy and delays in the initiation of biotherapy influenced the likelihood of steroid discontinuation. METHODS: A multicenter exploratory retrospective study included all patients diagnosed with AOSD and receiving biological treatments in three regional hospitals until 2018. Clinical and biological characteristics at diagnosis and treatment-related data were collected. The nonparametric Mann-Whitney test was used to perform univariate analysis for quantitative variables, and Fisher's exact test was used for qualitative variables. RESULTS: Twenty-seven patients were included. All but one patient achieved remission with either anakinra or tocilizumab. Treatment responses depended on disease phenotype: the presence of arthritis and a chronic articular phenotype were associated with a substantial response to tocilizumab with p = 0.0009 (OR 36 [2.6-1703]) and p = 0.017 (OR 10 [1.22-92.6]), respectively, whereas the systemic form and the absence of arthritis were associated with a substantial response to anakinra with p = 0.0009 (OR 36 [2.6-1703]) and p = 0.017 (OR 10 [1.22-92.6]), respectively. Tocilizumab increased the likelihood of corticosteroid withdrawal (p = 0.029) regardless of delays in initiation or when it was initiated relative to other treatment in the overall therapeutic strategy. CONCLUSION: This study highlights the therapeutic implications of the phenotypic dichotomy of AOSD and should help us better codify AOSD treatment.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Biomarkers effectively predict which patients with adult-onset Still's disease will have a response to anakinra or tocilizumab.
“Likewise, biomarkers were recently shown to effectively predict which patients with adult-onset Still’s disease would have a response to anakinra or tocilizumab.111”
From Cytokine storm (2020) · cites this paper as [111]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Gerfaud‐Valentin, M., Jamilloux, Y., Iwaz, J., & Sève, P. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.01.058 · Cited by 523 · see citing works
Lequerré, T., Quartier, P., Rosellini, D., Alaoui, F. Z., Bandt, M. D., Mejjad, O., Koné‐Paut, I., Michel, M., Dernis, E., Khellaf, M., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.076034 · Cited by 405 · see citing works
Self-citationMagadur-Joly, G., Billaud, É., Barrier, J.-H., PENNEC, Y. L., Masson, C., Renou, P., & Prost, A. (1995) · Annals of the Rheumatic Diseases · doi:10.1136/ard.54.7.587 · Cited by 307 · see citing works
Gabay, C., Fautrel, B., Rech, J., Spertini, F., Feist, E., Kötter, I., HACHULLA, E., Morel, J., Schaeverbeke, T., Hamidou, M. A., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-212608 · Cited by 291 · see citing works
Self-citationShimizu, M., Yokoyama, T., Yamada, K., Kaneda, H., Wada, H., Wada, T., Toma, T., Ohta, K., Kasahara, Y., & Yachie, A. (2010) · Rheumatology · doi:10.1093/rheumatology/keq133 · Cited by 255 · see citing works
Gerfaud‐Valentin, M., Maucort‐Boulch, D., Hot, A., Iwaz, J., Ninet, J., Durieu, I., Broussolle, C., & Sève, P. (2014) · Medicine · doi:10.1097/md.0000000000000021 · Cited by 243 · see citing works
Fautrel, B., Sibilia, J., Xavier Mariette, A., & Combe, B. G. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.024026 · Cited by 218 · see citing works
Self-citationSerum cytokine profiles in patients with adult onset Still's disease.
