The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine
Open accessAbstract
Mesenchymal stem cells (MSCs) are multipotent stem cells that have gained significant attention in the field of regenerative medicine. The differentiation potential along with paracrine properties of MSCs have made them a key option for tissue repair. The paracrine functions of MSCs are applied through secreting soluble factors and releasing extracellular vesicles like exosomes and microvesicles. Extracellular vesicles are predominantly endosomal in origin and contain a cargo of miRNA, mRNA, and proteins that are transferred from their original cells to target cells. Recently it has emerged that extracellular vesicles alone are responsible for the therapeutic effect of MSCs in plenty of animal diseases models. Hence, MSC-derived extracellular vesicles may be used as an alternative MSC-based therapy in regenerative medicine. In this review we discuss MSC-derived extracellular vesicles and their therapeutic potential in various diseases.
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Cites
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Cited by
Mesenchymal stromal/stem cell (MSC)-Derived exosomes in clinical trials
Lotfy, A., AboQuella, N. M., & Wang, H. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03287-7 · Cited by 482
Hong, P., Yang, H., Wu, Y., Li, K., & Tang, Z. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1358-y · Cited by 269
Microvesicles: ROS scavengers and ROS producers
Bodega, G., Alique, M., Puebla, L., Carracedo, J., & Ramírez, R. M. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1626654 · Cited by 258
Jurcău, M. C., Andronie-Cioara, F. L., Jurcău, A., Marcu, F., Ţiț, D. M., Pașcalău, N., & Nistor-Cseppentö, D. C. (2022) · Antioxidants · doi:10.3390/antiox11112167 · Cited by 226
Meftaul, I. M., Venkateswarlu, K., Dharmarajan, R., Annamalai, P., Asaduzzaman, M., Parven, A., & Megharaj, M. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114372 · Cited by 218
Metadata
- Authors
- Keshtkar, S., Azarpira, N., & Ghahremani, M. H.
- Venue
- Stem Cell Research & Therapy
- Published
- 2018-03-09
- Volume
- 9
- Issue
- 1
- Pages
- 63-63
- ISSN
- 1757-6512 (ISSN-L)
- OpenAlex
- W2796493184
- Cited by
- 907
- References
- 64
- FWCI
- 20.40
- Type
- journal article
- Language
- en
- Open access
- gold
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