The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index, and 1 are not checked yet.
Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis
Open accessAbstract
BACKGROUND: Dermatological illness can affect the quality of life and may coexist with psychiatric disorders. OBJECTIVE: The aim of this review was to systematically evaluate the published evidence of any psychiatric disorders that may coexist with chronic urticaria (CU) and any effect psychiatric interventions may have on CU. METHODS: Following the Cochrane guidance, we conducted a systematic literature search using web-based search engines provided by PubMed (for Medline database), Google Scholar and Scopus for studies that have investigated the existence of psychiatric comorbidity in patients with CU. To be included, a study had to possess features, such as: (1) distinction between chronic urticaria and allergic conditions, (2) direct collection of diagnostic psychiatric data by using clinical interview and standardized questionnaires, (3) International Classification of Disorders criteria or the Diagnostic and Statistical Manual of Mental Disorders criteria for the diagnosis of mental disorders, and (4) manuscripts written or published in the English language. Unpublished research and research in progress were not included. All the eligible studies were scrutinized for any reported psychiatric interventions that had any effect on CU. The systematic review has been registered on PROSPERO (registration number CRD42019122811) and was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). RESULTS: Twenty-five studies were identified. Almost one out of three CU patients have at least one underlying psychiatric disorder. None of the studies clarified whether the psychiatric disorders pre-existed the CU onset, and no association was found between CU severity and duration, and psychological functioning. Only one case report and two case series mentioned that treatment of psychiatric disorders with either anti-depressants, anti-anxiety drugs or psychological interventions might result in improvement of urticaria. CONCLUSIONS: Patients with CU frequently experience psychiatric disorders. This highlights the need for a multidisciplinary therapeutic approach involving prompt recognition and management of any potential psychiatric disorder in addition to urticaria treatment. Further studies are needed to assess whether psychiatric disorders coexist with CU independently or follow urticaria onset and whether any psychological or psychiatric intervention may help in CU control.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Psychotropic drugs (e.g., antidepressants and benzodiazepines) could have a positive effect on CSU treatment 11,31 .”
From Could distress tolerance levels be associated with the severity of chronic spontaneous urticaria? (2022) · cites this paper as [31]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Psychological stress and the human immune system: a meta-analytic study of 30 Years of inquiry
Segerstrom, S. C., & Miller, G. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.601 · Cited by 3,334
Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
Tsigos, C., & Chrousos, G. P. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00429-4 · Cited by 2,822
Zuberbier, T., Aberer, W., Asero, R., Latiff, A. H. A., Baker, D. R., Ballmer-Weber, B. K., Bernstein, J. A., Bindslev‐Jensen, C., Brzoza, Z., Bedrikow, R. B., et al. (2018) · Allergy · doi:10.1111/all.13397 · Cited by 1,479
Zuberbier, T., Aberer, W., Asero, R., Bindslev‐Jensen, C., Brzoza, Z., Canonica, G. W., Church, M. K., Ensina, L. F., Giménez‐Arnau, A. M., Godse, K. V., et al. (2014) · Allergy · doi:10.1111/all.12313 · Cited by 1,206
The diagnosis and management of acute and chronic urticaria: 2014 update
Bernstein, J. A., Lang, D. M., Khan, D. A., Craig, T., Dreyfus, D. H., Hsieh, F. H., Sheikh, J. K., Weldon, D., Zuraw, B. L., Bernstein, D. I., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.02.036 · Cited by 685
The impact of chronic urticaria on the quality of life
O’Donnell, C. P., LAWLOR, F., SIMPSON, J., Morgan, M., & GREAVES, M. W. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.d01-1168.x · Cited by 615
Association of Schizophrenia and Autoimmune Diseases: Linkage of Danish National Registers
Eaton, W. W., Byrne, M., Ewald, H., Mors, O., Chen, C.-Y., Agerbo, E., & Mortensen, P. B. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.521 · Cited by 527
The impact of chronic urticaria on the quality of life
O’Donnell, B. F., Lawlor, F., SIMPSON, J., Morgan, M., & Greaves, M. W. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb14895.x · Cited by 465
Psychiatric morbidity in dermatological outpatients: an issue to be recognized