Choi, J., Suh, C., Lee, Y. M., Suh, Y.-J., Lee, S.-K., Kim, S.-S., Nahm, D. H., & Park, H. (2003) · PubMed · Cited by 197 · see citing works
Kaneko, Y., Kameda, H., Ikeda, K., Ishii, T., Murakami, K., Takamatsu, H., Tanaka, Y., Abe, T., & Takeuchi, T. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213920 · Cited by 192 · see citing works
Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart
Jamilloux, Y., Gerfaud‐Valentin, M., Martinon, F., Bélot, A., Henry, T., & Sève, P. (2014) · Immunologic Research · doi:10.1007/s12026-014-8561-9 · Cited by 185 · see citing works
Fujii, T. (2001) · British journal of rheumatology · doi:10.1093/rheumatology/40.12.1398 · Cited by 169 · see citing works
Maria, A., le Quellec, A., Jorgensen, C., Touitou, I., Riviére, S., & Guilpain, P. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.08.032 · Cited by 147 · see citing works
Ortiz-Sanjuán, F. M., Blanco, R., Calvo-Río, V., Narváez, J., Romero, E. R., Olivé, A., Castañeda, S., Flores, A. G., Hernández, M. V., Mata, C., et al. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38398 · Cited by 141 · see citing works
Franchini, S., Dagna, L., Salvo, F., Aiello, P., Baldissera, E. M., & Sabbadini, M. G. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27532 · Cited by 139 · see citing works
Tolerance and efficacy of off-label anti-interleukin-1 treatments in France: a nationwide survey
Rossi‐Semerano, L., Fautrel, B., Wendling, D., HACHULLA, E., Galeotti, C., Semerano, L., Touitou, I., Koné‐Paut, I., & the MAIL1 (Maladies Auto-inflammatoires et Anti-IL-1) study Group on the behalf of CRI (Club Rhumatisme et Inflammation) (2015) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-015-0228-7 · Cited by 136 · see citing works
Self-citationShimizu, M., Nakagishi, Y., & Yachie, A. (2013) · Cytokine · doi:10.1016/j.cyto.2012.11.025 · Cited by 128 · see citing works
Adult-onset Still's disease: Advances in the treatment
Castañeda, S., Blanco, R., & González-Gay, M. Á. (2016) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2016.08.003 · Cited by 123 · see citing works
Ankara Rheumatology Study Group, Pay, S., Türkçapar, N., Kalyoncu, M., Şimşek, İ., Beyan, E., Ertenli, İ., Öztürk, M. A., Düzgün, N., Erdem, H., et al. (2005) · Clinical Rheumatology · doi:10.1007/s10067-005-0138-5 · Cited by 117 · see citing works
Giampietro, C., Ridene, M., Lequerré, T., Costedoat-Chalumeau, N., Amoura, Z., Sellam, J., Sibilia, J., Bourgeois, P., Fautrel, B., & Inflammation), O. B. O. T. C. (. R. E. (2012) · Arthritis Care & Research · doi:10.1002/acr.21901 · Cited by 112 · see citing works
Self-citationColafrancesco, S., Priori, R., Valesini, G., Argolini, L. M., Baldissera, E. M., Bartoloni, E., Cammelli, D., Canestrari, G. B., Cantarini, L., Cavallaro, E. C., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00369 · Cited by 103 · see citing works
Laskari, K., Tzioufas, A. G., & Moutsopoulos, H. Μ. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3366 · Cited by 102 · see citing works
Efficacy of Anakinra in Refractory Adult-Onset Still's Disease
Ortiz-Sanjuán, F. M., Blanco, R., Riancho‐Zarrabeitia, L., Castañeda, S., Olivé, A., Riveros, A., Velloso-Feijoó, M. L., Narváez, J., Moleón, I. J., Maiz, O., et al. (2015) · Medicine · doi:10.1097/md.0000000000001554 · Cited by 101 · see citing works
Potential role of Th17 cells in the pathogenesis of adult-onset Still's disease
Chen, D.-Y., Chen, Y., Lan, J.-L., Lin, C., Chen, H.-H., & Hsieh, C.-W. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq284 · Cited by 88 · see citing works
Ichida, H., Kawaguchi, Y., Sugiura, T., Takagi, K., Katsumata, Y., Gono, T., Ota, Y., Kataoka, S., Kawasumi, H., & Yamanaka, H. (2013) · Arthritis Care & Research · doi:10.1002/acr.22194 · Cited by 85 · see citing works
Therapeutic responses and prognosis in adult-onset Still’s disease
Kim, H., Sung, J.-M., & Suh, C. (2011) · Rheumatology International · doi:10.1007/s00296-011-1801-6 · Cited by 81 · see citing works
Efficacy and safety of biological agents in adult-onset Still’s disease
Cavalli, G., Franchini, S., Aiello, P., Guglielmi, B., Berti, A., Campochiaro, C., Sabbadini, M. G., Baldissera, E. M., & Dagna, L. (2015) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2014.992949 · Cited by 72 · see citing works
Ma, Y., Wu, M., Zhang, X., Xia, Q., Yang, J., Xu, S., & Pan, F. (2017) · Modern Rheumatology · doi:10.1080/14397595.2017.1416924 · Cited by 70 · see citing works
