Clinical profile and comorbidity of traumatic brain injury among younger and older men and women: a brief research notes
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OBJECTIVE: Comorbid disorders influence the course and outcomes of rehabilitation following traumatic brain injury (TBI), yet sex- and age-related disparities in the frequency distribution of these disorders remain poorly understood. We aimed to describe comorbid disorders by the International Classification of Diseases in patients with TBI undergoing inpatient rehabilitation in Ontario, Canada over a 3-year period, by sex and age, and discuss their potential impact on rehabilitation outcomes. RESULTS: The percentage of TBI patients with one or more comorbid disorder is higher among older (≥65 years) men and women than among those who are younger or middle-aged (<65 years). Among younger and middle-aged patients, multiple injuries and trauma, mental health conditions, and nervous system disorders were the most prevalent comorbidities. In older patients, circulatory, endocrine, nutritional, metabolic, and immune disorders were the most prevalent comorbidities. Our results suggest that a multisystem view of rehabilitation of men and women with TBI across age categories is needed to reflect the complex clinical profile of TBI patients undergoing rehabilitation.
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Because comorbidities and extracranial injuries might have different prevalence in men versus women, the absence of widespread reporting of these factors is an important limitation in interpreting findings of sex differences.
“Because comorbidities and extracranial injuries might have different prevalence in men versus women, 33,35 the absence of widespread reporting of these factors is an important limitation in interpreting findings of sex differences.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [35]
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- Authors
- Chan, V., Mollayeva, T., Ottenbacher, K. J., & Colantonio, A.
- Affiliations
- University Health Network (CA)
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Mollayeva, Tatyana
- Venue
- BMC Research Notes
- Published
- 2017-08-08
- Volume
- 10
- Issue
- 1
- Pages
- 371-371
- ISSN
- 1756-0500 (ISSN-L)
- PMC
- PMC5549298
- OpenAlex
- W2745254987
- Cited by
- 51
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 5 · 2020: 11 · 2019: 11 · 2018: 4 · 2017: 1
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Research Notes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health (NIH) (R24HD065702)
- NIH Research Award (1R21 HD08106-01)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Keywords
- traumatic brain injury, comorbidities, sex differences, age differences, inpatient rehabilitation, rehabilitation outcomes, polytrauma, mental illness, neurological disorders, circulatory diseases, endocrine disorders, nutritional disorders, metabolic disorders, immune disorders
- MeSH terms
- Brain Injuries, Traumatic, Adolescent, Adult, Age Factors, Aged, Mental Disorders, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Nervous System Diseases, Ontario, Retrospective Studies, Sex Factors, Comorbidity, Prevalence, Treatment Outcome
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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