Psychiatric Manifestations of Paraneoplastic Disorders
Abstract
Paraneoplastic disorders of the CNS result from immune responses to neuronal proteins expressed by tumors found elsewhere in the body. Limbic encephalitis, one of the most common manifestations of paraneoplastic disorders, is characterized by rapid onset of psychiatric and neurological symptoms that often culminate in severe neurological deterioration. Recent work has described paraneoplastic syndromes with prominent, and sometimes isolated, psychiatric symptoms for which patients are fi rst seen by a psychiatrist. Here the authors review the existing literature on psychiatric and behavioral manifestations of paraneoplastic disorders, the cellular mechanisms underlying these syndromes, and current treatment and outcomes. They also discuss the broad behavioral findings that highlight the need for psychiatrists to be aware of initial presentations of paraneoplastic disorders.
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Previous studies have shown that stress may play a role in CSU onset.
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- Authors
- Kayser, M. S., Kohler, C. G., & Dalmau, J.
- Affiliations
- University of Pennsylvania (US)
- Venue
- American Journal of Psychiatry
- Published
- 2010-09
- Volume
- 167
- Issue
- 9
- Pages
- 1039-1050
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2145155354
- Cited by
- 129
- References
- 90
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 9 · 2022: 10 · 2021: 2 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 11 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 14 · 2012: 13
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA89054-06A2, R01CA089054, R01CA107192)
- Topics
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- paraneoplastic syndrome, psychiatric symptoms, behavioral manifestations, limbic encephalitis, autoimmune encephalitis, tumor-associated immune response, neurological deterioration, psychiatric treatment
- MeSH terms
- Autoantibodies, Autoimmune Diseases, Mental Disorders, Diagnosis, Differential, Humans, Nerve Tissue Proteins, Paraneoplastic Syndromes, Nervous System, Limbic Encephalitis, ELAV Proteins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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