Cited by 395Sirtuins and Resveratrol in MedicineHistone Deacetylase Inhibitors ResearchBiochemical and Molecular Research

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Sirtuin functions and modulation: from chemistry to the clinic

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Carafa, Vincenzo, Rotili, Dante, Forgione, Mariantonietta, Cuomo, Francesca, Serretiello, Enrica, Hailu, Gebremedhin Solomon, Jarho, Elina, Lahtela-Kakkonen, Maija, Mai, Antonello, Altucci, Lucia·2016·Clinical Epigenetics

DOI 10.1186/s13148-016-0224-3PMC PMC4879741

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Abstract

Sirtuins are NAD(+)-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. Here, we review the role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators.

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1 retracted

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Authors: Carafa, V., Rotili, D., Forgione, M., Cuomo, F., Serretiello, E., Hailu, G. S., Jarho, E., Lahtela-Kakkonen, M., Mai, A., & Altucci, L.
Affiliations: University of Campania "Luigi Vanvitelli" (IT)
Sapienza University of Rome (IT)
Italian Institute of Technology (IT)
University of Eastern Finland (FI)
Istituto Pasteur (IT)
Corresponding author: Mai, Antonello
Altucci, Lucia
ORCID: Carafa, Vincenzo
Rotili, Dante
Forgione, Mariantonietta
Cuomo, Francesca
Serretiello, Enrica
Hailu, Gebremedhin Solomon
Lahtela-Kakkonen, Maija
Mai, Antonello
Altucci, Lucia
Venue: Clinical Epigenetics
Publisher: Springer Science and Business Media LLC
Published: 2016-05-25
Volume: 8
Issue: 1
Pages: 61-61
ISSN: 1868-7075 (ISSN-L)
1868-7083
DOI: 10.1186/s13148-016-0224-3
PMC: PMC4879741
OpenAlex: W2405840972
Cited by: 387
References: 119
Citations by year: 2026: 23 · 2025: 27 · 2024: 54 · 2023: 53 · 2022: 44 · 2021: 55 · 2020: 45 · 2019: 32 · 2018: 25 · 2017: 19 · 2016: 9
FWCI: 2.91
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Clinical Epigenetics (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
UEF eRepo (University of Eastern Finland) (submittedVersion, cc-by)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Iris (Roma Tre University) (submittedVersion)
Funders: EU-Blueprint (282510)
EU-A-PARADDISE (602080)
EU-Cost action EPICHEMBIO (CM1406)
PRIN-2012
AIRC (17217)
AIRC-Fondazione Cariplo TRIDEO (17515)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: sirtuins, NAD+-dependent histone deacetylase, sirtuin inhibitors, sirtuin activators, small molecule modulators, epigenetic regulation, caloric restriction, aging, neurodegenerative diseases, cardiovascular disease, cancer, cellular metabolism, apoptosis, DNA repair
MeSH terms: Cell Survival, DNA Repair, Enzyme Inhibitors, Gene Expression Regulation, Humans, Cellular Senescence, Sirtuins, Epigenesis, Genetic, Cell Proliferation

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Sirtuin functions and modulation: from chemistry to the clinic

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