Evidence-based clinical practice guideline for adult Still’s disease
Mimura, T., Kondo, Y., Ohta, A., Iwamoto, M., Ota, A., Okamoto, N., Kawaguchi, Y., Kono, H., Takasaki, Y., Takei, S., et al. (2018) · Modern Rheumatology · doi:10.1080/14397595.2018.1465633 · Cited by 70 · see citing works
Adult-Onset Still’s Disease: From Pathophysiology to Targeted Therapies
Mavragani, C. P., Spyridakis, E., & Koutsilieris, M. (2012) · International Journal of Inflammation · doi:10.1155/2012/879020 · Cited by 66 · see citing works
Tocilizumab in the treatment of the adult-onset Still's disease: current clinical evidence
de Boysson, H., Février, J., Nicolle, A., Auzary, C., & Geffray, L. (2012) · Clinical Rheumatology · doi:10.1007/s10067-012-2105-2 · Cited by 62 · see citing works
Mimori, T., Harigai, M., Atsumi, T., Fujii, T., Kuwana, M., Matsuno, H., Momohara, S., Takei, S., Tamura, N., Takasaki, Y., et al. (2018) · Modern Rheumatology · doi:10.1080/14397595.2018.1460230 · Cited by 60 · see citing works
Successful treatment of refractory adult onset Still's disease with rituximab
Ahmadi-Simab, K., Lamprecht, P., Jankowiak, C., & Gross, W. L. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.047621 · Cited by 59 · see citing works
Zhou, S., Qiao, J., Bai, J., Wu, Y., & Fang, H. (2018) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s155488 · Cited by 56 · see citing works
Ruscitti, P., Ursini, F., Cipriani, P., Sarro, G. D., & Giacomelli, R. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1375853 · Cited by 54 · see citing works
Banse, C., Vittecoq, O., Benhamou, Y., Gauthier-Prieur, M., Lequerré, T., & Levesque, H. (2013) · Joint Bone Spine · doi:10.1016/j.jbspin.2013.04.011 · Cited by 50 · see citing works
Biologic treatments for adult-onset Still's disease
Al-Homood, I. A. (2013) · Lara D. Veeken · doi:10.1093/rheumatology/ket250 · Cited by 50 · see citing works
How I treat patients with adult onset Still's disease in clinical practice
Govoni, M., Bortoluzzi, A., Rossi, D., & Modena, V. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.07.017 · Cited by 45 · see citing works
Anakinra for the treatment of adult-onset Still’s disease
Castañeda, S., Atienza‐Mateo, B., Martín-Varillas, J. L., López-Matencio, J. M. S., & González-Gay, M. Á. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2018.1536548 · Cited by 45 · see citing works
Adult Still's disease reflects a Th2 rather than a Th1 cytokine profile
Saiki, O., Uda, H., Nishimoto, N., Miwa, T., Mima, T., Ogawara, T., Azuma, N., Katada, Y., Sawaki, J., Tsutsui, H., et al. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.03.023 · Cited by 35 · see citing works
Refractory Adult-Onset Still Disease Successfully Treated With Abatacept
Ostrowski, R. A., Tehrani, R., & Kadanoff, R. (2011) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0b013e31822c53ad · Cited by 34 · see citing works
Efficacy of abatacept in a refractory case of adult-onset Still's disease.
Quartuccio, L., Maset, M., & Vita, S. D. (2010) · PubMed · Cited by 32 · see citing works
Rituximab treatment for pulmonary arterial hypertension in adult-onset Still's disease.
Padilla‐Ibarra, J., Sánchez-Ortíz, A., Sandoval-Castro, C., & Ramos-Remus, C. (2013) · PubMed · Cited by 28 · see citing works
Yoshida, Y., Sakamoto, M., Yokota, K., Sato, K., & Mimura, T. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.4771 · Cited by 25 · see citing works
Adult Onset Still's Disease and Autoinflammation
Efthimiou, P., Moorthy, L. N., Mavragani, C. P., Skokos, D., & Fautrel, B. (2012) · International Journal of Inflammation · doi:10.1155/2012/964751 · Cited by 24 · see citing works
Self-citationSuccessful Treatment of Refractory Adult-Onset Still Disease With Canakinumab
Barsotti, S., Neri, R., Iacopetti, V., d’Ascanio, A., Talarico, R., Tripoli, A., & Bombardieri, S. (2014) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000000082 · Cited by 24 · see citing works
Naniwa, T., Ito, R., Watanabe, M., Hayami, Y., Maeda, S., Sasaki, K., & Iwagaitsu, S. (2010) · Clinical Rheumatology · doi:10.1007/s10067-010-1562-8 · Cited by 22 · see citing works
Successful treatment of refractory adult onset Still’s disease with rituximab
Belfeki, N., Khanfir, M. S., Saïd, F., Hamzaoui, A., Salem, T. B., Ghorbel, I. B., Lamloum, M., & Houman, M. H. (2016) · Reumatismo · doi:10.4081/reumatismo.2016.888 · Cited by 20 · see citing works
Successful treatment of refractory adult-onset Still's disease with anti-CD20 monoclonal antibody.
