The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Sex differences in mood disorders: perspectives from humans and rodent models
Open accessAbstract
Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia. Notably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in mood are due to underlying biological sex differences, a better understanding of the biology is warranted to develop better treatment or even prevention of these debilitating disorders. In this review, our goals are to: 1) summarize the literature related to mood disorders with respect to sex differences in prevalence, 2) introduce the corticolimbic brain network of mood regulation, 3) discuss strategies and challenges of modeling mood disorders in mice, 4) discuss mechanisms underlying sex differences and how these can be tested in mice, and 5) discuss how our group and others have used a translational approach to investigate mechanisms underlying sex differences in mood disorders in humans and mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“the female gender was noted to have higher levels of depression, anxiety and stress as compared to the male gender.”
From Relationships between psychopathology, psychological process variables, and sociodemographic variables and comparison of quarantined and non-quarantined groups of malaysian university students in the covid-19 pandemic (2021) · cites this paper as [61]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Similar trends were reported during previous pandemics [61,62,63,64].”
From Relationships between psychopathology, psychological process variables, and sociodemographic variables and comparison of quarantined and non-quarantined groups of malaysian university students in the covid-19 pandemic (2021) · cites this paper as [61]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 1×
“Interestingly, neuroimaging studies show that features of sgACC dysfunction in MDD are sexually dimorphic, with women exhibiting higher levels of reactivity compared to males [33-35].”
BackgroundGlobal mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 1×
“In addition to the psychological stress on patients and families, MDD contributes to the development and progression of systemic and organ diseases [2-5].”
BackgroundDeep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Sinclair, A. H., Berta, P., Palmer, M. S., Hawkins, J. R., Griffiths, B. L., Smith, M. J., Foster, J. W., Frischauf, A., Lovell-Badge, R. H., & Goodfellow, P. N. (1990) · Nature · doi:10.1038/346240a0 · Cited by 3,234
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 1×
“, [54]).”
Male development of chromosomally female mice transgenic for Sry
Koopman, P. A., Gubbay, J., Vivian, N., Goodfellow, P. N., & Lovell-Badge, R. H. (1991) · Nature · doi:10.1038/351117a0 · Cited by 2,193
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166
National Health and Nutrition Examination Survey
Rothwell, C. J. (2009) · Springer eBooks · doi:10.1007/978-0-387-78665-0_6177 · Cited by 2,093
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980
Research works printed but not linked: 1
- WHO:World Health Organization - The Global Burden of Disease - 2004 Update. WHO Library, Geneva, Switzerland; 2004.
Cited by
Sorted by citations
Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593
Sex and gender differences in pain
Osborne, N. R., & Davis, K. D. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.06.013 · Cited by 261
Establishment of a repeated social defeat stress model in female mice
Takahashi, A., Chung, J.-R., Zhang, S., Zhang, H., Grossman, Y., Aleyasin, H., Flanigan, M. E., Pfau, M. L., Menard, C., Dumitriu, D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12811-8 · Cited by 256
Disrupted intrinsic functional brain topology in patients with major depressive disorder
Yang, H., Chen, X., Chen, Z.-B., Li, L., Li, X.-Y., Castellanos, F. X., Bai, T., Bo, Q.-J., Cao, J., Chang, Z.-K., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01247-2 · Cited by 259
Anhedonia and the Brain Reward Circuitry in Depression
Heshmati, M., & Russo, S. J. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0044-3 · Cited by 254
Metadata
- Authors
- Seney, M. L., & Sibille, E.
- Affiliations
- University of Pittsburgh (US)
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Seney, Marianne L
- Sibille, Etienne
- Venue
- Biology of Sex Differences
- Published
- 2014-12
- Volume
- 5
- Issue
- 1
- Pages
- 17-17
- ISSN
- 2042-6410 (ISSN-L)
- PMC
- PMC4268901
- OpenAlex
- W2120430663
- Cited by
- 181
- References
- 122
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 16 · 2022: 17 · 2021: 19 · 2020: 55 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 5 · 2015: 8
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Biology of Sex Differences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- TSpace (University of Toronto) (submittedVersion)
- Funders
- National Institute of Mental Health (MH084060, MH103473, MH085111, R21MH085111, K01MH103473, K02MH084060)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- mood disorders, sex differences, depression, anhedonia, cortico-limbic network, mood regulation, rodent models, mouse model of depression, translational research, sex differences in prevalence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
