Cited by 183Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionStress Responses and Cortisol

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Sex differences in mood disorders: perspectives from humans and rodent models

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Seney, Marianne L, Sibille, Etienne·2014·Biology of Sex Differences

DOI 10.1186/s13293-014-0017-3PMC PMC4268901

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Abstract

Mood disorders are devastating, often chronic illnesses characterized by low mood, poor affect, and anhedonia. Notably, mood disorders are approximately twice as prevalent in women compared to men. If sex differences in mood are due to underlying biological sex differences, a better understanding of the biology is warranted to develop better treatment or even prevention of these debilitating disorders. In this review, our goals are to: 1) summarize the literature related to mood disorders with respect to sex differences in prevalence, 2) introduce the corticolimbic brain network of mood regulation, 3) discuss strategies and challenges of modeling mood disorders in mice, 4) discuss mechanisms underlying sex differences and how these can be tested in mice, and 5) discuss how our group and others have used a translational approach to investigate mechanisms underlying sex differences in mood disorders in humans and mice.

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Figure 1 A novel model depicting a dynamic balance between sex chromosome complement and circulating testosterone on anxiety (black dotted line). A conventional interpretation in the sex difference field is that XY sex chromosome complement may exert a compensatory effect to reduce differences otherwise induced by circulating testosterone or vice versa. Data outlined in this review suggests that this is also the case for the regulation of mood and anxiety-like behaviors. Specifically, while male sex chromosome complement causes an increase in anxiety-like behavior, this effect is opposed by testosterone’s antianxiety effect. While sex chromosome complement appears to be acting via control of gene expression, we hypothesize that testosterone affects the activity of certain inhibitory GABA cell types (e.g., SST cells).CC BY · PubMed Central

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Authors: Seney, M. L., & Sibille, E.
Affiliations: University of Pittsburgh (US)
Centre for Addiction and Mental Health (CA)
Corresponding author: Seney, Marianne L
Sibille, Etienne
ORCID: Seney, Marianne L
Sibille, Etienne
Venue: Biology of Sex Differences
Publisher: Springer Science and Business Media LLC
Published: 2014-12
Volume: 5
Issue: 1
Pages: 17-17
ISSN: 2042-6410 (ISSN-L)
DOI: 10.1186/s13293-014-0017-3
PMC: PMC4268901
OpenAlex: W2120430663
Cited by: 181
References: 122
Citations by year: 2026: 7 · 2025: 12 · 2024: 11 · 2023: 16 · 2022: 17 · 2021: 19 · 2020: 55 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 5 · 2015: 8
FWCI: 3.51
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Biology of Sex Differences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
TSpace (University of Toronto) (submittedVersion)
Funders: National Institute of Mental Health (MH084060, MH103473, MH085111, R21MH085111, K01MH103473, K02MH084060)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: mood disorders, sex differences, depression, anhedonia, cortico-limbic network, mood regulation, rodent models, mouse model of depression, translational research, sex differences in prevalence

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Sex differences in mood disorders: perspectives from humans and rodent models

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