Bartoloni, E., Alunno, A., Luccioli, F., Santoboni, G., & Gerli, R. (2009) · PubMed · Cited by 18 · see citing works
Online First publication of Modern Rheumatology
Mimori, T., & Springer (2007) · Modern Rheumatology · doi:10.1007/s10165-007-0001-4 · Cited by 15 · see citing works
Clinical, biological and sonographic response to IL-1 blockade in adult-onset Still's disease.
Priori, R., Ceccarelli, F., Barone, F., Iagnocco, A., & Valesini, G. (2008) · PubMed · Cited by 15 · see citing works
The role of interleukin-1 receptor antagonist in the prevention and treatment of disease
Arend, W. P. (2003) · Modern Rheumatology · doi:10.3109/s101650300000 · Cited by 14 · see citing works
Cavalli, G., Franchini, S., Berti, A., Campochiaro, C., Guglielmi, B., Sabbadini, M. G., Baldissera, E. M., & Dagna, L. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-eular.2153 · Cited by 3 · see citing works
Guilpain, P., Quellec, A. L., & Maria, A. T. J. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213106 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [30]Gerfaud-Valentin M Maucort-Boulch D Hot A Iwaz J Ninet J Durieu I Adult-onset still disease: manifestations, treatment, outcome, and prognostic factors in 57 patients Medicine (Baltimore) 2014 93 2 91 99 24646465 PMC4616309
Cited by
Sorted by citations
Fajgenbaum, D. C., & June, C. H. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2026131 · Cited by 3,196 · see citing works
Efthimiou, P., Kontzias, A., Hur, P., Rodha, K., Ramakrishna, G. S., & Nakasato, P. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2021.06.004 · Cited by 200 · see citing works
Anakinra in children and adults with Still’s disease
Vastert, S. J., Jamilloux, Y., Quartier, P., Ohlman, S., Koskinen, L. O., Kullenberg, T., Franck‐Larsson, K., Fautrel, B., & Benedetti, F. D. (2019) · Lara D. Veeken · doi:10.1093/rheumatology/kez350 · Cited by 102 · see citing works
Self-citationRecent advances and evolving concepts in Still’s disease
Ruscitti, P., Cantarini, L., Nigrovic, P. A., McGonagle, D., & Giacomelli, R. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01065-6 · Cited by 81 · see citing works
Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review
Wang, M., Jia, J., Yang, C., & Hu, Q. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000538 · Cited by 78 · see citing works
Tofacitinib in refractory adult-onset Still's disease: 14 cases from a single centre in China
Hu, Q., Wang, M., Jia, J., Teng, J., Chi, H., Liu, T., Liu, H.-L., Cheng, X., Ye, J., Su, Y., et al. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-216699 · Cited by 71 · see citing works
Adult-Onset Still’s Disease—A Complex Disease, a Challenging Treatment
Macovei, L. A., Burlui, A., Bratoiu, I., Rezuș, C., Cardoneanu, A., Richter, P., Szalontay, A. S., & Rezuş, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112810 · Cited by 62 · see citing works
Benedetto, P. D., Cipriani, P., Iacono, D., Pantano, I., Caso, F., Emmi, G., Grembiale, R. D., Cantatore, F. P., Atzeni, F., Perosa, F., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235326 · Cited by 60 · see citing works
Giacomelli, R., Sota, J., Ruscitti, P., Campochiaro, C., Colafrancesco, S., Dagna, L., Iacono, D., Iannone, F., Lopalco, G., Sfriso, P., et al. (2021) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/fsq5vq · Cited by 52 · see citing works
Management of adult-onset Still's disease: evidence- and consensus-based recommendations by experts
Leavis, H. L., van Daele, P. L. A., Mulders‐Manders, C. M., Michels, R. E., Rutgers, A., Legger, G. E., Bijl, M., Hak, E. A., Lam‐Tse, W., Bonte‐Mineur, F., et al. (2023) · Lara D. Veeken · doi:10.1093/rheumatology/kead461 · Cited by 49 · see citing works
Bindoli, S., Baggio, C., Doria, A., & Sfriso, P. (2024) · Drugs · doi:10.1007/s40265-024-01993-x · Cited by 45 · see citing works
Autoinflammatory Pathogenesis and Targeted Therapy for Adult-Onset Still’s Disease
