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Cited by 93Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceAntimicrobial Resistance in Staphylococcus

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A systematic review: the current status of carbapenem resistance in East Africa

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Ssekatawa, Kenneth, Byarugaba, Dennis K., Wampande, Edward, Ejobi, Francis·2018·BMC Research Notes
DOI 10.1186/s13104-018-3738-2PMC PMC6119249
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Abstract

OBJECTIVE: In this systematic review, we present the molecular epidemiology and knowledge gaps of the carbapenem resistance in East Africa as well as the future probable research interventions that can be used to address the emergence of carbapenem resistance in the region. RESULTS: The 17 articles which presented concrete information about the prevalence of carbapenem resistance in East Africa were reviewed. Tanzania exhibited the highest level of carbapenem resistance at 35% while DRC had the lowest level at 0.96%. Uganda was the only country with studies documenting CR obtained amongst hospital environment isolates with incidence ranging from 21% in Pseudomonas aeruginosa to 55% in Acinetobacter baumannii. Carbapenem resistance was more exhibited in A. baumannii (23%), followed by P. aeruginosa (17%), Klebsiella pneumoniae (15%), Proteus mirabilis (14%) and Escherichia coli (12%) mainly isolated from respiratory tract, blood, urine and wound/pus. The regional genetic determinants of carbapenem resistance detected were blaIMP, blaVIM-1 blaSPM-l, blaNDM-1, blaOXA-23 blaOXA-24, blaOXA-58 and blaKPC.

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Fig. 1 Selection process of research articles for inclusion in this systematic reviewCC BY · PubMed Central

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Metadata

Authors
Ssekatawa, K., Byarugaba, D. K., Wampande, E., & Ejobi, F.
Affiliations
  • Kampala International University (UG)
  • Makerere University (UG)
Corresponding author
Ssekatawa, Kenneth
ORCID
Venue
BMC Research Notes
Publisher
Springer Science and Business Media LLC
Published
2018-08-31
Volume
11
Issue
1
Pages
629-629
ISSN
1756-0500 (ISSN-L)
DOI
10.1186/s13104-018-3738-2
PMC
PMC6119249
OpenAlex
W2889088251
Cited by
93
References
0
Citations by year
2026: 7 · 2025: 9 · 2024: 9 · 2023: 14 · 2022: 18 · 2021: 17 · 2020: 17 · 2019: 2
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Research Notes (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords
carbapenem resistance, carbapenemase genes, molecular epidemiology, East Africa, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, blaNDM-1, blaKPC, blaOXA, blaVIM, blaIMP, blaSPM, hospital isolates, antimicrobial resistance
MeSH terms
Africa, Eastern, Anti-Bacterial Agents, beta-Lactamases, Escherichia coli, Humans, Microbial Sensitivity Tests, Carbapenems, Drug Resistance, Bacterial, Acinetobacter baumannii

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Ssekatawa, K., Byarugaba, D. K., Wampande, E., & Ejobi, F. (2018). A systematic review: the current status of carbapenem resistance in East Africa. BMC Research Notes. https://doi.org/10.1186/s13104-018-3738-2