Picardi, A., Abeni, D., Melchi, C. F., Puddu, P., & Pasquini, P. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03831.x · Cited by 413
Recurrent urticaria: clinical investigation of 330 patients
JUHLIN, L. (1981) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1981.tb15306.x · Cited by 388
Neuroimmunoendocrine circuitry of the ‘brain-skin connection’
Paus, R., Theoharides, T. C., & Arck, P. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.10.002 · Cited by 348
Are some cases of psychosis caused by microbial agents? A review of the evidence
Yolken, R. H., & Torrey, E. F. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.5 · Cited by 327
Psychiatric morbidity in dermatological outpatients: an issue to be recognized
Aslam, R., Qadir, A., & Asad, F. (2016) · Journal of Pakistan Association of Dermatologists · doi:10.66344/jpad.v17i4.707 · Cited by 316
Losing your nerves? Maybe it's the antibodies
Diamond, B., Huerta, P. T., Mina-Osorio, P., Kowal, C., & Volpe, B. T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2529 · Cited by 247
Staubach, P., Eckhardt-Henn, A., Dechene, M., Vonend, A., Metz, M., Magerl, M., Breuer, P., & Maurer, M. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06976.x · Cited by 243
Dalman, C., Allebeck, P., Gunnell, D., Harrison, G. L., Kristensson, K., Lewis, G., Löfving, S., Rasmussen, F. E., Wicks, S., & Karlsson, H. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07050740 · Cited by 242
Psychosomatic concepts in dermatology. A dermatologist-psychoanalyst's viewpoint
Koblenzer, C. S. (1983) · Archives of Dermatology · doi:10.1001/archderm.119.6.501 · Cited by 190
Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
Maurer, M., Eyerich, K., Eyerich, S., Ferrer, M., Gutermuth, J., Hartmann, K., Jakob, T., Kapp, A., Kolkhir, P., Larenas‐Linnemann, D. E., et al. (2020) · International Archives of Allergy and Immunology · doi:10.1159/000507218 · Cited by 186
Prevalence and correlates of suicidal ideation among patients with skin disease.
Picardi, A., Mazzotti, E., & Pasquini, P. (2006) · Journal of American Academy of Dermatology · doi:10.1016/j.jaad.2005.11.1103 · Cited by 179
Lapi, F., Cassano, N., Pegoraro, V., Cataldo, N., Heiman, F., Cricelli, I., Levi, M., Colombo, D., Zagni, E., Cricelli, C. A., et al. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14470 · Cited by 161
Jones, A. L., Mowry, B. J., Pender, M. P., & Greer, J. M. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01305.x · Cited by 155
Selected Infectious Agents and Risk of Schizophrenia Among U.S. Military Personnel
Niebuhr, D. W., Millikan, A. M., Cowan, D. N., Yolken, R. H., Li, Y., & Weber, N. S. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06081254 · Cited by 153
Staubach, P., Dechene, M., Metz, M., Magerl, M. A. K., Siebenhaar, F., Weller, K., Zezula, P., Eckhardt‐Henn, A., & Maurer, M. (2011) · Acta Dermato Venereologica · doi:10.2340/00015555-1109 · Cited by 147
The role of infection in the pathogenesis of autoimmune disease
Rose, N. R. (1998) · Seminars in Immunology · doi:10.1006/smim.1997.0100 · Cited by 131
Psychiatric Manifestations of Paraneoplastic Disorders
Kayser, M. S., Kohler, C. G., & Dalmau, J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101547 · Cited by 129
Psychiatric morbidity and quality of life in patients with chronic idiopathic urticaria
Özkan, M., Oflaz, S., Kocaman, N., Özşeker, F., Gelincik, A. A., Büyüköztürk, S., Özkan, S., & Çolakoğlu, B. (2007) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60617-5 · Cited by 119
Anxiety and depression in patients with chronic urticaria and generalized pruritus
LSHEEHAN-DARE, R. A., HENDERSON, M. J., & COTTERILL, J. A. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb04195.x · Cited by 109
The Problems in Sexual Functions of Vitiligo and Chronic Urticaria Patients
Sukan, M., & Maner, F. (2006) · Journal of Sex & Marital Therapy · doi:10.1080/00926230600998482 · Cited by 105
Perugi, G., Quaranta, G., Belletti, S., Casalini, F., Mosti, N., Toni, C., & Dell’Osso, L. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.08.052 · Cited by 104
Antibody-mediated encephalitis: a treatable cause of schizophrenia
Lennox, B., Coles, A. J., & Vincent, A. C. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.095042 · Cited by 97
Psychosocial factors and chronic spontaneous urticaria: a systematic review
Ben‐Shoshan, M., Blinderman, I., & Raz, A. (2013) · Allergy · doi:10.1111/all.12068 · Cited by 86
Higher Levels of Depression and Anxiety in Patients with Chronic Urticaria
Tat, T. S. (2019) · Medical Science Monitor · doi:10.12659/msm.912362 · Cited by 73
Stress, insomnia, and chronic idiopathic urticaria--a case-control study.