Li, S., Zheng, S., Tang, S., Pan, Y., Zhang, S., Fang, H., & Qiao, J. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08747-8 · Cited by 41 · see citing works
Sota, J., Vitale, A., Lopalco, G., Pereira, R. M. R., Giordano, H. F., Antonelli, I. P. D. B., Makowska, J. S., Brzezińska, O. E., Lewandowska‐Polak, A., Ruscitti, P., et al. (2022) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2022.152089 · Cited by 32 · see citing works
Adult‐onset still’s disease and treatment results with tocilizumab
Kır, S., Özgen, M., & Zontul, S. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13936 · Cited by 29 · see citing works
Ruscitti, P., Masedu, F., Vitale, A., Cola, I. D., Caggiano, V., Muzio, C. D., Cipriani, P., Valenti, M., Berardicurti, O., Navarini, L., et al. (2023) · RMD Open · doi:10.1136/rmdopen-2023-003419 · Cited by 28 · see citing works
Ruscitti, P., Berardicurti, O., Giacomelli, R., & Cipriani, P. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2022.101632 · Cited by 26 · see citing works
Biologics for the treatment of adult-onset still’s disease
Yoo, D. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1652591 · Cited by 25 · see citing works
Cota-Arce, J. M., Cota, J. M., León-Nava, M. A. D., Hernández-Cáceres, A., Moncayo-Salazar, L. I., Valle, F., Cordero-Moreno, V. L., Bonfil-Solis, K. L., Bichara-Figueroa, J. E., Hernández-Hernández, J. A., et al. (2021) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2021.08.007 · Cited by 25 · see citing works
Guo, R., Liu, X., Li, Y., Meng, X., Li, R. Q., Chen, X., & Lu, L. (2022) · Lara D. Veeken · doi:10.1093/rheumatology/keac439 · Cited by 25 · see citing works
New insights on multigenic autoinflammatory diseases
Efthimiou, P., Petryna, O., Nakasato, P., & Kontzias, A. (2022) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x221117880 · Cited by 25 · see citing works
Systematic review on the use of biologics in adult-onset still's disease
Fautrel, B., Patterson, J. V., Bowe, C., Arber, M. R., Glanville, J., Mealing, S., Garcia, V. C., Fagerhed, L., Rabijns, H., & Giacomelli, R. (2022) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2022.152139 · Cited by 25 · see citing works
Self-citationRuscitti, P., Ursini, F., Sota, J., GIORGIO, R. D., Cantarini, L., & Giacomelli, R. (2020) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x20933133 · Cited by 24 · see citing works
Elevated serum levels of checkpoint molecules in patients with adult Still’s disease
Fujita, Y., Asano, T., Matsumoto, H., Matsuoka, N., Temmoku, J., Sato, S., Furuya, M. Y., Suzuki, E., Watanabe, H., Koga, T., et al. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02263-3 · Cited by 23 · see citing works
Wahbi, A., Tessoulin, B., Bretonnière, C., Boileau, J., Carpentier, D., Decaux, O., Fardet, L., Géri, G., Godmer, P., Goujard, C., et al. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02631-7 · Cited by 21 · see citing works
Giacomelli, R., Caporali, R. F., Ciccia, F., Colafrancesco, S., Dagna, L., Govoni, M., Iannone, F., Leccese, P., Montecucco, C., Pappagallo, G. L., et al. (2023) · Autoimmunity Reviews · doi:10.1016/j.autrev.2023.103400 · Cited by 21 · see citing works
Kedor, C., Tomaras, S., Baeumer, D., & Feist, E. (2021) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x211059598 · Cited by 20 · see citing works
Chen, P., & Chen, D. (2021) · Journal of Immunology Research · doi:10.1155/2021/8998358 · Cited by 19 · see citing works
Adachi, S., Takase‐Minegishi, K., Maeda, A., Nagai, H., Horita, N., Yoshimi, R., Kirino, Y., & Nakajima, H. (2023) · Rheumatology and Therapy · doi:10.1007/s40744-023-00600-x · Cited by 18 · see citing works
Ruscitti, P., McGonagle, D., Garcia, V. C., Rabijns, H., Toennessen, K., Chappell, M., Edwards, M., Miller, P., Hansell, N., Moss, J. W. E., et al. (2024) · The Journal of Rheumatology · doi:10.3899/jrheum.2023-0995 · Cited by 18 · see citing works
