Cited by 129Autoimmune Neurological Disorders and TreatmentsPeripheral Neuropathies and DisordersCancer Immunotherapy and Biomarkers

Psychiatric Manifestations of Paraneoplastic Disorders

Kayser, Matthew S., Kohler, Christian G., Dalmau, Josep·2010·American Journal of Psychiatry

Abstract

Paraneoplastic disorders of the CNS result from immune responses to neuronal proteins expressed by tumors found elsewhere in the body. Limbic encephalitis, one of the most common manifestations of paraneoplastic disorders, is characterized by rapid onset of psychiatric and neurological symptoms that often culminate in severe neurological deterioration. Recent work has described paraneoplastic syndromes with prominent, and sometimes isolated, psychiatric symptoms for which patients are fi rst seen by a psychiatrist. Here the authors review the existing literature on psychiatric and behavioral manifestations of paraneoplastic disorders, the cellular mechanisms underlying these syndromes, and current treatment and outcomes. They also discuss the broad behavioral findings that highlight the need for psychiatrists to be aware of initial presentations of paraneoplastic disorders.

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Crossref · 10.1176/appi.ajp.2010.09101547

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90 of 90 references verified0 citation errors · 0 not checkable

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Authors
Kayser, M. S., Kohler, C. G., & Dalmau, J.
Affiliations
University of Pennsylvania (US)
Venue
American Journal of Psychiatry
Published
2010-09
Volume
167
Issue
9
Pages
1039-1050
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2145155354
Cited by
129
References
90
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 9 · 2022: 10 · 2021: 2 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 14 · 2012: 13
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (R01CA89054-06A2, R01CA089054, R01CA107192)
Topics
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
paraneoplastic syndrome, psychiatric symptoms, behavioral manifestations, limbic encephalitis, autoimmune encephalitis, tumor-associated immune response, neurological deterioration, psychiatric treatment
MeSH terms
Autoantibodies, Autoimmune Diseases, Mental Disorders, Diagnosis, Differential, Humans, Nerve Tissue Proteins, Paraneoplastic Syndromes, Nervous System, Limbic Encephalitis, ELAV Proteins

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