Distinct subsets of patients with systemic juvenile idiopathic arthritis based on their cytokine profiles
Abstract
To assess the serum interleukin (IL)-6 and IL-18 levels in patients with systemic juvenile idiopathic arthritis (s-JIA) and to identify the clinical features of patient subsets with different cytokine profiles, we analyzed the serum levels of IL-6 and IL-18 in patients with s-JIA and compared them with the clinical features of s-JIA. Eighteen patients were analyzed. IL-6 and IL-18 levels were quantified in serum by enzyme-linked immunosorbent assays. Interestingly, two distinct s-JIA patient subsets based on their serum IL-6 and IL-18 levels were identified: an IL-6 dominant and an IL-18 dominant. The serum IL-6 and IL-18 levels were consistent both at relapse and at the onset of s-JIA in each subset. The IL-6-dominant subset had a significantly greater number of joints with active disease and higher serum levels of matrix metalloproteinase-3, whereas the IL-18-dominant subset was more likely to develop macrophage activation syndrome (MAS). These findings indicate that two subsets of patients with s-JIA, one which is prone for arthritis and another with prone for MAS, can be identified on the basis of their serum IL-6 and IL-18 levels. These two subsets appear to be characterized by certain distinct clinical features.
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In patients with systemic juvenile idiopathic arthritis, there are subgroups with cytokine profiles in which interleukin-6 and interleukin-18 predominate.
“A study involving patients with systemic juvenile idiopathic arthritis revealed subgroups of patients with cytokine profiles in which interleukin-6 and interleukin-18 predominated, pointing toward available therapeutic approaches.110”
From Cytokine storm (2020) · cites this paper as [110]
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Systemic Juvenile Idiopathic Arthritis
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- Authors
- Shimizu, M., Nakagishi, Y., & Yachie, A.
- Affiliations
- Kanazawa University (JP)
- Kobe Children's Hospital (JP)
- Corresponding author
- Shimizu, Masaki
- Venue
- Cytokine
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 61
- Issue
- 2
- Pages
- 345-348
- ISSN
- 1043-4666 (ISSN-L)
- OpenAlex
- W2025601895
- Cited by
- 128
- References
- 17
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 16 · 2020: 4 · 2019: 17 · 2018: 10 · 2017: 8 · 2016: 10 · 2015: 14 · 2014: 14 · 2013: 4
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cytokine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Surgery › Kawasaki Disease and Coronary Complications
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- systemic juvenile idiopathic arthritis, interleukin-6, IL-18, serum cytokine levels, macrophage activation syndrome, matrix metalloproteinase-3, disease subtypes, joint involvement, relapse, clinical features
- MeSH terms
- Arthritis, Juvenile, Child, Female, Humans, Male, Interleukin-6, Interleukin-18
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