Crnogaj, M. R., Čubelić, D., Babić, A., Mayer, M., & Anić, B. (2020) · Rheumatology International · doi:10.1007/s00296-020-04622-4 · Cited by 18 · see citing works
Vordenbäumen, S., Feist, E., Rech, J., Fleck, M., Blank, N., Haas, J., Kötter, I., Krusche, M., Chehab, G., Hoyer, B. F., et al. (2022) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-022-01276-4 · Cited by 17 · see citing works
Vitale, A., Caggiano, V., Maggio, M. C., Lopalco, G., Emmi, G., Sota, J., Torre, F. L., Ruscitti, P., Bartoloni, E., Conti, G., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1071732 · Cited by 16 · see citing works
Meng, J., Chi, H., Wang, Z., Zhang, H., Sun, Y., Teng, J., Hu, Q., Liu, H., Cheng, X., Ye, J., et al. (2021) · Lara D. Veeken · doi:10.1093/rheumatology/keab023 · Cited by 15 · see citing works
Tang, K., Hsieh, C., Chen, H., Chen, Y., Chang, S., Huang, P., Lan, J., & Chen, D. (2021) · Clinical Rheumatology · doi:10.1007/s10067-021-05921-2 · Cited by 15 · see citing works
Vordenbäumen, S., Feist, E., Rech, J., Fleck, M., Blank, N., Haas, J., Kötter, I., Krusche, M., Chehab, G., Hoyer, B. F., et al. (2022) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-022-01294-2 · Cited by 13 · see citing works
Efficacy of Baricitinib in Patients with Refractory Adult-Onset Still’s Disease
Sun, Z., Li, R., Wang, Y., Feng, H., Wei, W., & Li, X. (2023) · Drugs in R&D · doi:10.1007/s40268-023-00417-7 · Cited by 13 · see citing works
Jamilloux, Y., Georgin‐Lavialle, S., Sève, P., Bélot, A., & Fautrel, B. (2019) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2019.06.001 · Cited by 13 · see citing works
Self-citationAdult Still's disease: New horizons
Nasonov, E. L., & Feist, E. (2021) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2021-643-663 · Cited by 12 · see citing works
Nasonov, E. L., & MIu, S. (2022) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2022-280-298 · Cited by 12 · see citing works
Exploring the Potential of Mitochondria‐Targeted Drug Delivery for Enhanced Breast Cancer Therapy
Ghazizadeh, Y., Sharifi-Ardani, S. E., Tajik, N., Mirzaei, R., & Pourahmad, J. (2025) · International Journal of Breast Cancer · doi:10.1155/ijbc/3013009 · Cited by 11 · see citing works
Interleukin-18: a biomarker with therapeutic potential in adult-onset Still’s disease
Chen, P., Wey, S.-J., & Chen, D. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2096592 · Cited by 10 · see citing works
Perspectives on the use of non-biological pharmacotherapy for adult-onset Still’s disease
Cola, I. D., Cipriani, P., & Ruscitti, P. (2022) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2022.2126764 · Cited by 9 · see citing works
Więsik–Szewczyk, E., Felis‐Giemza, A., Dziuk, M., & Jahnz‐Różyk, K. (2020) · International Journal of General Medicine · doi:10.2147/ijgm.s265482 · Cited by 8 · see citing works
Ruscitti, P., Feist, E., Garcia, V. C., Rabijns, H., Toennessen, K., Bartlett, C., Gregg, E. E., Miller, P., & McGonagle, D. (2023) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2023.152264 · Cited by 7 · see citing works
Kondo, F., Sugihara, T., Umezawa, N., Hasegawa, H., Hosoya, T., Kimura, N., Mori, M., & Yasuda, S. (2022) · Arthritis Research & Therapy · doi:10.1186/s13075-022-02780-3 · Cited by 7 · see citing works
Muller, R., Briantais, A., Faucher, B., Borentain, P., Nafati, C., Blasco, V., Grégoire, É., Bernit, E., Seguier, J., Meunier, B., et al. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05383-y · Cited by 7 · see citing works
Kaneko, Y., Kameda, H., Ikeda, K., Yamashita, K., Ozaki, R., & Tanaka, Y. (2023) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.14848 · Cited by 6 · see citing works
Disease activity score for still’s disease
Daghor, K. A., LARABA, N., Dahou-Makhloufi, C., Mechid, F., Ait-Hamadouche, N., Makrelouf, M., Otmane, A., Otmani, F., Smail, N., Boucelma, M., et al. (2024) · Clinical Rheumatology · doi:10.1007/s10067-024-07127-8 · Cited by 5 · see citing works