Yang, H., Sun, C. C., Wu, Y., & Wang, J. (2005) · PubMed · Cited by 71
Chu, C., Cho, Y., Jiang, J.-H., Lin, E. I.-C., & Tang, C. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.07.006 · Cited by 66
The relation of psychogenic excoriation with psychiatric disorders: a comparative study.
Çalıkuşu, C., Yücel, B., Polat, A., & Baykal, C. (2003) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(03)00041-5 · Cited by 65
Depression in adult dermatology outpatients.
Bashir, K., Dar, N. R., & Rao, S. U. (2010) · PubMed · Cited by 61
Huang, C., Yen, D. H.-T., Huang, H., Kao, W., Wang, L.-M., Huang, C., & Lee, C.-H. (2005) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(09)70146-7 · Cited by 61
Gregoriou, S., Rigopoulos, D., Katsambas, A., Κατσαρού, Α., Papaioannou, D., Gkouvi, A., Kontochristopoulos, G., Danopoulou, I., Stavrianeas, N. G., & Kalogeromitros, D. (2009) · Journal of Cutaneous Medicine and Surgery · doi:10.2310/7750.2008.08035 · Cited by 59
Hergüner, S., Kılıç, G., Karakoç, S., Tamay, Z., Tüzün, Ü., & Güler, N. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10138.x · Cited by 59
Chung, M. C., Symons, C., Gilliam, J., & Kaminski, E. R. (2009) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2009.02.005 · Cited by 58
Axis I and Axis II diagnoses in patients with chronic idiopathic urticaria
Uğuz, F., Engіn, B., & Yılmaz, E. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.08.006 · Cited by 52
Psychological Components and the Role of Adjunct Interventions in Chronic Idiopathic Urticaria
Sperber, J., Shaw, J. A., & Bruce, S. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000288147 · Cited by 46
Sorour, F. A., Abdelmoaty, A. A., Bahary, M. H., & Birqdar, B. E. (2017) · Journal of the Egyptian Womenʼs Dermatologic Society · doi:10.1097/01.ewx.0000503397.22746.bd · Cited by 43
Potocka, A., Turczyn-Jabłońska, K., & Merecz, D. (2009) · PubMed · Cited by 40
Obsessive–compulsive disorder in a dermatology outpatient clinic
Demet, M. M., Deveci, A., Taskin, E. O., Ermertcan, A. T., Yurtsever, F., Deniz, F., Bayraktar, D., & Öztürkcan, S. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2005.04.006 · Cited by 34
Lindsay, K., Goulding, J., Solomon, M., & Broom, B. (2015) · Clinical and Translational Allergy · doi:10.1186/s13601-015-0082-7 · Cited by 32
Gupta, M. A., & Gupta, A. K. (2012) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2012.01.012 · Cited by 31
Psychiatric morbidity in dermatology patients: Frequency and results of consultations
Seyhan, M., Akı, T., Karıncaoğlu, Y., & Özcan, H. (2006) · Indian Journal of Dermatology · doi:10.4103/0019-5154.25181 · Cited by 30
Psychiatric morbidity among dermatology inpatients.
Pulimood, S. A., Rajagopalan, B., Rajagopalan, M., Jacob, M., & John, J. K. (1996) · PubMed · Cited by 28
Gupta, M. A., & Gupta, A. K. (1995) · PubMed · Cited by 26
Dysthymic states and depressive syndromes in physical conditions of presumably psychogenic origin
Lyketsos, C. G., Lyketsos, G. C., Richardson, S. C., & Beis, A. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02914.x · Cited by 25
Zur Beziehung zwischen chronischer Urtikaria und Depression/ Somatisierungsstörung
Hein, U. R., Henz, B. M., Haustein, U. F., Seikowski, K., Aberer, W., Lautenschlager, S., & Klapp, B. F. (1996) · Der Hautarzt · doi:10.1007/s001050050369 · Cited by 23
A Cohort Study of the Relationship Between Anger and Chronic Spontaneous Urticaria
Altınöz, A. E., Taşkıntuna, N., Altınöz, Ş. T., & Ceran, S. (2014) · Advances in Therapy · doi:10.1007/s12325-014-0152-6 · Cited by 23
A reappraisal of the role of ‘mindbody’ factors in chronic urticaria
Broom, B. (2010) · Postgraduate Medical Journal · doi:10.1136/pgmj.2009.096446 · Cited by 20
Skin and brain: itch and psychiatric disorders.