Ursini, F., Gregg, E. E., Garcia, V. C., Rabijns, H., Toennessen, K., Bartlett, K., & Graziadio, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1257413 · Cited by 5 · see citing works
Wawrzycki, B., Krasowska, D., Pietrzak, A., Wielosz, E., Majdan, M., & Lotti, T. (2019) · Dermatologic Therapy · doi:10.1111/dth.13041 · Cited by 5 · see citing works
Anakinra in the management of adult-onset still’s disease: a single-center experience
Kılıç, B., Parlar, K., Karup, S., Öztürk, A., Karaahmetli, K., & Uğurlu, S. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-024-03766-6 · Cited by 4 · see citing works
Adult-onset and Juvenile-onset Still’s Disease: A Comparative Study of Both Sides
Aicha, B. T., Hannech, E., Olfa, S., Bouden, S., Rouached, L., Rawda, T., Ines, M., Slim, A., & ABDELMOULA, L. (2022) · Current Rheumatology Reviews · doi:10.2174/1573397118666220617101447 · Cited by 4 · see citing works
Cluster analysis defines four groups of Japanese patients with adult-onset Still’s disease
Shirahama, Y., Kokuzawa, A., Yamauchi, Y., Kirino, Y., Nagai, H., Inoue, Y., Ota, T., Chifu, Y., Mitoma, H., Akahoshi, M., et al. (2024) · Modern Rheumatology · doi:10.1093/mr/roae023 · Cited by 4 · see citing works
Kontzias, A., Petryna, O., Nakasato, P., & Efthimiou, P. (2024) · Mediterranean Journal of Rheumatology · doi:10.31138/mjr.290323.dat · Cited by 4 · see citing works
Adult-onset Still’s disease presenting with aseptic meningitis: a case report
Li, X., Ker, A., Liao, H.-L., Liu, Y., & Wei, J. C.-C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1660434 · Cited by 3 · see citing works
Toward a personalized therapy of still’s disease based on immunologic endotypes: a narrative review
Chen, P., Wey, S.-J., & Chen, D. (2025) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2025.2465406 · Cited by 3 · see citing works
Refractory Adult-onset Still’s Disease Treated with a Combination of Methotrexate and Etanercept
Hasbani, G. E., Ahmad, Y., & Cassetta, M. (2023) · Current Rheumatology Reviews · doi:10.2174/0115733971244440230921100912 · Cited by 2 · see citing works
Maruyama, A., Kokuzawa, A., Yamauchi, Y., Kirino, Y., Nagai, H., Inoue, Y., Ota, T., Chifu, Y., Inokuchi, S., Mitoma, H., et al. (2021) · Modern Rheumatology · doi:10.1093/mr/roab083 · Cited by 2 · see citing works
Kondo, F., Sugihara, T., Umezawa, N., Hasegawa, H., Hosoya, T., Kimura, N., Mori, M., & Yasuda, S. (2021) · Research Square · doi:10.21203/rs.3.rs-1001506/v1 · Cited by 2 · see citing works
Application of IL-6 antagonists in autoimmune disorders
Borges, T., Barbosa, A., & Silva, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824390-9.00002-5 · Cited by 1 · see citing works
Felix, A., de Fritsch, E., Delion, F., Abel, A., Louis‐Sidney, F., Dramé, M., Hatchuel, Y., Deligny, C., & Suzon, B. (2024) · Joint Bone Spine · doi:10.1016/j.jbspin.2024.105821 · Cited by 1 · see citing works
Tomelleri, A., Campochiaro, C., Luca, G. D. D., Farina, N., Cavalli, G., & Dagna, L. (2021) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2021.1904395 · Cited by 1 · see citing works
Use of the rheumatic drug tocilizumab for treatment of SARS-CoV-2 patients
Grygiel‐Górniak, B., Shaikh, O., Kumar, N. N., Hsu, S. H., & Samborski, W. (2021) · Reumatologia/Rheumatology · doi:10.5114/reum.2021.108554 · Cited by 1 · see citing works
Ruscitti, P., Conforti, A., Pavlych, V., & Giacomelli, R. (2019) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2019.1701431
Influencia de la metodología y otros factores en la enseñanza de Física y Química
Ortiz, M. G. (1985) · Enseñanza de las Ciencias Revista de investigación y experiencias didácticas
Off-Label Use of Biologics in Rheumatological Disorders
Mondal, S., & Ghosh, A. (2022) · Springer eBooks · doi:10.1007/978-981-16-7200-2_25
(2019) · Reactions Weekly · doi:10.1007/s40278-019-61168-5
A CASE REPORT OF ADULT ONSET OF STILL'S DISEASE.