Caccavale, S., Bove, D., Bove, R. M., & Montagna, M. L. (2016) · PubMed · Cited by 17
Kuo, C., Chen, C. Y., Huang, H. L., Chen, W., Lee, H. C., Chang, C.-Y., Chou, C.-C., Ho, S., Wu, H. P., & Lin, Y. (2014) · BMC Pediatrics · doi:10.1186/1471-2431-14-181 · Cited by 16
Psychosomatic Treatment of a Case of Chronic Urticaria
Hashiro, M. (1995) · The Journal of Dermatology · doi:10.1111/j.1346-8138.1995.tb03899.x · Cited by 10
[Psychological factors in chronic urticaria].
Sg, C. (2003) · PubMed · Cited by 8
Is There an Association between Restless Legs Syndrome and Urticaria?
Tuna, S., Alan, S., Samancı, N., & Karakaş, A. A. (2016) · Journal of Korean Medical Science · doi:10.3346/jkms.2016.31.5.790 · Cited by 7
The role of allergy in neuropsychiatry
Clarke, T. W. (1940) · Psychiatric Quarterly · doi:10.1007/bf01566798 · Cited by 2
Psychological Status in Patients with Chronic Urticaria
Peyghambari, S., Rahimi, M., Atefi, N., & Ghourchian, S. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 2
[Mental disorders in patients suffering from allergy].
Czubalski, K. (1972) · PubMed · Cited by 1
[Neuropsychological findings in chronic urticaria].
Drunkenmölle, R. (1971) · PubMed · Cited by 1
Psychosomatic Concepts in Dermatology
Koblenzer, C. S. (1983) · Archives of Dermatology · doi:10.1001/archderm.1983.01650300055017
Research works printed but not linked: 1
- Mehta V, Malhotra SK. Psychiatric evaluation of patients with psoriasis vulgaris and chronic urticaria. German J Psychiatry, 2007;10(4):104–10.
Cited by
Sorted by citations
The global burden of chronic urticaria for the patient and society*
Gonçalo, M., Giménez-Arnau, A. M., Al-Ahmad, M. S., Ben‐Shoshan, M., Bernstein, J. A., Ensina, L. F., Fomina, D. S., Galván, C. A., Godse, K. V., Grattan, C. E. H., et al. (2020) · British Journal of Dermatology · doi:10.1111/bjd.19561 · Cited by 387
Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
Maurer, M., Eyerich, K., Eyerich, S., Ferrer, M., Gutermuth, J., Hartmann, K., Jakob, T., Kapp, A., Kolkhir, P., Larenas‐Linnemann, D. E., et al. (2020) · International Archives of Allergy and Immunology · doi:10.1159/000507218 · Cited by 186
Predictors of treatment response in chronic spontaneous urticaria
Fok, J. S., Kolkhir, P., Church, M. K., & Maurer, M. (2021) · Allergy · doi:10.1111/all.14757 · Cited by 164
Kolkhir, P., Bonnekoh, H., Metz, M., & Maurer, M. (2024) · JAMA · doi:10.1001/jama.2024.15568 · Cited by 156
Sánchez‐Borges, M., Ansotegui, I. J., Baiardini, I., Bernstein, J., Canonica, G. W., Ebisawa, M., Gómez, M. R., Díaz, S. N. G., Martin, B. L., Morais‐Almeida, M., et al. (2021) · World Allergy Organization Journal · doi:10.1016/j.waojou.2021.100533 · Cited by 138
Metadata
- Authors
- Konstantinou, G. N., & Konstantinou, G. N.
- Affiliations
- Hellenic Air Force (GR)
- Venue
- Clinical and Translational Allergy
- Publisher
- Wiley
- Published
- 2019-08-23
- Volume
- 9
- Issue
- 1
- Pages
- 42-42
- ISSN
- 2045-7022 (ISSN-L)
- PMC
- PMC6706894
- OpenAlex
- W2969929864
- Cited by
- 110
- References
- 66
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 9
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical and Translational Allergy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Urticaria and Related Conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- chronic urticaria, psychiatric comorbidity, mental illness, depression, anxiety, antidepressants, anxiolytics, psychological intervention, urticaria severity, multidisciplinary care
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