Dhoat, P. S., Kaur, A., Verma, N., Kansal, M., Chaudhary, D., Jain, D., Garg, H., Samal, S., & Singh, A. (2022) · Indian Journal Of Applied Research · doi:10.36106/ijar/8604659
Adult onset Still disease: A retrospective study including 65 patients in Tunisia
Frikha, O., Ghribi, M., Derbel, A., Mekki, S., Snoussi, M., Salah, R. B., Frikha, F., Marzouk, S., & Bahloul, Z. (2025) · Electronic Journal of Medical and Dental Studies · doi:10.29333/ejmds/16004
Kondo, F., Sugihara, T., Umezawa, N., Hasegawa, H., Hosoya, T., Kimura, N., Mori, M., & Yasuda, S. (2022) · Figshare · doi:10.6084/m9.figshare.19687444
Kondo, F., Sugihara, T., Umezawa, N., Hasegawa, H., Hosoya, T., Kimura, N., Mori, M., & Yasuda, S. (2022) · Figshare · doi:10.6084/m9.figshare.19687441
Zhong, S.-L., Lei, Y.-P., Zhou, L.-X., Niu, A.-X., Liu, B., He, Y., & Yang, Q.-B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1732826
Acar, B., Kizilkaya, O. O., Aktaş, B., Kilinc, O. C., & Ugurlu, S. (2026) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2026.2656045
Expanding the therapeutic landscape of still’s disease: the emerging role of JAK inhibitors
Ruscitti, P., Ursini, F., Giacomelli, R., Cantarini, L., & Caso, F. (2026) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2026.2723582
- Authors
- Vercruysse, F., Barnetche, T., Lazaro, E., Shipley, E., Lifermann, F., Balageas, A., Delbrel, X., Fautrel, B., Richez, C., Schaeverbeke, T., & Truchetet, M.-E.
- Affiliations
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier de Dax –Côte d’Argent (FR)
- Centre Hospitalier De Pau (FR)
- Pitié-Salpêtrière Hospital (FR)
- Corresponding author
- Vercruysse, François
- ORCID
- Venue
- Arthritis Research & Therapy
- Published
- 2019-02-12
- Volume
- 21
- Issue
- 1
- Pages
- 53-53
- ISSN
- 1478-6354 (ISSN-L)
- 1478-6362
- PMC
- PMC6373016
- OpenAlex
- W2925874700
- Cited by
- 74
- References
- 53
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 18 · 2021: 14 · 2020: 9 · 2019: 8
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Arthritis Research & Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Surgery › Kawasaki Disease and Coronary Complications
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- adult-onset Still's disease, biologic therapy, anakinra, tocilizumab, disease phenotypes, corticosteroid withdrawal, treatment response prediction, remission
- MeSH terms
- Adult, Cartilage, Articular, Female, Hospitals, Community, Humans, Male, Middle Aged, Phenotype, Remission Induction, Retrospective Studies, Still's Disease, Adult-Onset, Outcome Assessment, Health Care, Antirheumatic Agents, Interleukin 1 Receptor Antagonist Protein, Young Adult, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
